DNA FragmentationApoptosisCaspasesCaspase 3Apoptosis Regulatory ProteinsProto-Oncogene Proteins c-bcl-2In Situ Nick-End LabelingInhibitor of Apoptosis Proteinsbcl-2-Associated X ProteinCaspase InhibitorsCell SurvivalCell Line, TumorMitochondriaApoptosis Inducing FactorX-Linked Inhibitor of Apoptosis ProteinCaspase 9Enzyme ActivationSignal TransductionCytochromes cCells, CulturedCaspase 8Tumor Cells, CulturedCASP8 and FADD-Like Apoptosis Regulating ProteinAmino Acid Chloromethyl KetonesAnnexin A5Tumor Suppressor Protein p53Fas Ligand ProteinCysteine Proteinase Inhibitorsbcl-X ProteinPoly(ADP-ribose) PolymerasesCell LineCell DeathBlotting, WesternFlow CytometryCell ProliferationHL-60 CellsCell CycleProto-Oncogene ProteinsReactive Oxygen SpeciesAntineoplastic AgentsEnzyme InhibitorsDNA DamageMembrane Potential, MitochondrialCaspase 7Jurkat CellsCell DivisionNecrosisDose-Response Relationship, DrugTime FactorsTransfectionCytochrome c GroupGenes, bcl-2StaurosporineRNA, Small InterferingTNF-Related Apoptosis-Inducing LigandDown-RegulationTumor Necrosis Factor-alphaPhosphorylationSpectrometry, Mass, Electrospray IonizationCell Nucleusbcl-2 Homologous Antagonist-Killer ProteinRNA, MessengerMembrane GlycoproteinsHeLa CellsAntineoplastic Agents, PhytogenicOxidative StressUp-RegulationCysteine EndopeptidasesMice, Inbred C57BLBH3 Interacting Domain Death Agonist ProteinMolecular Sequence DataProto-Oncogene Proteins c-aktReverse Transcriptase Polymerase Chain ReactionCeramidesNF-kappa BMyeloid Cell Leukemia Sequence 1 Proteinbcl-Associated Death ProteinCaspase 2ProteinsPhosphatidylserinesDNACarrier ProteinsProtein-Serine-Threonine KinasesMembrane ProteinsImmunohistochemistryHydrogen PeroxideMice, KnockoutCaspase 1Gene Expression Regulation, NeoplasticDrug SynergismGene Expression RegulationModels, BiologicalRNA InterferenceGene ExpressionNeoplasm ProteinsRats, Sprague-DawleyU937 CellsMutationElectrophoresis, Agar GelMitogen-Activated Protein Kinases