• Antibiotic
  • These hospital-associated clones are characterized by the acquisition of adaptive genetic elements, including genes involved in metabolism, biofilm formation, and antibiotic resistance. (uu.nl)
  • The scope of the review is to summarize recent trends in the emergence of antibiotic resistance and explore recent developments in the molecular epidemiology, population structure and mechanisms of adaptation of E. faecium and E. faecalis. (uu.nl)
  • ABSTRACT: Introduction: Enterococci are members of the healthy human intestinal flora, but are also leading causes of highly antibiotic-resistant infections. (scirp.org)
  • Found on the mucous membranes and the human skin of around a third of the population, it is extremely adaptable to antibiotic pressure. (wikipedia.org)
  • 2002). The Enterococci: Pathogenesis, Molecular Biology, and Antibiotic Resistance. (wikipedia.org)
  • Using synthetic chemistry, we have developed a series of marine antibiotic-inspired molecules that target a problem conventional antibiotics are unable to address because cells housed within bacterial biofilms are tolerant of them," said Robert Huigens, Ph.D., an assistant professor medicinal chemistry at the UF College of Pharmacy, a part of UF Health, and lead investigator of a study published in the Angewandte Chemie journal's online edition. (ufl.edu)
  • strains
  • The new approach shows promise against the most severe strains of MRSA as well as the toughest type of MRSA infection for antibiotics to infiltrate - bacteria enmeshed in biofilms. (rochester.edu)
  • Some strains of E. faecium are used as probiotics in both animals and humans. (wikipedia.org)
  • In contrast to E. faecium, clones of E. faecalis isolated from hospitalized patients, including strains causing clinical infections, are not exclusively found in hospitals but are also present in healthy individuals and animals. (uu.nl)
  • Microbiology
  • A collaborative effort that included researchers from UF's departments of medicinal chemistry, molecular genetics and microbiology, and epidemiology helped to learn more about the special biofilm-eradicating compounds that are also effective against TB. (ufl.edu)
  • virulent
  • CoNS and enterococci are low virulent bacteria and predominantly cause infections in individuals with underlying illness, individuals that have undergone surgery or with suppressed immune-system. (diva-portal.org)
  • Pseudomonas
  • The study experimented with the Pseudomonas aeruginosa biofilms and found that a disruption of relA and spoT genes produced an inactivation of the Stringent response (SR) in cells with nutrient limitation, which provides cells be more susceptible to antibiotics. (wikipedia.org)
  • bacteria
  • Today's antibiotics have a tough time breaking through MRSA biofilms on equipment like catheters, but RNPA1000 brought the bacteria to a halt even when they were ensconced within biofilms. (rochester.edu)
  • The enterococcal surface protein (Esp) allows the bacteria to aggregate and form biofilms. (wikipedia.org)
  • Enterococci are Gram-positive bacteria that are found in plants, soil and as commensals of the gastrointestinal tract of humans, mammals, and insects. (uu.nl)
  • It was one of the earlier bacteria in which penicillin resistance was found-in 1947, just four years after the drug started being mass-produced. (wikipedia.org)
  • MRSA
  • The team found one, a small molecule called RNPA1000, that brings MRSA nearly to a standstill. (rochester.edu)
  • Commensals
  • This observation suggests that the division between commensals and hospital-adapted lineages is less clear for E. faecalis than for E. faecium. (uu.nl)
  • tolerant
  • Though they are not capable of forming spores, enterococci are tolerant of a wide range of environmental conditions: extreme temperature (10-45 °C), pH (4.5-10.0), and high sodium chloride concentrations. (wikipedia.org)
  • eradication
  • citation needed] Enterococci are able to form biofilm in the prostate gland, making their eradication difficult. (wikipedia.org)
  • HP compounds not only proved effective in eradication efforts but also selectively targeted the biofilms without breaking down the encasing cell membrane of healthy human cells. (ufl.edu)
  • genetic
  • We will use fruit flies to find neuronal cells that regulate the release of dopamine and produce an anatomical database and genetic tools to manipulate them. (wellcome.ac.uk)
  • patients
  • E. faecium has a defined sub-population that is associated with hospitalized patients and is rarely encountered in community settings. (uu.nl)
  • and candida were found in three patients. (annals.org)
  • Discovering and developing potent biofilm-killing agents is the first step toward eradicating biofilms in patients. (ufl.edu)
  • Common biofilm infections include pneumonia in cystic fibrosis patients, chronic wounds and implant- and catheter-associated infections. (ufl.edu)
  • Hospital
  • Lebreton F, Manson AL, Saavedra JT, Straub TJ, Earl AM, Gilmore MS (2017) Tracing the Enterococci from Paleozoic origins to the hospital. (wikipedia.org)
  • cells
  • Cells in the early embryo are of particular interest as they harbour the potential to form all cell types found in the adult body. (wellcome.ac.uk)
  • Previous biofilm-eradicating compounds have been difficult to develop as they destroy cell membranes of both bacterial cells and healthy human cells," he said. (ufl.edu)
  • Our discovery offers the potential for future drug therapies to selectively target the cells within biofilms without killing human cell types. (ufl.edu)
  • study
  • Prior to his study, most compounds that have been able to kill biofilms operate by punching holes in cell membranes, Huigens said. (ufl.edu)
  • often
  • Enterococci are Gram-positive cocci that often occur in pairs (diplococci) or short chains, and are difficult to distinguish from streptococci on physical characteristics alone. (wikipedia.org)
  • agents
  • Phage-derived lysins as potential agents for eradicating biofilms and persisters. (annals.org)
  • This research is a prime example where the marine environment provided a template that upon further chemical modification resulted in excellent biofilm-eradicating agents. (ufl.edu)