Found drosophila melanogaster. Medical search. Frequent questions

It is known from earlier studies that the heat shock (HS) response in Malpighian tubules (MTs) of Drosophila larvae is different from that in other tissues because instead of the Hsp70 and other common heat shock proteins, Hsp64 and certain other new proteins are induced immediately after HS. (bioone.org)
This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. (nih.gov)
Based on this domain structure, four additional HP1 family proteins have been identified in Drosophila melanogaster. (uab.edu)
Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
Drosophila melanogaster porcupine and its mouse homologue PORCN gene encode transmembrane bound endoplasmic reticulum proteins needed for the secretion of Wnt (Wingless and INT-1) proteins. (medscape.com)

Made using the fly model Drosophila melanogaster, this finding has been published in PloS Genetics this week. (sciencedaily.com)

Drosophila melanogaster flies can sense air currents with the hairs on their backs. (wikipedia.org)
Here, we demonstrate that in a two-choice task Drosophila fruit flies spontaneously prefer sets containing more objects. (biorxiv.org)
Using a numerical visual conditioning paradigm, we found that flies are capable of associating sucrose with numerical quantities and can be trained to reverse their spontaneous preference for large quantities. (biorxiv.org)
New research on fruit flies, detailed online last week in the journal Proceedings of the National Academy of Sciences, finds males have fewer genetic obstacles to prevent them from responding quickly to selection pressures in their environments. (nbcnews.com)
Before you reach for the bottle, though, the researchers who found the behaviour caution that flies are very different to us, and their results don't say anything about the health benefits of a hot toddy. (newscientist.com)
The flies even have a taste for grapes and are commonly found in wineries. (newscientist.com)
We found that Xrp1 expression is increased in cabeza mutant fruit flies, leading to neuronal dysfunction. (europa.eu)
Flies are fascinating creatures that can be found in a variety of environments across the globe. (whatsthatbug.com)
A study from the University of California San Diego discovered that fruit flies (Drosophila melanogaster) have advanced cognitive abilities. (whatsthatbug.com)
Female flies emit Z 4-11Al for species-specific communication and mate-finding. (biorxiv.org)
Studies of fruit flies (Drosophila melanogaster) may help to understand the supremacy of iron control in the aging process. (curezone.com)
Erythritol, the main component of the sweetener Truvia®, was toxic to Drosophila melanogaster fruit flies in a dose-dependent manner in the Drexel team's study, published in PLOS ONE . (drexel.edu)
Indeed what we found is that the main component of Truvia®, the sugar erythritol, appears to have pretty potent insecticidal activity in our flies," Marenda said. (drexel.edu)
Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI. (lu.se)
A method utilizing Drosophila-melanogaster-fruit-flies for screening chemicals for teratogenicity was described. (cdc.gov)
For each sample five male and five virgin female Oregon-R-Drosophila-flies were placed in a 30 milliliter (ml) cotton stoppered shell vial containing 2.5 grams of fresh intact Drosophila medium to which 7.5ml fresh distilled water was added. (cdc.gov)
The authors conclude that Drosophila flies give significant and reproducible responses to a variety of chemicals. (cdc.gov)

I found that about 50% of each genome belongs to the Providencia core genome and about 15% of each genome consists of genes unique to that species. (cornell.edu)
When I compared orthologs of all eight sequenced Providencia genomes, I found that the percent of each genome that consists of the core genome and the unique genes stays largely the same. (cornell.edu)
Jordi Casanova's team examined various genes, among them Serpent (homologue of GATA in Drosophila), and demonstrated that the overexpression of this gene is indeed sufficient to drive tumour growth. (sciencedaily.com)
Once again, studies on Drosophila have contributed to our basic understanding of the behaviour of genes involved in cancer and metastasis, knowledge that will allow cancer researchers to pursue this line further," says the scientist. (sciencedaily.com)
We found evidence that gene expression is constrained by both univariate and multivariate shared genetic variation between genes, sexes and developmental stages, but may be resolved by differential splicing. (biorxiv.org)
Wayne and her colleagues examined more than 8,500 genes shared by both sexes of the fruit fly Drosophila melanogaster. (nbcnews.com)
Many genes are found on the X chromosome, whereas few are associated with the Y chromosome. (nbcnews.com)
We find direct evidence that the expression of the genes on the X has this covering behavior in females whereas in males they're out in the open," said study team member Lauren McIntyre, also of UF. (nbcnews.com)
While not as prominent a trend, they also found a similar pattern in so-called autosomal genes, which are those found on any chromosome save the sex chromosomes. (nbcnews.com)
Ovarian tumors are characteristically found in adult Drosophila melanogaster females homozygous for certain recessive genes (fes, nw and fu). (degruyter.com)
Antimicrobial peptides (AMPs) are innate immune effector genes, playing a key role in pathogen clearance in many species, including Drosophila. (ku.edu)
Although arthropods represent the largest and most diverse animal group, most other Fox genes have not been investigated in detail, not even in the arthropod model species Drosophila melanogaster. (lu.se)

The fly homolog of NIPBL, Nipped-B, facilitates enhancer-promoter communication and regulates Notch signaling and other developmental pathways in Drosophila melanogaster. (nih.gov)

Drosophila melanogaster ER membrane protein complex 8-9 (EMC8-9), mRNA. (genscript.com)
Here we report the production of full-length PfRH5 protein using a cGMP-compliant platform called ExpreS 2 , based on a Drosophila melanogaster Schneider 2 (S2) stable cell line system. (nature.com)
It is a protein_coding_gene from Drosophila melanogaster. (yeastrc.org)
A very important finding reported in this paper is that ALS-mutant FUS protein is toxic to both skeletal muscle cells and motor neurons. (europa.eu)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
In Drosophila melanogaster , the PORCN gene is involved in the processing of the wingless protein. (medscape.com)

There are four distinct stages in a Drosophilas life cycle: egg, larva, pupa, and adult. (nmmra.org)
We characterized the genomic structure of NIPBL and found that it is widely expressed in fetal and adult tissues. (nih.gov)
1. Catinozzi M, Mallik M, Frickenhaus M, Been M, Sijlmans C, Kulshrestha D, Alexopoulos I, Weitkunat M, Schnorrer F, Storkebaum E. The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling. (europa.eu)
however, it has not yet been reported in adult Drosophila melanogaster. (lu.se)

The developmental period for D. melanogaster varies with temperature, as with many ectothermic species. (wikipedia.org)
Within a quantitative genetic framework, we sequenced RNA from Drosophila melanogaster at different developmental stages to examine sex-biased gene expression and how selection acts upon it. (biorxiv.org)
This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. (wikipedia.org)
Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. (wikipedia.org)
Here, we investigated, in females of both D. melanogaster and D. nigrosparsa , the gene expression between animals uninfected and infected with w Mel, using RNA sequencing to see if the two Drosophila species respond to the infection in the same or different ways. (nature.com)
A recent study in three black fly species in the genus Simulium found differential Wolbachia prevalence among species, suggesting host-specific interactions 16 . (nature.com)
Multiple strains representing four species of bacteria belonging to the genus Providencia have been isolated from wild caught Drosophila melanogaster: Providencia sneebia, Providencia burhodogranariea strain B, Providencia burhodogranariea strain D, Providencia rettgeri, and Providencia alcalifaciens. (cornell.edu)
Since Rcd-1 is a regulator of differentiation in other species, it suggests that Rcd-1r may serve a similar role during spermatogonial differentiation in Drosophila . (plos.org)
Chan Y-S, Huen DS, Glauert R, Whiteway E, Russell S (2013) Optimising Homing Endonuclease Gene Drive Performance in a Semi-Refractory Species: The Drosophila melanogaster Experience. (plos.org)

Drosophila melanogaster are so popular when studying genetics because they have a short life cycle of 10-14 days, they are inexpensive to care for, and because they have numerous mutations that can be studied. (nmmra.org)
In certain geographically isolated or ethnic populations, particular mutations are found with increased frequency relative to other populations. (nmmra.org)
It does not induce sex-linked recessive lethal mutations or nondisjunction in Drosophila melanogaster . (inchem.org)

Schlenke and his team raised healthy and parasitised fruit fly larvae ( Drosophila melanogaster ) in Petri dishes that contained both regular food and food laced with alcohol. (newscientist.com)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin. (genscript.com)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. (genscript.com)
While HP1a binds large domains in heterochromatin, it also shows binding to active transcription start sites, where it is generally found in the company of HP1B and/or HP1C. (uab.edu)

We evaluated the impact of curcumin on life span, fecundity, feeding rate, oxidative stress, locomotion, and gene expression in two different wild-type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. (escholarship.org)

Extensive images are found at FlyBase. (wikipedia.org)

In recent years, the fruit fly Drosophila melanogaster has become a valuable model system for unraveling basic mechanistic insights into the regulation of metabolism 7 , 8 , 9 . (jove.com)
The research was conducted on the fruit fly Drosophila, an established model for studying epithelial tumours. (sciencedaily.com)
The investigators also found that they could reduce the effects of uric acid accumulation and improve fruit fly survival by inhibiting free radicals -- unstable atoms that cause damage to cells -- using antioxidants like Vitamin C or by suppressing a gene called NOX. (sciencedaily.com)
Her lab at UAB utilizes a classical genetics model system, the fruit fly Drosophila melanogaster , to study various open questions in the area of epigenetics and chromatin. (uab.edu)
My lab uses the fruit fly Drosophila melanogaster as a model system to investigate epigenetic systems and their influence on development and gene regulation. (uab.edu)
We are using the fruit fly Drosophila melanogaster as a model for exercise biology. (uab.edu)
The fruit fly, Drosophila melanogaster , is a widely studied model organism in the field of genetics and neuroscience. (whatsthatbug.com)

Under optimal growth conditions at 25 °C (77 °F), the D. melanogaster lifespan is about 50 days from egg to death. (wikipedia.org)

Used with the highly versatile genetic model organism Drosophila melanogaster , it provides a powerful means of gaining new insights into regulatory mechanisms of food intake. (jove.com)
The model organism Drosophila melanogaster , with its great variety of genetically traceable tools for labeling and manipulating single neurons, allows mapping of neuronal networks and identification of molecular signaling cascades involved in the regulation of food intake. (jove.com)

D. melanogaster is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. (wikipedia.org)
We have previously found empirical evidence for antagonistic coevolution between the sex chromosomes in Drosophila melanogaster (see Lund-Hansen et al 2021, https://www.pnas.org/doi/full/10.1073/pnas.2003359118 ) and are now interested in determining how expression is altered in males with mis-matched sex chromosomes. (lu.se)
To investigate the antagonistic coevolution between the sex chromosomes, we carried out a round robin crossing scheme, where we swapped either the X or the Y chromosome between five populations of D. melanogaster stemming from different places in the world. (lu.se)

We present measurements of genetic variation in preadult viability in a laboratory-adapted population of Drosophila melanogaster, made at four different densities. (bioone.org)
Title: A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila. (genscript.com)
This paper identifies Xrp1 as genetic interactor of the Drosophila FUS ortholog cabeza. (europa.eu)

The CAFE assay is one of several behavioral paradigms used to measure feeding in Drosophila melanogaster and researchers have to choose the most appropriate one for their specific question. (jove.com)
May 17, 2021 Researchers have found out how microscopic structures called lipid droplets may help to prevent a high-fat diet causing kidney damage. (sciencedaily.com)
The researchers engineered Drosophila melanogaster in such a way that neurons activated by DEET glowed fluorescent green. (genengnews.com)
Following the glow, the researchers found activated receptors lining the inside of a poorly studied region of the antenna called the sacculus. (genengnews.com)
Researchers find that males can respond quicker than females to sexual selection, resulting in glitzier garbs like the male peacock's tail feather, which outshows any drab peahen. (nbcnews.com)
In a study that began as a sixth-grade science fair project, researchers at Drexel University have found that a popular non-nutritive sweetener, erythritol, may be an effective and human-safe insecticide. (drexel.edu)

Z )-4-undecenal ( Z 4-11Al) is the volatile pheromone produced by females of the vinegar fly Drosophila melanogaster . (biorxiv.org)
Since only females produce Z 4-11Al, and not males, we can reliably distinguish between single D. melanogaster males and females, according to their scent. (biorxiv.org)

This web tool allows you to estimate rates of recombination anywhere in the Drosophila melanogaster genome. (stanford.edu)
Please pick the release of the D. melanogaster genome you would like to use. (stanford.edu)

Scientists at the University of California, Riverside have identified neurons in Drosophila antennae that express a highly conserved, DEET-sensitive olfactory receptor, Ir40a. (genengnews.com)
Additionally, the connectome of an insect brain was mapped, revealing intricate networks of interconnected neurons in the Drosophila larva. (whatsthatbug.com)

Coinfections in D. melanogaster with P. sneebia and P. rettgeri, which induces greater antimicrobial peptide expression and is less virulent than P. sneebia, allowed me to conclude that P. sneebia is actively avoiding recognition by the immune response. (cornell.edu)
Founded in 2013, CBER is the latest expression of UCL's commitment to research in ecology and evolution, its application to conserving biodiversity, and sustaining human economies & well-being. (ucl.ac.uk)
We show that homing in Drosophila responds to increased expression of HEGs specifically during the spermatogonia stage and this could be achieved through improved construct design. (plos.org)
We found that 3′-UTR choice was important to maximise expression levels, with HEG activity increasing as we employed Hsp70, SV40, vasa and βTub56D derived UTRs. (plos.org)
We also searched for spermatogonium-specific promoters and found that the Rcd-1r promoter was able to drive specific expression at this stage. (plos.org)
We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)

Drosophila melanogaster is a holometabolous insect, so it undergoes a full metamorphosis. (wikipedia.org)

Although the amino acid sequences of mammalian and Drosophila calmodulins differ by only three conservative amino acid changes, the refined model reveals a number of significant differences between the two structures. (rcsb.org)

Camptothecin Effectively Regulates Germline Differentiation through Bam-Cyclin A Axis in Drosophila melanogaster . (bvsalud.org)

Here we show how to quantify the number and spatial distribution of synaptic active zones in Drosophila melanogaster photoreceptors, highlighted with a genetically encoded molecular marker, and their modulation after prolonged exposure to light. (jove.com)

In Drosophila melanogaster, this is most clearly observed in ancestral African populations. (ku.edu)

Title: Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor. (genscript.com)
Using this laboratory-friendly and natural host, D. melanogaster, I determined how these bacteria differ in their ability to cause host mortality, replicate within the fly and trigger the fly's immune response as measured by transcription of antimicrobial peptides. (cornell.edu)

Find that Viral miRNAs Mimic Human. (genengnews.com)

The observed positive effects of curcumin on life span and health span in two different D. melanogaster strains demonstrate a potential applicability of curcumin treatment in mammals. (escholarship.org)
To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. (lu.se)

A sensory panel finds that synthetic Z 4-11Al has a characteristic flavour, which we perceive even at the small amounts produced by one female fly. (biorxiv.org)

They are usually found beside the main nucleus and are similar in shape, color, and chromatinic body distribution [14]. (bvsalud.org)

The crystal structure of calmodulin (Mr 16,700, 148 residues) from Drosophila melanogaster as expressed in a bacterial system has been determined and refined at 2.2-A resolution. (rcsb.org)

Dunet (methomyl) a newly introduced carbamate pesticide, was analysed for its toxic effects on Drosophila melanogaster. (uni-mysore.ac.in)

The aim of this task was to find out whether gender affects the compliance levels in humans. (nmmra.org)

No aneuploidy or chromosomal aberration is found in cultured human lymphocytes. (inchem.org)

The finding could also shed light on why diseases show up differently in men and women. (nbcnews.com)
This corroborates the observation that a glass of wine is spoilt by a single D. melanogaster fly falling into it, which we here show is caused by Z 4-11Al. (biorxiv.org)
Here, we use both a linear model and control-gene-based approach to show that balancing selection is an important force shaping AMP diversity in Drosophila. (ku.edu)

I found that each bacterium has type 3 secretion system, a known virulence factor. (cornell.edu)
This means that presence of a type 3 secretion system does not correlate to those found to be virulent toward D. melanogaster. (cornell.edu)

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. (genscript.com)

This work establishes D. melanogaster-Providencia as a model system for the study of host-pathogen interactions. (cornell.edu)

In this study we found that CPT, a cell cycle -specific anticancer agent , reduced fecundity and exhibited significant cytotoxicity toward GSCs and two- cell cysts . (bvsalud.org)

Specifically, these materials recapitulate the biochemical cues, physicochemical stimuli, and native architecture found in these tissues. (leica-microsystems.com)

Those studies that have, found low or no heritability and have not examined evolvability. (datadryad.org)
Our previous studies showed that HEG drive was more difficult to achieve in Drosophila melanogaster than Anopheles gambiae and we therefore investigated ways of improving homing performance in Drosophila . (plos.org)
Dr. Brohawn studies life's electrical system from a molecular and biophysical perspective, with a focus on finding the answer to the question "How do we feel? (berkeley.edu)

The CApillary FEeder (CAFE) assay for Drosophila melanogaster was established in the lab of Seymour Benzer in 2007 inspired by an earlier work by Dethier in blowfly 10 , 11 . (jove.com)

Ten type IV scales were found on 606 wings of treated animals, leading to an estimale of 10 -4 -10 -5 for aberrant scales. (degruyter.com)

The CAFE assay made it possible to directly measure food intake in Drosophila melanogaster . (jove.com)

The Wolbachia strain w Mel was recently found to increase locomotor activities and possibly trigger cytoplasmic incompatibility in the transinfected fly Drosophila nigrosparsa . (nature.com)

A convenient tool to build experimental workflows and find products to match your needs. (qiagen.com)

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