Found gene alleles alleles with haplotype haplotypes. Medical search. Frequent questions

Allele frequencies for each Y-STR locus in pooled sample and estimated value of gene diversity (GD) were evaluated. (nih.gov)
The results of the haplotype distribution and the allele frequencies for each of the factor IX gene polymorphisms in Amerindians were similar to the results reported for Asian populations but differed from results for other ethnic groups. (wayne.edu)
globin gene cluster haplotypes but agree with our recent findings on the distribution of a-globin gene cluster haplotypes and the allele frequencies for six VNTRs in the same Amerindian tribes. (wayne.edu)
The genotype and allele frequencies of two polymorphism in patients with NTG and normal controls were compared using the Fisher exact test and the chi test. (nih.gov)
Frequencies of haplotypes and haplotypes groups were also analyzed to assess the combined effect of two polymorphisms. (nih.gov)
Database comparisons of the NAT2 minor allele frequencies support that Romanians belong to Caucasians and Kyrgyz are in between Caucasians and East Asians. (aacrjournals.org)
Inconsistencies might be caused by differences in study design, study populations (geographic and ethnic background), statistical methods and power, allele frequencies, and gene-environment interactions. (cdc.gov)
There was no significant difference in allele and genotype frequencies of +276G>T between type T2DM patients and controls. (who.int)

B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. (wikipedia.org)
The increase in frequency of the mutant gene though is balanced by the fact that mutant homozygotes have decreased fitness. (discovermagazine.com)
Natural selection quickly increases in frequency any alleles which confer protection against the exogenous stress. (discovermagazine.com)
The frequency of the IC haplotype (shared between I75V and C159T) was 0.44 in DA + workers vs. 023 among DA- subjects (p=0.04). (cdc.gov)
The QC haplotype frequency (Q576R, C159T) of 0.667 in the DA + group was more frequent (0.425) than in the DA- groups (p=0.03). (cdc.gov)
Furthermore, the frequency of IQC haplotype (l75V, Q576R, C159T) was 0.44 in DA + workers vs. 0.217 in the DA - group (p=0.04). (cdc.gov)
In order to meet the grand challenge of human genetics, that is, to understand what causes disease and translate this knowledge to improve health outcomes, we need to know the number and population frequency of disease variants, the magnitude of their effects on phenotype and gene-gene and gene-environment interactions. (nature.com)
Negative frequency-dependent selection (NFDS) is an evolutionary mechanism suggested to govern host-parasite coevolution and the maintenance of genetic diversity at host resistance loci, such as the vertebrate MHC and R-genes in plants. (pacb.com)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
Out of total 661 SNPs, only 37 validated SNPs having minor allele frequency ≥0.10 were considered for the present study. (springeropen.com)

We, therefore, targeted this research to find the pathogen-resistant pea lines and further decipher the diversity at er locus among resistant pea lines. (nature.com)
These resistant lines have er ( Erysiphe resistant) locus having MLO gene (responsible for resistant mechanism in pea) which was detected using various molecular approaches. (nature.com)
the average population still shows a mean of 6.86 alleles per locus compared to a mean of 7.80-8.93 for nonisolated populations. (bioone.org)
We fine-map one locus associated with D. magna resistance to P. ramosa and genetically characterize two haplotypes of the Pasteuria resistance (PR-) locus using de novo genome and transcriptome sequencing. (pacb.com)
Sequence comparison of PR-locus haplotypes finds dramatic structural polymorphisms between PR-locus haplotypes including a large portion of each haplotype being composed of non-homologous sequences resulting in haplotypes differing in size by 66 kb. (pacb.com)
The high divergence of PR-locus haplotypes suggest a history of multiple, diverse and repeated instances of structural mutation events and restricted recombination. (pacb.com)
Moreover, in natural populations, we find that the PR-locus polymorphism is associated with variation in resistance to different P. ramosa genotypes, pointing to the PR-locus polymorphism as being responsible for the matching-allele interactions that have been previously described for this system. (pacb.com)
Using either a single affected subject per family or all affected subjects, evidence for excess transmission was found by the Transmission Disequilibrium Test for rs2056202, rs2292813, and a two-locus G*G haplotype. (neurotransmitter.net)
Finally, based on the outcomes of the analysis, we define a set of testable hypotheses with respect to the placement of particular alleles in complex IGHV locus haplotypes, and discuss the evolutionary relatedness of particular heavy chain variable genes based on sequences of their upstream regions. (lu.se)

Stargardt disease (STGD1) is a form of inherited retinal dystrophy attributed to variants affecting function of the large ABCA4 gene and is arguably the most complex monogenic disease. (nature.com)
For monogenic disorders, the genetic architecture is simplified as disease variants are, by definition, highly penetrant and environmental and gene-gene interactions are minimized. (nature.com)
Patients with ABCA4 -related disease have pathogenic variants in the ABCA4 gene which encodes a large, 2273 amino acid photoreceptor-specific transporter involved in the removal of toxic retinoid compounds from photoreceptors [ 20 ]. (nature.com)
The polymorphic variants of the IGF genes may serve as a susceptibility factor for pancreatic cancer. (aacrjournals.org)
Our survey found cytogenetically visible chromosomal anomalies in ~7.4% (129/1749) of autistic patients documented as well as several sub-microscopic variants. (neurotransmitter.net)
Based on pharmacological studies indicating a critical role of the mineralocorticoid receptor (MR) in the stress-induced bias toward dorsal striatal learning, we hypothesized that MR gene variants contribute to these individual differences. (eneuro.org)
Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. (cdc.gov)
We report the significant associations of blood lipids with variants and haplotypes in APOE , ITGB3, NOS3 , and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. (cdc.gov)
Several novel upstream region variants were validated, for instance by their segregation to a single haplotype in heterozygotic subjects. (lu.se)

However, combinations of snps in the IL-4Ralpha and CD14 genes were found to be significantly associated with DA. (cdc.gov)
Two single nucleotide polymorphisms (SNPs) that showed evidence for divergent distribution between autistic and nonautistic subjects were identified, both within SLC25A12, a gene encoding the mitochondrial aspartate/glutamate carrier (AGC1). (neurotransmitter.net)
RESULTS: Linkage and association were observed between autistic disorder and the two SNPs, rs2056202 and rs2292813, found in SLC25A12. (neurotransmitter.net)
CONCLUSIONS: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated. (neurotransmitter.net)
In spite of being exhaustively studied molecule, no attempt has been made till date to comprehensively and systematically analyze the SNPs of MBL2 gene. (springeropen.com)
The present study was carried out to identify and prioritize the SNPs of MBL2 gene for further genotyping and functional studies. (springeropen.com)
These 37 SNPs includes one in 3′ near gene, nine in 3′ UTR, one non-synonymous SNP (nsSNP), thirteen intronic SNPs and thirteen in 5′ near gene. (springeropen.com)
Out of these, 4 SNPs from 3′ UTR were found to play role in miRNA binding, 7 SNPs from 5′ near and intronic region were predicted to involve in transcription factor binding and expression of MBL2 gene. (springeropen.com)
Thus, findings of the present study indicated 12 SNPs of MBL2 gene to be functionally important. (springeropen.com)
2007 ). SNPs of MBL2 gene cover both coding and non-coding regions. (springeropen.com)

Furthermore, the email address details are in keeping with a job for non-coding HLA hereditary variations in the pathogenesis of MG. ancestral haplotype, known as AH8 also.1 (19), or particular alleles which lay upon this haplotype have already been found to become strongly connected with AChR-MG and EOMG in a number of Western european populations (20C24). (roma2024.com)

Lactose tolerance is a relatively recent adaptation, found among a variety of West Eurasian and African populations. (discovermagazine.com)
The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry. (blogspot.com)
To gain insight into when and where this mutation arose, we defined common haplotypes in the genomic region around SLC24A5 across diverse human populations and deduced phylogenetic relationships between them. (blogspot.com)
Virtually all chromosomes carrying the A111T allele share a single 78-kb haplotype that we call C11, indicating that all instances of this mutation in human populations share a common origin. (blogspot.com)
The list below shows all populations in AFND that contains the allele. (allelefrequencies.net)
We found that Malanis have lost some genetic variability compared with the present-day cosmopolitan caste populations and highly mobile pastoral cultures of India. (bioone.org)
As part of a project on environmental disasters in minority populations, this study aimed to evaluate differences in the sequence of N-acetyltransferase 2 ( NAT2 ) as a metabolic susceptibility gene in yet unexplored ethnicities. (aacrjournals.org)
We found pronounced ethnic differences in NAT2 genotypes with yet unknown effect on the health risks for environmental or occupational exposures in minority populations. (aacrjournals.org)
We analyzed the distribution of KIR genes in the Tibetan ethnic minority of Lhasa city, the Uyghur and Kazakh ethnic minorities of Urumqi city populations in China. (biomedcentral.com)
We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
For everyone three populations, alleles and haplotype blocks in the ancestral haplotype AH8 present.1 were connected with risk in AChR-EOMG sufferers. (roma2024.com)
These research highlight the hereditary heterogeneity in HLA alleles predisposing to different sets of MG among different populations. (roma2024.com)

But, baked into the cake of how genetics in complex organisms usually works, one allele may often have multiple downstream consequences. (discovermagazine.com)
The underlying genetics of matching-allele interactions are unknown even in host-parasite systems with empirical support for coevolution by NFDS, as is the case for the planktonic crustacean Daphnia magna and the bacterial pathogen Pasteuria ramosa. (pacb.com)
Here, we identified the red glume 1 (Rg-B1) gene using association genetics and haplotype analyses in ten reference grade wheat genomes. (tamu.edu)

Germline loss of function mutations followed by somatic loss of non-mutant alleles in the tumours 2- 4 suggests a tumour suppressor role for mitochondrial complex II in the paraganglia. (bmj.com)
Based on these previous analyses and clinical findings, CLRN1 was directly sequenced in 17 patients susceptible to carrying mutations in this gene. (molvis.org)
After CLRN1 sequencing, we found two novel mutations, p.R207X and p.I168N. (molvis.org)
The haplotype without mutations was more common in Kyrgyz (40.1% in Kyrgyz, 29.3% in Romanians). (aacrjournals.org)
The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)

The IC, QC and IQC haplotypes are significantly associated with the DA phenotype. (cdc.gov)

METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)

Plant breeders typically focus on immune receptors or impaired susceptibility genes to develop resistant crops, but these can present challenges in terms of strength, durability or pleotropic effects. (elifesciences.org)

A network analysis indicates that two closely related haplotypes account for a large proportion of Malani Y chromosomes. (bioone.org)

While they noted that more work will be necessary to confirm this discovery, they found that individuals carrying the HLA-B7 genetic marker, which represents 35% of the population worldwide, are more likely to have a less effective immune response to covid-19. (wikipedia.org)
Allele reported 287 time(s) and present in 134 population(s). (allelefrequencies.net)
Allele reported 217 time(s) and present in 180 population(s). (allelefrequencies.net)
Only five haplotypes were identified within the entire Amerindian study population, and the haplotype distribution was significantly different among the five tribes, with one (Arara) to four (Wayampf) haplotypes being found per tribe. (wayne.edu)
C) were recently found to be strongly associated with NTG in a Caucasian population. (nih.gov)
We have characterized and analyzed the interaction between the two QTLs, by crossing TR20 that has O. rufipogon alleles at qLTG1 and qLTG3 in a Hwaseong background, with Hwaseong, to develop an F 2 population. (springeropen.com)
NGS of prolonged HLA gene sections continues to be applied effectively in population-based and trait-association research to recognize allelic variations in non-coding areas, and to attain mainly unambiguous HLA genotyping (28C31). (roma2024.com)
Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color. (tamu.edu)

In this scholarly study, we record the analyses of HLA haplotypes and alleles, described using high-resolution NGS, connected with safety and susceptibility to EOMG and LOMG in Italian, Norwegian, and Swedish cohorts. (roma2024.com)

The study showed also B*0702 in cooperation with B*27, the HLA-B*07/B*27 combination with D6S273-134 genomic marker allele and was found not to be the result of linkage disequilibrium. (wikipedia.org)

Susceptibility to scrapie is largely controlled by three polymorphic amino acid positions (136, 154, 171) of the ovine prion protein gene ( prnp ) [ 4 ] and reliable genotyping of the corresponding DNA polymorphism is required as a basis for selection decisions. (biomedcentral.com)
C) in the OPA1 gene were determined using the restriction fragment length polymorphism method. (nih.gov)

The present investigation, therefore, was carried out to find the presence of MLO gene among selected resistant cultivars of pea and decipher the diversity of er gene present among these resistant cultivars. (nature.com)
The Malanis are characterized by a generally low Y-chromosome haplotype diversity. (bioone.org)
Genetic drift and limited gene flow leading to reduced genetic diversity were important in determining the present genetic structure of the highly endogamous Malana village. (bioone.org)
The distributions of predicted haplotypes differed significantly between the two ethnicities where the Kyrgyz showed a higher genetic diversity. (aacrjournals.org)

Next-generation sequencing (NGS) can be an appealing choice for variant characterization of HLA genes because of its comparatively low priced, high-accuracy and impartial variant finding. (roma2024.com)

Haplotypes were constructed based on polymorphic markers within and outside the gene. (edu.pe)

This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. (cancerindex.org)

According to the numbers and types, KIR haplotypes are broadly classified into two groups: group A haplotypes have a fixed KIR gene ( 2DL1 , 2DL3 - 4 , 3DL1 - 3 , 2DS4 , 2DP1 and 3DP1 ), in contrast, group B haplotypes have variations in genetic content which is comprised of several genes and alleles that are not found in A haplotypes. (biomedcentral.com)
To understand the cause of the LTG variations between the parents, we genotyped three sequence variations of qLTG3-1 , that were identified in 98 Asian cultivated rice accessions ( Oryza sativa L.). The 98 accessions were classified into 5 haplotypes, based on three variations and a 71-bp deletion. (springeropen.com)
Access to pan-genome information greatly facilitates the assessment of structural variations and rapid candidate gene identification. (tamu.edu)
Our study demonstrates the value of multiple high-quality genomes to rapidly resolve copy number and haplotype variations in regions controlling agriculturally important traits. (tamu.edu)

B*2705 was found to be dominant allele associated. (wikipedia.org)
Monogenic resistance caused by dominant resistance ( R ) genes, typically encoding immune receptors that belong to the class of nucleotide-binding leucine-rich repeat receptors (NLRs), are successfully employed by plant breeders to develop varieties with strong qualitative disease resistance. (elifesciences.org)
OPA1, the gene responsible for autosomal dominant optic atrophy, represents a good candidate gene for normal-tension glaucoma (NTG). (nih.gov)
was the dominant risk allele in Italians (OR = 3.28, = 1.83E?05), Norwegians (OR = 3.52, = 4.41E?16), and in Swedes was the principal risk allele (OR = 4.24, P 2.2E-16). (roma2024.com)

The cloning of agriculturally important genes is often complicated by haplotype variation across crop cultivars. (tamu.edu)
We found extensive haplotype variation across the ten cultivars, with a particular group of MYB alleles that was conserved in red glume wheat cultivars. (tamu.edu)
Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)

The HFE gene responsible for haemochromatosis is distal on chromosome 6 from HLA-A and more so from HLA-B, the distance suffices (3 million nucleotides) to allow equilibration of the loci. (wikipedia.org)
Up to now, 16 KIR gene loci have been identified, including two pseudogenes (KIR 2DP1 and 3DP1 ). (biomedcentral.com)

The distributions of C11 and its parental haplotypes make it most likely that these two last steps occurred between the Middle East and the Indian subcontinent, with the A111T mutation occurring after the split between the ancestors of Europeans and East Asians. (blogspot.com)
The parental haplotypes causing for this mutation are also found in Americas and East Asians. (blogspot.com)

To our knowledge, this is the first report to detect a new qLTG3-1 allele and analyze the interaction of the two LTG QTLs in a nearly isogenic background. (springeropen.com)
analyze sequence deviation at eleven HLA genes in early-onset (EO) and late-onset (LO) non-thymomatous MG sufferers positive for the acetylcholine receptor (AChR) antibodies and ethnically matched up handles from Italy, Norway, and Sweden. (roma2024.com)

Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. (lu.se)
Upstream sequences were also identified for a set of previously uncharacterized germline gene alleles. (lu.se)

The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model. (pacb.com)
Matching-allele interactions of hosts and parasites that prevent the emergence of host and parasite genotypes that are universally resistant and infective are a genetic mechanism predicted to underpin NFDS. (pacb.com)

KIR 2DS4 - v alleles differ from the KIR 2DS4 - f alleles in that the former have a 22-bp deletion in exon 5, which leads to a frame shift mutation and produces a premature stop codon, preventing the formation of a functional membrane-bound receptor domain [ 10 ]. (biomedcentral.com)

Molecular studies revealed that the Erysiphe resistant ( er1 ) gene was present in 40 lines out of selected 50 pea lines and the mutational character was conferred up to 36 genotypes with 11 haplotype groups. (nature.com)
In particular, a group of glycosyltransferase genes that is present in the susceptible but absent in the resistant haplotype. (pacb.com)

These results do not support the results in Caucasians and indicate that ethnic differences may exist in the association between polymorphisms in the OPA1 gene and NTG. (nih.gov)
Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). (cdc.gov)

However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. (cdc.gov)

Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

The gene contains four exons and three introns. (springeropen.com)

We report on retinal disease progression in homozygous patients, providing valuable allele-specific insights. (nature.com)
2012) and are also consistent with the lower limit for the origin of A111T set by the finding that the Alpine "iceman" dated to 5.3 kya was homozygous for this variant (Keller et al. (blogspot.com)

But than we still don't know when exactly this mutation took place it could very well be that the West Eurasian admixture Amerindians got stems from a time when West Eurasian still hadn't developed this light skin allele. (blogspot.com)

The distributions of C11 and its parental haplotypes make it most likely that these two last steps occurred between the Middle East and the Indian subcontinent,' Looks to me more like between West Asia (minus Arabia) and western part of South_Central Asia (minus India). (blogspot.com)

genotypes from these divergent haplotypes can be used in pea resistance breeding to avoid genetic homogeneity and genetic vulnerability. (nature.com)
We cloned two atypical resistance genes that can provide complete resistance to Alternaria solani and Colorado potato beetle through the production of tetraose steroidal glycoalkaloids. (elifesciences.org)
Alternatively, susceptibility ( S ) genes provide recessive resistance that can be both broad-spectrum and durable ( 22 - 24 ). (elifesciences.org)

abstract = "Background and purpose: Spinocerebellar ataxia type 10 is a neurodegenerative disorder that is due to an expanded ATTCT repeat tract in the ATXN10 gene. (edu.pe)

Not only the four framework genes were present in all individuals, but the pseudogene 2DP1 could also be detected in all Uyghur individuals. (biomedcentral.com)
In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)
Small series insurance coverage of HLA genes implies that stage and allele ambiguities will tend to be present, diminishing the accuracy from the alleles and haplotypes described thereby. (roma2024.com)

Over the long term one assumes that 'better solutions' will emerge which do not have so high a fitness drag, perhaps through the evolution of modifier genes which mask the deleterious outcomes of the initial mutant. (discovermagazine.com)
One nsSNP Gly54Asp (rs1800450) was found to be deleterious and damaging by both SIFT and Polyphen-2 servers and thus affecting MBL2 protein stability and expression. (springeropen.com)

Especially, KIR 2DS1 - 3 , 2DS5 , 2DL2 , 2DL5 and 3DS1 are associated only with group B haplotypes, thus B haplotypes generally encode more activating KIR receptors than A haplotypes which encode a single activating receptor (KIR 2DS4 ). (biomedcentral.com)

Corresponding region of chromosome 6 contains nearly one million nucleotides thus these genes, or another closely linked gene could be involved in such massing of inflammatory granulomata. (wikipedia.org)

Microvariant alleles were found for the DYS458 and DYS385 markers and sequenced. (nih.gov)
Haplotypes of IL-4 receptor and CD14 genetic polymorphisms are markers of susceptibility for diisocyanate asthma. (cdc.gov)
Although the functional significance of these findings is uncertain, these haplotypes could be susceptibility markers for DA and may be useful aids in the diagnosis of DA. (cdc.gov)

We predicted Y-chromosome haplogroups and found that J2 and R1a were the most prevalent. (bioone.org)

Methods: Expanded alleles were detected by repeat-primed polymerase chain reaction. (edu.pe)

Haplotype comparisons across ten high-quality wheat genomes revealed a MYB transcription factor as candidate gene. (tamu.edu)

Sickle-cell disease one of the classical illustrations of heterozygote advantage, whereby those who carry one copy of the mutation on the gene have increased fitness vis-a-vis those who carry two normal copies of the gene. (discovermagazine.com)
Many individuals carry two copies of A haplotypes (AA genotypes). (biomedcentral.com)
The remainders carry Bx genotypes, which are consisted of either one copy of A haplotype and one copy of B haplotype (AB genotypes) or two copies of B haplotypes (BB genotypes). (biomedcentral.com)

In line with pharmacological studies pointing to a critical role of the mineralocorticoid receptor (MR) in the stress-induced learning bias, we report here that a MR haplotype associated with enhanced MR expression facilitates habit learning under stress. (eneuro.org)

The rare G allele of +45T>G occurred more frequently than the common T allele in T2DM patients compared with controls, and was associated with lower serum adiponectin levels. (who.int)

See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)

In addition, an excess of oxidative free radicals also increases the expression of proinflammatory genes and activates the inflammation process [ 18 , 19 ]. (hindawi.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Annotation of the haplotypes reveals striking differences in gene content. (pacb.com)

In persistent sarcoidosis this haplotype appears elevated, further study eliminated risk contributed by A3-Cw7 and DQ6.2 indicating B7-DR15 haplotype contains risk of disease (OR = 2.5). (wikipedia.org)
In Croatian children, two HLA-B27 alleles were found associated with disease, B*2702, B*2705. (wikipedia.org)
A more recent study looked at a number of linked gene-alleles and found I82-2:D6S265-1:HLA-A3:D6S128-2:HLA-F1:D6S105-8 was constantly associated while B7 appeared beyond the haplotype linked to disease. (wikipedia.org)
Therefore, the demand on genotyping capacities of the polymorphisms of the prion protein gene ( prnp ) relevant to presently known disease associations and EU regulations is steadily increasing. (biomedcentral.com)

The serotype identifies the more common HLA-B*07 gene products. (wikipedia.org)
A common serologically defined haplotype in Europeans is HLA A3-Cw7-B7-DR15-DQ6.2 which is composed of alleles A*0301:Cw*0701:B*0702:DRB1*1501:DQA1*0102:DQB1*0602. (wikipedia.org)
According to the maps, C10 is found in East Asia, PNG and Australia, while C3 is common in the New World, while rare in East Asia and absent from the Pacific. (blogspot.com)
A common haplotype, 19CGGC14, was found in 11/13 of Brazilian and in 1/3 of Peruvian families. (edu.pe)
A consistently recurrent intragenic haplotype was found, suggesting a common ancestry for most, if not all, patients. (edu.pe)

Nevertheless, previous studies had been limited by the tiny amount of HLA genes interrogated in one study, and limited insurance coverage of genes. (roma2024.com)

MBL1 and MBL2 , but in human the first of them is pseudogene leaving one functional gene MBL2 (Guo et al. (springeropen.com)

Usually, Group B haplotypes encode more activating KIR genes. (biomedcentral.com)

Our aim was to describe clinical characteristics and intragenic haplotypes of patients with spinocerebellar ataxia type 10 from Brazil and Peru. (edu.pe)

Taking the 12.4ky estimate and multiplying by two (for the slower autosomal mutation rate) yields an estimate of 25ky, so it seems that this allele did not accompany the earliest modern human colonists of West Eurasia but emerged in some region and spread from there. (blogspot.com)

1998 ). The MBL2 gene is composed of 7461 bases and lies between the regions 52765380 to 52772841 bp of chromosome no. 10 (NCBI reference sequence number NC_000010.11). (springeropen.com)

Anatomy12

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Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology2

Phenomena and Processes92

Disciplines and Occupations6

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Analyze2

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