Found cell nucleus. Medical search. Frequent questions

In eukaryotic cells , a membrane barrier called the nuclear envelope separates the nucleus from the cytoplasm. (phys.org)
Jan. 31, 2022 The nucleus is guarded by a highly secure door, the so-called nuclear pore, that controls the transport of substances from the cytoplasm to the cell nucleus and back. (sciencedaily.com)
The cytoplasm forms the inner contents of all cells. (visiblebody.com)
Organelles are specialized subunits in a cell that are contained within the cytoplasm. (visiblebody.com)
A cell has three main parts: the plasma membrane, the cytoplasm, and the nucleus. (visiblebody.com)
The Golgi body (Golgi apparatus, Golgi complex) is a membrane-bound organelle located in the cytoplasm of eukaryotic cells. (visiblebody.com)
Mitochondria are membrane-bound organelles located in the cytoplasm of eukaryotic cells. (visiblebody.com)
This arrangement creates a selectively permeable barrier, enabling the plasma membrane to surround and protect the cytoplasm while allowing the passage of certain materials in and out of the cell. (visiblebody.com)
Together, both allow for a proper communication between the nucleus and cytoplasm, which is essential for the cell functioning. (cosmeticsbusiness.com)
All cells contain a fluid called cytoplasm and a nucleus, and are enclosed in a cell membrane. (jainworld.com)
Cell expansion is primarily driven by water uptake into the cells cytoplasm, which accumulates in the cells central vacuole. (hightimes.com)
Sometimes things like RNA need to traffic between the nucleus and the cytoplasm.There are pores in this nuclear membrane that allow molecules to go in and out of the nucleus. (topperone.com)
Polygonal cells are uniform, with finely granular eosinophilic cytoplasm with central nuclei. (medscape.com)
The cells of the hair matrix have vesicular nuclei and deeply basophilic cytoplasm. (medscape.com)

PL: nuclei) is a membrane-bound organelle found in eukaryotic cells. (wikipedia.org)
Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. (wikipedia.org)
The nucleus is a large membrane-bound organelle that contains the genetic information of eukaryotic cells. (visiblebody.com)
But it's completely opposite to the usual genome packaging in the rods of day-living animals like primates, pigs and squirrels, and indeed, in almost all other eukaryotic cells. (nationalgeographic.com)
Bell proposed a viral origin for the eukaryotic nucleus back in 2001 and refreshed the theory in September. (uncommondescent.com)
Nucleus is specially found in eukaryotic cells. (topperone.com)
Cell biology breaks cell types into eukaryotic (those with a defined nucleus) and Prokaryotes(those with no defined nucleus). (topperone.com)
The nucleus is the control centre of the eukaryotic cell. (topperone.com)
So without the nucleus, most of the eukaryotic cells will die. (topperone.com)
in eukaryotic cells the most important of these proteins are the histones . (wikipedia.org)

Although the interior of the nucleus does not contain any membrane-bound subcompartments, a number of nuclear bodies exist, made up of unique proteins, RNA molecules, and particular parts of the chromosomes. (wikipedia.org)
14 Embedded within the inner membrane, various proteins bind the intermediate filaments that give the nucleus its structure. (wikipedia.org)
This size selectively allows the passage of small water-soluble molecules while preventing larger molecules, such as nucleic acids and larger proteins, from inappropriately entering or exiting the nucleus. (wikipedia.org)
The research, performed by Vivien Nagy, a visiting graduate student, André Hoelz, a research associate, and colleagues in Rockefeller University's Laboratory of Cell Biology, uncovered the molecular structure of three interacting proteins that form the centerpiece of the Nup84 complex - an important structural component of the nuclear pore complex. (sciencedaily.com)
8, 2020 Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. (sciencedaily.com)
Looking at the distribution of DNA in the nucleus, they discovered that much of the change in the viscoelastic nature of the nuclei is to do with the aggregation of chromatin, multi-component structures made of DNA and proteins. (scitechdaily.com)
Enzymes in the cisternae modify these proteins and pack them into vesicles that bud off the Golgi body and transport the proteins to different areas in the cell. (visiblebody.com)
Ribosomes are made mostly of rRNA (ribosomal ribonucleic acid), and bacterial cells contain more than 50 associated proteins, whereas plant and animal cells contain 80 associated proteins. (visiblebody.com)
Proteins synthesized by ribosomes are used by organelles in the cell, by the plasma membrane, or by structures outside the cell. (visiblebody.com)
Why would RNA stick around in the cell nucleus, instead of rushing out to make proteins? (scienceblogs.com)
Merajver's lab at the Rogel Cancer Center worked with a Michigan Engineering team led by Allen Liu, Ph.D., and postdoctoral researcher Luciana Rosselli-Murai, Ph.D. They focused on a protein called clathrin, which impacts how metabolites, hormones and other proteins enter into a cell. (eurekalert.org)
Signals must get from outside the cell into its nucleus to produce proteins. (eurekalert.org)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
The scientists found out how intrinsically disordered proteins in the center of the pore can form a spaghetti-like mobile barrier that is permeable for important cellular factors but blocks viruses or other pathogens. (mpg.de)
As the control center of the cell, the nucleus must be able to exchange important messenger molecules, metabolites or proteins with the rest of the cell. (mpg.de)
Proteins are essential molecules that perform various functions in the cell, such as catalyzing chemical reactions, providing structural support, and regulating gene expression. (proprofs.com)
Therefore, the correct answer is nucleus, proteins. (proprofs.com)
In our cells, massive lengths of DNA are packaged into small spaces by wrapping them around proteins. (nationalgeographic.com)
An array of holes, or pores, in the nuclear membrane allows for the selective passage of some certain molecules (such as proteins and nucleic acids) into and out of the nucleus. (topperone.com)
It possesses DNA, which directs the formation of proteins and enzymes in the cell, it controls the gene expression and regulates other functions performed by the cell. (topperone.com)
When studying the LTD4 induced signalling pathways we found that CysLT1R mediated stress fibre formation and a calcium response through two heterotrimeric G-proteins, Ga12 and Gai3, respectively and that the LTD4 induced calcium response is dependent on PKCe. (lu.se)

The genes within these chromosomes are structured in such a way to promote cell function. (wikipedia.org)
The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expression. (wikipedia.org)
In higher organisms, cells are very selective about what passes in and out of their nuclei, where the genes reside. (sciencedaily.com)
We have found a connection between the cancer cell 'swallowing' certain molecules and its ability to activate tumor suppressor genes," says study author Sofia Merajver, M.D., Ph.D., professor of internal medicine and epidemiology at the University of Michigan. (eurekalert.org)
PTEN and other tumor suppressor genes are desirable targets for cancer therapy, but they have proven elusive: no drugs have yet been found to restore function of these mutated or deleted genes. (eurekalert.org)
Genes are found in the __________ of a cell. (proprofs.com)
Genes are now known to be implemented as sequences of genetic code that direct specific cells to produce a particular protein at a particular time. (jainworld.com)
When growth stimulating genes are activated, cells begin to grow and increase in size. (hightimes.com)
Genes are located on chromosomes, thread-like structures found within the nucleus of cells. (realdetroitweekly.com)
It contains all of our genetic information and only genes that are necessary for skin cells are expressed.Thus, producing the unique cell type needed for the epidermis. (topperone.com)
Most of us have learnt in school that our DNA is the same in all our cells that we cannot influence our genes. (lu.se)
the cells of the body can activate and deactivate genes, which means that the function of the cells can be altered. (lu.se)

Although most DNA is found inside the cell's nucleus, mitochondria also contain a small amount of DNA, known as mitochondrial DNA. (medicalnewstoday.com)

This 3D medical animation depicts electrical impulses transmitting across nerve cells, or neurons. (doereport.com)
From within a vast matrix of neurons we see bright flashes representing impulses traveling across the axons, dendrites, and cell bodies of the neurons. (doereport.com)
It not only corresponds to the co-ordinated management of such cells as functional circuits, but also just as much with neurons as silicon chips in a computer. (positivehealth.com)
Neurons are nerve cells specialized to receive, disseminate, or transmit electrochemical impulses. (positivehealth.com)
Neurons are also endowed with specialized branched projections from the cell body. (positivehealth.com)
While neurons in our brain are vast, with a surface area about ten thousand times that of an average cell, it is, indeed, a big question as to where all the membrane components emerge from to 'spawn' the composite surface of growing dendrites. (positivehealth.com)
They found that the SHMOOSE microprotein accumulates in the mitochondria of neurons (nerve cells), where it binds to the inner mitochondrial membrane protein mitofilin. (medicalnewstoday.com)

However, as the result of recent advancements in microscopic imaging technology and computational image processing techniques [ 1 ], there has been significant growth of research towards translational computational systems that can detect, analyze, classify, and quantify cell nuclei from microscopic images. (hindawi.com)
To analyse the time-series 3D microscopic images of developing embryos with fluorescently labelled nuclei, these studies used image segmentation. (nature.com)
There are different types of leukemia that hematologists in cell transplant laboratories can differentiate/diagnose based on microscopic images. (hindawi.com)

Chromosomes are protein structures found within the nucleus of each cell that contain DNA. (glycemicindex.com)

organisms whose cells have a nucleus. (news-medical.net)
Calmodulin is a protein found in all living organisms, or at least those whose cells have a nucleus. (pasteur.fr)

These two cells like all other carry within them material that forms a definite number of chromosomes. (jainworld.com)
Each human cell typically contains 46 chromosomes, grouped into 23 pairs. (realdetroitweekly.com)
In more scientific terms, telomeres protect the integrity of information carrying throughout each cell cycle by serving as specialized DNA caps on chromosomes. (glycemicindex.com)
When people look at a picture of the cell,it's found in the middle of the cell.The nucleus bears all of the cell's chromosomes, which encode the genetic material. (topperone.com)
The nucleus has a membrane surrounding it that keeps all the chromosomes inside and makes the distinction between the chromosomes being inside the nucleus,the other organelles and components of the cell staying outside. (topperone.com)
Cells are normally diploid - this means that they have a pair - two sets of homologous chromosomes, and hence two copies of each gene or genetic locus. (topperone.com)
Chromosomes are normally visible under a light microscope only during the metaphase of cell division (where all chromosomes are aligned in the center of the cell in their condensed form). (wikipedia.org)
[5] In animal cells, chromosomes reach their highest compaction level in anaphase during chromosome segregation . (wikipedia.org)
The conventional MN assay does not discriminate between MN produced by acentric chromosome fragments from those arising due to whole lagging chromosomes that were not incorporated into daughter nuclei at the time of cell division. (cdc.gov)

In eukaryotes the nucleus in many cells typically occupies 10% of the cell volume. (wikipedia.org)
RBC and platelets present in eukaryotes also do not have the nucleus. (topperone.com)

It is theorised that telomere shortening may lead to premature pancreatic β-cell death, decreasing β-cell mass and subsequently reducing insulin secretion and glucose tolerance. (glycemicindex.com)
Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. (lu.se)
We found that C3 is upregulated in pancreatic islets during T2D as a factor against β cells dysfunction caused by attenuated autophagy. (lu.se)
C3 was found intracellularly in isolated human pancreatic β cells. (lu.se)
We found that IRIS-1 localizes in the nuclei of pancreatic β cells. (lu.se)

HIV infection requires the virus to enter a cell and gain access to the well-guarded nucleus in order for the viral components to be integrated into the healthy cell's DNA. (israelnationalnews.com)
To infect cells productively, HIV-1 must traverse the nuclear envelope to enable integration of the viral DNA into the genomic DNA of host cells. (phys.org)
The absence of detectable viral antigen-positive cells in previous reports may relate to the fact that the patients died during the late phase of the disease after intensive treatment with antiviral drugs. (cdc.gov)
The study of the human genome has found that a significant portion of the human genome consists of remnants of viral DNA and similar virus-like entities called transposons. (medicalnewstoday.com)
He points to the "viral factories" that giant viruses build inside prokaryotic cells. (uncommondescent.com)
To infect, the viral genome must enter the cell, where it hijacks the host cell's machinery and synthesizes multiple copies of virions. (lu.se)
Alternatively, following viral DNA release into a cell, cell-virus interaction leads to a dormant (so-called latent) state for a virus where its genome remains in the cell without replication which can later reactive and result in cell lysis. (lu.se)
This pressure is capable of powering ejection of the entire viral genome into a host cell nucleus, leading to infection. (lu.se)
The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pressure, and blocks viral genome ejection into a cell nucleus, preventing viral replication. (lu.se)
This pivotal finding presents a platform for discovery of a new class of broad-spectrum treatments for herpesviruses and other viral infections with genome-pressure-dependent replication. (lu.se)

In 2009, we wrote: In the future, the interface between brain and artificial system might be based on nerve cells grown for that purpose. (scienceblogs.com)
PEG10, primarily known for its role in placental development, has been found to accumulate in excessive amounts in ALS patients' spinal cord tissue, potentially disrupting communication between brain and nerve cells. (medicalnewstoday.com)
In this new study, researchers revealed that ALS patients have high levels of PEG10 in their spinal cord tissue, where it likely disrupts the mechanisms responsible for communication between brain and nerve cells. (medicalnewstoday.com)
These are known as dendrites - they not only receive information, but also form synaptic contacts with other nerve cells and allow nerve impulses to be broadcast. (positivehealth.com)
The researchers used a technique called immunoprecipitation to isolate the SHMOOSE microprotein from the mitochondria of nerve cells. (medicalnewstoday.com)
In neuroanatomy, a nucleus is a group of cell bodies of nerve cells in the brain or spinal cord. (topperone.com)

An antibody that binds to the nuclei of the body's own cells. (lupus.org)
In order to induce its effects on the intestinal epithelial cells, LTD4 binds to its receptor CysLT1R. (lu.se)

A cell nuclei segmentation algorithm incorporating unsupervised color clustering, morphological operations, and local thresholding has been proposed to distinguish the cancerous and noncancerous areas in histologically stained images and then segment the clustered cell nuclei [ 3 ]. (hindawi.com)
To quantify the nuclear region of every cell from a time-series 3D fluorescence microscopic image of living cells, we developed QCANet, a convolutional neural network-based segmentation algorithm for 3D fluorescence bioimages. (nature.com)

This study was designed to examine whether the unconventional spicing of XBP1 mRNA could occur in the nucleus and its possible biological relevance. (mdpi.com)
We use RT-PCR reverse transcription system and the expand high fidelity PCR system to detect spliced XBP1 mRNA, and fraction cells to determine the location of the unconventional splicing of XBP1 mRNA. (mdpi.com)

5 . Luthman J, Hoebeek FE, Maex R, Davey N, Adams R, De Zeeuw CI, Steuber V (2011) STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. (yale.edu)

To help explain, we need to recall that deoxyribonucleic acid, or DNA, is the molecule found inside all of our body's cells that contains the genetic information responsible for growth, function and reproduction. (glycemicindex.com)

The two forms of chromatin are found in different areas, with euchromatin spread throughout the nucleus and heterochromatin concentrated at its edges. (nationalgeographic.com)
Some use the term chromosome in a wider sense, to refer to the individualized portions of chromatin in cells, either visible or not under light microscopy. (wikipedia.org)
Others use the concept in a narrower sense, to refer to the individualized portions of chromatin during cell division, visible under light microscopy due to high condensation. (wikipedia.org)

Accurate results of cell nuclei segmentation are often adapted to a variety of applications such as the detection of cancerous cell nuclei and the observation of overlapping cellular events occurring during wound healing process in the human body. (hindawi.com)
We found evidence that lncRNAs are distributed in distinct cellular compartments in P. falciparum . (news-medical.net)
This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
However, other large cellular molecules needed in the nucleus can pass as they carry very specific signals. (mpg.de)
The study, published in eLife , found elevated levels of PEG10 in the nerve tissue of ALS patients, suggesting it can alter cellular behavior, thereby playing a role in the development of ALS. (medicalnewstoday.com)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
The Golgi apparatus is a cellular depot, responsible for receiving, cataloguing and transporting the cargo of newly synthesised molecules needed for cell growth and function. (positivehealth.com)
Cell signaling in plant development usually involves a receptor (i.e. for a hormone or light molecule) and a signal transduction pathway, which concludes with a cellular response that is relevant to the plants development. (hightimes.com)
METHODS: In vitro cellular experiments were conducted to examine the effects of Andro on cell viability and elucidate its mechanisms of action. (bvsalud.org)

Shifting transmission of physical stimuli plays key role in cell differentiation. (scitechdaily.com)
Less force is transmitted to its inner parts, leaving cells to commit to a certain differentiation pathway. (scitechdaily.com)
How stem cells choose and keep to differentiation paths continues to be a crucial question for medical science. (scitechdaily.com)
The motion of a tiny, inert bead inside the cell nucleus at different stages of the differentiation process. (scitechdaily.com)
This was the first time that the viscoelasticity of nuclei was tracked through the whole differentiation process in human stem cells. (scitechdaily.com)
As it becomes more fluid-like, the nucleus becomes less susceptible to external forces as it differentiates, committing more and more to the differentiation path it has chosen, a balance between what is known as plasticity (responsiveness to change) and homeostasis (resistance to change). (scitechdaily.com)
Now, the team's findings show that it also serves a completely different purpose, careful tuning how responsive the nucleus is to external forces, particularly in ensuring that it can commit to a certain differentiation path. (scitechdaily.com)
Reference: "Intranuclear mesoscale viscoelastic changes during osteoblastic differentiation of human mesenchymal stem cells" by Kojiro Matsushita, Chiharu Nakahara, Shun Kimura, Naoya Sakamoto, Satoshi Ii and Hiromi Miyoshi, 25 November 2021, The FASEB Journal . (scitechdaily.com)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
Notch-1, Jagged-1, Jagged-2, and stem cell marker Nanog are expressed in SHED cultured in KGM which may be involved in the differentiation into epithelial-like cells in human dental pulp tissues. (bvsalud.org)
Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)
Notch signaling pathway is also involved in the regulation of epithelial cell differentiation in various tissues 5-6 . (bvsalud.org)
Since robust localisation of IRIS-1 in the nucleus is observed only in some nuclei, it can suggest that IRIS-1 is localising in the nucleus depending on the differentiation state of the cells or in a subset of cells with different functional relevance. (lu.se)

A critical role of autophagy was identified in rat nucleus pulposus (NP) cells: Inhibition of autophagy suppresses, while activation of autophagy enhances, the catabolic effect of cytokines. (spandidos-publications.com)

A cell is the basic structural and functional unit of an organism and is often called the "building block of life. (visiblebody.com)
There are certain differences between the cells of different living beings as well as the cells in the different part of the living organism. (jainworld.com)
Nucleus contains the genetic information for that organism. (topperone.com)

Bacteria are prokaryotes, meaning that they are living organisms with no nucleus. (pasteur.fr)
Prokaryotes(meaning 'before nucleus') are cells without a definite nucleus. (topperone.com)

LncRNAs are found also to regulate genome structure and gene expression. (news-medical.net)
Depending on their localization, they are found to play important roles in regulating gene expression and the malaria parasite's life cycle progression. (news-medical.net)
The identification of PEG10 as a contributor to ALS through its influence on gene expression and axon remodeling is a significant finding," Dr. Janson said. (medicalnewstoday.com)

The cell nucleus contains nearly all of the cell's genome. (wikipedia.org)
For decades, researchers have been fascinated by the three-dimensional structure and function of these nuclear pores, which act as guardians of the genome: substances that are required for controlling the cell are allowed to pass, while pathogens or other DNA-damaging substances are blocked from entry. (mpg.de)
Except for mature red blood cells, all human cells contain a complete genome. (jainworld.com)

The primary tasks involved in the analysis of histologically stained tissue sections are cell nuclei counting, detecting abnormal cell nuclei, and the presence of antigens within the target cells. (hindawi.com)
In addition, they were negative for the natural killer cell antigens CD56 and CD57. (nih.gov)

In paper II, we showed that silencing of CD59 expression in rat β cells significantly suppressed insulin secretion. (lu.se)
Glucose-induced insulin secretion depends on β-cell electrical activity. (lu.se)
Yoda1, a specific PIEZO1 agonist, activates a small membrane current and thereby triggers β-cell electrical activity with resultant stimulation of Ca 2+ -influx and insulin secretion. (lu.se)
β-cell-specific Piezo1-knockout mice show impaired glucose tolerance in vivo and reduced glucose-induced insulin secretion, β-cell electrical activity and Ca 2+ elevation in vitro. (lu.se)

The nuclear envelope separates the fluid inside the nucleus, called the nucleoplasm, from the rest of the cell. (wikipedia.org)
A viscous liquid inside called nucleoplasm contains the contents of the nucleus, which include one or more spherical bodies, known as nucleoli. (visiblebody.com)

They focused their attention on nuclei as they differentiated into osteoblasts (bone cells). (scitechdaily.com)
SHED has the ability to be differentiated to specific cell lineages such as odontoblasts and osteoblasts as well as epithelial like cells. (bvsalud.org)

These large molecules must be actively transported into the nucleus instead. (wikipedia.org)
The movement of large molecules through the nuclear envelope and into the cell nucleus is regulated by large protein structures called nuclear pore complexes. (phys.org)

MX2, which is localized at the cytoplasmic face of the nuclear envelope, inhibits infection by blocking the nuclear import of HIV-1 DNA and preventing its accumulation within the nucleus. (phys.org)
TGF-β1 activated accumulation of phosphorylated SMAD2 (pSMAD2-C) at centrioles of motile cilia and at cell nuclei. (springer.com)
C3 was required to maintain autophagy activity in β cells, as evidenced by the massive accumulation of LC3-II puncta, indicating that in the absence of C3 autophagosomes do not fuse with lysosomes. (lu.se)
The dermal papilla consists of an egg-shaped accumulation of mesenchymal cells surrounded by ground substance that is rich in acid mucopolysaccharides (AMPs). (medscape.com)

A double membrane known as the nuclear envelope, similar in composition to the plasma membrane, surrounds the nucleus, and openings in the nuclear membrane called nuclear pores control the flow of substances in and out. (visiblebody.com)
Furthermore, we observed that CysLT1R is located in the plasma membrane and in the outer nuclei membrane. (lu.se)

The first story arose from a simple question: How do secretory cells - those that produce copious amounts of such substances as tears, saliva or all those bodily fluids - manage to get their contents out of the cell? (scienceblogs.com)
Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. (lupus.org)
The Act further directs that where feasible, ATSDR shall develop methods to determine the health effects of substances in combination with other substances with which they are commonly found. (cdc.gov)
Immunologically detectable substances found in the CELL NUCLEUS. (bvsalud.org)

A study published in the journal Nature Communications has identified a new pathway that human immunodeficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells. (israelnationalnews.com)
12 In human cells, the diameter of the nucleus is approximately six micrometres (µm). (wikipedia.org)
Finally, IKKβ knockdown was used to further confirm the effect of the NF‑κB signal on human NP cells autophagy, and the data showed that IKKβ knockdown upregulated the autophagy of NP cells during inflammatory conditions. (spandidos-publications.com)
The mechanisms of immune privilege in human nucleus pulposus (NP) remain unclear. (medsci.org)
We aimed for addressing the role of FasL expression in human intervertebral disc degeneration (IDD) and immune privilege in terms of the interaction between NP cells and immunocytes via the FasL-Fas machinery. (medsci.org)
FCM analysis found that human NP cells with increased FasL expression resulted in significantly increased apoptosis ratio of macrophages and CD8 + T cells. (medsci.org)
Moreover, studies with human disc cells, especially focusing on nucleus pulposus (NP) cells, are seldom found in the literature. (medsci.org)
A team led by Associate Professor Hiromi Miyoshi of Tokyo Metropolitan University have been looking at the nuclei of human mesenchymal stem cells, a type of cell that can mature (or "differentiate") into a wide range of cell types, including muscle, fat, bone, and cartilage. (scitechdaily.com)
There are about 200 different types of specialized cells in the human body. (visiblebody.com)
Both are changing our understanding of how the human cell functions, and both are going to contribute, in the future, to human health and welfare. (scienceblogs.com)
Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
Human cells shield their genetic material inside the cell nucleus, protected by the nuclear membrane. (mpg.de)
For the first time, we could visualize the gate to the control center of human cells. (mpg.de)
An example of a nucleus in real life is the nucleus of human skin cells. (topperone.com)
2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
Stem cells from human exfoliated deciduous teeth (SHED) are multipotent stem cells derived from the pulp tissues of extracted deciduous teeth 1 . (bvsalud.org)
Stem cells from human exfoliated deciduous teeth (SHED) (ALLCells, Alameda, CA, USA) were employed in the current study. (bvsalud.org)

It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
This abnormal phenomenon is caused by excessive proliferation and immature growth of blood cells, which can damage red blood cells, bone marrow, and the defense system. (hindawi.com)
Interestingly, stimulation of CysLT1R located in the nuclei induced the activation of ERK1/2, an enzyme which have been shown to mediate LTD4 induced proliferation. (lu.se)

The study, HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells , was the result of a collaboration of researchers from Touro University Nevada College of Osteopathic Medicine, Touro College of Osteopathic Medicine in New York, researchers from the Biotechnology Center (BIOTEC) of TUD Dresden University of Technology in Germany, and researchers from Italy. (israelnationalnews.com)
Researchers from Tokyo Metropolitan University have discovered how the sponginess and stickiness of stem cell nuclei controls how they "differentiate" into specialized cells. (scitechdaily.com)
Researchers have described other characteristics of the abnormal sperm cells that make fertilization of an egg cell difficult, although it is not clear how changes in the DPY19L2 gene are involved in development of these characteristics. (medlineplus.gov)
In this study, published in the Journal of Cell Science , researchers looked at breast cancer cells that did not express PTEN, a protein known to be mutated or deleted in about a third of breast cancers. (eurekalert.org)
The researchers hope that by understanding the role of PTEN at a mechanistic level - what are the steps that cause PTEN to modulate how cancer cells communicate with the outside - it could provide a new approach to targeting the consequences of decreased function of this critical tumor suppressor. (eurekalert.org)
Growing evidence has persuaded some researchers, however, that the nucleus might have arisen through a symbiotic partnership much like the one believed to have produced mitochondria. (uncommondescent.com)
Having identified a microprotein associated with a higher risk of Alzheimer's disease, the researchers followed up on their discovery by carrying out studies in rats and cell culture experiments. (medicalnewstoday.com)

To investigate tumor necrosis factor α (TNF α) and interleukin-1β (IL-1 β) regulation of CCL3 expression in nucleus pulposus (NP) cells and in macrophage migration. (shu.ac.uk)
Although they have not yet answered every one of their questions, they have uncovered a new level of regulation in the cell - one that is not immediately intuitive. (scienceblogs.com)
Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)

RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)

We report here that SMN deficiency, induced in the astroglioma cell line U87MG after lentiviral transduction with a shSMN construct, was associated with an increase in the expression of the main components of Notch signaling pathway, namely its ligands, Jagged1 and Delta1, the Notch receptor and its active intracellular form (NICD). (mdpi.com)
Knowledge on the expression analysis of Notch signaling pathway molecules in SHED cultured in KGM could highlight its involvement in controlling the biological activity of these stem cells, particularly during odontogenesis and other developmental process. (bvsalud.org)

for example, the quantification of total cells and abnormal cells was performed through manual hand counting. (hindawi.com)
While some techniques only perform the task of cell nuclei segmentation and quantification, techniques that are capable of further detecting and classifying abnormal tumors (cell nuclei) that cause various types of cancer have also been proposed. (hindawi.com)
At least 17 DPY19L2 gene mutations have been found in men with globozoospermia, a condition characterized by abnormal sperm cells that have a round head and no acrosome. (medlineplus.gov)
The abnormal sperm are unable to get through the outer membrane of an egg cell to fertilize it, leading to an inability to father biological children (infertility) in affected men. (medlineplus.gov)

It's a double-membraned organelle containing genetic material and other instructions required for celluar systems.Accordong to cell biology,the nucleus function is to act as the control center of the cell. (topperone.com)

The nucleus contains nearly all of the cell's DNA, surrounded by a network of fibrous intermediate filaments called the nuclear matrix, and is enveloped in a double membrane called the nuclear envelope. (wikipedia.org)
Artificially colored electron micrographs of HSV-1 at the cell membrane (a), in transport to the nucleus (b), and bound at a nuclear pore complex (NPC) embedded within the nuclear envelope (c). (lu.se)

649 Together, these membranes serve to separate the cell's genetic material from the rest of the cell contents, and allow the nucleus to maintain an environment distinct from the rest of the cell. (wikipedia.org)
Despite their close apposition around much of the nucleus, the two membranes differ substantially in shape and contents. (wikipedia.org)

Adapting to robust automated image processing techniques for primary tasks such as cell nuclei segmentation and quantification will not only prove to be time efficient for pathologists, but these techniques will also be capable of producing consistent results. (hindawi.com)
A robust and accurate algorithm to acquire the 3D positions of the cells would help to reveal the mechanisms of embryogenesis. (nature.com)

Tiny pores in the cell nucleus play an essential role for healthy aging by protecting and preserving the genetic material. (mpg.de)
The large membrance enclosed organelle which contains the genetic material in the form of multiple linear DNA molecules with the structure of chromosome is called cell nucleus. (topperone.com)

Although the mechanisms by which SARS-CoV-2 enters host cells are increasingly well documented, the direct molecular interactions between virus and host remain. (pasteur.fr)
PURPOSE: This study aims to investigate the molecular mechanisms by which p53 and p62 collectively affect Andro-induced HCC cell death, using both in vitro and in vivo models. (bvsalud.org)
Thus, in order t o find good therapeutics and better treatment options, we first need to better understand the disease mechanisms at play. (lu.se)

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. (abcam.com)
Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
T-cell receptor gamma (TCRgamma) displayed monoclonal-type rearrangement in four cases studied. (nih.gov)
Our results show that CysLT1R can be found in increased levels in colon cancer enterocytes (50% of 84 patients) and that high expression of this receptor in Dukes`B staged tumours predicts a poor disease outcome. (lu.se)

And macrophages and CD8 + T cells were harvested for apoptosis analysis by FCM after 2 days of co-cultures. (medsci.org)
Usually, this will make the cell initiate apoptosis leading to its own death, but sometimes mutations in the cell hamper this process and thus cause progression of cancer . (wikipedia.org)
Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. (lu.se)
It is now understood that several components drive β cells dysfunction and apoptosis. (lu.se)

We found that when UBQLN2 is mutated, the strange virus-like protein called PEG10 accumulates in the cell. (medicalnewstoday.com)

On the other hand, in botany, the nucleus may also refer to the central kernel of a nut or seed, or the center of a starch granule. (topperone.com)

And perhaps most importantly, we found that PEG10 protein levels are high in both UBQLN2-mediated, as well as sporadic ALS tissue samples compared to healthy individuals," Dr. Whiteley said. (medicalnewstoday.com)
Tissue Cell. (glycemicindex.com)
After being transferred to our hospital for laparoscopic surgery, it was found that the left spermatic cord and testis were transversely transverted to the right, the left testis was fixed at the right inner ring, and agglomerated soft tissue could be seen in the right inguinal canal, which was suspected to be Muller tube. (bvsalud.org)

We found that IRIS-1 expressing cells displayed significantly higher expression levels of Urocortin 3 and Pdx 1 (markers of mature β cells, which loss marks the beginning of β cells dedifferentiation), suggesting that IRIS-1 may be required for maintaining β cells identity and function. (lu.se)

Neurobiology is the study of the nervous system and how the brain works, its anatomy, physiology, or functioning, with emphasis on how our cells generate and control behaviour. (positivehealth.com)

The acrosome contains enzymes that break down the outer membrane of egg cells, allowing the sperm to fertilize an egg. (medlineplus.gov)

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. (abcam.com)
The cell is the fundamental structural and functional unit of all living organisms. (jainworld.com)
Diisocyanates are reactive compounds, MDI can react under physiological conditions with various functional groups found on biological molecules resulting in conjugate formation or undergo non-enzymatic hydrolysis to form 4,4'-methylenedianiline (MDA). (cdc.gov)

They found that the nucleus starts solid-like but becomes more fluid-like over time. (scitechdaily.com)

178 The nucleus is the largest organelle in animal cells. (wikipedia.org)
The nucleus is a large organelle that contains most of a cell's DNA. (visiblebody.com)

The nuclcleus controls & regulates the activities of cell. (topperone.com)
It is often called 'Brain of cell' as it Regulates the cell activities. (topperone.com)

In his famous textbook The Cell in Development and Heredity , Wilson linked together the independent work of Boveri and Sutton (both around 1902) by naming the chromosome theory of inheritance the Boveri-Sutton chromosome theory (the names are sometimes reversed). (wikipedia.org)

During embryogenesis, cells repeatedly divide and dynamically change their positions in three-dimensional (3D) space. (nature.com)
Over time, telomere length decreases until the telomere becomes too short for the cell to divide, eventually resulting in the death of the cell. (glycemicindex.com)
It guides the cells to divide. (topperone.com)
The hair matrix is the actively growing portion of the follicle consisting of a collection of epidermal cells that rapidly divide, move upward, and give rise to the hair shaft and the internal root sheath. (medscape.com)

Anatomy78

Organisms18

Diseases1

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology1

Phenomena and Processes62

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science5

Cytoplasm14

Eukaryotic10

Proteins21

Genes12

Cell's nucleus1

Neurons7

Microscopic images3

Structures found within the nucleus1

Whose cells have a nucleus2

Chromosomes9

Eukaryotes2

Pancreatic5

Viral10

Nerve cells6

Binds2

Segmentation algorithm2

MRNA2

Neuron1

Body's1

Chromatin3

Cellular9

Differentiation14

Inhibition1

Organism3

Prokaryotes2

Gene expression3

Genome3

Antigens2

Insulin secretion4

Nucleoplasm2

Osteoblasts2

Large molecules2

Accumulation4

Plasma membrane2

Substances4

Human17

Proliferation3

Researchers7

Regulation3

Stem cell1

Pathway2

Abnormal4

Biology1

Nuclear envelope2

Membranes2

Robust2

Genetic material2

Mechanisms3

Receptor4

Apoptosis4

Accumulates1

Kernel1

Tissue3

Function1

Anatomy1

Outer membrane1

Functional3

Fluid1

Organelle2

Regulates2

Chromosome1

Divide4