• Friedreich's
  • frataxin absence is associated with overexpression of cell death-related genes, cell cycle arrest and oxidative related genes, as well as DNMT1, supporting the notion that DNA repair and epigenetic mechanisms are implicated in Friedreich's ataxia disease. (nih.gov)
  • nucleotide
  • Using the concept of "intermediate bubble NSC 74859 says" and our recently established criterion for DNA base pair "thickness" through the base pairs common displacement (BAD) characteristic we compare the breathing dynamics of TRS against random sequences with identical nucleotide composition as well as repeats with different lengths and G/C content. (cancer-basics.com)
  • onset
  • In compound heterozygotes, expression of partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to those with no frataxin expression from the non-expanded allele. (nih.gov)
  • transcription
  • We record that repeats possess the to hinder the binding of transcription elements with their consensus series by changed DNA inhaling and exhaling dynamics in closeness from the binding sites. (cancer-basics.com)
  • genomic
  • Trinucleotide repeats sequences (TRS) represent a common type of genomic DNA theme whose enlargement is connected with a lot of individual diseases. (cancer-basics.com)
  • The trinucleotide repeats sequences (TRS) represent the most common type of tandem microsatellites in the vertebrate genomic DNA. (cancer-basics.com)
  • It is likely that the local base pair dynamics may display some sequence and number of repeats specificity that could underline the propensity for growth and possibly alteration in genomic DNA functions. (cancer-basics.com)
  • precursor
  • The collective propensity for DNA strand parting of repeated sequences acts as a precursor for outsized intermediate bubble expresses independently from the G/C-content. (cancer-basics.com)
  • iron
  • The function of frataxin is not entirely clear, but it seems to be involved in assembly of iron-sulfur clusters. (wikipedia.org)