• The genome sequence of Schizosaccharomyces pombe. (genscript.com)
  • Schizosaccharomyces pombe YEATS family histone acetyltransferase subunit Yaf9 (yaf9), mRNA. (genscript.com)
  • A model system where the targeting of the chromosomes to the spindle can be studied is meiosis I in the fission yeast Schizosaccharomyces pombe ( S. pombe ). (nature.com)
  • At the onset of meiosis I in the fission yeast S. pombe , the KCs are far apart from SPBs and telomeres, and SPBs are clustered together 2 . (nature.com)
  • The secret behind BeBella's powerful anti-aging properties lies in the combination of nutrient-rich extracts harvested from fermentation of the probiotic Lactobacillus casei and fission yeast Schizosaccharomyces pombe . (prnewswire.com)
  • The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. (embl.de)
  • Homologues could be found, however, in predicted protein sequences from Schizosaccharomyces pombe. (pasteur.fr)
  • We have reconstructed with unprecedented spatiotemporal resolution the molecular networks that regulate cell polarity using an interdisciplinary strategy - combining genetics, microscopy and computational approaches - and focusing on the polarity machinery of the archetypal model organism Schizosaccharomyces pombe (fission yeast). (imperial.ac.uk)
  • We have characterized a Schizosaccharomyces pombe homologue of the ORC subunit, Orc4p. (embl.de)
  • Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha , which mate to form viable hybrid diploids that efficiently complete meiosis, but generate few viable gametes. (elifesciences.org)
  • have now looked at two species of fission yeast- S. pombe and S. kambucha -that share 99.5% of their DNA sequence. (elifesciences.org)
  • We have cloned the RAD6 homolog from Drosophila melanogaster and find that its encoded protein displays a very high degree of identity in amino acid sequence with the homologous RAD6 proteins from the two divergent yeasts, S. cerevisiae and Schizosaccharomyces pombe, and from human. (eur.nl)
  • To examine DSB formation, Smith and co-first authors Kyle Fowler, then a research scientist in the Smith Lab (now a graduate student at the University of California, San Francisco), and Smith Lab research scientist Randy Hyppa turned to the yeast species Schizosaccharomyces pombe . (fredhutch.org)
  • Several yeast TPR genes are also required for mitosis, including Saccharomyces cerevisiae CDC27 and Schizosaccharomyces pombe nuc2+, which appear to be functional homologs of bimA. (rupress.org)
  • Ow's team first moved mustard genes into a simple-structured yeast,Schizosaccharomyces pombe, so they could be more easily copied and examined for function. (usda.gov)
  • When I first read the works of Percival Greg in Jamaica and his descriptions of yeast no. 18, I became wildly curious about Schizosaccharomyces Pombe. (bostonapothecary.com)
  • Pombe is a fission yeast, as opposed to a budding yeast, so they divide differently. (bostonapothecary.com)
  • All brewers yeasts are budding yeasts and pretty much no beverage uses Pombe yeasts but rum (industrial wineries are exploring Pombe to reduce malic acid because they can metabolize it into alcohol). (bostonapothecary.com)
  • Not even all rums use Pombe yeasts, but typically those of the grand arôme tradition do (I use that term without nationality because I like the ô ). (bostonapothecary.com)
  • Typically, producers of heavy rums, are keener on their science and with great care, coax their Pombe yeasts into producing tons of gorgeous aroma. (bostonapothecary.com)
  • Fermentor at Hampden estate in Jamaica, likely a top fermenting Pombe yeast and closely matches the description of Percival Greg's. (bostonapothecary.com)
  • Schizosaccharomyces Pombe yeasts have sub categories just like budding yeasts and there are top fermenting and bottom fermenting varieties. (bostonapothecary.com)
  • Pombe yeasts do not produce all the aroma themselves, and the slowness of their ferment means that favorable bacteria can take hold and produce desirable aroma compounds. (bostonapothecary.com)
  • It also leaves room for undesirable bacteria and Pombe yeasts typically require more care which is why many distilleries avoid them. (bostonapothecary.com)
  • Pombe yeasts relate to the dunder process because, as another rule of thumb, they have significantly higher osmotolerance than budding yeasts. (bostonapothecary.com)
  • Jamaica and many other areas likely ended up discovering Pombe yeasts via sloppy fermentation practices where things weren't measured properly. (bostonapothecary.com)
  • When acidity is high, Pombe will take hold as the dominant yeast, but bacteria will not and this is a way to get particularly light rums as a result of using Pombe. (bostonapothecary.com)
  • The low frequency of occurrence, coupled with being abandoned by the industry, and the rise of in house research by certain sophisticated firms means there are no industrial catalogs of Pombe yeasts to choose from like there is with budding yeasts. (bostonapothecary.com)
  • In a new study in the Journal of Agricultural and Food Chemistry , Wang and coworkers were able to toughen up budding yeast against caffeine by adding bfr1 , a gene from Schizosaccharomyces pombe that encodes the ABC transporter that shunts caffeine out of the cell. (yeastgenome.org)
  • The strain included a gene for malolactic enzyme from the bacterium Oenococcus oeni and a malate permease gene from the fission yeast Schizosaccharomyces pombe . (i-sis.org.uk)
  • Human Rad 9 ( hRad9 ) was originally identified as a structural homologue of yeast schizosaccharomyces pombe rad 9 , which can partially rescue the sensitivity of rad 9 null yeast to hydroxyurea, radiation damage and the associated checkpoint defects [ 1 ]. (biomedcentral.com)
  • His PhD dissertation entitled "Genetic approaches to the study of Rheb GTPase" utilized the model organisms, Saccharomyces cerevisiae and Schizosaccharomyces pombe , to elucidate Rheb's function in arginine uptake and nutrient sensing. (usc.edu)
  • He further utilized the model organism, Schizosaccharomyces pombe , to investigate the role of the SPN/FACT complex in eukaryotic DNA replication. (usc.edu)
  • In this study, we demonstrate that S-palmitoylation mediated by Erf2-Erf4 and Akr1 palmitoylacyltransferases is required at multiple meiotic stages in the fission yeast Schizosaccharomyces pombe . (life-science-alliance.org)
  • Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. (umbc.edu)
  • To understand better the contribution of hypermutagenesis to tumour development, we have modelled the most recurrent POLE-EDM (POLE-P286R) in Schizosaccharomyces pombe. (ox.ac.uk)
  • Telomeric silencing has been demonstrated in organisms ranging from yeasts to humans (reviewed in [ 9 ]) but it has been best characterized in S. cerevisiae , Schizosaccharomyces pombe and Drosophila melanogaster , organisms that have no, or very little, DNA methylation. (biomedcentral.com)
  • The fission yeast S. pombe lacks Sir3p and Sir4p but employs methylation of histone H3 lysine 9 (K9) plus a Sir2p homologue (Sir2) for silencing [ 15 ]. (biomedcentral.com)
  • Slx1 and Slx4 are subunits of a structure-specific DNA endonuclease that is found in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other eukaryotic species. (crcm-marseille.fr)
  • To download a certificate of analysis for Schizosaccharomyces pombe Lindner ( MYA-230 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of Schizosaccharomyces pombe Lindner ( MYA-230 ) is not currently available online. (atcc.org)
  • Sap1 was identified as a protein involved in mating-type switching in Schizosaccharomyces pombe, and has been shown to be involved in programmed replication fork stalling. (le.ac.uk)
  • The origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae as a protein that specifically binds to origins of DNA replication. (embl.de)
  • The RAD6 gene of the yeast Saccharomyces cerevisiae is required for DNA repair, for DNA damage-induced mutagenesis, and for sporulation, and it encodes a ubiquitin-conjugating enzyme. (eur.nl)
  • Meiosis and sporulation in the budding yeast Saccharomyces cerevisiae is a well-studied example. (rupress.org)
  • In 2003, the United States Food and Drug Administration (FDA) designated the GM yeast strain Saccharomyces cerevisae ML01 'generally recognized as safe' (GRAS). (i-sis.org.uk)
  • Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available to probe its biology. (asm.org)
  • However, major genetic engineering limitations have kept this yeast from replacing the commonly used yeast Saccharomyces cerevisiae in industrial applications. (asm.org)
  • The yeast Saccharomyces cerevisiae has served as the major eukaryotic organism for synthetic biology, but lacks the metabolic potential that could be exploited in many of the more than one thousand yeast species that have been identified to date. (asm.org)
  • Both homologous recombination, in which the ends of the broken DNA seek out intact templates with the same sequence, and nonhomologous end-joining pathways are found in Saccharomyces as they are in humans. (brandeis.edu)
  • Thus the budding yeast Saccharomyces cerevisiae sports TG 1-3 repeats on the ends of its chromosomes [ 2 ], while telomeres of both the filamentous fungus Neurospora crassa and humans comprise TTAGGG repeats [ 3 , 4 ]. (biomedcentral.com)
  • Certain molds have been found to alter the flavor of the ham, the most predominant were the members of the genera Penicillium and Aspergillus, Eight species of Aspergillus were found including A. fumigates which account for more than one third of all Aspergillus, and four species of Penicillium were discovered. (wikipedia.org)
  • We determined the detailed network topology and the functional hierarchy among polarity regulators in this species and incorporated these results into a mathematical model that captures the polarity pattern changes throughout the cell cycle of fission yeast cells. (imperial.ac.uk)
  • Although ORC appears to play an essential role in the initiation of DNA replication in the cells of all eukaryotes, its interactions with DNA have not been defined in species other than budding yeast. (embl.de)
  • In an effort to understand the fundamental signaling elements, or 'core machinery', required for the function of these GTPases, we describe here the conservation and functional similarities of Cdc42 and Rac effectors in five different species: plant, yeast, fruit fly, roundworm and human. (biomedcentral.com)
  • Although hybrids of these two species inherit three chromosomes from each parent, the majority of spores (the yeast equivalent of sperm) that these hybrids produce fail to develop into new yeast cells. (elifesciences.org)
  • Since these two yeast species are so closely related, the findings of Zanders et al. (elifesciences.org)
  • Yeasts are eukaryotic microorganisms, classified in the kingdom fungi, with about 1500 species currently identified and described. (scirp.org)
  • The study aimed at isolation and identification of yeast species in palm sap (palm wine), to ascertain their ability to degrade petroleum hydrocarbons. (scirp.org)
  • Analyzing the genomes of 11 yeasts, we show that the lower size limit on promoter-containing regions is species-specific within a relatively narrow range (80-255 bp). (biomedcentral.com)
  • We further find that young, species-specific regions are on average much longer than older regions, suggesting either a bias towards deletions or selection for genome compactness in yeasts. (biomedcentral.com)
  • The minimal chromosomal space required for transcriptional regulation appears to be relatively similar across yeast species, and is the same for uni-directional and bi-directional promoters. (biomedcentral.com)
  • This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
  • When they looked at the mutant, Wang and coworkers found that there were 11 amino acid substitutions scattered across the protein. (yeastgenome.org)
  • The yeast released for commercial wine production, ML01, was found to be only somewhat substantially equivalent to unmodified wine yeast, as a cytochrome p450 enzyme protein appeared to have been altered from the parental strain based on a comprehensive analysis of the yeast cell proteins, and a number of codon changes were observed in the inserted malolactic gene cassette, but those changes were not considered significant. (i-sis.org.uk)
  • The fate of yeast and plant DNA, as monitored by yeast chitinase gene and the plant chlorophyll a/b binding protein gene and micro-satellite markers showed that large DNA markers were present in must (the starting fermentation mixture of mainly yeast and grape juice), while the 250 base pair micro-satellites were present in both must and young wine for up to six months [9]. (i-sis.org.uk)
  • No complex found for this protein. (yeastrc.org)
  • No mass spectrometry results found for this protein. (yeastrc.org)
  • No yeast two-hybrid interactions found for this protein. (yeastrc.org)
  • No microscopy data found in the PDR for this protein. (yeastrc.org)
  • The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
  • In order to shed light on this process we carried out structural investigations on the essential fission yeast protein Sap1. (le.ac.uk)
  • bimA is a member of a gene family defined by a repeated motif called the Tetratrico Peptide Repeat (TPR), which is found in genes from bacteria, yeast and insects. (rupress.org)
  • There was a time where distillers were just learning about bacteria and how it was inhibited by acidity, so to protect yields they were heavy handed and eventually ended up with a rare yeast type. (bostonapothecary.com)
  • Genetic modification of yeast and bacteria differs fundamentally from modification of plants. (i-sis.org.uk)
  • The modification of bacteria and yeast is based on homologous recombination while modification of plants is based on illegitimate recombination. (i-sis.org.uk)
  • For yeast genetic engineering 'shuttle' vectors are used, which are propagated in bacteria for insertion in yeast. (i-sis.org.uk)
  • Diverse microbial population bacteria, yeasts or molds have been reported for degradation of hydrocarbons. (scirp.org)
  • 9] reported that palm wine is a suspension of different types of microorganisms including bacteria, filamentous fungi, and yeasts. (scirp.org)
  • If you lack interest in organisms, such as yeast and bacteria, which have "stuck with" the anaerobic tradition, the products of these chemical reactions may still intrigue you. (psychosocialsomatic.com)
  • Chitin, the second most abundant biopolymer on earth after cellulose, is found in probably all fungi, many animals (mainly invertebrates), several protists and a few algae, playing an essential role in the development of many of them. (biomedcentral.com)
  • Debaryomyces fungi are budding yeasts commonly found in the environment and used in the food industry. (bvsalud.org)
  • Here, we engineered the thermotolerant yeast Kluyveromyces marxianus to create a new synthetic biology platform. (asm.org)
  • IMPORTANCE The yeast Kluyveromyces marxianus grows at high temperatures and on a wide range of carbon sources, making it a promising host for industrial biotechnology to produce renewable chemicals from plant biomass feedstocks. (asm.org)
  • When Wang and coworkers added the gene to S. cerevisiae , this newly engineered yeast could now better tolerate caffeine. (yeastgenome.org)
  • For example, when they tested the bfr1-B mutant with theophylline , a structurally similar compound, and atropine , a structurally distinct compound, they found that S. cerevisiae expressing the mutant were, if anything, more sensitive to these compounds. (yeastgenome.org)
  • While Sir2p homologues (sirtuins) have been found in all eukaryotes examined, Sir3p and Sir4p are restricted to close relatives of S. cerevisiae . (biomedcentral.com)
  • Mitochondrial ribosomal proteins were studied best in yeast, where the small subunit was shown to contain about 35 proteins. (pasteur.fr)
  • Using a recently described affinity purification technique and tagged versions of yeast Ykl155c and Mrp1, we isolated this mitochondrial ribosomal subunit and identified a total of 20 proteins, of which 12 are new. (pasteur.fr)
  • For a subset of the newly described ribosomal proteins, we showed that they are localized in mitochondria and are required for the respiratory competency of the yeast cells. (pasteur.fr)
  • The C-terminal domain shows strong sequence similarity to human, frog, and yeast Orc4 proteins, including conserved ATP-binding motifs. (embl.de)
  • The N-terminal domain contains nine copies of the AT-hook motif found in a number of DNA-binding proteins, including the members of the HMG-I(Y) family of chromatin proteins. (embl.de)
  • We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)
  • RePub, Erasmus University Repository: DHR6, a Drosophila homolog of the yeast DNA repair gene RAD6. (eur.nl)
  • DHR6, a Drosophila homolog of the yeast DNA repair gene RAD6. (eur.nl)
  • No genome locations found for this sequence. (rnacentral.org)
  • Spindle pole bodies (SPBs) provide a structural basis for genome inheritance and spore formation during meiosis in yeast. (rupress.org)
  • New intergenic regions created by genome rearrangements tend to evolve towards the more narrow size distribution found among older regions. (biomedcentral.com)
  • Of course unlike even the most grizzled 30 year coffee drinker with ideal genetics, the yeast almost certainly gets no joy from its morning Joe. (yeastgenome.org)
  • Wine making involves alcoholic fermentation via the metabolic pathways of yeast and the malolactic pathway to convert malic acid to lactic acid, to reduce the acidity of the wine. (i-sis.org.uk)
  • Chitin has also been sporadically found in structures from a diverse range of eukaryotic microorganisms, such as the cell wall of a few chlorophyta (green microalgae), the cyst wall or lorica, of ciliophora (ciliated protozoans), the theca of choanoflagellida (flagellated protozoans), and the test or cyst wall, of amoebozoa (amoeboid protozoans) [ 6 ]. (biomedcentral.com)
  • In the present study, we combine experiments and theory to explore the mechanisms of kinetochore capture at the onset of meiosis I in fission yeast. (nature.com)
  • The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. (embl.de)
  • Here, we present evidence that fission yeast Slx1-Slx4 initiates homologous recombination events in the rDNA repeats that are processed by a mechanism that requires Rad22 (Rad52 homologue) but not Rhp51 (Rad51 homologue). (crcm-marseille.fr)
  • Cdc42 and/or Rac homologs are found in fruit flies, round-worms and budding yeast. (biomedcentral.com)
  • The yeast ML01 was modified using a shuttle vector containing a chromosome integration cassette with genes for malolactic enzyme, malate transporter (permease), regulatory genes and a sequence directing homologous recombination at a chromosomal locus (not specified in the FDA report), and the antibiotic phleomycin gene was used as a selectable marker via another plasmid. (i-sis.org.uk)
  • In work published today in the Proceedings of the National Academy of Sciences, Hutch molecular biologist Dr. Gerry Smith and his team outline just such a model in yeast that explains how chromosomes find their happy medium during sex-cell formation. (fredhutch.org)
  • We find that chromosomal rearrangements and related recombination defects are major but not sole causes of hybrid infertility. (elifesciences.org)
  • Recombination between vector and chromosomal gene disrupts the target chromosomal gene and inserts the transgene, and frequently also a selectable marker, into the yeast target locus [3]. (i-sis.org.uk)
  • Yeast cells in wine were found to be hyperactive in mitotic recombination, contributing to the observed instability of wine yeasts [7]. (i-sis.org.uk)
  • They have found that some genes boost the test plants' ability to withstand high levels of metals. (usda.gov)
  • After culturing the selected antibiotic resistant lactic-acid producing yeast, a phleomycin-sensitive lactic acid producing strain was isolated and found to contain the integrated malolactic-malate transporter genes. (i-sis.org.uk)
  • In plants the recombinant gene insertions are not precise and disrupt genes that are not specifically targeted, while in yeast, gene insertions disrupt genes that are targeted. (i-sis.org.uk)
  • The shuttle vector may also replicate autonomously in the yeast nucleus and express genes equipped with promoter and terminator genes. (i-sis.org.uk)
  • Regions flanked by divergently transcribed genes have a bi-modal length distribution, with short lengths found preferentially among older regions. (biomedcentral.com)
  • The company distributing the GM yeast, Springer Oenologie, Lesaffre Group of North America, stated that the malate transporter gene and malolactic gene were both controlled by the phosphoglycerate kinase gene (PGK1) promoter and transcription terminator. (i-sis.org.uk)
  • Other yeasts that could solve many of these problems remain difficult to manipulate genetically. (asm.org)
  • We have recently shown that MTs explore the space by pivoting around the SPB, which accelerates KC capture in mitosis in fission yeast 9 . (nature.com)
  • Interestingly, small GTPases related to Rac are found even in organisms that lack Ras, such as plants. (biomedcentral.com)
  • The recombinant yeast softened the wine's 'mouth feel' by decreasing its acidity, and also reduces buttery flavours (diactyl) due to lactic acid secondary metabolism [2]. (i-sis.org.uk)
  • TTG transitions are not elevated, likely due to the absence of cytosine methylation in fission yeast. (ox.ac.uk)
  • Found 0 clusters of similar sequences. (lbl.gov)
  • We have been fascinated by the process of yeast mating-type gene switching, in which cells replace about 700 bp of Ya or Y-specific DNA sequences at the MAT locus by recombining with one of two donor loci, called HMLDescription: image3 and HMRa. (brandeis.edu)
  • Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. (cdc.gov)
  • You can imagine adding the caffeine pathway from coffee to yeast and having the yeast merrily exporting caffeine to the culture medium where it can be harvested. (yeastgenome.org)
  • Using model predictions, we designed and characterized 47 additional pathway variants to navigate its activity space, find optimal expression regions with desired activity response curves, and relieve rate-limiting steps in metabolism. (omictools.com)
  • And who knows, maybe they can have the yeast make caffeine and alcohol at the same time creating the equivalent of a vodka and Red Bull in a single step! (yeastgenome.org)
  • Maybe this genetic engineered yeast can make the equivalent of a Red Bull and vodka all in one step! (yeastgenome.org)
  • While not as robust as bfr1-B , this mutant allowed yeast expressing it to tolerate caffeine concentrations up to 15 mg/ml, conditions under which cells with wild type bfr1 failed to grow. (yeastgenome.org)
  • Yeasts isolated from an enriched medium and palm wine showed similarities. (scirp.org)
  • All cells - including those in our body - possess some degree of asymmetry or 'polarity', which is key to their healthy function and if disrupted can lead to serious cellular malfunctions like those found in cancer. (imperial.ac.uk)
  • Finding of hyperphosphorylated forms of hRad9 in the nucleus of cancer cells is in keeping with its function in ameliorating DNA instability, whereby it inadvertently assists tumor growth. (biomedcentral.com)
  • When we probed neutral-neutral 2D gels for subtelomere regions, we found no Y-arc-shaped replication intermediates in cycling cells. (nih.gov)
  • We find that there is a 1000-fold increase in mutation rate and that about half the mutations have a distinctive "signature" suggesting that the DNA polymerase frequently dissociates and re-anneals with its template. (brandeis.edu)
  • The expression vector comes equipped with a sequence homologous with a yeast chromosomal gene. (i-sis.org.uk)
  • The Microbiology Society's Council's Statement on Brexit can also be found here. (microbiologysociety.org)
  • Find out who our staff are at the Microbiology Society. (microbiologysociety.org)
  • Having published advances across the field of microbiology for 75 years, Microbiology - the Microbiology Society's founding journal - is now fully Open Access (OA). (microbiologysociety.org)
  • Factory design and equipment purchases, Arroyo explains, are dependent on yeast choices. (bostonapothecary.com)
  • Yeast type seems to be something beverage people have forgotten about and connoisseurs don't even know to make the distinction. (bostonapothecary.com)
  • For example, whereas wild type yeast barely grew with 8 mg/ml caffeine, the engineered yeast did OK. (yeastgenome.org)
  • We have focused a lot of attention on yeast mating-type gene switching ( MAT switching) as an example of DSB repair that we can study in great detail. (brandeis.edu)
  • This domain is found in the RNase Z enzymes, which are closely related structurally to the Lactamase B family members. (embl.de)
  • Numerous translocations have been observed uniquely in wine yeasts and such chromosome rearrangements involving transgenes can lead to unexpected toxicity in the final product [8]. (i-sis.org.uk)
  • Recent immunochemical studies have found that normal human sera (NHS) contain bactericidal anti-LOS antibodies that bind to the oligosaccharide (OS) moiety of neisserial LOS. (go.jp)
  • We found transient and modest single-stranded G-strand exposure, but did not find any evidence of checkpoint activation in stn1-1 at the restrictive temperature. (nih.gov)
  • PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. (umbc.edu)
  • Collectively, we propose that fission yeast Stn1 primarily safeguards the semi-conservative DNA replication at telomeres and subtelomeres. (nih.gov)
  • We find that Sap1 mutations which alleviate replication-fork blockage at Tf2 transposons in CENP-B mutants map to the head-to-tail interface. (le.ac.uk)
  • If non-functional yeast DNA tends to be removed either by selection or by a mutational bias [ 6 ], then convergent inter-CDS regions should on average be shorter than either 'uni-directional' or 'divergent' regions, and they should not have a 'hard' lower limit. (biomedcentral.com)
  • For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. (atcc.org)
  • We are also interested in gene targeting methods and in figuring out why these types of gene replacement and modification are quite inefficient, even in yeast. (brandeis.edu)