Our studies indicate that Nek1 deficiency leads to disordered kidney maturation, and cysts throughout the nephron. (biomedcentral.com)
By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
Proteins2
Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing. (xenbase.org)
Differentiation6
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
Loss of -KTS variants blocked gonadal differentiation in mice, whereas increased expression, as found in Frasier syndrome, induced precocious differentiation of ovaries independently of their genetic sex. (bvsalud.org)
As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)
Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
Proximal4
In mammals, the nephron consists of the renal glomerulus inside Bowman's capsule, the proximal convoluted tubule, the proximal straight tubule, the loop of Henle, and the distal convoluted tubule. (wikipedia.org)
Bowman's capsule also has a structural function and creates a urinary space through which filtrate can enter the nephron and pass to the proximal convoluted tubule. (worldsrichpeople.com)
These CIC-5 channels are predominantly expressed in the proximal tubule and in the intercalated cells of the distal nephron. (medscape.com)
Later, during nephron segmentation, expression becomes restricted to the intermediate tubule region of the proximal-distal axis. (silverchair.com)
Glomeruli4
The glomerulus (plural glomeruli) is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the kidney. (worldsrichpeople.com)
Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. (worldsrichpeople.com)
Efferent arterioles of glomeruli closest to the medulla (those that belong to juxtamedullary nephrons ) send branches into the medulla, forming the vasa recta. (wikidoc.org)
Collectively, these studies prove that the maternal diet programs the embryonic kidney, altering cell turnover and gene expression at a time when nephrons and glomeruli have yet to form. (ox.ac.uk)
Kidneys of mammals1
The kidneys of mammals have a portion of the nephron called the loop of Henle or nephritic loop, which allows mammals to produce urine with a high concentration of solutes, higher than that of the blood. (edu.vn)
Renal corpuscle1
There is a blood-filtering part of the nephron in the cortex - the renal corpuscle, from which the renal tubule extends to the medulla into the loop of Henle, then the tubule returns back to the cortex and with its distal end flows into its collecting duct that is common to several nephrons. (wikipedia.org)
Compartments1
OCRL1 has been localized to the trans -Golgi network and various compartments of the endocytic pathway (traffic), where it is found in the clathrin-coated pits, clathrin-coated vesicles, variable functioning endosomes (early, signaling, recycling), and the basal body of primary cilia. (medscape.com)
The cortex and medulla are based on nephrons together with an extensive network of blood vessels and capillaries, as well as collecting ducts, into which nephrons empty, and renal interstitium. (wikipedia.org)
Nek1 is a mammalian ortholog of the fungal kinase NIMA (never in mitosis A in Aspergillus nidulans ), which functions in DNA damage responses, regulates G2-M phase progression, and helps keep chromosome transmission to daughter cells faithful [ 5 ]-[ 10 ]. (biomedcentral.com)
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. (genscript.com)
Nephron progenitors, the self-renewing cells that give rise to nephrons, are particularly metabolically active, relying primarily on glycolysis for energy generation early in development. (lww.com)
Mammalian erythrocytes (red blood cells) do not have nuclei, whereas the erythrocytes of other vertebrates are nucleated. (edu.vn)
The existence of specific receptors for plant-derived molecules in mammalian cells initiated a search for specific endogenous ligands. (degruyter.com)
During normal metanephrogenesis, prox-1 protein was first detected in mesenchymal cells around the ureteric tree and thereafter in nascent nephron epithelia, whereas cofilin-1 immunolocalized to bud derivatives and condensing mesenchyme. (ox.ac.uk)
PC1 and PC2 are found on the primary cilium, a hair-like structure present on the apical membrane of a cell, in addition to the cell membranes and cell-cell junctions of tubular epithelial cells. (basicmedicalkey.com)
Tissues2
Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). (nih.gov)
There is also an AT2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. (nih.gov)
Segmentation1
In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. (mdpi.com)
Urinary1
The mammalian kidneys are the paired organ of the urinary system of mammals, which is a type of metanephric kidney. (wikipedia.org)
Regulator1
Moreover, the FXYD protein family was found to be a regulator of NKA. (ijbs.com)
Respiration1
VHL knockout nephron progenitors also exhibit persistent Six2 and Wt1 expression, as well as decreased mitochondrial respiration and prolonged reliance on glycolysis. (lww.com)
Hypoxia2
online: A involvement which, while as thereby increased by patient or found by NOTE, can be understood or characterized in stress of a hypoxia which is itself observing heart or approach. (ajw-service.de)
Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
Clinical1
Radical nephrectomy and nephron-sparing surgery are still the only effective treatments for localized RCC, but the characteristics of RCC recurrence and metastasis lead to a 5-year survival rate of approximately 12%, posing a great challenge to clinical therapies [ 4 ]. (biomedcentral.com)
Gene1
We tested the hypothesis that maternal diet alters gene expression in the metanephros, the precursor of the definitive mammalian kidney. (ox.ac.uk)
Mice1
To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
Amongst the vertebrates, only mammals and birds have kidneys that can produce urine more concentrated (hypertonic) than the blood plasma, but only in mammals do all nephrons have the loop of Henle. (wikipedia.org)
Hanging on desperately by her Loop of Henle, Nellie manages to find a dark puckered crack in the landscape and finds her way back into the welcome darkness of her world. (rifters.com)
If Henle's loop were absent from mammalian nephron, which one of the following is to be expected? (examside.com)
Cell2
Cytokine defects have also been reported in mammalian cell lines lacking OCRL1 attributed to dysregulation of actin assembly. (medscape.com)
Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
Blood1
What is the main function of each of the following regions of the nephron in filtering blood? (studyres.com)
Present1
The coating antibody at 1 µg/ml concentration and 1:500 dilution of enzyme conjugate were found to be effective and economical in the detection of recombinant N protein of TSWV and the virus present naturally in the infected hosts. (chxa.com)
Background1
The thumping of the heart can of course be heard down in the kidneys, but it is a distant sound, an endless and unquestioned bit of background noise as far as Nellie's fellow nephrons are concerned. (rifters.com)
Patients3
Sp patients toward nephron loss with a multivitamin and caffeine works by salve pharmaceuticals include reviews of patients. (myjuicecup.com)
It was found that nearly 37% (18/49) were TSC patients, with the mean ± standard deviation diagnostic age being 34.22±17.73 years old in the 6 pedigrees, 61% (11/18) of whom suffered from TSC‑RAML. (spandidos-publications.com)
Multiple and bilateral renal angiomyolipomas are found in ~70-90% of adult patients with TSC as reported by O'Callaghan et al and Rakowski et al ( 4 , 5 ), tend to grow slowly and often result in spontaneous bleeding when tumor diameter is beyond 4 cm ( 1 ). (spandidos-publications.com)
Questions1
These are important questions, and we are going to find the answers in this lesson. (newnails-fl.de)
Fish liver morphology and histology, unlike mammalian liver structure, is the absence of its basic morphological unit, liver lobules, and portal triads [7]. (peertechzpublications.com)
Enter1
Enter search terms to find related medical topics, multimedia and more. (msdmanuals.com)
Water1
Concept 32.5: The mammalian kidney's ability to conserve water is a key terrestrial adaptation 18. (studyres.com)
Disease3
A 59-year-old Caucasian woman with chronic kidney disease stage 3bA1 of unknown aetiology, IBS, osteoporosis, controlled hypertension and hyperthyroidism was found to have acute-on-chronic kidney injury during routine follow-up with her nephrologist. (bmj.com)
The current therapeutic methods to treat DN are limited to slowing disease progression without repair and regeneration of the damaged nephrons. (emjreviews.com)
Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. (biomedcentral.com)
Article1
Can't find an article you're looking for? (xenbase.org)
Death1
We also are studying the interactions and functions of a 'death domain' that is found in all ankyrins. (dana-farber.org)
Specific1
Find support for a specific problem in the support section of our website. (mdpi.com)