EGFRCreatinineMildly reduced ejection fractionUrineRenal vascular resistanceCapillaryArterialGlomerulusArteriolesLeftKidneysKidney functionDysfunctionDiabetesMarkerHFpEFMortality rateCardiovascularFluidConcentrationEstimateReductionEfferentChronicSimultaneousAdverseTissueIncidenceIncreaseFlowSignificantlyParticipantsHeart rateRisk
EGFR5
- Background: In a post hoc analysis, the frequency of occurrence of an early decline ("dip") in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin, and its association with outcomes, was evaluated in patients with heart failure and reduced ejection fraction (HFrEF) randomized in the Dapagliflozin and Prevention of Adverse outcomes in Heart Failure trial. (gla.ac.uk)
- 10% decline in eGFR on dapagliflozin were older age, lower eGFR, higher ejection fraction, and type 2 diabetes. (gla.ac.uk)
- Despite an initial drop in estimated glomerular filtration rate (eGFR) after 1 month of dapagliflozin, researchers say this is not associated with subsequent risk of cardiovascular or kidney events for patients with heart failure with mildly reduced ejection fraction (HFmrEF) or preserved ejection fraction (HFpEF). (ajmc.com)
- Secondary outcomes included kidney function (eGFR) at three months, rates of procedural myocardial infarction (MI), and major adverse cardiac events (MACE - a composite of death, non-fatal MI, and unscheduled revascularization) at 12 months. (cardiologynownews.org)
- As a result, one should look at the calculated eGFR (estimated glomerular filtration rate), as reported from the measured serum creatinine, to assess renal function. (medscape.com)
Creatinine7
- The creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. (wikipedia.org)
- All of the estimating equations depend on a prediction of the 24-hour creatinine excretion rate, which is a function of muscle mass which is quite variable. (wikipedia.org)
- With a higher muscle mass, serum creatinine will be higher for any given rate of clearance. (wikipedia.org)
- This study was performed to quantify the fraction of excreted creatinine not attributable to creatinine filtration for accurately determining the glomerular filtration rate in mice. (researchgate.net)
- To measure this we compared creatinine filtration with the simultaneous measurement of inulin clearance using both single-bolus fluorescein isothiocyanate (FITC)-inulin. (researchgate.net)
- In AKI, the deterioration of renal excretory function, i.e., a reduction of the glomerular filtration rate (GFR), leads to retention of nitrogen metabolism waste products, detectable as an increased serum creatinine concentration. (biomedcentral.com)
- Creatinine measurement serves as a test for normal glomerular filtration. (cdc.gov)
Mildly reduced ejection fraction1
- Circulating iFGF23 is associated with disease severity and outcome in HF patients with reduced and mildly reduced ejection fraction. (biomedcentral.com)
Urine3
- The rate therefore measured is the quantity of the substance in the urine that originated from a calculable volume of blood. (wikipedia.org)
- G F R = Urine Concentration × Urine Flow Plasma Concentration {\displaystyle GFR={\frac {{\mbox{Urine Concentration}}\times {\mbox{Urine Flow}}}{\mbox{Plasma Concentration}}}} There are several different techniques used to calculate or estimate the glomerular filtration rate (GFR or eGFR). (wikipedia.org)
- Renal plasma flow, renal blood flow, glomerular filtration rate, renal fraction and the rate of urine flow decreased over the period of 2 h after venom injection. (chula.ac.th)
Renal vascular resistance1
- After venom injection, the renal fraction (% cardiac output) was reduced while the ratio of renal vascular resistance and total peripheral resistance was markedly increased. (chula.ac.th)
Capillary1
- If the perfusion of the juxtaglomerular apparatus in the kidney's macula densa decreases, then the juxtaglomerular cells (granular cells, modified pericytes in the glomerular capillary) release the enzyme renin . (wikipedia.org)
Arterial2
- Controls were matched on age, left ventricular ejection fraction, arterial lactate, estimated glomerular filtration rate and cardiac arrest before PCI. (bmj.com)
- During initial postinjection period, mean arterial blood pressure, pulse pressure and heart rate showed to decrease significantly, thereafter it returned to the control level in a short period of 2 h after injection. (chula.ac.th)
Glomerulus1
- To do this, angiotensin II constricts efferent arterioles, which forces blood to build up in the glomerulus, increasing glomerular pressure. (wikipedia.org)
Arterioles1
- In the kidneys, angiotensin II constricts glomerular arterioles, having a greater effect on efferent arterioles than afferent. (wikipedia.org)
Left5
- In 51 442 patients with a recorded ejection fraction (EF), 39.1% (30.3-47.8%) had a reduced, 18.8% (13.5-24.0%) had a mildly reduced and 42.1% (31.5-52.8%) had a preserved left ventricular EF. (bmj.com)
- Diabetes can cause heart failure independently of ischemic heart disease by causing a diabetic cardiomyopathy that may manifest in the setting of normal or reduced left ventricular ejection fraction. (diabetes.ca)
- Since heart failure with reduced ejection fraction (HFrEF) accounts for approximately 50% of cases in the general HF population, we aimed to evaluate the effect of insulin treatment on left ventricular (LV) remodeling and contractility abnormalities in a HFrEF cohort and assess whether insulin was a predictor of adverse outcomes in this entity. (lcqyy.com)
- In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤ 35 percent), VASOTEC decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure (see CLINICAL PHARMACOLOGY , Heart Failure , Mortality Trials for details and limitations of survival trials ). (rxlist.com)
- Left ventricular ejection fraction greater than 45% or the institutional lower limit of normal by either ECHO or MUGA at entry. (survivornet.com)
Kidneys2
- citation needed] GFR is equal to the renal clearance rate when any solute is freely filtered and is neither reabsorbed nor secreted by the kidneys. (wikipedia.org)
- However, the kidneys must continue to filter enough blood despite this drop in blood flow, necessitating mechanisms to keep glomerular blood pressure up. (wikipedia.org)
Kidney function1
- and activation of vitamin D. One of the measures of kidney function is the glomerular filtration rate (GFR). (wikipedia.org)
Dysfunction1
- The increase in heart rate was related to the severity of organ dysfunction. (lu.se)
Diabetes1
- Their mean glomerular filtration rate was below 30 mL/min/1.73 m 2 in 26%, 90% had chronic kidney disease , 98% had peripheral edema, and 46% had diabetes. (medscape.com)
Marker1
- Renal blood flow and glomerular filtration rate were measured using infusion clearance of para-aminohippuric acid and a filtration marker, respectively. (biomedcentral.com)
HFpEF1
- We looked at heart failure with reduced ejection fraction (HFrEF) and predialysis chronic kidney disease (CKD), HFrEF and dialysis CKD, heart failure with preserved ejection fraction (HFpEF) and predialysis CKD, and HFpEF and dialysis CKD. (medscape.com)
Mortality rate1
- CONCLUSION: The district hospital had a high COVID-19 mortality rate among PLWH. (bvsalud.org)
Cardiovascular1
- The prognosis value of apelin-12 in predicting short-term (during hospitalisation) and long-term (2.5 years) major adverse cardiovascular events, respectively, was analysed among patients with estimated glomerular filtration rate exceeding and below 90 mL/min×1.73m 2 . (bmj.com)
Fluid2
- Glomerular filtration rate describes the flow rate of filtered fluid through the kidney. (wikipedia.org)
- Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. (wikipedia.org)
Concentration1
- It can also be activated by a decrease in the filtrate sodium chloride (NaCl) concentration or a decreased filtrate flow rate that will stimulate the macula densa to signal the juxtaglomerular cells to release renin. (wikipedia.org)
Estimate2
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- Estimate the post complete/partial remission failure-free survival rate in these patients. (knowcancer.com)
Reduction1
- These findings suggest that an intrarenal mechanism seem to be responsible for the reduction of renal blood flow and filtration rate in the second hour after venom injection. (chula.ac.th)
Efferent1
- In other words, the filtration rate is dependent on the difference between the higher blood pressure created by vasoconstriction of the afferent arteriole versus the lower blood pressure created by lesser vasoconstriction of the efferent arteriole. (wikipedia.org)
Chronic2
- In 1 69 518 patients with recorded estimated glomerular filtration rate, 49% had chronic kidney disease (CKD) stages III-V. Event rates were highest for cardiorenal disease (HF or CKD) and all cause mortality (19.3 (95% CI 11.3 to 27.1) and 13.1 (11.1 to 15.1), respectively), and lower for myocardial infarction, stroke and peripheral artery disease. (bmj.com)
- Reduced glomerular filtration rate (GFR) is strongly associated with reduced survival in patients with chronic heart failure (CHF). (eur.nl)
Simultaneous1
- Change in heart rate with change in body temperature was assessed by extracting pairs of simultaneous body temperature and corresponding heart rate measurements from the electronic medical record: 472,941 simultaneous pairs were obtained from the 9,046 patients admitted during the study period. (lu.se)
Adverse1
- Given that heart failure with reduced ejection fraction (HFrEF) accounts for approximately 50% of cases in the general HF population and is increasing in prevalence in the aging population, it is necessary to specifically clarify the adverse LV remodeling and mechanical alterations in patients with HFrEF and T2DM who take insulin [12]. (lcqyy.com)
Tissue1
- It combines a decrease in heart rate and the stigma of tissue hypoxia, in the absence of signs of hypovolemia. (scirp.org)
Incidence1
- Despite controlling these risk factors, the incidence rate of PAD is still high, whereas the awareness rate, treatment rate and control rate are low. (researchsquare.com)
Increase5
- Plasma concentrations increase at a much slower rate after the first few hours, and approach steady state at 24 to 48 hours. (nih.gov)
- Levosimendan, an inodilatating agent, has been shown to increase renal blood flow and glomerular filtration rate in uncomplicated postoperative patients and in patients with the cardiorenal syndrome. (biomedcentral.com)
- There was a trend for a minor increase in glomerular filtration rate with levosimendan (4.5%, p = 0.079), which did differ significantly from the placebo group ( p = 0.440). (biomedcentral.com)
- Each 1°C increase in body temperature between 32.0°C and 42.0°C was associated with an 8.35 beats/min increase in heart rate. (lu.se)
- CONCLUSIONS: Increase in body temperature is associated with a linear increase in heart rate of 9.46 beats/min/°C in female and 7.24 beats/min/°C in male patients. (lu.se)
Flow3
- The Poiseuille law predicts this outcome-the rate of flow is decreased exponentially by any change in the radius of the lumen. (medscape.com)
- As with a smaller pediatric airway, even relatively minute changes in diameter have dramatic consequences in flow rates. (medscape.com)
- Thus, when a lumen is narrowed by one fifth, the flow rate is decreased by about one half. (medscape.com)
Significantly1
- Mortality rates were progressively and significantly higher in babies with lower admission weights and earlier gestations. (bvsalud.org)
Participants1
- Participants with heart failure with preserved ejection fraction will undergo 12 weeks of cardiac rehabilitation for exercise training (ET) and be randomized to either nebulized sodium nitrite inhalation solution or placebo inhalation solution (normal saline) through the training period. (mayo.edu)
Heart rate3
- Heart rate was monitored continuously and hourly values were recorded in the electronic medical record. (lu.se)
- Crude linear regression showed an r2of 0.855 between body temperature and heart rate. (lu.se)
- These observations will help to correctly interpret heart rate values at different body temperatures and enable more accurate evaluation of other factors associated with tachycardia. (lu.se)
Risk1
- In 2019, Discovery Health published a risk adjustment model to determine standardised mortality rates across South African private hospital systems, with the aim of contributing towards quality improvement in the private healthcare sector. (bvsalud.org)