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  • atypical
  • Two separate studies by researchers from Hospital for Special Surgery (HSS) and Columbia University Medical Center revealed data suggesting that long-term suppression of bone remodeling by bisphosphonate treatments may alter the material properties of bone, potentially affecting the bone's mechanical integrity and potentially contributing to the risk of atypical fractures. (healthcanal.com)
  • Recent research suggests that suppressed bone remodeling from long-term bisphosphonate use might result in brittle bone that is prone to atypical fractures," said Gladnick. (healthcanal.com)
  • The study found that, although there were no differences in bone micro-architecture between groups, the material properties of bone in bisphosphonate-treated patients displayed reduced bone tissue heterogeneity, which may be associated with reduced strength and potentially may contribute to the presentation of atypical fractures. (healthcanal.com)
  • This tells us that there may be some measurable differences in bone quality parameters in patients on long-term bisphosphonate therapy, which might contribute to the development of atypical fractures. (healthcanal.com)
  • Heterotopic ossification is a process resulting in the formation of bone tissue that is often atypical, at an extraskeletal location. (wikipedia.org)
  • soft tissue
  • Due to soft tissue tightness and poor regenerative ability in the affected limb, cautions should be taken to prevent regenerate fracture and/or malalignment of the limb. (hindawi.com)
  • Prior to realignment and splinting an assessment is performed to ensure there are no open wounds, soft-tissue contusions, or neurovascular injuries. (wikipedia.org)
  • 3. Massive soft tissue injury. (saiorthocare.com)
  • Decomposition in animals is a process that begins immediately after death and involves the destruction of soft tissue, leaving behind skeletonized remains. (wikipedia.org)
  • The chemical process of decomposition is complex and involves the breakdown of soft tissue, as the body passes through the sequential stages of decomposition. (wikipedia.org)
  • The decomposition of soft tissue is characterized by the breakdown of these macromolecules, and thus a large proportion of the decomposition products should reflect the amount of protein and fat content initially present in the body. (wikipedia.org)
  • During the early stages of decomposition, soft tissue proteins are broken down. (wikipedia.org)
  • skull
  • Intramembranous ossification forms the flat bones of the skull, clavicle and mandible. (wikipedia.org)
  • Cranial deficiencies are marked by the presence of having a long skull relative to its width, or protrusive foreheads due to increased thickness of the cranial bones and premature closing of the associated sutures in the skull. (wikipedia.org)
  • In the skull, individual bones may calcify only at their centers. (wikipedia.org)
  • A trephine is an instrument used for cutting out a round piece of skull bone. (wikipedia.org)
  • Evidence also suggests that trepanation was primitive emergency surgery after head wounds to remove shattered bits of bone from a fractured skull and clean out the blood that often pools under the skull after a blow to the head. (wikipedia.org)
  • There is significant evidence of healing of the bones of the skull in prehistoric skeletons, suggesting that many of those that proceeded with the surgery survived their operation. (wikipedia.org)
  • Orthopaedics
  • Safe Orthopaedics commenced full launch of its SteriSpineā„¢ kyphoplasty system, used for vertebral augmentation.The system consists of vertebral augmentation balloon and injectable cement, along with implants for post-fracture stabilizing. (orthoworld.com)
  • brittle
  • Other symptoms include heart palpitations, increased cholesterol levels, slowed pulse rates, insomnia, brittle nails and eczema. (nkfs.org)
  • Muscles
  • This type of pain can be somatic, meaning it's associated with musculoskeletal elements of the body like skin, muscles, and bones. (inquisitr.com)
  • It is essential to form and maintain bones and teeth, and needed for normal functioning of muscles, clotting of blood and transmitting nerve signals. (nkfs.org)
  • Sharp pain when any movement is made Referred pain: dull to extreme ache in and around clavicle area, including surrounding muscles Possible nausea, dizziness, and/or spotty vision due to extreme pain Clavicle fractures are commonly known as a breaking of the collarbone, and they are usually a result of injury or trauma. (wikipedia.org)
  • The adductor muscles of the arm, such as the pectoralis major, may pull the distal fragment medially, causing the bone fragments to override. (wikipedia.org)
  • osteoporosis
  • Researchers at Columbia evaluated the bone structure of 111 postmenopausal women with primary osteoporosis, 61 of whom had been taking bisphosphonates for a minimum of four years and 50 controls taking calcium and vitamin D supplements. (healthcanal.com)
  • The investigators added that more research is needed to determine the true efficacy of the long-term clinical use of bisphosphonates for the treatment of osteoporosis, and that the results of their studies will not likely affect clinical practice in the near future. (healthcanal.com)
  • distal
  • The cause of this disease is a mutation in the DLX3 (distal-less 3) gene, which controls hair follicle differentiation and induction of bone formation. (wikipedia.org)
  • scar tissue
  • It results in the formation of scar tissue and produces a characteristic gait where the horse prematurely "slaps" the ground with its hind foot, shortening the stride length in the damaged leg. (wikipedia.org)
  • medullary cavity
  • A perichondrium layer surrounding the cartilage forms the periosteum, which generates osteogenic cells that then go on to make a collar that encircles the outside of the bone and remodels the medullary cavity on the inside. (wikipedia.org)
  • The device is inserted into the medullary cavity of the broken bone and. (google.co.uk)
  • The device is inserted into the medullary cavity of the broken bone and the bladder is inflated to expand the bladder and extend the bone-contacting surfaces to the inner wall of the bone, where they adhere to and stabilize the bone. (google.co.uk)
  • prevents
  • Bisphosphonate use still is a very effective solution that prevents bone loss in most patients and no one is recommending that physicians avoid prescribing these," said Dr. Rosenwasser. (healthcanal.com)
  • patients
  • Severe joint contracture and LLD inevitably cause significant physical disability in patients with the linear type of LS, linear morphea (LM), for whom bone shortening or amputation has been indicated, whereas extensive bone lengthening has rarely performed. (hindawi.com)
  • Patients with tibial shaft fractures present with pain and localized swelling. (wikipedia.org)
  • Recent technological advances, such as intensity-modulated radiotherapy (IMRT) and stereotactic body radiotherapy (SBRT), can be used in a particular setting of oligometastatic patients to deliver a substantial dose of radiation to the tumor and spare healthy normal tissues. (springer.com)
  • respiratory
  • Its job is to give tensile strength to both articular (found as supportive tissues in the ears, nose, trachea, larynx, and smaller respiratory tubes) and hyaline (found covering the articular surfaces of bones in synovial joints) cartilage, as well as the eye. (algaecal.com)
  • Neonates who manage to survive suffer increasing respiratory compromise due to softening of the bones (osteomalacia) and underdeveloped lungs (hypoplastic). (wikipedia.org)
  • Defects in the chest, such as flail chest resulting from rib fractures, lead to respiratory compromise and pneumonia. (wikipedia.org)
  • femoral
  • In a second unrelated prospective pilot study , conducted at HSS and funded in part by the NIH, researchers evaluated the bone composition of 21 post-menopausal women who were treated for femoral fractures. (healthcanal.com)
  • A healing index exceeded 100 days/cm except for the first femoral lengthening that was complicated by regenerate fracture. (hindawi.com)
  • causes
  • Dystrophic calcification Mechanostat, a model describing ossification and bone loss Ossicone, the horn-like (or antler-like) protuberances on the heads of giraffes and related species Osteogenesis imperfecta, a juvenile bone disease Fibrodysplasia ossificans progressiva, an extremely rare genetic disease which causes fibrous tissue (muscle, tendon, ligament etc.) to ossify when damaged Primrose syndrome, a rare genetic disease in which cartilage becomes ossified. (wikipedia.org)
  • Mantyh P. Bone cancer pain: causes, consequences, and therapeutic opportunities. (springer.com)
  • Infectious causes of lameness are the result of inflammation and damage to tissue. (wikipedia.org)
  • Tricho-dento-osseous syndrome (TDO) is a rare, systemic, autosomal dominant genetic disorder that causes defects in hair, teeth, and bones respectively. (wikipedia.org)
  • complex
  • For pelvic bone metastases, a more complex field assessment could be considered to lessen the dose to the organs at risk, leading to a better tolerability of the treatment itself. (springer.com)
  • Complex fractures in horses: what's the prognosis? (horseandhound.co.uk)
  • Osteoblasts
  • Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts. (wikipedia.org)
  • The epiphyseal arteries and osteogenic cells invade the epiphysis, depositing osteoblasts and osteoclasts which erode the cartilage and build bone. (wikipedia.org)
  • Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, leading to rickets or osteomalacia. (wikipedia.org)
  • clavicle
  • A clavicle fracture, also known as a broken collarbone, is a bone fracture of the clavicle. (wikipedia.org)
  • Incidents that may lead to a clavicle fracture include automobile accidents, biking accidents (especially common in mountain biking), horizontal falls on the shoulder joint, or contact sports such as football, rugby, hurling, or wrestling. (wikipedia.org)
  • Newborns often present clavicle fractures following a difficult delivery. (wikipedia.org)
  • After fracture of the clavicle, the sternocleidomastoid muscle elevates the medial fragment of the bone. (wikipedia.org)
  • The clavicle is the bone that connects the trunk of the body to the arm, and it is located directly above the first rib. (wikipedia.org)
  • The basic method to check for a clavicle fracture is by an X-ray of the clavicle to determine the fracture type and extent of injury. (wikipedia.org)
  • In former times, X-rays were taken of both clavicle bones for comparison purposes. (wikipedia.org)
  • skeletal
  • Clinical features of metastatic bone disease and risk of skeletal morbidity. (springer.com)
  • Since it was done to thousands of people and involved nails, you'd probably assume we have skeletal evidence of crucifixion. (forbes.com)
  • growth
  • The exact mechanisms by which bone development is triggered remains unclear, but it involves growth factors and cytokines in some way. (wikipedia.org)
  • normal
  • Bone drugs interfere with normal bone regeneration, leaving older bone in place. (wellnessresources.com)
  • It can take up to five months for the strength of the bone to return to normal. (wikipedia.org)
  • In the long bones, there is an abrupt change from a normal appearance in the shaft (diaphysis) to uncalcified regions near the ends (metaphysis), which suggests the occurrence of an abrupt metabolic change. (wikipedia.org)
  • There are five digits attached to the hand, notably with a nail fixed to the end in place of the normal claw. (wikipedia.org)
  • structural
  • This study found that bisphosphonate use improved structural integrity early in the course of treatment, but those gains were diminished with long-term treatment. (healthcanal.com)
  • However, after four years of use, these trends reversed, revealing an association between prolonged therapy and declining cortical bone structural integrity. (healthcanal.com)
  • Several hypotheses have been proposed for how bone evolved as a structural element in vertebrates. (wikipedia.org)
  • broken
  • the broken bone had to be splinted, extended and adjusted, and if this was not sufficient an incision was made at the end of the bone, and a branch of fir was inserted into the cavity of the medulla. (wikipedia.org)
  • teeth
  • It is found primarily in bones and teeth. (nkfs.org)
  • Changes in the long bones tend to appear later in development, but changes in the teeth appear once the teeth being to form, called primary dentition. (wikipedia.org)
  • bony
  • However, other possibilities include bony tissue evolving as an osmotic barrier, or as a protective structure. (wikipedia.org)
  • Injury
  • Although pain can cause both short-and long-term discomfort, pain actually serves an important purpose-it alerts the brain and may even prevent injury. (inquisitr.com)
  • extent
  • In the case of head wounds, surgical intervention was implemented for investigating and diagnosing the nature of the wound and the extent of the impact while bone splinters were removed preferably by scraping followed by post operation procedures and treatments for avoiding infection and aiding in the healing process. (wikipedia.org)
  • surfaces
  • The device includes an elongate support rod and an inflatable bladder which is attached to the support rod and includes a plurality of bone-contacting surfaces. (google.co.uk)
  • 3. A device in accordance with claim 2 further comprising an adhesive layer applied to each of said bone-contacting surfaces. (google.co.uk)
  • cement
  • We had to remove some of these fragments and use an artificial bone cement to fill the gaps, to allow the plate to fit neatly. (horseandhound.co.uk)
  • wherein
  • inserting the reducer into a medullary canal of the second segment, wherein the reducer is used to assist aligning the segments of the fractured bone. (google.co.uk)
  • 2. A device in accordance with claim 1 wherein said bone-contacting surface is serrated. (google.co.uk)
  • collagen
  • Vitamin C deficiency, although uncommon in North America, results in your bones being unable to properly manufacture collagen and its connective tissues. (algaecal.com)
  • While collagen's overall function is the same in every tissue, to accommodate stretching of each tissue, the collagen shape depends on the type of tissue. (algaecal.com)
  • Collagen type I and type III are often found together, with type I being the predominant collagen in the tissue. (algaecal.com)
  • Acute
  • On the most basic level, pain can be classified as two types: acute (short-term) or chronic (long-term). (inquisitr.com)
  • literally
  • Like death by guillotine in early modern times, crucifixion was a public act, but unlike the swift action of the guillotine, crucifixion involved a long and painful - literally, excruciating - death. (forbes.com)
  • cartilage
  • Cartilage is progressively eroded and replaced by hardened bone, extending towards the epiphysis. (wikipedia.org)
  • Specifically, calcium-based minerals were stored in cartilage and bone was an exaptation development from this calcified cartilage. (wikipedia.org)
  • include
  • Embodiments of the present invention include products and methods for reducing fractures with the aid of image guidance. (google.co.uk)
  • In the postoperative setting, the treatment field should include the entire interlocking device, nails, or prosthesis in order to remove any microscopic dissemination of disease. (springer.com)
  • These include proteins that: line the gastrointestinal tract and pancreatic epithelium form the brain, liver, and kidneys During later stages of decomposition, more resistant tissue proteins are degraded by the effects of putrefaction. (wikipedia.org)
  • pain
  • Mercadante S. Malignant bone pain: pathophysiology and treatment. (springer.com)
  • Vakaet LA, Boterberg T. Pain control by ionizing radiation of bone metastasis. (springer.com)
  • the resulting compound fracture of the shin bones may have resulted in hemorrhage and fat embolisms, not to mention significant pain, causing earlier death. (forbes.com)
  • Non-nociceptive pain can originate in the pathway between a specific tissue and the spinal cord, such as the pain from a shingles infection. (inquisitr.com)
  • These issues may result from chronic, or long-term pain. (inquisitr.com)
  • Pain sensations are what tell our bodies that something is wrong or trigger a reactive response that may prevent further pain, like when you step on a nail or stub your toe. (inquisitr.com)
  • Pain, particularly with arm movement or on the front part of upper chest Swelling Often, after the swelling has subsided, the fracture can be felt through the skin. (wikipedia.org)