• regenerate
  • While scientists do not know its exact function, the protein is thought to have a role in stabilizing the structure of adult stem cells as they regenerate and divide into daughter cells. (eurekalert.org)
  • Injecting the mice with a common inflammatory agent that increases the production of TNF-α, called complete Freund's adjuvant (CFA), and a preparation of spleen cells reversed type 1 diabetes in mice with end-stage disease and allowed the beta islet cells to regenerate. (wikipedia.org)
  • Reports of the heart's ability to repair itself have started to appear in peer reviewed journals and a paper has been published that has shown the potential of bone marrow cells to regenerate myocardium (myogenesis). (wikipedia.org)
  • receptors
  • When activated, these receptors kick the stem cells and immature blood cells into action, enlisting them to help fight whatever pathogen is attacking the body. (eurekalert.org)
  • Another key, he said, will be to figure out how best to control the receptors in stem cells. (eurekalert.org)
  • In a retrospective study of breast cancer tumors lacking estrogen receptors, progesterone receptors and Her2, DiRenzo and his colleagues found extremely high amounts of nestin in 14 of 16 tumor samples examined. (eurekalert.org)
  • In her presentation, "Design and Fabrication of Stimuli to Reveal Spatial Regulation of Cellular Signaling," she explained, "We want to understand how the receptors on cell surfaces mediate cellular responses, how cells work on a molecular level. (bio-medicine.org)
  • To study how receptors on cell membranes jump-start cellular responses, Baird and her colleagues chose to work with mast cells. (bio-medicine.org)
  • Typically, two or more receptors cluster together when they bind with an antigen (allergen or foreign body), and this causes transmembrane activation of enzymes within the cell that eventually lead to the release of histamines. (bio-medicine.org)
  • there are 25,400 microns in an inch), are arranged in patterns that contain antigens and cause IgE-receptors to cluster when the cells attach to the surface. (bio-medicine.org)
  • Bats use touch receptors on wings to fly, catch prey, study finds ( Bats have an ear for flying in the da. (bio-medicine.org)
  • It is believed that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such as receptors) between the daughter cells. (wikipedia.org)
  • These cells are activated by a mixture of transcriptional factors, genes, growth factors, receptors, the extracellular matrix and signalling pathways. (wikipedia.org)
  • Therapy
  • Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. (phys.org)
  • Besides the ethical concerns of stem cell therapy (see stem cell controversy), there is a technical problem of graft-versus-host disease associated with allogeneic stem cell transplantation. (wikipedia.org)
  • The company's research and development focus lies in the fields of cell immune therapy and adult stem cell therapy. (wikipedia.org)
  • Cell Therapy for Acute Myocardial Infarction. (wikipedia.org)
  • Two months thereafter, with the patient's condition deteriorating rapidly, the Director of Bone Marrow Transplantation, Cell Therapy and Transplantation Research Center at Hadassah felt that all available options had been exhausted and turned to Pluristem's PLX cells. (wikipedia.org)
  • Hundreds of clinical trials are currently underway studying the effects of stem cell therapy. (wikipedia.org)
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific type or all), however other types of adult stem cells may be used, such as adipose-derived stem cells. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • mice
  • In studies in mice, Xin and his colleagues found that disrupting the Notch signal did not have much effect on the basal cells. (phys.org)
  • humans
  • This type of stem cells, possessed by humans of all ages, are not to be confused with embryonic stem cells, which are found only in early-stage embryos. (eurekalert.org)
  • The domes contain Merkel cells, a type of "touch" cell common in bumps on the skin of most mammals, including humans. (bio-medicine.org)
  • The belief that humans are born with a fixed number of cardiomyocytes, and that the growth of these cells was directly responsible for the growth of the heart, has also been disproven. (wikipedia.org)
  • Quaini F, Cigola E, Lagrasta C, Saccani G, Quaini E, Rossi C, Olivetti G and Anversa P. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. (wikipedia.org)
  • Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G and Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. (wikipedia.org)
  • embryos
  • These stem cells come from embryos that are four to five days old. (abovetopsecret.com)
  • Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells. (wikipedia.org)
  • Isolating the embryoblast or inner cell mass (ICM) results in destruction of the blastocyst, which raises ethical issues, including whether or not embryos at the pre-implantation stage should be considered to have the same moral or legal status as embryos in the post-implantation stage of development. (wikipedia.org)
  • isolate
  • If StemBioSys' new intellectual property can successfully isolate the stem cells, Hutchens says they could grow more of them with StemBioSys' core product. (xconomy.com)
  • It should also be possible to isolate stem cells from the transplanted individual, which can themselves be transplanted into another individual without HSCs, demonstrating that the stem cell was able to self-renew. (wikipedia.org)
  • treatments
  • Treatments that use patients' own stem cells may be safer than using stem cells from someone else because they might reduce the potential for an immune response, according to StemBioSys CEO Bob Hutchens. (xconomy.com)
  • Regenestem is an international medical practice company focused on providing comprehensive solutions for adult stem cell treatments and research. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • research
  • A paper in the journal Stem Cell Reports has reignited debate among a section of the stem cell research community. (bionews.org.uk)
  • Stem cell research isn't a topic you'd expect to see in a comic book, particularly when the aim is to give a realistic insight into the subject, avoiding hype and sensationalism. (bionews.org.uk)
  • Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. (eurekalert.org)
  • Zook's research also points to the importance of a second type of receptor cell in the membranous part of bats' wings. (bio-medicine.org)
  • However, the derivation of such cell types from ESs is not without obstacles and hence current research is focused on overcoming these barriers. (wikipedia.org)
  • Dutch researcher Mark Post, who led the research on the lab-made hamburger, initially started working with pig cells before switching to cows. (wkbn.com)
  • StemBioSys, which was founded based on other University of Texas System research, acquired a portfolio of issued and pending patents. (xconomy.com)
  • The plan calls for $1 billion in research funding (about half for work on stem cells) and the creation of a post for a science and technology director. (scienceblogs.com)
  • If anyone knows Tommy Thompson's current position on stem cell research you get a prize. (blogspot.com)
  • Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation. (wikipedia.org)
  • He is the chairman of the Task Force on Stem Cell Research set up by the Department of Biotechnology of the Government of India. (wikipedia.org)
  • Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. (wikipedia.org)
  • In research, adult zebrafish are often fed with brine shrimp, or paramecia. (wikipedia.org)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • generate
  • Scientific interest in adult stem cells is centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (wikipedia.org)
  • regeneration
  • The present disclosure relates to compositions and methods for the regeneration and/or restoration of hair cells utilizing a composition or an agent that. (patents.com)
  • Faustman hypothesized that this regeneration may be attributed in part to the re-differentiation of the spleen cells - that although the splenic stem cells were not obligatory for regeneration to occur, these cells could hasten regeneration. (wikipedia.org)
  • The source of islet cell regeneration is debated. (wikipedia.org)
  • This group found that adult stem cells from the spleen did play a role in regeneration. (wikipedia.org)
  • The PNS has some, but limited, regeneration of neural cells. (wikipedia.org)
  • Other studies into the regeneration of myocardium have reported evidence of angiogenesis, although such studies have been found to contain discrepancies. (wikipedia.org)
  • donor
  • Donor animals are needed for the muscle cells, but taking those samples doesn't hurt the animal. (wkbn.com)
  • Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. (wikipedia.org)
  • divide
  • StemBioSys sells a so-called extracellular matrix product made of proteins that provide a hospitable environment for stem cells, helping them divide and produce more stem cells. (xconomy.com)
  • successfully
  • The dose finding portion of the study was successfully concluded and data showed that PLX-R18 treated subjects had an 85% survival rate compared to the placebo group which had a 50% survival rate. (wikipedia.org)
  • young stem cells
  • StemBioSys believes its new technology can potentially identify a few thousand high-quality, young stem cells from a sample of tens of thousands of cells taken from a patient, Hutchens says-potentially being a key word. (xconomy.com)
  • induce
  • Faustman hypothesizes that BCG could induce a permanent gene expression that restores regulatory T cells (Tregs), helping to prevent the immune system attack which characterizes type 1 diabetes. (wikipedia.org)
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • progenitors
  • They look and behave just like embryonic beta cell progenitors. (eurekalert.org)
  • Previous studies had failed to demonstrate the existence of bona fide beta cell progenitors in the pancreas after birth. (eurekalert.org)
  • Neuroepithelial stem cells, the early progenitors for much of the nervous system, need to maintain a keen sense of direction in order to properly manage replication, migration and maturation. (phys.org)
  • Progenitors can go through several rounds of cell division before finally differentiating into a mature cell. (wikipedia.org)
  • immune
  • We have long known that so-called hematopoietic (blood) stem cells create the blood cells that are the front-line soldiers in the body's immune system," said Paul Kincade, Ph.D., the senior author on the paper. (eurekalert.org)
  • A former president of both the American Association of Immunologists and the Federation of American Societies for Experimental Biology, his laboratory focuses on understanding the development and function of cells in the immune system. (eurekalert.org)
  • They were chosen because mast cells secrete chemicals and histamines (substances released in allergic reactions that cause runny nose, watery eyes and other character istic allergy symptoms) and they are the gatekeepers for the allergic immune response. (bio-medicine.org)
  • In 1986, Kimberlin co-founded the Immune Response Corporation with Jonas Salk. (wikipedia.org)
  • 2001
  • Pluristem was founded in 2001 by Shai Meretzki of the Technion, who made use of a stem cell patent which was developed during his Ph.D studies at The Rappaport Faculty Of Medicine, Technion, under the supervision of Dr. Shosh Merchav, together with Professors Dov Zipori and Avinoam Kadouri from the Weizmann Institute of Science. (wikipedia.org)
  • proliferate
  • However, when they disrupted both Notch and TGF beta signal, the basal cells begin to proliferate a lot," he said. (phys.org)
  • The cAMP response element CREB is closely related to the cell decision to proliferate or not. (wikipedia.org)
  • diseases
  • In two different attempts to treat degenerative eye diseases with stem cells, three patients have been blinded, while disease progression has been stopped in a separate patient. (bionews.org.uk)
  • They may offer a renewable source of replacement cells to treat diseases, conditions, and disabilities. (scienceblogs.com)
  • Faustman's hypothesis is that certain autoimmune diseases can be treated by stimulating TNF-α to trigger apoptosis in autoimmune T cells. (wikipedia.org)
  • A former secretary general of The World Academy of Sciences, he has served as the project coordinator of Translational Centre in Eye Diseases of Champalimaud Foundation (C-TRACER) and the Affordable Healthcare Project of the Wellcome Trust for finding solutions for the use of scaffolds for cultivating stem cells. (wikipedia.org)
  • replication
  • A new study has found that up to 66 percent of cancer-causing mutations can be attributed to random mistakes made during DNA replication. (bionews.org.uk)
  • Two mechanisms exist to ensure that a stem cell population is maintained: Obligatory asymmetric replication: a stem cell divides into one mother cell that is identical to the original stem cell, and another daughter cell that is differentiated. (wikipedia.org)
  • ethical
  • In this review, we will discuss the interest and the feasibility to establish hPS cells bank, as well as some economics and ethical issues. (hindawi.com)
  • Osiris Therapeutics, also co-founded by Kevin Kimberlin, uses adult stem cells to bypass the ethical and moral controversy surrounding this scientific breakthrough. (wikipedia.org)
  • vitro
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. (wikipedia.org)
  • However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells. (wikipedia.org)
  • It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
  • One method to treat CNS injury involves culturing stem cells in vitro and implanting the non-directed stem cells into the brain injury site. (wikipedia.org)
  • Direct stem cell delivery has an increased beneficial effect if they are directed to be neuronal cells in vitro. (wikipedia.org)