• In these stimuli, spatial frequency is expressed as the number of cycles per degree of visual angle. (wikipedia.org)
  • Measuring both contrast threshold and contrast sensitivity is possible using both periodic and non-periodic stimuli, with the former a measurement performed in the spatial frequency domain and the latter a measurement performed in the space domain. (scielo.br)
  • However, some recent studies also support the possibility that the effects attributed to deficits in frequency selectivity and temporal processing in hearing-impaired listeners may in fact result from abnormal rates of growth of response to acoustic stimuli in the impaired ear. (nih.gov)
  • Let us assume that we want to explore the human contrast sensitivity function and need to generate appropriate sinewave-grating stimuli on a CRT. (michaelbach.de)
  • To evaluate whether the full-field flicker test, a psychophysical test employing full-field flickering stimuli to measure temporal contrast sensitivity, can detect glaucomatous optic nerve damage in patients with increased intraocular pressure and glaucomatous optic disk abnormalities but normal visual fields. (nih.gov)
  • The contrast sensitivity stimuli were horizontally orientated Gabor patches (0.5 octave bandpass) with carrier frequencies of 0.25 - 2.8 c/deg, which were presented for 140 msec duration. (arvojournals.org)
  • With stimuli of 1 or 2 c/deg, the losses in contrast sensitivity usually preceded losses by standard perimetry and the depth of high frequency defects became unmmeasurable if the standard perimetry defect exceeded about 12 dB. (arvojournals.org)
  • It's a simple test - cover one eye, once we know your visual acuity (being able to see better than 20/50), and we look at this patented, published device, a card that has 5 different frequencies of stimuli (called bars), with 9 different patches for each of the five frequencies. (publichealthalert.org)
  • Sensory-processing sensitivity (SPS) is a temperamental trait that describes individual differences in sensitivity to environmental stimuli. (researchgate.net)
  • The stimuli were shown at three spatial frequencies (0.5, 1 and 2 c/deg). (psych.ac.cn)
  • We have conducted a series of psychophysical experiments to explore contrast sensitivity using a state-of-the-art HDR display, taking into account not only the spatial frequency and luminance of the stimuli but also their surrounding luminance levels. (kaist.ac.kr)
  • Five spatial frequency stimuli were applied to the right, left and both eyes in order to assess the visual processing of patients with sports-related mild traumatic brain injuries who exhibited visual abnormalities, i.e., photophobia, blurriness, etc., and controls. (mdpi.com)
  • We examined in vitro frequency versus current (f-I) relationships of layer 5 (L5) pyramidal cells of the rat medial prefrontal cortex (mPFC) using fluctuating stimuli. (sissa.it)
  • In the study of visual perception, sinusoidal gratings are frequently used to probe the capabilities of the visual system, such as contrast sensitivity. (wikipedia.org)
  • The theory (for which empirical support has yet to be developed) states that in each functional module of the visual cortex, Fourier analysis (or its piecewise form ) is performed on the receptive field and the neurons in each module are thought to respond selectively to various orientations and frequencies of sine wave gratings. (wikipedia.org)
  • Contrast sensitivity to sine-wave gratings of low spatial frequencies in children. (bvsalud.org)
  • Contrast sensitivities for horizontal and vertical gratings at spatial frequencies ranging from 1 to 8 cycles per degree (cpd) were measured immediately before and after adaptation to +3.00 diopters cylinder (DC) with-the-rule or against-the-rule astigmatism. (nova.edu)
  • In with-the-rule conditions, contrast sensitivity for horizontal gratings was significantly increased, whereas that for vertical gratings was significantly decreased. (nova.edu)
  • Similarly, in against-the-rule conditions, contrast sensitivity for vertical gratings was significantly increased, whereas that for horizontal gratings was significantly decreased. (nova.edu)
  • Subjects viewed sinusoidal gratings of various spatial frequencies, orientations, and contrasts. (brad.ac.uk)
  • Results: Contrast sensitivity to drifting gratings of very low spatial and temporal frequency was greatly impaired yet measurable in all patients. (pisavisionlab.org)
  • Many people have visual acuity that is better than 20/20, and real-world visual performance also includes low-contrast objects under low or high illumination. (medscape.com)
  • Some features are conserved across species as a shape of the function, but other features, such as the contrast sensitivity peak value, spatial frequency contrast sensitivity peak, and visual acuity have changed. (scielo.br)
  • Here, we review contrast sensitivity across different classes of vertebrates, with an emphasis on the frequency contrast sensitivity peak and visual acuity. (scielo.br)
  • We also correlate the data obtained from the literature to test the power of the association between visual acuity and the spatial frequency of the contrast sensitivity function peak. (scielo.br)
  • We administered to this now adult study population vision tests to assess acuity, contrast sensitivity, and color discrimination. (nih.gov)
  • Introduction Contrast sensitivity function (CSF) may better estimate a patient's visual function compared with visual acuity (VA). Our study evaluates the quick CSF (qCSF) method to measure visual function in eyes with macular disease and good letter acuity. (bmj.com)
  • Acuity and Contrast Sensitivity of Infant Vision. (pucrs.br)
  • Visual acuity charts only measure the eases, history of previous ocular surgery high frequency component of the contrast or photocoagulation and systemic diseases sensitivity function and are markedly af- other than diabetes. (who.int)
  • Afterwards, the best corrected ocular diseases, including optic neuritis and visual acuity was determined on a subjec- glaucoma, where contrast sensitivity can be tive basis. (who.int)
  • The chart luminance was regularly checked acuity and Cambridge low-contrast grating using a spot photometer. (who.int)
  • We measured the serum superoxide dismutase (SOD) activity, an important marker of antioxidant defense, best-corrected visual acuity (BCVA), contrast sensitivity, and Chinese-Version Low Vision Quality of Life (CLVQOL) before and after LA or placebo intervention. (go.jp)
  • Contrast sensitivity was tested with best spectacle-corrected visual acuity preoperatively and 3, 6, 12, 18, and 24 months postoperatively. (bvsalud.org)
  • An examination of visual acuity, contrast sensitivity, stereoacuity and flashlight illuminance levels was also performed in 16 of the 23 speleologists at two caves deprived of natural lightning. (usf.edu)
  • His work is dedicated to discovering how Contrast, Visual acuity are connected with Optometry and other disciplines. (research.com)
  • In his study, Age related, Stereoscopic acuity, Stereopsis and Spatial frequency is inextricably linked to Audiology, which falls within the broad field of Monocular. (research.com)
  • His work deals with themes such as Emmetropia, Visual acuity, Binocular vision and Contrast, which intersect with Monocular. (research.com)
  • Differences in visual acuity, contrast sensitivity, and macular thickness were evaluated. (ucm.es)
  • Visual acuity was also related to a lower M100 latency and a greater power time-frequency cluster in the high-risk group. (ucm.es)
  • In most cases, these spatial distortions arose at spatial frequencies far below the contrast detection acuity cutoff. (brad.ac.uk)
  • Spatial luminance contrast or simultaneous luminance contrast stands in the domain of space, as opposed to temporal luminance contrast or successive luminance contrast, which stands in the domain of time. (scielo.br)
  • Temporal expectation enhances contrast sensitivity by phase entrainment of low-frequency oscillations in visual cortex. (ox.ac.uk)
  • In the present study, we combined a psychophysical paradigm with electrophysiological recordings to investigate the putative contribution of low-frequency oscillatory activity in mediating the modulation of visual perception by temporal expectation. (ox.ac.uk)
  • Psychophysical results indicated that temporal expectation enhanced the contrast sensitivity of visual targets. (ox.ac.uk)
  • In all participants, poorer visual contrast sensitivity was significantly associated with amyloid and tau deposits in certain parts of the brain, as well as a lower temporal lobe volume. (nih.gov)
  • No second-order motion system sensitive to high temporal frequencies. (pucrs.br)
  • Early studies have shown that both frequency and temporal resolution are poorer in listeners with sensorineural hearing loss than in listeners with normal hearing. (nih.gov)
  • Temporal contrast sensitivity was determined with a sinusoidally flickering light (frequency, 37.1 Hz) of constant mean photopic luminance (10 cd/m2) presented in a full-field bowl of 58-cm diameter. (nih.gov)
  • A relative loss of spatial contrast sensitivity has been suggested as an early sign of optic neuropathy from glaucoma, but the effects of spatial frequency have not been studied systematically. (arvojournals.org)
  • The purpose of the present study was to investigate the alterations of spatial contrast sensitivity functions in areas with depressed visual sensitivity from glaucoma. (arvojournals.org)
  • By behavioral testing, perimetry by standard clinical procedures and by contrast sensitivity measurements were assessed over the time course of the development of visual field defects from experimental glaucoma in six rhesus monkeys. (arvojournals.org)
  • Early visual field defects from glaucoma represent selective spatial frequency effects where the losses of contrast sensitivity at high spatial frequencies precede losses at lower spatial frequencies. (arvojournals.org)
  • Lowered sensitivity of spatial contrast, decreased color discrimination, oculomotor control abnormalities, diplopia, dry eye illness, visual hallucinations (VHs), and open-angle glaucoma have been reported in PD. (beingmedicos.com)
  • Methylmercury-exposed monkeys exhibited reduced contrast sensitivity thresholds, particularly at the higher spatial frequencies. (nih.gov)
  • Reductions in CS thresholds were most notable at low and intermediate spatial frequencies (1.5 cpd, 3 cpd and 6 cpd). (bmj.com)
  • We measured detection thresholds in each eye independently for a large number of test and mask spatial frequencies. (nyu.edu)
  • For each test spatial frequency, detection thresholds were elevated in the presence of the mask. (nyu.edu)
  • Spatial contrast sensitivities were determined for locations at 3x3 deg, 9x9 deg and 15x15 deg in each visual field quadrant. (arvojournals.org)
  • The spatial frequency effects were evaluated via a fitted low-pass model for spatial contrast sensitivity functions. (arvojournals.org)
  • The luminance contrast sensitivity function has been investigated using behavioral and electrophysiological methods in many vertebrate species. (scielo.br)
  • Based on these findings, the authors suggest that visual contrast sensitivity may detect very early-stage Alzheimer's more easily, less invasively and less expensively than current imaging and spinal-tap methods. (nih.gov)
  • In contrast to some former studies, -514T allele affected triglyceride levels and insulin sensitivity. (nih.gov)
  • Moreover, since HL and adiponectin showed an additive effect on insulin sensitivity, these genetic variations can be independently associated with insulin sensitivity. (nih.gov)
  • They found that average insulin sensitivity gradually fell for the metformin and metformin plus lifestyle groups, while for the metformin plus rosiglitazone group it improved significantly in the first six months of the trial, but later gradually fell back to initial levels. (nih.gov)
  • Thus, at the end of the trial, average insulin sensitivity among those youth getting both medicines was about where it began, but it had worsened among those getting just metformin or metformin plus lifestyle. (nih.gov)
  • Results: Participants exposed to higher PCE levels exhibited lower contrast sensitivity at intermediate and high spatial frequencies compared with unexposed participants, although the differences were generally not statistically significant. (nih.gov)
  • Contrast sensitivity has been found to be reduced, particularly at intermediate and high frequencies in central and peripheral regions. (beingmedicos.com)
  • Additionally, some data suggest that the hearing-impaired subjects' poor performance can be explained largely on the basis of differences in audibility due to decreased hearing sensitivity, masking effects, and/or speech presentation level. (nih.gov)
  • Recall, for example, that we have greater sensitivity to differences in dark versus light. (telestream.net)
  • When the first postoperative examination was not considered, there were no statistically significant differences in contrast sensitivity values at different postoperative periods . (bvsalud.org)
  • We show that there is an interocular delay in anisomyopia and myopia in the range of low spatial frequencies. (psych.ac.cn)
  • Research on spatial frequency detection by visual neurons complements and extends previous research using straight edges rather than refuting it. (wikipedia.org)
  • In an effort to reveal the structure underlying the spatial vision deficits associated with strabismic amblyopea, we measured the performance of monkeys (Macaca nemestrina) with experimental strabismus in a contrast detection task with oblique masks. (nyu.edu)
  • The sensitivity of grey scale ultrasound (US) for the detection of CD disease activity of the terminal ileum ranges from 63% to 100%, with a specificity in the range of 77-100% [ 8 , 12 - 15 ]. (plos.org)
  • MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. (nih.gov)
  • One study has suggested that this UV sensitivity detects a greater contrast between the upper and lower surfaces of leaves in dense foliage, making each leaf's position and orientation stand out very clearly. (bindt.org)
  • abstract = "Sensitivity encoding (SENSE) and partial Fourier (PF) techniques both reduce MRI acquisition time. (elsevierpure.com)
  • The correlation between contrast sensitivity and macular thickness, and the electrophysiological measures were not significant after correction. (ucm.es)
  • Together, these results show a strong correspondence between psychophysical and neurophysiological data, suggesting that the phase entrainment of low-frequency oscillations to external sensory cues can serve as an important and flexible mechanism for enhancing sensory processing. (ox.ac.uk)
  • RESULTS: Adapting to astigmatic blur enhanced contrast sensitivity at the blurred power meridian but reduced contrast sensitivity at the least affected axis meridian. (nova.edu)
  • This pattern of results is consistent with the idea that the tests are detected by a discrete number of channels tuned to a narrow range of spatial frequencies. (nyu.edu)
  • Contrast-enhanced MR angiography (CE-MRA) results from experiments using four receiver coils in phantom and volunteer studies are shown. (elsevierpure.com)
  • In contrast, our results show that mPFC L5 pyramidal neurons retain an increased sensitivity to input fluctuations, whereas their sensitivity to the input mean diminishes to near zero. (sissa.it)
  • In particular, we quantify how the force sensitivity is affected by dynamical back-action, Joule heating and frequency noise upon increasing the number of pump photons inside the cavity. (nature.com)
  • Pearson correlation coefficients were calculated to explore the relationship between contrast sensitivity values and CLVQOL scores. (go.jp)
  • Sensitivity and specificity values of MRE and CEUS were compared by the McNemar test. (plos.org)
  • Optimal diagnostic accuracy in CEUS was obtained at a peak intensity value of 10%, showing 100% sensitivity, 92% specificity and an accuracy of 99% in demonstrating ileal mucosal inflammation. (plos.org)
  • Objectives: Using a population-based retrospective cohort study, we examined the association between prenatal and early childhood exposure to PCE-contaminated drinking water on Cape Cod, Massachusetts, and deficits in adult color vision and contrast sensitivity. (nih.gov)
  • Brief exposure to astigmatic blur altered contrast sensitivity in the opposite direction at the two principal meridians, indicating that the mature visual system possesses functional plasticity to recalibrate the response characteristics of orientationally tuned cortical filters and thus promote substantial reductions of meridional anisotropy in astigmatic vision, to some extent counterbalancing the elongated oval shape of astigmatic blur. (nova.edu)
  • While hypertension does not alter responses of vagally-mediated heart rate variability to cold, it is not known how hypertension modifies baroreflex sensitivity (BRS) and blood pressure variability during cold exposure. (frontiersin.org)
  • The degree of image receptor sensitivity determines appropriate exposure setting reductions to produce images with adequate density and contrast necessary for diagnosis. (dimensionsofdentalhygiene.com)
  • The spatial-frequency theory refers to the theory that the visual cortex operates on a code of spatial frequency, not on the code of straight edges and lines hypothesised by Hubel and Wiesel on the basis of early experiments on V1 neurons in the cat. (wikipedia.org)
  • Most neurons in the primary visual cortex respond best when a sine-wave grating of a particular frequency is presented at a particular angle in a particular location in the visual field. (wikipedia.org)
  • The present review emphasizes findings regarding the visual system processing of spatial luminance distribution at very low contrast levels. (scielo.br)
  • Two measurements of luminance contrast are frequently used in spatial vision: contrast threshold and contrast sensitivity. (scielo.br)
  • Visual impairment was evaluated by means of psychophysical testing, where patient were asked to discriminate the drifting direction of a contrast modulated grating. (pisavisionlab.org)
  • Monocular and binocular VCS values were significantly lower at all spatial frequencies among AFSHS employees. (cdc.gov)
  • The researchers wanted to know if a test for impaired visual contrast sensitivity could detect Alzheimer's when amyloid and tau abnormalities are just beginning to occur in the brain. (nih.gov)
  • The spatial frequency is a measure of how often sinusoidal components (as determined by the Fourier transform) of the structure repeat per unit of distance. (wikipedia.org)
  • MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. (nih.gov)
  • We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. (nih.gov)
  • Built on OmniVision's advanced PureCel pixel architecture, the OS08A10 leverages backside illumination (BSI) technology with improved low-light sensitivity to deliver high-resolution images and capture ultra-high-resolution 4K2K video, even in challenging high-contrast lighting conditions. (camera-module.com)
  • Scientists have worked on increasing the sensitivity of MRI, image contrast and spatial resolution. (ma-eir.nl)
  • T allele frequency was much higher than in Caucasian subjects. (nih.gov)
  • The contrast sensitivity measured at middle and low spatial frequency was significantly higher after LA treatment. (go.jp)
  • In NDT we also use ultraviolet light in the augmentation of the dye penetrant process: fluorescent dye is stimulated by an ultraviolet lamp, allowing a higher sensitivity inspection compared to standard red dye. (bindt.org)
  • Most of the vowels fall below about 2.0 kHz, while the higher frequencies mainly contain consonants. (theconversation.com)
  • However, a consequence of a larger static magnetic field B0 is a higher Larmor frequency and a shorter wavelength. (ma-eir.nl)
  • Errors in perception became more severe at higher spatial frequencies, with low spatial frequencies being mostly perceived veridically. (brad.ac.uk)
  • Contrast had a much smaller effect on misperceptions, although there were cases in which severity was greater at higher contrasts. (brad.ac.uk)
  • Early symptoms may be loss of contrast, glare (ie, halos and starbursts around lights, not photophobia), needing more light to see well, and problems distinguishing dark blue from black. (msdmanuals.com)
  • Health hazard evaluation report: HETA-2005-0135-3116, comparison of mold exposures, work-related symptoms, and visual contrast sensitivity between employees at a severely water-damaged school and employees at a school without significant water damage, Alcee Fortier Senior High School, New Orleans. (cdc.gov)
  • To test this hypothesis, we conducted a cross-sectional study on 358 adults who completed a survey that included self-report measures of sensitivity, perceived stress, sleep reactivity, and insomnia symptoms. (researchgate.net)
  • This compares with our lower capabilities based on green frequencies. (bindt.org)
  • Such wavefields allow for large magnification factors that, according to current imaging capabilities, will allow for nanoradian angular sensitivity and nanoscale sample projection imaging. (iucr.org)
  • Striate cortical thickness did not correlate with visual sensitivity. (pisavisionlab.org)
  • Abnormal contrast sensitivity was ob- retinopathy, mild, moderate, severe, or very served in 27.1% of eyes with diabetic retin- severe non-proliferative diabetic retinopa- opathy, compared with 9.0% in unaffected thy (NPDR), early proliferative diabetic eyes. (who.int)
  • Importantly, patients with less severe impairment of contrast sensitivity showed stronger V1 BOLD responses. (pisavisionlab.org)
  • Significant improved contrast sensitivity was observed with 450 nm filters for 6 cpd (p = 0.034) and 18 cpd (p = 0.026) spatial frequencies. (usf.edu)
  • High-risk groups presented trends towards a greater contrast sensitivity that did not remain significant after correction for multiple comparisons. (ucm.es)
  • Given the significant carrier frequency for ABCA4 alleles, reaching as much as 5-10% in the general population, the association between ABCA4 variants and retinal pathology is now broader than previously thought. (eyewiki.org)
  • The threshold evaluations showed a peak for a particular spatial frequency that was typically similar to the test spatial frequency. (nyu.edu)
  • One of the major concerns about the increasing frequency with which type 2 diabetes is appearing in young people is that data from studies in adults show that the onset and severity of diabetes complications correlate with the duration of the disease. (nih.gov)
  • 10. [Critical (foveal) flicker fusion frequency (CFF) is helpful in differential diagnosis of organic lesions from orthoptic amblyopias]. (nih.gov)
  • 17. The efficacy of microperimetry and contrast sensitivity test in the diagnosis of optic chiasm compression due to pituitary adenomas. (nih.gov)
  • In mathematics, physics, and engineering, spatial frequency is a characteristic of any structure that is periodic across position in space. (wikipedia.org)
  • Part of the Frequency family of lenses, Frequency 38 Sphere is a great choice when your eye care practitioner recommends a lower water content lens. (flatbushoptical.com)
  • Frequency 38 lenses' lower water-content material ensures superior handling, while patented UltraSync® manufacturing and a superior lens design work together to give you outstanding comfort and performance. (flatbushoptical.com)
  • This increased frequency complicates RF electronics and detector design and therefore the technology developed for lower fields such as 3 Tesla is difficult to adapt and transfer directly to the ultra-high field 7 Tesla. (ma-eir.nl)
  • Larger studies are needed to further test visual contrast sensitivity as a potential biomarker for Alzheimer's and to probe the underlying biological causes of eye changes in people with the disease. (nih.gov)
  • On each test session, a single spatial frequency was presented across five levels of contrast, each differing by 3 dB. (nih.gov)
  • One of the nice things, thanks to work done by a neurotoxicologist at the U.S.E.P.A. (United States Environmental Protection Agency) and the National Health and Environmental Effects Research Lab, particular deficits can be identified with a special test called Visual Contrast Sensitivity (VCS). (publichealthalert.org)
  • His Contrast research incorporates elements of Vision test and Spatial frequency. (research.com)
  • it also includes a special contrast sensitivity test. (eu5.net)
  • The force sensitivity in these ultra-light resonators is often limited by the imprecision in the measurement of the vibrations, the fluctuations of the mechanical resonant frequency and the heating induced by the measurement. (nature.com)
  • The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex / Arsiero, M. (sissa.it)
  • The following information was recorded on a standard paper collection form: 1) the presence of liver-to-kidney contrast 2) the degree of the brightness of the liver parenchyma, 3) the presence of deep beam attenuation, 4) the presence of echogenic walls in the small intrahepatic vessels, and 5) the definition of the gallbladder walls. (cdc.gov)
  • Physiological effects have been observed in a human subject in response to stimulation of the skin with weak electromagnetic fields that are pulsed with certain frequencies near ½ Hz or 2.4 Hz, such as to excite a sensory resonance. (google.com)
  • A forced-choice tracking procedure was utilized with spatial frequencies of 1, 4, 10, and 20 cycles per degree of visual angle. (nih.gov)
  • In the first study, researchers from the Indiana Alzheimer Disease Center , Indianapolis, assessed visual contrast sensitivity - the ability to distinguish objects from their background - in 74 older adults, including 31 cognitively healthy individuals and others at various stages of cognitive impairment. (nih.gov)
  • Artificial intelligence, Computer vision, Contrast, Optics and Spatial frequency are his primary areas of study. (research.com)
  • The Spatial frequency study combines topics in areas such as Motion perception, Acoustics and Masking. (research.com)
  • Here we study the force sensitivity of multilayer graphene mechanical resonators coupled to superconducting cavities. (nature.com)
  • Purpose: We evaluated the potential of magnetic resonance imaging in identifying signs of cortical visual processing with greater sensitivity than standard ophthalmological measures in RP patients at advanced stage. (pisavisionlab.org)
  • To prospectively examine the feasibility and accuracy of Contrast Enhanced Ultrasound (CEUS) in the assessment of Crohn's disease (CD) activity in the terminal ileum in comparison to Magnetic Resonance Enterography (MRE), using endoscopy as a reference standard. (plos.org)
  • Horjus Talabur Horje CS, Bruijnen R, Roovers L, Groenen MJM, Joosten FBM, Wahab PJ (2015) Contrast Enhanced Abdominal Ultrasound in the Assessment of Ileal Inflammation in Crohn's Disease: A Comparison with MR Enterography. (plos.org)
  • Contrast enhanced ultrasound (CEUS) with new intravenous contrast agents allows visualisation of bowel wall perfusion. (plos.org)
  • Taken together, HL gene might be one of the important susceptibility genes of type 2 diabetes and the high incidence of type 2 diabetes could be explained by high frequency of -514T allele in the Japanese population. (nih.gov)
  • Examples include the T1428M allele which, although extremely rare in populations of European descent, is rather frequent in the Japanese with an estimated frequency of approximately 8%, and the G863A/delG863 allele, which is currently considered a founder mutation in Northern Europe. (eyewiki.org)
  • 1. Usefulness of critical flicker fusion frequency measurement and its laterality for evaluating compressive optic neuropathy due to pituitary neuroendocrine tumors. (nih.gov)