Found tumor microenvironment. Medical search. Frequent questions

Tumor microenvironment possesses complexity because of a mixture of growth-promoting and inhibiting growth factors, nutrients, chemokines, and other noncancer types, which interact with each other and associate with tumor growth, disease progression, drug resistance, and especially, infiltrating T lymphocytes and tumor growth [ 2 ]. (hindawi.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
To analyze tumors at comparable stages of progression, lymphoma, colon, and melanoma cancers that could be transplanted were selected, based on their susceptibility to therapeutic drugs. (nih.gov)
Since then, however, researchers have learned that the "malignant progression of cancer" also depends on cancerous cells participating in an "intricate network of interactions" with other parts of the tissue that surrounds them, or the tumor microenvironment. (medicalnewstoday.com)
We are applying our knowledge of how tumor cells interact with immune cells and other components of the tumor microenvironment to play a critical role in cancer initiation, progression, metastasis, and drug resistance. (janssen.com)
Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
Importantly, this ever-changing interaction is a key source of cancer cells' plasticity and plays an important role in every aspect of tumour progression. (irbbarcelona.org)
Further compounding this conundrum is the difficulty in accurately assessing response, as an increase in contrast enhancement on standard post-contrast MRI can be seen in treatment-related changes and true tumor progression. (abta.org)
Mar. 28, 2023 Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. (sciencedaily.com)
In a single-institution phase II study reported in the Journal of Clinical Oncology, Kim A. Reiss, MD, and colleagues found that maintenance treatment with the poly (ADP-ribose) polymerase (PARP) inhibitor rucaparib produced responses and was associated with good progression-free survival in. (ascopost.com)
PMN cell (Ly6G)-specific depletion of IRF4, however, did not influence tumor progression or MDSC accumulation in vivo in accordance with our finding that IRF4 is not expressed in PMN-MDSC. (uni-muenchen.de)
Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating the neutrophil chemotaxis in the tumour microenvironment. (bvsalud.org)
We aimed to determine the significance of Porphyromonas gingivalis (P. gingivalis) in promoting tumour progression in the tumour microenvironment (TME) of oral squamous cell carcinoma (OSCC). (bvsalud.org)
Our research is focused on elucidating the molecular events involved in the formation and progression of malignant tumors, and on the development of novel strategies for targeted therapy of cancer. (lu.se)
Accumulation of Tumor-Associated Macrophages (TAMs) is associated with tumor progression and poor survival in most cancers, including breast cancer. (lu.se)
It is therefore of interest to further investigating the effect of LTD4/CysLT1R in tumor progression. (lu.se)
These findings show that the presence and ratio of fungal species in cancer cells - the intratumour mycobiome - can, despite their low abundance, promote tumour progression by inducing an immunosuppressive microenvironment. (who.int)
This study adds to the observations that the mycobiome, as well as the microbiome, contributes towards a microenvironment that plays a critical role in promoting tumour progression, by diverting human immune-suppressing responses. (who.int)

In most solid tumors, the presence of a specific type of immune cell, the CD8+ T cell is a good thing. (news-medical.net)
It is well known that the rapid growth of tumor cells and distortion of tumor blood vessels often results in insufficient oxygen supply and acidification in solid tumors. (nature.com)
While angiogenesis can reduce this effect, the partial pressure of oxygen is below 5 mm Hg (venous blood has a partial pressure of oxygen at 40 mm Hg) in more than 50% of locally advanced solid tumors. (wikipedia.org)
Our results indicate that proteolyzed PTPmu and its novel peptide detection agent, SBK4, allow for the visualization of tumor-specific changes in cell adhesion molecules by tissue-based staining, providing a rationale for further development as an imaging agent in aggressive solid tumors, including gynecological cancers. (nih.gov)
Our overall aim is to understand how TAM immunosuppressive and pro-metastatic functions are regulated and if these TAMs can be used as mechanistic, predictive and prognostic tools for different solid tumors, including breast cancer, adult and pediatric sarcoma, and other solid tumors. (lu.se)

In two new studies published today in Cancer Cell , researchers from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard used the emerging technology of single-cell RNA sequencing to draw a clearer picture of how kidney tumors' microenvironments change in response to immunotherapy. (news-medical.net)
Researchers have found that reducing glycosylation on the T cell surface may offer new approaches to cancer immunotherapy. (medicine.net)
NCI scientists found that tumors of germ-free mice (mice completely lacking these microorganisms), or mice treated with antibiotics to deplete the gut of bacteria, were largely impaired in their ability to respond to immunotherapy that slows cancer growth and prolongs survival. (nih.gov)
The tumors were then treated with an immunotherapy that included CpG-oligonucleotides, which stimulated the immune system, or with the chemotherapy drugs oxaliplatin and cisplatin, which attacked the tumors. (nih.gov)
Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. (postdocjobs.com)
Their findings offer a new way of looking at cancer immunotherapy that matches the immune environment around the tumor and points the way to personalized immunotherapies. (ucsf.edu)
In addition, a growing number of clinical cases have found that pancreatic cancer exhibits significant resistance to traditional treatment options, including chemotherapy, radiation, and immunotherapy [ 6 , 7 ]. (hindawi.com)
Feb. 16, 2023 Cancer immunotherapy involves using activated T cells to destroy tumors, but it doesn't work for all patients. (sciencedaily.com)
Since this discovery, the possibility to reverse tumor-mediated immunosuppression has received increasing attention, changing the paradigm of cancer treatment from chemotherapy to immunotherapy. (benthamscience.com)
The presence of immune cells in the microenvironment suggests that immunotherapy may be effective against TNBC. (cancer.org)
The authors proposed a few possible explanations, including that "exhausted CD8+ T cells could be reactivated in the tumor microenvironment during vaccination, facilitating immunotherapy. (medscape.com)

Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
Metastasis is the complex process through which cancer cells become mobile, detach themselves from primary tumors, invade nearby tissue, migrate, and then set up secondary tumors in other parts of the body. (medicalnewstoday.com)
The study that Dr. Rohani and her colleagues undertook adds to the growing body of knowledge about tumor microenvironments and their contribution to metastasis. (medicalnewstoday.com)
In these acidic tumor surface regions, the cells had altered their genes to switch on processes that favor invasion and metastasis. (medicalnewstoday.com)
Other studies have also found that this reduces metastasis in mice. (medicalnewstoday.com)
His research focuses on translational aspects of tumor microenvironment, metastasis and biomarkers in breast cancer. (unifr.ch)
Tumour cells and their microenvironment establish a synergistic cooperation that characterizes all aspects of tumour growth, from onset to metastasis. (irbbarcelona.org)
Pharmacologic inhibition of the leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) reduces metastasis, revealing the efficacy of using targeted therapy against a specific tumour microenvironment component ( 2 ). (irbbarcelona.org)
We have already shown that age-related changes in the tumor microenvironment are accountable for the higher metastatic potential of melanoma in older patients," Ashani Weeraatna, Ph.D., Ira Brind professor, program leader of the Tumor Microenvironment and Metastasis Program at Wistar and lead author of the study, said in a press release. (upi.com)
Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. (lu.se)
By targeting these mechanisms, the overarching aim is to reprogram pro-tumoral TAMs into an anti-tumoral state, affecting various components of the non-cancer cells residing in the tumor microenvironment, ultimately inhibiting tumor growth and metastasis ( Figure 1 ). (lu.se)
Silencing of Mnks in TAMs reprograms them into an anti-tumor phenotype, entailing activation of TILs and induction of vessel normalization, which hampers distant metastasis. (lu.se)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)

In one study, researchers performed single-cell RNA and T cell receptor sequencing on 164,722 individual cells from tumor and adjacent non-tumor tissue. (news-medical.net)
However, researchers found that in advanced stage disease these CD8+ T cells were "exhausted," and not able to carry out their usual function. (news-medical.net)
In advanced disease samples, macrophages produce molecules that support CD8+ T cell exhaustion, at the same time those CD8+ T cells make molecules that supported the life of pro-tumor macrophages. (news-medical.net)
Why do tumor cells grow more aggressively in an acidic microenvironment? (ukaachen.de)
Glioblastoma stem cells grow more aggressively in an acidic microenvironment. (ukaachen.de)
These nontumor cells dilute the tumor purity in lung cancer tissues. (hindawi.com)
In addition to tumor cells, there are also other components such as stromal cells, inflammatory cells, vasculature, and the extracellular matrix [ 1 ]. (hindawi.com)
We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)
With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
Much attention has been given to the role of glycans in studies on cancer cells, which proliferate and metastasize depending on their interaction with their microenvironment. (medicine.net)
To examine for tumour cell growth, the scientists subcutaneously transplanted weakly immunogenic and strongly immunogenic tumour cells into B4GALT3 knockout and wild-type mice. (medicine.net)
Only the knockout mice suppressed the growth of strongly immunogenic tumour cells. (medicine.net)
The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). (wikipedia.org)
Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (wikipedia.org)
In 1960, Klein and colleagues found that in mice, primary methylcholanthrene-induced sarcomas exhibited an antitumor immune response mediated by lymph node cells to cancer cells derived from the primary tumor. (wikipedia.org)
The discovery of melanoma-specific T cells in patients led to the strategy of adoptively transferring large numbers of in vitro-expanded tumor-infiltrating lymphocytes (TILs) which has proven that the immune system has the potential to control cancer. (wikipedia.org)
While a lack of oxygen can cause glycolytic behavior in cells, some tumor cells also undergo aerobic glycolysis, in which they preferentially produce lactate from glucose even given abundant oxygen, called the Warburg effect. (wikipedia.org)
No matter the cause, this leaves the extracellular microenvironment acidic (pH 6.5-6.9), while the cancer cells themselves are able to remain neutral (ph 7.2-7.4). (wikipedia.org)
In cancer biology, the stroma is defined as the nonmalignant cells which are present in the tumor microenvironment. (wikipedia.org)
These processes are impeded by PD-1, a coinhibitory molecule expressed on T cells that is elevated in tumor-infiltrating lymphocytes (TIL). (nih.gov)
Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
Humans also harbor gut commensal microbiota that can influence local and body-wide inflammation as well as modify the tumor microenvironment, which consists of cells, signaling molecules and mechanisms that may support tumor growth and also cause drug resistance. (nih.gov)
Cancer cells from these tumors were then injected under the skin of the mice, where they formed tumors that grew to reach a diameter of one-fifth of an inch or more. (nih.gov)
This resulted in a lower production of cytokines (proteins secreted by lymph cells that affects cellular activity and controls inflammation) as well as lower tumor death therefore demonstrating that optimal responses to cancer therapy required an intact commensal microbiota. (nih.gov)
Following recent laboratory discoveries, her group is exploring novel approaches to target the microenvironment/oncogene cooperation driving chemoresistance and relapse in T-ALL leukemia stem cells. (postdocjobs.com)
Study the microenvironment and leukemic stem cells interactions. (postdocjobs.com)
In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
This work will help clinicians find the right biology to target and avoid targeting cells that aren't present in the tumor. (ucsf.edu)
Tumors are more than just out-of-control cells. (ucsf.edu)
The researchers characterized different microenvironments in the tumors, looking at which immune cells were present and which genes were expressed. (ucsf.edu)
To their surprise, the tumors contained a wide range of immune cells, such as macrophages, NK and B cells - beyond the T cells which are the focus of current immunotherapies. (ucsf.edu)
We may have been targeting cells that weren't even in the tumor. (ucsf.edu)
In the recent issue of Science Advances , cancer researchers from the iCAN Digital Precision Cancer Medicine Flagship at the University of Helsinki and HUS Helsinki University Hospital report novel research findings on stem cells in benign tumors of the gut, in which colorectal cancer originates. (eurekalert.org)
Cancer stem cell-targeted therapies play a key role in the treatment of cancer because other, more differentiated cells in the tumors have a relatively short lifespan even without treatment. (eurekalert.org)
By probing what happens to cells in acid regions of tumors, scientists have uncovered new information about cancer's invasiveness and spread. (medicalnewstoday.com)
Researchers at the Massachusetts Institute of Technology (MIT) in Cambridge found that acidic, or low-pH, tumor regions alter gene expression in cancer cells in ways that make them more aggressive. (medicalnewstoday.com)
There was a time when scientists believed that the potential for tumors to metastasize depended only on alterations to cancerous cells. (medicalnewstoday.com)
There is now a good understanding among scientists that tumors are not simply collections of multiplying cancerous cells, but "living entities," comprising many different types of cell. (medicalnewstoday.com)
However, what was not clear was how acidity varied in a tumor, and how it might alter genes to make tumor cells more invasive. (medicalnewstoday.com)
In this way, the researchers can tag and identify cells in acidic regions of the tumors. (medicalnewstoday.com)
It appeared that the metabolism of many of the cells on the surface of the breast tumors had changed to aerobic glycolysis. (medicalnewstoday.com)
Another was one that makes tumor cells more able to penetrate their surrounding tissue. (medicalnewstoday.com)
We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
Using intra-exosomal metabolomics, we provide compelling evidence that CDEs contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates that are avidly utilized by cancer cells for central carbon metabolism and promoting tumor growth under nutrient deprivation or nutrient stressed conditions. (elifesciences.org)
Studying a deadly type of breast cancer called triple negative, scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors. (sciencedaily.com)
More specifically, Ewald and Johns Hopkins postdoctoral fellow Eloïse Grasset, Ph.D., and others on the research team found several unique properties in the cells of mice engineered to have the mouse-version of triple negative breast cancers, and mice implanted with tumors from people with triple negative breast cancer. (sciencedaily.com)
The scientists found that when triple negative breast cancer cells invade other tissues on their way to another part of the body, they gain two cellular properties: better movement and survival. (sciencedaily.com)
To do this, breast cancer cells gain a cellular skeleton protein dubbed vimentin, which enhances the migratory ability of so-called mesenchymal cells, a cell type typically found in bones and bone marrow that moves around and makes new cells. (sciencedaily.com)
Triple negative breast cancer cells also gain survival advantages by producing a protein called E-cadherin, typically found in epithelial cells that line the ducts and coverings of organs and frequently renew themselves. (sciencedaily.com)
To look more closely at molecules involved in hybrid EMT states, the scientists sought the help of Elana Fertig, Ph.D., division director and associate director of quantitative sciences and co-director of the Convergence Institute at the Johns Hopkins Kimmel Cancer Center, to track the molecular patterns of individual cells in cell assays that model invasion out of the primary tumor and formation of a colony in a metastatic site. (sciencedaily.com)
The scientists found that most of the metastatic cells morph into the more mobile, better surviving, hybrid EMT state. (sciencedaily.com)
The theory behind interception is that finding pre-malignant cells will allow us to target them before they become more aggressive and resistant to treatment. (janssen.com)
We pursue a deep understanding of the relationships between cancer cells and the tumor microenvironment - the cellular environment in which tumors exist. (janssen.com)
We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
Dr. Ravid Straussman of the Weizmann Institute of Science found that bacteria living inside cancer cells are likely to have a profound effect on how different types of tumors behave. (washingtonjewishweek.com)
While bacteria were first detected in human tumors more than 100 years ago, Straussman reported in a paper in the May 29 issue of Science that he found bacteria live inside the cells of many cancer types, and that each type of cancer houses unique populations of bacteria. (washingtonjewishweek.com)
People think of tumors as a mass of cells that grows uncontrollably," Straussman said in a recent interview at his 15-person laboratory at Weizmann's Department of Molecular Cell Biology. (washingtonjewishweek.com)
The unique finding of Straussman's paper is that the collections of bacteria within tumor cells vary from tumor type to tumor type," Israel said. (washingtonjewishweek.com)
They must be providing some sort of advantage to the tumor cells, or doing something that contributes to the tumor's behavior. (washingtonjewishweek.com)
Tumors are complex ecosystems that are known to contain immune cells, stromal cells, blood vessels, nerves and many more components in addition to cancer cells. (washingtonjewishweek.com)
Importantly, we find that neutrophil-derived leukotrienes aid the colonization of distant tissue by selectively expanding the sub-pool of cancer cells that retain high tumorigenic potential. (irbbarcelona.org)
A study by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center found cancer cells grow more rapidly in "fatty, obese tissue," particularly cells that cause breast cancer. (newsweek.com)
We're interested in something called the 'microenvironment,' which is basically cells around the tumor and the chemicals those cells produce," Liza Makowski, a UNC Lineberger member and associate professor in the UNC Gillings School of Global Public Health, said in a statement released Friday. (newsweek.com)
Immunofluorescence image of micro-organospheres created from a human lung tumor, showing tumor cells (yellow and green) and T cells (red). (cancer.gov)
And because PDX mice lack functioning immune systems , he added, they can't capture the important interactions between immune cells and tumors, which can influence how cancer treatments work. (cancer.gov)
Organoids, which are created using specific types of stem cells in tumor tissue, are grown in laboratory dishes. (cancer.gov)
Several galectins are released by tumor cells and macrophages and accumulate in the tumor microenvironment. (raysahelian.com)
Acquisition of these mutations by normal cells can lead to microscopic abnormalities starting years before detectable tumors appear. (abta.org)
Brain tumors in general are derived mostly from glial cells, astrocytes and oligodendrocytes, but not neurons. (abta.org)
July 27, 2023 Investigators have designed an innovative RNA-based strategy to activate dendritic cells--which play a key role in immune response -- that eradicated tumors and prevented their recurrence in mouse models of melanoma. (sciencedaily.com)
July 5, 2023 A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. (sciencedaily.com)
June 23, 2023 B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown. (sciencedaily.com)
Katelyn T. Byrne, PhD, of the Perelman School of Medicine at the University of Pennsylvania, discusses the first in-depth analysis of the impact of selicrelumab, an anti-CD40 antibody, which was found to enrich T cells in pancreatic tumors, activate the immune system, and alter the tumor stroma (Abstract CT005). (ascopost.com)
Here, we show that IRF4 deficiency accelerates tumor growth and reduces survival, accompanied with a dense tumor infiltration with PMN-MDSC and reduced numbers of CD8+ T cells. (uni-muenchen.de)
We previously characterized CD45+ cells infiltrating T3 sarcomas using complementary forms of high-dimensional profiling (scRNAseq and CyTOF) and identified key immune cell populations that became associated either with growing tumors in mice treated with control antibody (cmAb) or rejecting tumors in mice treated with immune-checkpoint therapy (ICT) i.e., anti-PD-1 and/or anti-CTLA-4. (bmj.com)
Whole tumor tissue raw TIFF images were subjected to an image processing pipeline developed by Akoya Biosciences, Inc, where dapi+ cells used for cell segmentation by the Startdist method. (bmj.com)
Results When compared to the cmAb group, a-PD-1/a-CTLA-4 tumors harvested on day 10 displayed a marked increase in percentage as well as density of CD4+ and CD8+ T cells, Ly6G neutrophils, MHC-II+cd11c+cd24+DCs and a decrease of CD140a+ tumor cells. (bmj.com)
Specifically, immune cells were found at the border of the tumor in cmAb treated mice and heavily infiltrated tumors following ICT. (bmj.com)
Neighborhood identification analysis revealed changes in the composition of the main neighborhood clusters, of which the top three clusters present in cmAb treated tumors (macrophage, tumor, and other immune cells) were substituted by clusters of CD4+ and CD8+ T cells, neutrophils, and macrophages. (bmj.com)
Conclusions These results not only confirm the remodeling of both the lymphoid and myeloid compartments previously observed with scRNAseq and CyTOF but also suggest that changes in the spatial organization of immune cells are drivers of the tumor rejection process upon treatment with ICT. (bmj.com)
An ACS-funded researcher learns how cells that typically kill infected and diseased cells switch sides in the tumor microenvironment to help TNBC grow. (cancer.org)
The tumor microenvironment consists of a variety of cells, a meshwork of fibers, and blood vessels that surround a tumor. (cancer.org)
Compared to the microenvironment of other subtypes of breast cancer, the microenvironment around a triple-negative tumor has a large number of immune cells. (cancer.org)
These nearby immune cells seem to help the tumor grow and become resistant to drugs. (cancer.org)
Cholesterol increases expression of exhaustion markers in tumor-infiltrating CD8 + T cells. (aacrjournals.org)
Ma and colleagues found that high intracellular cholesterol levels positively correlated with exhaustion marker levels in CD8 + T cells in metastatic lung lesions in a mouse melanoma model and that intracellular cholesterol levels increase in T cells after tumor homing. (aacrjournals.org)
These initial observations were confirmed in human patient samples, as cholesterol content in CD8 + T cells isolated from primary colon tumors or myeloma samples correlated with increased PD-1 and 2B4 expression. (aacrjournals.org)
XBP1 knockdown or treatment with an ER stress inhibitor decreased PD-1 and 2B4 expression on tumor-infiltrating CD8 + T cells and also significantly decreased tumor burden, suggesting that cholesterol-induced ER stress affected T-cell antitumor functionality. (aacrjournals.org)
As our understanding of oncology has increased, it's become clear that each cancer consists of much more than just the tumour cell - a whole ecosystem of vessels, immune cells, and connective tissues form the tumour micro-environment (TME). (pharmaphorum.com)
The germ cell theory postulates that these tumors arise from primordial germ cells that have migrated aberrantly during embryonic development and subsequently undergone malignant transformation. (medscape.com)
Researchers recreated the interactions of melanoma cells with a young or aged tumor microenvironment and found an association between Klotho, Wnt5A, melanoma cells and the tumor microenvironment. (upi.com)
In these studies, we ask provocative questions about, and challenge the current perception of how tumor cells receive and transfer complex biological information. (lu.se)
However, the identification of internalizing surface antigens for specific drug targeting of tumor cells remains a challenge of high clinical relevance. (lu.se)
A CXCL2/CXCR2 signalling axis inhibitor significantly decreased the invasion and proliferation ability of cells and the tumour volume in mice . (bvsalud.org)
As therapeutic compounds become available to enhance migration, as in the case of tumor infiltrating cytotoxic immune cells, or to inhibit migration, perhaps in the case of autoimmune diseases where immunopathology is of concern, this method can be used as a screening tool. (cdc.gov)
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. (lu.se)
Genetic or pharmacologic inhibition of NOS1 reduced the growth of CXCL14-expressing fibroblasts along with their ability to promote tumor formation following coinjection with prostate or breast cancer cells. (lu.se)
TAMs are plastic cells that exhibit a spectrum of states spanning from an anti-tumor/immunoactivating (sometimes referred to as M1-like) to a pro-tumor/immunosuppressive (sometimes referred to as M2-like) phenotype. (lu.se)
These TAMs further stimulate activation of cytotoxic T cells that kill tumor cells, resulting in suppression of tumor growth. (lu.se)
I found that activation of CysLT1R via LTD4 increased the translocation and accumulation of β-catenin to the nucleus which induce proliferation of HCT116 colon cancer cells through phosphorylation of GSK-3β and activation of Tcf/Lef. (lu.se)
It was also found that LTD4 could induce Epithelial-Mesenchymal Transition (EMT) in SW480 colon cancer cells by i) reducing membrane E-cadherin, ii) increase levels of nuclear β-catenin, iii) increase EMT marker such as vimentin and snail which leads to increase migration of SW480 colon cancer cells. (lu.se)
In conclusion my data suggests that LTD4 in the tumor microenvironment can induce β-catenin signaling leading to increase cell proliferation and migration of colon cancer cells. (lu.se)

Tumor purity-related coexpression factors in the tumor microenvironment have essential clinical, genomic, and biological significance in lung cancer. (hindawi.com)

Using data from over 300 patient tumors, UC San Francisco researchers have described 12 classes of "immune archetypes" to classify cancer tumors. (ucsf.edu)
The UCSF researchers, led by first co-authors Alexis Combes , PhD, and Bushra Samad, MS, and senior author, Max Krummel , PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment. (ucsf.edu)
Researchers also found that the human Lef1 gene is not active in so-called serrated cancers of the large intestine, referring to the serrated pattern on the surface of the tumor formed by proliferating stem cell crypts. (eurekalert.org)
For their investigation, the MIT researchers used a "pH-probe" to map acidity in breast cancer tumors in mice. (medicalnewstoday.com)
The researchers reduced tumor acidity in the mice by adding sodium bicarbonate to their drinking water. (medicalnewstoday.com)
The researchers used a combination of machine learning, cellular imaging, and biochemical analysis to identify differences in the genetic expression patters of initial and metastatic tumors. (sciencedaily.com)
Researchers came up with their findings after analyzing a particular type of breast cancer, called triple-negative breast cancer, which they implanted in laboratory models of fat microenvironments-the mammary glands that surround a tumor. (newsweek.com)
Although formerly obese fat models had more and larger tumors than in mice with lean microenvironments, the number and size of tumors did decrease after weight loss, leading researchers to speculate that the risks of developing cancer could be mitigated by weight loss. (newsweek.com)
Although instances of cancer increased in fatty microenvironments, when researchers analyzed gene expression patterns within the tumors specifically, they found only "extremely subtle" changes were produced between obese, lean and formerly lean models. (newsweek.com)
And in a small study of eight people with advanced colorectal cancer, the researchers used the model to accurately predict whether the chemotherapy drug oxaliplatin would shrink their tumors . (cancer.gov)
But over the past decade, researchers have taken these representations of cancer to the next level, developing personalized models created from individual patients' tumor tissue. (cancer.gov)
As researchers look for potential drug targets, they're studying the microenvironments of TNBC tumors. (cancer.org)
Feb. 23 (UPI) -- Researchers at The Wistar Institute in Philadelphia have found an anti-diabetic drug activates an anti-aging gene that can inhibit growth of melanoma in older patients. (upi.com)
12, 2022-Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis. (vumc.org)
The researchers also found that whereas the ratio of certain fungal species was similar in non-tumour tissues and some tumour tissues, other, more aggressive tumour subtypes had a greater difference in the proportion of these species. (who.int)

This study demonstrates a critical role of IRF4 in the generation of an immunosuppressive tumor microenvironment in pancreatic cancer, which is independent of IRF4 expression in PMN-MDSC. (uni-muenchen.de)
Tumor microenvironments can be immunosuppressive and promote T-cell exhaustion. (aacrjournals.org)
Our research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. (lu.se)

In prospectively collected cancer tissues, we found that TIL exhibited dampened Tc1/Th1 skewing and activation compared with peripheral blood lymphocytes (PBL). (nih.gov)
2014. A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes. (raysahelian.com)
Galectin-1 and -3 were found to bind to glycosylated receptors at the surface of tumor-infiltrating lymphocytes (TIL), forming glycoprotein-galectin lattices that could reduce the motility and therefore the functionality of surface molecules. (raysahelian.com)
This is an effective system for determining the chemokinetics of lymphocytes, but, understandably, does not mimic the complexities found in the in vivo organ microenvironments. (cdc.gov)

The structure of tumor tissue is complex. (hindawi.com)
The importance of a stromal microenvironment, especially "wound" or regenerating tissue, has been recognized since the late 1800s. (wikipedia.org)
This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
The enhanced permeability and retention effect (EPR) is the observation that the vasculature of tumors is often leaky and accumulates molecules in the blood stream to a greater extent than in normal tissue. (wikipedia.org)
In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
In fact, the complexity of tumor tissue "may even exceed" the complexity of healthy tissues. (medicalnewstoday.com)
The surfaces of tumors - where they connect to the stroma, or "structural tissue" that surrounds them - also contained acidic regions. (medicalnewstoday.com)
As a person becomes obese, that can change the adipose tissue, or change this microenvironment where the cancer can start or progress. (newsweek.com)
To create the micro-organospheres, the research team takes tissue from a patient's tumor biopsy and runs it through a desktop device, about the size of a standard printer. (cancer.gov)
Creating the models required much less tumor tissue than is usually required to grow other cancer models that use a patient's own tumor tissue, Dr. Shen and his colleagues reported. (cancer.gov)
Because they grow as human tumors in living tissue, there was initially great hope that PDXs might be used to direct care for individual patients, explained Konstantin Salnikow, Ph.D., of NCI's Division of Cancer Biology and who oversees NCI's Patient-Derived Models of Cancer program . (cancer.gov)
We previously demonstrated its tissue specific distribution in high-grade brain tumors. (nih.gov)
To extend those studies to other aggressive solid tumor types, we assessed the tissue distribution of PTPmu/SBK4 in a set of matched gynecologic cancer patient derived xenografts (PDXs) and primary patient tumors, as well as a limited cohort of tumors from gynecological cancer patients. (nih.gov)
We used the peptide agent SBK4 conjugated to the fluorophore Texas Red (TR) to label tumor tissue microarrays (TMAs) containing patient and/or PDX samples from several high-grade gynecologic cancer types, and quantified the level of staining with Image J. In one TMA, we were able to directly compare the patient and the matched PDX tissue on the same slide. (nih.gov)
While normal tissue had very little SBK4-TR staining, both primary tumor tissue and PDXs have higher labeling with SBK4-TR. (nih.gov)
Scientists from the International Agency for Research on Cancer (IARC) and partner institutions investigated the amount of fungus present in lung adenocarcinoma tissue and found that the abundance of fungi in tumour tissue was higher than that in matched non-tumour tissue. (who.int)

In this research funded by the CCA, we focus on rewiring macrophages into a tumor-killing phenotype by intervening with their metabolism with the ultimate goal of finding therapeutic strategies targeting cancers with a high macrophage content such as glioblastoma. (vumc.nl)

Recently, scientists at Kyoto University and Yokohama City University have discovered that B4GALT3 deficiency in mice TIME inhibits tumour growth. (medicine.net)
The mice received these antibiotics in their drinking water, starting three weeks prior to tumor inoculation. (nih.gov)
Germ-free mice, or mice that received the antibiotic cocktail, responded poorly to drug therapy for their tumors. (nih.gov)
In next steps, Goldszmid and Trinchieri will work in mice to fully characterize the molecular signaling by which the bacteria in the gut can actually send messages to distant organs or tumors and change the type and level of inflammation present in those organs. (nih.gov)
In a paper that appears in the journal Cancer Research , they describe how, by reducing tumor acidity, they were able to reverse the process in mice. (medicalnewstoday.com)
Scientists looked at microenvironments of lean, obese and formerly obese lab mice during the study. (newsweek.com)
The mice retain the genetics of human tumors from which they were created. (cancer.gov)
Myeloid (LysM)-specific depletion of IRF4 led to increased tumor weight and a moderate splenic M-MDSC expansion in tumor-bearing mice. (uni-muenchen.de)
Methods T3 tumor bearing syngeneic mice were treated with cmAb or a-PD-1/a-CTLA-4 on days 6,9 and 12, harvested on different days, fresh frozen, cut in 8µM sections, transferred to coverslips, and stained with a panel of commercially available and custom-made CODEX antibodies following optimized staining conditions using the manufacturer's protocol. (bmj.com)
Their latest study found that by treating mice with a drug to promote Klotho expression, Wnt5A levels are lowered and growth of therapy-resistant melanoma is decreased in older mice -- but not young mice. (upi.com)

Tumor purity plays an essential role in the immune response to lung cancer. (hindawi.com)
At present, the biological processes related to the purity of lung cancer tumors remains unclear. (hindawi.com)
A lung cancer tumor purity correlated coexpression network was determined. (hindawi.com)
We explored the coexpression factors most related to tumor purity and related biological functions and demonstrated the most relevant biological functions and mechanism of action affecting tumor purity in the lung cancer tumor microenvironment. (hindawi.com)
The interplay between the tumor and its microenvironment was part of Stephen Paget's 1889 "seed and soil" theory, in which he postulated that metastases of a particular type of cancer ("the seed") often metastasizes to certain sites ("the soil") based on the similarity of the original and secondary tumor sites. (wikipedia.org)
Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture. (lu.se)
Cheng, K. K.W. , Dickson, A. , Gujam, F. J.A. , McMillan, D. C. and Edwards, J. (2017) The relationship between oestrogen receptor-alpha phosphorylation and the tumour microenvironment in patients with primary operable ductal breast cancer. (gla.ac.uk)
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. (postdocjobs.com)
Their research indicates that the immune archetype of a tumor is not necessarily tied to a type of cancer. (ucsf.edu)
Cancer stem cell niches can support stem cell growth as distinct regions within the tumor microenvironment. (eurekalert.org)
It is amongst these genes that future research may find new treatment targets for blocking of cancer stem cell niches. (eurekalert.org)
How does tumor acidity help cancer spread? (medicalnewstoday.com)
Tumor acidosis," says first study author Nazanin Rohani Ph.D., who was a postdoctoral researcher in the Koch Institute for Integrative Cancer Research at MIT when she completed the work, "gives rise to the expression of molecules involved in cell invasion and migration. (medicalnewstoday.com)
Previous research had already established that acidity in the tumor microenvironment had a powerful effect on cancer invasiveness. (medicalnewstoday.com)
Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. (elifesciences.org)
Many current breast cancer therapies work by targeting those flags, rendering them of little use to those with triple negative tumors. (sciencedaily.com)
He co-founded two start-ups companies active in the field of cancer detection and monitoring (Diagnoplex and Novigenix) and conceived a blood test for the non-invasive detection of colorectal cancer (COLOX®) now on the market. (unifr.ch)
In Straussman's most recent project , he and his team took tumor samples from 1,526 patients with seven cancer types - breast, lung, ovarian, pancreatic, melanoma, bone and brain - and found different assortments of bacteria that correlated with specific tumor types. (washingtonjewishweek.com)
Interestingly, he discovered that about 70% of breast cancer patients have bacteria in their tumors. (washingtonjewishweek.com)
We hope that by finding out how exactly they fit into the general tumor ecology, we can figure out novel ways of treating cancer. (washingtonjewishweek.com)
For instance, we identify neutrophils as the main component and driver of metastatic establishment within the pre-metastatic lung microenvironment in mouse breast cancer models. (irbbarcelona.org)
Every person's cancer is different, and even when a tumor has a genetic change for which there's a matching targeted therapy , there's no guarantee a given treatment is going to work. (cancer.gov)
Cancer models, including tumor cell lines and animal models , are widely used research tools. (cancer.gov)
Efforts to create these patient-derived tumor models, as they're called, are considered to be an important part of a concept known as precision oncology: treating a patient's cancer based on its unique clinical and molecular features. (cancer.gov)
The Qadan laboratory focuses on the tumor microenvironment in pancreas cancer. (massgeneral.org)
This is COOL SCIENCE: Cristae inside mitochondria (purple) align themselves to keep 'feeding' certain lung cancer tumors. (cancer.org)
Although the overall mortality in cancer is steadily decreasing, major groups of patients with malignant tumors of e.g. the brain, pancreas, and lung still respond poorly to available treatments and have a dismal prognosis. (lu.se)
Our recent studies have provided novel insights into the central role of lipoproteins and extracellular vesicles (EVs) in cancer, and the utility of EVs in non-invasive diagnosis of brain tumors (e.g. (lu.se)
PDXs isolated from the tissues of cancer patients have been shown to yield experimentally manipulatable models that replicate the clinical characteristics of individual patients' tumors. (nih.gov)
In this study, gynecological cancer PDXs and patient biopsies were examined to determine if tumor-specific proteolyzed PTPmu was present. (nih.gov)
28, 2022-A Vanderbilt study found that the bacterium Clostridioides difficile (C. difficile) may be a previously unrecognized contributor to colorectal cancer. (vumc.org)
Li and colleagues have previously found that patients with metastatic lung, liver, or intestinal tract cancers receiving PD-1 inhibitors had no significant differences in outcomes after COVID-19 vaccination, and wanted to extend their research to patients being treated for nasopharyngeal cancer. (medscape.com)
Although the potential association between COVID-19 vaccination and increased efficacy of anti-PD-1 therapy in recurrent metastatic nasopharyngeal cancer is "interesting," the finding "needs to be validated in a larger cohort study," Li and colleagues conclude. (medscape.com)
We make genetic and functional maps of cancer cell evolution in patients by analysing multiple tumour samples from the same patient. (lu.se)
Also, we compare patterns of evolution to parameters of the tumour microenvironment in order to find out how surrounding factors shape the cancer genome through selection. (lu.se)
Mission To find new strategies to prevent and manage relapse in children with cancer. (lu.se)
I also found that membrane expression of β-catenin is associated with good prognosis while nuclear GSK-3β is associated with poor prognosis in colon cancer patient. (lu.se)
The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. (cdc.gov)
Private Payer and Medicare Coverage Policies for Use of Circulating Tumor DNA Tests in Cancer Diagnostics and Treatment. (cdc.gov)
The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)

Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
We proposed already in 2011 that TAMs of an anti-tumoral phenotype located in the vicinity of tumor vessels (perivascular TAMs) promote vessel normalization that hampers metastatic dissemination. (lu.se)

This immune response did not however affect the primary tumor. (wikipedia.org)
The primary tumor instead established a microenvironment that is functionally analogous to that of certain normal tissues, such as the eye. (wikipedia.org)

This type of metabolism produces lactic acid, which made the tumor microenvironment more acidic. (medicalnewstoday.com)

Potential drug targets in the tumor microenvironment. (cancer.org)
My research is funded by the Netherlands Heart Foundation and focusses on macrophage metabolism with the final aim to find new targets for the treatment of atherosclerosis. (vumc.nl)
Signals supporting CAF function are thus emerging as candidate therapeutic targets in the tumor microenvironment. (lu.se)
Figure 1: Finding Novel Targets that Reprogram the Immunosuppresive Tumor Microenvironment (TME). (lu.se)
In my research project we will aim to increase the understanding of the disease for better diagnosis, prognosis and to find new therapeutic targets. (lu.se)

By evaluating the tumor microenvironment, we observed that the immune and metabolic microenvironments of the two groups were substantially different. (hindawi.com)
Ongoing studies have identified novel, and potentially targetable immune cell entities in the tumor microenvironment, suggesting myeloid cell (TAN and TAM) metabolic polarization into a pro-malignant state. (lu.se)

In an independent co-submitted study that will appear in the same issue of Science, Laurence Zitvogel, M.D., Ph.D., Gustave Roussy Institute, Paris, and colleagues showed that a different type of chemotherapy drug, cyclophosphamide, altered the composition of the intestinal microbiota and damaged the intestinal wall, thereby affecting optimal anti-tumor immune response and the therapeutic effectiveness of cyclophosphamide. (nih.gov)

Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. (lu.se)
Aims: Although the role of phosphorylation of oestrogen receptor (ER) at serines 118 (p-S118) and 167 (p-S167) has been studied, the relationship between p-S118, p-S167 and the tumour microenvironment in ER-positive primary operable ductal breast cancers have not been investigated. (gla.ac.uk)
The aims of this study are to investigate (i) the relationship between p-S118/p-S167 and the tumour microenvironment, and (ii) the effect of p-S118/167 on survival and recurrence in ER-positive primary operable ductal breast cancers. (gla.ac.uk)
The research team found that a variety of cancers come in prescribed forms, each of which represents a unique subversion of the body's immune defenses. (ucsf.edu)

Thus, targeting non-tumour-derived cellular components represents a promising avenue to better therapeutic interventions. (irbbarcelona.org)
Background Tumors contain spatially organized microenvironments in which the location and composition of the cellular components ultimately determine tumor fate. (bmj.com)
The fact that these tumors vary widely between patients, as well as in their cellular makeup, only adds to the challenges of developing effective treatments. (cancer.org)
Cellular microenvironment and metastases. (medlineplus.gov)

Within the tumor microenvironment, different macrophage subsets exist, eradicating tumors or supporting their growth. (vumc.nl)
Tumor analysis revealed reduced macrophage infiltration, with NOS1 downregulation in CXCL14-expressing CAF and lymphangiogenesis as a novel component of CXCL14-promoted tumor growth. (lu.se)

In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. (nature.com)
The key clinical challenge addressed by our group relates to the inherent adaptive capacity of tumors, resulting in resistance to conventional oncological treatments, but that also offers new avenues for therapeutic intervention. (lu.se)

Our studies are focused on but not limited to primary brain tumors, which integrates well with the PI's clinical proficiency as a consultant Neuro-oncologist. (lu.se)

This inflammation effect is not only seen in tumors, but in hypoxic areas of cardiac muscles following a myocardial infarction. (wikipedia.org)
This project is nested on a larger program directed by Dr. Carlesso that focuses on the relationships between the tumor microenvironment, inflammation, and stem cell biology in hematopoietic diseases. (postdocjobs.com)

Brain metastases (BM) are the most common tumor within the brain and carry a poor prognosis due to limitations in current treatment options. (abta.org)

We measured tumor purity in 486 lung carcinoma tissues from TCGA-LUAD FPKM by using the "estimate" R package. (hindawi.com)
On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)

The two most common patient-derived models are mouse models called patient-derived xenografts (PDXs) and tumor-like cell clusters called organoids that are grown in lab dishes. (cancer.gov)

Overall, these results defined a PD-1/SHP-2/STAT1/T-bet signaling axis mediating the suppressive effects of PD-1 on Th1 immunity at tumor sites. (nih.gov)
Our findings argue that PD-1 or SHP-2 blockade will be sufficient to restore robust Th1 immunity and T-cell activation and thereby reverse immunosuppression in the tumor microenvironment. (nih.gov)
In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)

In a clinical phenotype analysis, we found that these five factors can be used as independent prognostic risk factors. (hindawi.com)

Evidence in support of this theory includes a genome-wide methylation profiling study of 61 GCTs that found pure germinomas are characterized by global low DNA methylation, a unique epigenetic feature making them distinct from all other GCT subtypes. (medscape.com)

On closer investigation, the scientists found a different cause of microenvironment acidity at the tumor surface. (medicalnewstoday.com)

We found that the nitric oxide synthase NOS1 is upregulated in CXCL14-expressing CAF and in fibroblasts stimulated with CXCL14. (lu.se)

Jan. 9, 2023 Fewer cases of melanoma were observed among regular users of vitamin D supplements than among non-users, a new study finds. (sciencedaily.com)
Study finds an anti-diabetic drug activates an anti-aging gene, and has potential to treat melanoma in older people. (upi.com)

CXCL2 was selected by bioinformatics analysis and was found to be related to a poor prognosis in OSCC patients . (bvsalud.org)

This research will be the first of its kind, improving our understanding of brain tumor initiation but also in providing the basis for developing sensitive methods for detecting incipient tumors where no manifestation is evident. (abta.org)

Immunohistochemistry and immunofluorescence analysis of samples, cell biological behaviour experiments, and tumour-bearing animal experiments were used to verify the results in vivo and in vitro . (bvsalud.org)

The combination of rosiglitazone and targeted therapy reduced tumor growth in both young and aged models. (upi.com)
This finding suggests a potential correlation between fungal growth and the aggressiveness of lung adenocarcinoma. (who.int)
This study provides the first definitive proof of the impact of within-tumour fungal infections in promoting tumour growth. (who.int)

Dr. Shen and Dr. Hsu, along with a third member of the team, Hans Clevers, M.D., Ph.D., of the pharmaceutical company Roche and a pioneer in organoid technology, jointly founded Xilis in 2019 to commercialize the technology. (cancer.gov)

They also plan to characterize, in humans, the role of gut bacteria on the bodies' inflammatory response and tumor response to therapy. (nih.gov)
Inflammatory microenvironment is an essential component of most tumors. (lu.se)

In this study, we constructed a tumor purity coexpression network based on weighted gene coexpression network analysis (WGCNA) [ 8 ]. (hindawi.com)
Before the recent study, the prevailing view was that high acidity in tumors occurred mainly in oxygen-starved areas with a poor blood supply. (medicalnewstoday.com)
In a single-institution study reported in JAMA Oncology, Reyngold et al found that definitive hypofractionated ablative radiation therapy following induction chemotherapy was associated with prolonged locoregional control and favorable survival in patients with inoperable locally advanced. (ascopost.com)

Five coexpressed genes (CD4, CD53, EVI2B, PLEK, and SASH3) were identified as tumor purity coexpressed genes that negatively correlated with tumor purity. (hindawi.com)
Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
We also found that the TCR-regulated phosphatase SHP-2 was expressed higher in TIL than in PBL, tightly correlating with PD-1 expression and negative regulation of TCR target genes. (nih.gov)
Then, marker genes were calculated and 709 genes were identified to play a vital role in the microenvironment of LUAD. (aging-us.com)
To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)

Immune rejection of tumors is mediated by IFNγ production and T-cell cytolytic activity. (nih.gov)
Tumor microenvironment-induced T-cell exhaustion can be overcome by modulating cholesterol levels. (aacrjournals.org)
Cholesterol induces CD8 + T cell exhaustion in the tumor microenvironment. (aacrjournals.org)
CNS GCTs are broadly classified as germinomatous and nongerminomatous germ cell tumors (NGGCTs) on the basis of clinicopathological and laboratory features, including tumor markers. (medscape.com)
However, some bifocal nongerminomatous germ cell tumors (NGGCTs) may have similar radiographic features, detectable hCG levels, and normal or modestly elevated AFP. (medscape.com)
We developed a fluorophore-conjugated peptide agent, SBK4, that detects a tumor-specific proteolyzed form of the cell adhesion molecule, PTPmu, found in the tumor microenvironment. (nih.gov)
Samples with P. gingivalis infection in the TME of OSCC had the strongest cell invasion and proliferation and the largest tumour volume in tumour-bearing animal experiments and exhibited JAK1/STAT3 signalling pathway activation and epithelial-mesenchymal transition (EMT). (bvsalud.org)
This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

CNS GCTs may secrete tumor markers, the most common being alpha fetoprotein (AFP) and β-human chorionic gonadotropin (β-HCG). (medscape.com)
Measurement of serum and cerebrospinal fluid (CSF) levels of tumor markers may aid in the diagnosis and treatment plan. (medscape.com)
Krasnick BA, Goedegebuure SP, Fields R. Tumor biology and tumor markers. (medlineplus.gov)

In the future, these findings could contribute to a better tumor therapy. (ukaachen.de)
The new research findings help to understand mechanisms that lead to different types of intestinal tumors. (eurekalert.org)

Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
Advances in diagnostic imaging, surgical and anesthetic techniques, and radiation therapy and the addition of chemotherapy have improved the outcome in patients with these tumors. (medscape.com)

These companion studies shed important new light on the biology of advanced kidney tumors and their surrounding environments. (news-medical.net)

The classification scheme not only identifies which tumors are likely to be vulnerable to current immunotherapies, it also helps identify which patients might be most responsive in which clinical trial. (ucsf.edu)
Our preliminary and published studies uncovered a remarkably better response to standard care in female glioblastoma patients than in male patients as well as sex-specific differences in signaling networks and interactions in the tumor microenvironment. (abta.org)
Our proposal is an unprecedented opportunity specifically tailored to patients with BM in which we will obtain detailed tumor blood vessel changes and the genomic basis for such changes during treatment. (abta.org)
GETNE1509) reported in the Journal of Clinical Oncology, Jaume Capdevila, MD, and colleagues found that lenvatinib produced durable responses in patients with previously treated advanced grade 1 or 2 gastroenteropancreatic neuroendocrine tumors. (ascopost.com)
[ 2 , 3 ] GCTs account for approximately 3-5% of all intracranial tumors seen in patients younger than 20 years of age. (medscape.com)
From 5% to 10% of patients have tumors arising in both the suprasellar and pineal locations, and the histology is most frequently a germinoma. (medscape.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
13 ). Increased levels of IL-10 have procedures is highly operator depend- cers and remains the leading cause of been found in the plasma of patients ent. (who.int)

Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. (nature.com)

The discovery could lead to better treatments for aggressive tumors. (medicalnewstoday.com)

Lung carcinoma tumor mutation burden was calculated by analyzing TCGA single nucleotide polymorphism data. (hindawi.com)
Based on the tumor purity and lung carcinoma gene matrix, we performed weighted gene coexpression network analysis (WGCNA), and the tumor purity-related module was identified. (hindawi.com)
Carcinoma in situ (CIS) is frequently found in association with high-grade or extensive TCC. (medscape.com)

Anatomy38

Organisms9

Diseases54

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes46

Disciplines and Occupations2

Information Science3

Health Care5

Progression18

Solid tumors5

Immunotherapy11

Metastasis13

Inhibited tumor growth1

Cells103

Factors in the tumor microenvironment1

Researchers15

Immunosuppressive3

Lymphocytes4

Tissue16

Macrophages1

Mice10

Cancer41

Metastatic2

Primary tumor2

Acidic1

Targets5

Metabolic2

Anti-tumor1

Cancers4

Cellular4

Macrophage2

Therapeutic2

Brain tumors1

Inflammation2

Metastases1

Tissues2

Patient-derived xenografts1

Immunity3

Phenotype1

Subtypes1

Scientists1

Fibroblasts1

Melanoma2

Prognosis1

Methods1

Vivo1

Growth3

20191

Inflammatory2

Study3

Genes5

Cell9

Markers3

Findings2

Chemotherapy2

Biology1

Patients8

Synergistic1

Aggressive1

Carcinoma3