Fraction of the genetic genetic variation. Medical search. Frequent questions

Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. (uni-muenchen.de)
Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. (foodnavigator.com)
Now that it seems clear that common genetic variants have only small effects on disease risk, the field has shifted toward studies of rare variants with large effects. (cdc.gov)
[9] Although over 200 gene variants have been associated with longevity according to a US-Belgian-UK research database of human genetic variants [10] these explain only a small fraction of the heritability. (wikipedia.org)
Hundreds of genetic variants are expected to influence its complex development, but few have been identified. (scienceoxygen.com)
This strategy is especially useful in comparing children with their parents, because children have very few genetic variants - de novo mutations, by definition - that are not in one or the other parent. (neurosciencenews.com)
Finding de novo variants in a child compared to their parents is technically relatively simple," says McCombie, and presents scientists with a particularly strong "signal" of potentially significant genetic variation in children who have an illness like schizophrenia that is not evident in either parent. (neurosciencenews.com)
Since that discovery, rare genetic variants in other ion channel genes have been found to cause familial atrial fibrillation. (medlineplus.gov)
Common genetic variants that increase the risk of atrial fibrillation can also be passed through generations in families. (medlineplus.gov)
The researchers identified 27 common variants associated with reduced BDR, which accounted for 23%, 16% and 18% of variation in albuterol response in Puerto Ricans, Mexicans and African Americans, respectively. (medscape.com)
Dr. Michael Wechsler, director of the NJH Cohen Family Asthma Institute at National Jewish Health in Denver, said, "In this study, several new genetic variants associated with responsiveness or lack of responsiveness to albuterol were identified that may potentially give clues to what is causing asthma in these minority patients specifically. (medscape.com)

The aim of this study was to examine the structure of common variation ascertained in major U.S. populations by resequencing the exons and flanking regions of 3,873 genes in 154 chromosomes from European, Latino/Hispanic, Asian, and African Americans generated by the Genaissance Resequencing Project. (blogspot.com)
Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
First, we have identified only a fraction of the genes associated with autism. (zmescience.com)
Due mainly to the rapidly decreasing cost of sequencing (currently below $5k per genome), it is likely that within the next 5-10 years we will identify genes which account for a significant fraction of total IQ variation. (discovermagazine.com)
One intriguing question is to what extent variation in gene expression within a population is controlled by sequence variation within the gene itself ( in cis ) compared with variations in unlinked regulatory genes ( in trans ). (biomedcentral.com)
and translation, folding, modification, trafficking and degradation of protein), and variation in genes that act in any layer could produce systematic variation in gene expression among individuals in a population. (biomedcentral.com)
Identify genes downstream of SHROOM2 in the pathway that are indirectly affected by variation. (ukri.org)
Its goal is to generate an informed and current understanding of the impact of genetic variation on cancer risk across the iconic cancer predisposition genes, BRCA1 and BRCA2 . (plos.org)
These results have implications for identification of complex trait genes, developmental and physiological studies of phenotypic variation, and opportunities to engineer phenotypic outcomes in complex biological systems. (nih.gov)
Published this week in Nature Genetics , the study revealed the DNA locations of 64 genetic variations that increased the risk of BD - more than doubling the number of regions previously identified- and showed what specific genes and pathways they impacted. (edu.au)
The preliminary study apparently evaluated genetic variations in the candidate genes in about 124 people with CFLD and in 843 control patients without CFLD. (healthjockey.com)
According to Shane McCarthy, Ph.D., a CSHL research investigator who is lead author of the new study, three genes found among the 42 affected children in the study - AUTS2, CDH8 and MECP2 - have been identified in prior genetic studies of people with autism. (neurosciencenews.com)
This is the small fraction - some 3%-4% of the total human genome sequence - that contains protein-encoding genes. (neurosciencenews.com)
Most tests look at single genes and are used to diagnose rare genetic disorders, such as Fragile X Syndrome and Duchenne Muscular Dystrophy. (cdc.gov)
In addition, some genetic tests look at rare inherited mutations of otherwise protective genes, such as BRCA1 and BRCA2 , which are responsible for some hereditary breast and ovarian cancers. (cdc.gov)
However, relatively common variations (polymorphisms) in more than two dozen genes appear to influence the likelihood of developing the condition. (medlineplus.gov)

How do naturally occurring polymorphisms in DNA sequence relate to variation in gene expression? (biomedcentral.com)
Interpreting the functional significance of genetic polymorphisms in natural populations poses a major challenge. (biomedcentral.com)
A synthetic view from these experiments would suggest that gene expression is not randomly distributed along chromosomes, that variations in mRNA and protein expression within a single species result from a surprising balance between polymorphisms acting in cis and polymorphisms acting in trans to the regulated gene, and consequently that relatively few adaptive changes could have major impacts in remodeling gene expression patterns over the course of evolution. (biomedcentral.com)
The International HapMap Project has estimated that CNVs constitute approximately 12% of the human genome and involve a greater fraction of nucleotides than single-nucleotide polymorphisms (SNPs). (bio-rad.com)
The first genetic linkage map of maize was constructed in 1986 based on restriction fragment length polymorphisms (RFLP) in the F 2 mapping population of a cross between H427 and 761 [ 7 ]. (biomedcentral.com)
It is possible that genetic polymorphisms in CBR1 and CBR3 are key for the wide interindividual variability in the disposition of CBR drug substrates. (aspetjournals.org)
From a clinical perspective, a rare variant with large penetrance (such as the Z allele) may be more useful than a common variant with low penetrance in screening for genetic polymorphisms. (healthjockey.com)

Genetic variation among for genotyping species with highly variable genomes. (cdc.gov)
Although the importance of genetic diversity is recognized by most Parties to the CBD, genetic diversity targets mainly addressed variation within crops and livestock (a small fraction of all species). (usgs.gov)
Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. (elifesciences.org)
The presence of CNVs contributes to genetic variability among individuals within a species. (bio-rad.com)
AFLP technology could be very efficient for discriminating species of chrysanthemum and its related genera and reconstruct their genetic relatedness. (ashs.org)
Here we test the effect of genetic variation on colony efficiency and reproductive skew in a rhinotermitid termite, Reticulitermes speratus , a species in which female-female pairs can facultatively found colonies. (biomedcentral.com)
The survival of species often depends on genetic diversity at the population level, so understanding this variation is particularly important to conservation efforts. (uwgb.edu)
And although only a fraction of the actual number of species is described, they are also one of the largest. (lu.se)
This project will include both morphological and genetic work, and probably the discovery and description of new species. (lu.se)

However, the CBD and similar policy agreements have often neglected genetic diversity. (usgs.gov)
This is a critical gap because genetic diversity underlies adaptation to environmental change and ecosystem resilience. (usgs.gov)
Here we aim to inform future policy, monitoring, and reporting efforts focused on limiting biodiversity loss by conducting the largest yet evaluation of how Parties to the CBD report on genetic diversity. (usgs.gov)
A large, globally representative sample of 114 CBD National Reports was examined to assess reported actions, progress, values and indicators related to genetic diversity. (usgs.gov)
Reported actions to conserve genetic diversity primarily concerned ex situ facilities and legislation, rather than monitoring and in situ intervention. (usgs.gov)
The most commonly reported status indicators are not well correlated to maintaining genetic diversity. (usgs.gov)
Lastly, few reports mentioned genetic monitoring using DNA data, indigenous use and knowledge of genetic diversity, or development of strategies to conserve genetic diversity. (usgs.gov)
We make several recommendations for the post-2020 CBD Biodiversity Framework, and similar efforts such as IPBES, to improve awareness, assessment, and monitoring of genetic diversity, and facilitate consistent and complete reporting in the future. (usgs.gov)
At present little is known about the genetic diversity of rDNA amongst the hundreds of copies within an individual genome or across the genomes of individuals, i.e. at a population level in humans. (foodnavigator.com)
Chrysanthemums have beautiful flowers with high ornamental value and rich genetic diversity. (ashs.org)
Molecular technology has been widely used in analyzing genetic relationships and diversity. (ashs.org)
Genetic diversity is the amount and nature of genetic variability within populations. (uwgb.edu)
Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. (bvsalud.org)

The researchers detected inter-individual genetic and methylomic variability at rDNA, but no diet-induced effects that were consistent. (foodnavigator.com)
Severe liver disease distinguished by cirrhosis with portal hypertension may be developed by a small fraction about 3 - 5 percent with cystic fibrosis (CF). Prior study has claimed that genetic variability that is not related with the cystic fibrosis transmembrane conductance regulator (CFTR) gene may add to the danger for severe liver disease. (healthjockey.com)

In natural populations, local mate selection and dispersal create correlations between geographic location and genetic variation - each individual's genome is a mosaic of material inherited from recent ancestors that are usually geographically nearby. (elifesciences.org)
and also offers a way to analyze variation in geographic ancestry without assuming the existence of discrete ancestral populations. (elifesciences.org)
Human genome epidemiology has grown, too, but studies of genetic variation and disease in populations-i.e., groups of people not defined by family relationships-still accounts for only a small fraction of the total (Figure 1). (cdc.gov)
The creation of ultra-high density genetic maps using large populations of advanced recombinant inbred lines (RILs) is an efficient way to identify QTL for complex agronomic traits. (biomedcentral.com)
Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)

In a population of genetically diverse individuals, the extent of genetic variation of a phenotype measures the overall sensitivity of individuals to mutations segregating in the population. (nature.com)
Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. (lu.se)
Although SLE is generally a complex genetic illness, there are several examples of mutations that can produce a monogenetic form of the illness. (medscape.com)

A significant fraction of the dead corals were still standing a year after the incident. (wikipedia.org)
Human carbonyl reductase (CBR) activity accounts for a significant fraction of the metabolism of endogenous and xenobiotic carbonyl compounds. (aspetjournals.org)

Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and nonoverlapping genetic differences, thereby providing measures of phenotypic effects that are attributable to individual chromosomes. (nih.gov)
Specifically, individual chromosome substitutions often conferred surprisingly large effects (often a substantial fraction of the entire phenotypic difference between the parental strains), with the result that the sum of these individual effects often dramatically exceeded the difference between the parental strains. (nih.gov)

We found that facial shape and size phenotypes are highly heritable, and additionally are highly genetically correlated, and that a large fraction of the genetic component of facial differences can be explained by common variation genome-wide. (scienceoxygen.com)
Stay completely up-to-date on the RII Track-2 FEC: Using Biophysical Protein Models to Map Genetic Variation to Phenotypes (National Science Foundation award OIA-1736253) via the Genotypes to Phenotypes website . (uidaho.edu)
Here, investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing Kupffer cell phenotypes, including leptin signaling in Kupffer cells from a steatohepatitis-resistant strain. (bvsalud.org)

However, because the effects of genetic variation on these two colony characteristics have been tested independently, it remains unclear whether they are affected by genetic variation independently or in a related manner. (biomedcentral.com)
Cell-autonomous and non-cell-autonomous effects of genetic variation were resolved by analysis of F1 hybrid mice and cells engrafted into an immunodeficient host. (bvsalud.org)
During homeostasis, non-cell-autonomous trans effects of genetic variation dominated control of Kupffer cells, while strain-specific responses to acute lipopolysaccharide injection were dominated by actions of cis-acting effects modifying response elements for lineage-determining and signal-dependent transcription factors. (bvsalud.org)
These findings demonstrate that epigenetic landscapes report on trans effects of genetic variation and serve as a resource for deeper analyses into genetic control of transcription in Kupffer cells and macrophages in vitro. (bvsalud.org)

So far, only a small fraction of affected individuals has been linked to a certain genetic risk factor. (harvard.edu)
"The genetic variation of ribosomal DNA could be the reason why we've only been able to explain a small fraction of the heritability of many health conditions, which makes a lot of sense in the context of metabolic diseases, such as type 2 diabetes," added Rakyan. (foodnavigator.com)
A group of Uppsala researchers has shown that a small fraction of the bacteria often continues to grow, sometimes up to 10 generations. (uu.se)
Among the vast number of possible mutational combinations, only a small fraction are expected to be viable. (uidaho.edu)
A small fraction (about 1%) are a striking blue. (uwgb.edu)
Despite the many scientific advances in genetics, researchers have only identified a small fraction of the genetic component of most diseases. (cdc.gov)
However, these cases represent only a small fraction of all individuals with atrial fibrillation. (medlineplus.gov)
Given that African Americans, Puerto Ricans and Mexicans still represent a small fraction of people included in genome-wide association studies, the authors were not able to identify a second population in which to replicate the findings. (medscape.com)

Under the leadership of Hákon Hákonarson, the CAG has conducted tens of thousands of genome-wide screens, using mainly Illumina arrays, to assemble a large database of copy number variation that it can use to better resolve the relationship between rare genetic variation and human diseases and disorders. (genomeweb.com)

What we've witnessed over the past decade is a shift from merely describing the heart's physical attributes-its thickness, its strength, the ejection fraction's variations-towards delving into a profound comprehension of the molecular and genetic foundations underpinning these diseases. (hcplive.com)

The U.S. Preventive Services Task Force (USPSTF) has also released recommendations on specific genetic tests used in selected clinical scenarios involving breast cancer , colorectal cancer, and hemochromatosis. (cdc.gov)

Moreover, this study suggests that low genetic variation (high relatedness) between founding females increases reproductive skew via one female preferentially channeling her relatives along the reproductive track. (biomedcentral.com)

Researchers analyzed data from more than 46,000 23andMe customers, finding that we owe a tenth of our empathy to genetic factors. (zmescience.com)
Researchers were also interested in how these genetic differences can be connected to autism. (zmescience.com)
The BRCA Challenge has brought together the existing international Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium expert panel, along with expert clinicians, diagnosticians, researchers, and database providers, all with a common goal of advancing our understanding of BRCA1 and BRCA2 variation. (plos.org)
This allowed the researchers to look at the genetic component of attractiveness. (scienceoxygen.com)
Researchers studied over 7.5 million common variations in the DNA sequence, finding that nearly 8600 common variations explain the majority of risk attributed to this particular class of genetic variation, but there is yet more to discover in the genome to fully explain genetic risk. (edu.au)
Biodiversity researchers work to understand the nature of biological variation and the processes that affect it. (uwgb.edu)
Researchers are working to determine how a combination of genetic changes, environmental influences, and lifestyle factors contribute to a person's risk of developing atrial fibrillation. (medlineplus.gov)

Twin studies have estimated that approximately 20-30% of the variation in human lifespan can be related to genetics , with the rest due to individual behaviors and environmental factors which can be modified. (wikipedia.org)
In 2008, the former Secretary's Advisory Committee on Genetics, Health and Society of the U.S. Department of Health and Human Services released a report identifying gaps in the regulation, oversight, and usefulness of genetic testing. (cdc.gov)

They discovered this gene variation in what Young calls "a large fraction of the population," by doing a gene database search. (earth.com)

However, the low density of molecular markers in existing genetic maps has limited the efficiency and accuracy of QTL mapping. (biomedcentral.com)

The HuGE published literature database will continue to be updated weekly with automatic indexing of gene symbols, study type (meta-analysis, GWAS), and category (pharmacogenomics, genetic testing). (cdc.gov)
Genome-wide genetic association studies (GWAS) have been performed in large collections of SLE patients and controls. (medscape.com)

0.05) were reported as regards the mass fractions of polyphenols and anthocyanins in the fruit of the analysed cultivars. (researchgate.net)
The fruit of common cranberry contained the highest quantities of resveratrol (712.3 ng/g of fresh mass), and its mass fraction in the investigated cultivars ranged from 533.4 (cv. (researchgate.net)

Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. (uni-muenchen.de)
Next, I discuss ongoing Genome Wide Association Studies which investigate the genetic basis of intelligence. (discovermagazine.com)
Variations in abundance: genome-wide responses to genetic variation. (biomedcentral.com)
Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome-wide expression profiles of both RNA and protein. (biomedcentral.com)
Until recently, real-time quantitative PCR (qPCR) assays and microarray hybridization have been the main methods used to determine copy number variation (CNV) in the genome. (bio-rad.com)
Copy number variation is defined as the presence of variable numbers of copies of a particular DNA segment relative to a reference genome. (bio-rad.com)
Our results demonstrated a relatively high degree of collinearity between the genetic map and the B73 reference genome. (biomedcentral.com)
Excitingly, we seem to be at an inflection point in genome discovery for bipolar at present - and with continued collaborative efforts, we will see a dramatic increase in genetic findings in the coming years. (edu.au)
In addition to the approximately 2300 tests for individual genetic disorders, recent advances in technology have enabled the development of clinical tests which quickly and economically analyze the entire human genome. (cdc.gov)

rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation. (uni-muenchen.de)
These studies, however, generally do not identify the actual genetic polymorphism that actually imparts the increased risk of disease. (medscape.com)

By combining the chromosomal interaction information and the expression quantitative trait loci data, I found that Autism Spectrum Disorder specific copy-number variations were enriched in the non-coding regions, especially in the enhancer regions. (harvard.edu)

However, this difference isn't genetic - instead, this difference can be explained either by biological differences (such as prenatal hormone influences) or non-biological factors (such as socialization), both of which also differ between the sexes. (zmescience.com)

Previous genetic studies focused on analyses of the protein-coding regions in the genomes of Autism Spectrum Disorder affected individuals whereas the relationship between the non-coding regions and Autism Spectrum Disorder development was largely unexplored. (harvard.edu)
Both genetic and environmental factors affect the protein content of sorghum and millets. (fao.org)
In solubility fractionation studies with sorghum and pearl, finger and foxtail millets, five protein fractions were obtained (Table 23). (fao.org)

Ongoing work includes direct contact with national centers with access to BRCA1 and BRCA2 diagnostic data to encourage data sharing, development of methods suitable for extraction of genetic variation at the level of individual laboratory reports, and engagement with participant communities to enable a more comprehensive understanding of the clinical significance of genetic variation in BRCA1 and BRCA2 . (plos.org)

The data set is based on shared information from existing clinical databases-Breast Cancer Information Core (BIC), ClinVar, and the Leiden Open Variation Database (LOVD)-as well as population databases, all linked to a single point of access. (plos.org)
To begin addressing this need for reliable information, CDC's Office of Genomics and Precision Public Health (OGPPH) established the Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) Initiative project to systematically evaluate genetic tests and other applications of genomic technology that are in transition from research to clinical and public health practice. (cdc.gov)
In 2004, the Centers for Disease Control and Prevention launched the EGAPP initiative to establish and test a systematic, evidence-based process for evaluating genetic tests and other applications of genomic technology that are in transition from research to clinical and public health practice. (cdc.gov)
Author Manuscript clinical laboratories, but are not available for most genetic tests offered by only one or a few laboratories. (cdc.gov)
Author Manuscript and led to an increased role for clinical genetic testing in patient management. (cdc.gov)

Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1. (nih.gov)
A frequent claim about human population structure is that most common variation is shared among all populations11-13. (blogspot.com)
We studied these changes in human large bowel epithelium and showed a very strong relationship between the genotype and SHROOM2 expression, indeed so strong that the DNA sequence explained most of the variation in SHROOM2 expression in the colon. (ukri.org)
The HuGE Navigator will remain online as a freely accessible resource for all who are interested in human genetic variation and population health. (cdc.gov)
Is human behavior genetic or learned? (scienceoxygen.com)
Human behavior is subject to genetic variations. (scienceoxygen.com)
For almost three decades, Huntington's disease has been a prototype for the application of genetic strategies to human disease. (biomedcentral.com)
The major histocompatibility complex (MHC) on chromosome 6, which contains the human lymphocyte antigens (HLA), was the first described genetic link to SLE. (medscape.com)
Impact of inter- and intra-individual variation, sample storage and sampling fraction on human stool microbial community profiles. (cdc.gov)

The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. (medscape.com)

Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. (lu.se)

Autism Spectrum Disorders have a strong genetic basis. (harvard.edu)
The Stanley Institute is dedicated to discovering the genetic causes of bipolar disorder, schizophrenia, depression and other cognitive disorders. (neurosciencenews.com)

Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
For the first five years, a complex PubMed query was used to identify studies of genotype prevalence, gene-disease association, gene-environment interaction, and the performance characteristics of genetic tests. (cdc.gov)
In addition, DNA variation panels from 10 ethnic groups presented a wide range of CBR3 V244M genotype distributions. (aspetjournals.org)

10.3201/eid2009.140554 tent variation ( 5 ) and substantial levels of recombination ( 6 ). (cdc.gov)
A high-density genetic map was constructed using 4183 bin markers (100-Kb intervals with no recombination events). (biomedcentral.com)

Sex-chromosome copy number variations are also implicated in the risk of SLE. (medscape.com)

We have discovered 20 new genetic regions that are inherited markers of the risk of developing CRC and have shown that genetic marker data, family history, gender and age can be combined into risk profiling models that can identify high risk subgroups within the general population. (ukri.org)
The total genetic distance covered by the linkage map was 1545.65 cM and the average distance between adjacent markers was 0.37 cM with a physical distance of about 0.51 Mb. (biomedcentral.com)

Grain proteins are broadly classified into four fractions according to their solubility characteristics: albumin (water soluble), globulin (soluble in dilute salt solution), prolamin (soluble in alcohol) and glutelin (extractable in dilute alkali or acid solutions). (fao.org)
Recent evolutionary theories predict that genetic variation among group members can affect characteristics of social insect colonies in two ways. (biomedcentral.com)
Thus, it remains unknown whether genetic variation has a direct impact on both characteristics. (biomedcentral.com)
A study testing these two effects would provide us an opportunity to understand how intracolonial genetic variation affects evolution and maintenance of colony characteristics. (biomedcentral.com)

I systematically evaluated the effect of copy-number variations in the non-coding regions of Autism Spectrum Disorder genomes. (harvard.edu)

In this study, I assessed the copy-number variations recorded in SFARI Gene, an on-going database that collects copy-number variations reported in the published scientific literature. (harvard.edu)

The ways in which individuals differ in their intellectual abilities, personalities, and mental health are, to a large extent, functions of their inherited genetic predispositions. (scienceoxygen.com)

If we can identify the genetic risk factors for bipolar, we are more able to understand the biology of the disorder, and with hope, better treat it," A/Prof. Fullerton said. (edu.au)
For example, predictive gene tests may be used to help determine the risk of developing common diseases, and pharmacogenetic tests may be used to help identify genetic variations that can influence a person's response to medicines. (cdc.gov)
In addition to these common genetic variations, risk factors for atrial fibrillation include high blood pressure ( hypertension ), diabetes mellitus, a previous stroke, or an accumulation of fatty deposits and scar-like tissue in the lining of the arteries ( atherosclerosis ). (medlineplus.gov)
In fact, only a fraction of the genetic risk for SLE has so far been identified. (medscape.com)
Rationale: Tobacco is an established risk factor for ESCC, but sex-specific population attributable fractions (PAFs) are not well characterized in Africa. (who.int)

Mosaicism - or genetic variation between cells is common and can be compatible with a healthy baby being born. (globalchange.com)

Genetic approaches identified a gene (HMGCR) that influences blood cholesterol levels and it is the gene product of HMGCR (HMGcoA reductase) which is inhibited by statins. (ukri.org)

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. (nih.gov)

Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. (biomedcentral.com)

This allows us to predict the location of origin of a genetic sample by comparing it to a set of samples of known geographic origin. (elifesciences.org)

Fighting bacterial diseases is a perpetual arms race between medical scientists developing new therapeutics and the pathogenic bacteria continuously changing their genetic makeup to survive the drugs. (uu.se)
Genetic tests have been developed for thousands of diseases. (cdc.gov)
Therefore, genetic tests for many diseases are developed on the basis of limited scientific information and may not yet provide valid or useful results to individuals who are tested. (cdc.gov)

Additionally he alludes to future directions in the study of the genetic basis of intelligence using genomics. (discovermagazine.com)
This study thus demonstrated that, in social insects, intracolonial genetic variation can simultaneously affect both colony efficiency and reproductive skew. (biomedcentral.com)
Their study is the first to point towards a gene mutation in the development of DSPD, and sheds light on the genetic basis behind this sleep disorder. (earth.com)

A smoothed map describing variation in allele frequencies over space is first estimated for each allele based on the genotypes of individuals with known locations, and locations of new samples are then predicted by maximizing the likelihood of observing a given combination of alleles at the predicted location. (elifesciences.org)
Individuals can learn more about specific genetic tests by visiting the Web sites listed below or by talking with their doctor. (cdc.gov)

Angela, you seriously think that Google would not be interested in finding the genetic basis for high IQ? (blogspot.com)
I don't think Google is stupid enough to step into the political minefield of the genetic basis of IQ. (blogspot.com)
All they need is high IQ employees, not the genetic basis of high IQ. (blogspot.com)
Plant architecture attributes, such as plant height, ear height, and internode number, have played an important role in the historical increases in grain yield, lodging resistance, and biomass in maize ( Zea mays L . ). Analyzing the genetic basis of variation in plant architecture using high density QTL mapping will be of benefit for the breeding of maize for many traits. (biomedcentral.com)

following up on these discoveries to unravel genetic contributions to disease, however, remains extremely challenging. (cdc.gov)
Other methods are needed to integrate genetic data into ways of thinking that can help us understand, prevent and treat disease. (cdc.gov)
A genetic disorder which is known to be a hereditary disease of the secretory glands, as well as the glands that makes mucus and sweat is called as cystic fibrosis. (healthjockey.com)
A genetic analysis now points out that a particular gene variation in patients suffering from cystic fibrosis could considerably add to their possibility of developing severe liver disease. (healthjockey.com)

Anatomy13

Organisms25

Diseases5

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology2

Phenomena and Processes101

Disciplines and Occupations12

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture3

Humanities1

Information Science9

Named Groups7

Health Care39

Geographicals13

Variants11

Genes17

Polymorphisms7

Species9

Diversity13

Variability2

Populations5

Mutations3

Significant fraction2

Phenotypic2

Phenotypes3

Effects of genetic variation4

Small8

Rare genetic1

Ejection1

Colorectal Cancer1

Relatedness1

Researchers7

Genetics2

Large fraction1

Molecular1

GWAS2

Cultivars2

Genome10

Polymorphism2

Loci1

Differences1

Protein3

Significance of genetic1

Clinical5

Human9

Mendelian1

Mutational1

Disorders2

Genotype4

Recombination2

Chromosome1

Markers2

Characteristics4

Genomes1

Copy-number variations1

Extent1

Risk5

Common1

Influences1

Complex traits1

Trans effects1

Predict1

Diseases3

Study3

Individuals2

Basis4

Disease4