• cells
  • In adults, marrow in large bones produces new blood cells. (medicalxpress.com)
  • 1 MF occurs when the bone marrow cells that produce blood cells are gradually replaced by scar tissue. (novartis.com)
  • Cancer is basically an uncontrolled growth of a group of cells, invading the adjacent tissues or spreading to far off places in the body, through lymph or blood. (iloveindia.com)
  • It is one of the myeloproliferative disorders, diseases of the bone marrow in which excess cells are produced at some stage. (wikipedia.org)
  • The decrease in hematopoietic tissue impairs the patient's ability to generate new blood cells, resulting in progressive pancytopenia, a shortage of all blood cell types. (wikipedia.org)
  • This phase I clinical trial will evaluate the safety and efficacy of intra-coronary injection of AC133 selected autologous marrow-derived stem cells in patients with chronic coronary arter. (bioportfolio.com)
  • Conditioning protocols were tested for their efficacy in increasng the incidence of engraftment of histoincompatible dog bone marrow cells. (osti.gov)
  • Cyclophosphamide and total body irradiation (TBI), Corynebacterium parvum and TBI, a 3- or 5-day delayed transfusion of bone marrow cells after TBI, or an increase in the number of donor bone marrow cells or lymphocytes appeared to be ineffective. (osti.gov)
  • Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
  • The increased differential activity usually results in fewer troubling side effects for cancer patients, particularly less nausea, vomiting, and death of cells in the bone marrow and gastrointestinal tract, and increased effectiveness against tumor cells. (wikipedia.org)
  • This, however, changes once neoangiogenesis begins and endothelial cells become active in places like tumor vessels, inflamed tissues, skin with psoriasis, vascular injury and during embryogenesis. (wikipedia.org)
  • Other cells in which endoglin is expressed consist of monocytes, especially those transitioning into macrophages, low expression in normal smooth muscle cells, high expression vascular smooth muscle cells and in kidney and liver tissues undergoing fibrosis. (wikipedia.org)
  • It has been found on endothelial cells in all tissues, activated macrophages, activated monocytes, lymphoblasts fibroblasts, and smooth muscle cells. (wikipedia.org)
  • Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. (wikipedia.org)
  • Myelodysplastic syndromes, or dysplasia of blood-forming cells, show increased numbers of immature cells in the bone marrow, and a decrease in mature, functional cells in the blood. (wikipedia.org)
  • Another important area where one can talk of "clones" of cells is neoplasms. (wikipedia.org)
  • Paroxysmal nocturnal hemoglobinuria is a disorder of bone marrow cells resulting in shortened life of red blood cells, which is also a result of clonal expansion, i.e., all the altered cells are originally derived from a single cell, which also somewhat compromises the functioning of other "normal" bone marrow cells. (wikipedia.org)
  • clonal
  • This assay can be used to detect clonal immunoglobulin receptor heavy chain gene rearrangements in blood, bone marrow, and tissue specimens. (labcorp.com)
  • A clonal colony would be well exemplified by a bacterial culture colony, or the bacterial films that are more likely to be found in vivo (e.g., in infected multicellular hosts). (wikipedia.org)
  • Clonal Origin and Expansions in Neoplasms: Biologic and Technical Aspects Must Be Considered Together - Pozo-Garcia et al. (wikipedia.org)
  • lesions
  • The analysis of brain tissue revealed large, partly confluent lesions in the white matter of both cerebral hemispheres as well as the spinal cord. (upmc.edu)
  • The spread of myeloblasts was most severe within the lesions, but they could also be found throughout the whole brain parenchyma outside the lesions. (upmc.edu)
  • Patients
  • Also, I found out recently he had reacted the same way to other patients who had developed secondary lymphedema from their cancer. (lymphedemapeople.com)
  • The primary objective of the study is to determine the feasibility and safety of prospectively identifying patients at risk for clinically significant cardiac dysfunction following a myocardial infarction and the ability to isolate and infuse via the affected coronary circulation an autologous bone marrow derived CD34+ cell product at four dose levels. (bioportfolio.com)
  • Once an optimal dose has been found, up to an additional 30 patients will be studied at that dose level. (wikipedia.org)
  • diseases
  • The proton MRS is often used in evaluating the central nervous system and 31P MRS is used in muscular diseases or neoplasms. (clinicaltrials.gov)
  • Ballon used the STEAM technique, and Schick used the PRESS technique, to investigate the lipid and water spectra of the bone marrow and also correlated those with hematological diseases and post-treatment effects. (clinicaltrials.gov)
  • Lymphoma
  • It can be used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic neoplasms, and ovarian carcinoma. (wikipedia.org)
  • The typical clinical finding in a patient with hepatosplenic T-cell lymphoma is hepatosplenomegaly. (wikipedia.org)
  • reactive
  • The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a B-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive condition. (labcorp.com)
  • lung
  • It is the most common type of cancer and is caused by an uncontrolled cell growth in lung tissues. (iloveindia.com)
  • Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants recognized under the 4th revision of the World Health Organization (WHO) typing system, currently the most widely used lung cancer classification scheme. (wikipedia.org)
  • Inhibitor of EML4-ALK crizotinib shows benefit in a subset of non-small cell lung cancer that is characterized by the EML4-ALK fusion oncogene, found in some relatively young, never or light smokers with adenocarcinoma. (wikipedia.org)
  • relatively
  • It binds collagen and hydroxyapatite in separate domains, is found in relatively large amounts in immature bone, and promotes mineralization of collagen. (wikipedia.org)
  • collagen
  • Osteonectin also shows affinity for collagen in addition to bone mineral calcium. (wikipedia.org)
  • Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. (wikipedia.org)
  • vascular
  • Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) Iridocyclectomy - Removal of the iris plus the ciliary body muscle. (wikipedia.org)
  • cancer
  • A recent study has shown Chlorambucil to be detoxified by human glutathione transferase Pi (GST P1-1), an enzyme that is often found over-expressed in cancer tissues. (wikipedia.org)
  • Astra zantec is currently under review as to the benefits in bone cancer. (wikipedia.org)
  • However, this form of cancer remains localized, and has not invaded past the basement membrane into tissues below the surface. (wikipedia.org)
  • gene
  • Although these two isoforms have different tissue distributions and FGF-binding affinities, FGFR1-IIIc appears responsible for most of functions of the FGFR1 gene while FGFR1-IIIb appears to have only a minor, somewhat redundant functional role. (wikipedia.org)
  • EGFR-TKI's have been found to be active against variants exhibiting certain mutations in the EGFR gene. (wikipedia.org)
  • the gene is expressed in virtually all cell types and tissues. (wikipedia.org)
  • Two unrelated kindreds were found to have autosomal dominant inherited mutations in the ETV6 gene, one family with a germline DNA substitution termed L349P that lead to replacing leucine with proline at amino acid 349 in the DNA binding domain of the ETV6, the second, termed N385fs, in germline DNA caused the lose of five base pairs ETV6 and a truncated ETV6 protein. (wikipedia.org)
  • cell
  • This molecule has been implicated in several biological functions, including mineralization of bone and cartilage, inhibiting mineralization, modulation of cell proliferation, facilitation of acquisition of differentiated phenotype and promotion of cell attachment and spreading. (wikipedia.org)
  • The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
  • CD74: a new candidate target for the immunotherapy of B-cell neoplasms. (wikipedia.org)
  • rare
  • The presented mouse model can be used to gain insights into the molecular and cellular origins of this rare neoplasm and provide a preclinical model in which to test novel therapeutic strategies. (aacrjournals.org)