• biopsy
  • A bone-marrow biopsy three years ago had not retrieved enough bone marrow cells at that time to be conclusive, the blood leukocyte levels in the previous three years were around, the high normal limit (but never above). (upmc.edu)
  • Both the enlarged spleen and clotting were clear signs of a blood disorder, and a bone marrow biopsy confirmed that I had myelofibrosis (MF). (novartis.com)
  • Formalin fixed paraffin embedded tumor tissue or 5 mm x 5 mm fresh tumor biopsy in transport medium. (specialtylabs.com)
  • Ultimately, a bone marrow biopsy is essential to be done to diagnose hairy cell leukemia. (healthtap.com)
  • On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:erythroid ratio of 20:1 or greater. (wikipedia.org)
  • There is a reported association between CNL and multiple myeloma, so the bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells. (wikipedia.org)
  • Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell macrocytosis. (wikipedia.org)
  • PDGFRA
  • Human chromosome translocations between the PDGFRB gene and at least any one of 30 genes on other chromosomes lead to myeloid and/or lymphoid neoplasms that are many ways similar to the neoplasm caused by the fusion of the PDGFRA (i.e. platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see FIP1L1-PDGFRA fusion gene. (wikipedia.org)
  • multiple myeloma
  • Multiple myeloma is a hematologic cancer, originating in the bone marrow, which also frequently presents as one or more bone lesions. (wikipedia.org)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • lesions
  • The analysis of brain tissue revealed large, partly confluent lesions in the white matter of both cerebral hemispheres as well as the spinal cord. (upmc.edu)
  • The spread of myeloblasts was most severe within the lesions, but they could also be found throughout the whole brain parenchyma outside the lesions. (upmc.edu)
  • diseases
  • The proton MRS is often used in evaluating the central nervous system and 31P MRS is used in muscular diseases or neoplasms. (clinicaltrials.gov)
  • Ballon used the STEAM technique, and Schick used the PRESS technique, to investigate the lipid and water spectra of the bone marrow and also correlated those with hematological diseases and post-treatment effects. (clinicaltrials.gov)
  • Patients
  • Also, I found out recently he had reacted the same way to other patients who had developed secondary lymphedema from their cancer. (lymphedemapeople.com)
  • Once an optimal dose has been found, up to an additional 30 patients will be studied at that dose level. (wikipedia.org)
  • analogous
  • Mouse bone marrow infected with retroviral vectors expressing analogous truncated Notch1/TAN-1 failed to demonstrate transformation in vitro but, when reconstituted into irradiated syngeneic mice, gave rise to T-cell neoplasms with a latency of 11 to 40 weeks ( 3 , 67 ). (pubmedcentralcanada.ca)
  • proliferation
  • Interaction between Notch and its proposed ligand, Delta or Serrate/Jagged, initiates a signaling cascade that governs cell fate decisions such as differentiation, proliferation, and apoptosis in numerous tissue types ( 2 , 9 , 27 , 57 , 58 , 69 ). (pubmedcentralcanada.ca)
  • This molecule has been implicated in several biological functions, including mineralization of bone and cartilage, inhibiting mineralization, modulation of cell proliferation, facilitation of acquisition of differentiated phenotype and promotion of cell attachment and spreading. (wikipedia.org)
  • lung
  • It is the most common type of cancer and is caused by an uncontrolled cell growth in lung tissues. (iloveindia.com)
  • Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants recognized under the 4th revision of the World Health Organization (WHO) typing system, currently the most widely used lung cancer classification scheme. (wikipedia.org)
  • Inhibitor of EML4-ALK crizotinib shows benefit in a subset of non-small cell lung cancer that is characterized by the EML4-ALK fusion oncogene, found in some relatively young, never or light smokers with adenocarcinoma. (wikipedia.org)
  • relatively
  • It binds collagen and hydroxyapatite in separate domains, is found in relatively large amounts in immature bone, and promotes mineralization of collagen. (wikipedia.org)
  • mutations
  • EGFR-TKI's have been found to be active against variants exhibiting certain mutations in the EGFR gene. (wikipedia.org)
  • Two unrelated kindreds were found to have autosomal dominant inherited mutations in the ETV6 gene, one family with a germline DNA substitution termed L349P that lead to replacing leucine with proline at amino acid 349 in the DNA binding domain of the ETV6, the second, termed N385fs, in germline DNA caused the lose of five base pairs ETV6 and a truncated ETV6 protein. (wikipedia.org)
  • collagen
  • Osteonectin also shows affinity for collagen in addition to bone mineral calcium. (wikipedia.org)
  • Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. (wikipedia.org)
  • vascular
  • Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) Iridocyclectomy - Removal of the iris plus the ciliary body muscle. (wikipedia.org)
  • FGFR1
  • Although these two isoforms have different tissue distributions and FGF-binding affinities, FGFR1-IIIc appears responsible for most of functions of the FGFR1 gene while FGFR1-IIIb appears to have only a minor, somewhat redundant functional role. (wikipedia.org)
  • rare
  • The presented mouse model can be used to gain insights into the molecular and cellular origins of this rare neoplasm and provide a preclinical model in which to test novel therapeutic strategies. (aacrjournals.org)