• TFMPP
  • Piperazine derivatives such as trifluoromethylphenylpiperazine (TFMPP) have also been shown to exert a major part of their mechanism of action as nonselective serotonin receptor agonists, and MeOPP has also been demonstrated to act in this way. (wikipedia.org)
  • imatinib
  • At the time of its discovery, in the absence of structural information, no clear explanation for the impressive selectivity of imatinib could be found. (wikipedia.org)
  • Finally a trifluoromethyl group at position 3 was found to give the best results, with approximately 36-fold improvement over imatinib. (wikipedia.org)
  • Finally to improve the hydrogen bonding of the piperazine ring of imatinib with Ile-360 and His-361, pyrrolidine and azetidine derivatives were introduced. (wikipedia.org)
  • unlike
  • As cations, they bind to DNA, and, in structure, they represent compounds with cations that are found at regularly spaced intervals (unlike, say, Mg2+ or Ca2+ , which are point charges). (wikipedia.org)
  • interactions
  • This finding is consistent with the in vivo interactions observed between buspirone and these inhibitors or inducers of cytochrome P450 3A4 (CYP3A4), among others: Itraconazole: Increased plasma level of buspirone Rifampicin: Decreased plasma levels of buspirone Nefazodone: Increased plasma levels of buspirone Haloperidol: Increased plasma levels of haloperidol Carbamazepine: Decreased plasma levels of buspirone Grapefruit: Significantly increases the plasma levels of buspirone. (wikipedia.org)
  • sold
  • The synthetic substance, JWH-018 , a cannabinoid receptor agonist from the aminoalkylindole family, has been found in herbal mixtures sold legally under various ' spice ' names, such as Spice Gold and Spice Yucatan Fire. (drugs-forum.com)
  • Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex, among others, is an estrogen which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms. (wikipedia.org)
  • Heroin
  • COPENHAGEN (Reuters) - Danish police said on Wednesday they had found heroin worth more than $1 million that had been smuggled into the country from Pakistan in the hollowed-out blades of 25 antique sword replicas. (drugs-forum.com)
  • Detectives found 740 grams of heroin of 70 percent purity in the metro-long engraved blades of the decorative swords. (drugs-forum.com)
  • drugs
  • The blades were the last place we thought to look and it was a surprising place to find the drugs,' Ole Wagner of the drugs squad told Reuters. (drugs-forum.com)
  • What they found, about 7am, was a shed which had been modified to conceal more than a quarter of a millon dollars worth of drugs. (drugs-forum.com)
  • Three men were arrested on suspicion of smuggling £8 million of drugs into Britain after suspect packages were found in lobster pots off the coast. (drugs-forum.com)
  • A fisherman alerted police after he pulled the lobster pots up of off the seabed on Sunday morning and found rucksacks attached to themAround 200 kilos of what is believed to be class A drugs were recovered after the rucksacks were hauled from The Solent. (drugs-forum.com)
  • Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with a number of other piperazine derivatives into Class C of the New Zealand Misuse of Drugs Act 1975. (wikipedia.org)
  • Elevated prevalence of cardiac fibrosis and related valvopathies was found to be associated with use of a number of unrelated drugs following long-term statistical analysis once the drugs had been on the market for some time. (wikipedia.org)
  • drug
  • The toddler found at the premises is now in the care of his mother but Supt Moore said he was placed in great danger being near the drug manufacturing equipment. (drugs-forum.com)
  • Tuesday's search warrant comes after the January 28 raids of properties at Bankstown, Hinchinbrook, Merrylands and West Ryde, where officers allegedly found two drug labs, $3.7 million in ice and hundreds of thousands of dollars in cash. (drugs-forum.com)
  • Piperazine is the drug of choice. (wikipedia.org)
  • The drug has also been found to be effective in the treatment of depression as a standalone drug. (wikipedia.org)
  • company
  • Listing your company for PIPERAZINE DI-HCL allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo! (poulvet.com)
  • It had passed phase IIb human trials without any concerns but the company, Laguna Pharmaceuticals, found safety issues which prompted them to shut down their company and the $30 million effort to produce a new heart medication. (wikipedia.org)
  • effects
  • Osemozotan was found to decrease the number of fighting incidences in mice similar to buspirone, diazepam, and tandospirone but required a lower pharmacologic dose to produce beneficial effects. (wikipedia.org)
  • illegal
  • A ban was intended to come into effect in New Zealand on December 18, 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1 April 2008. (wikipedia.org)
  • addition
  • Analysis of the data of this case showed that a maximum yield for the desired mono-protected piperazine ( 251356 ) was achieved with the addition of 0.8 equivalents of Boc-anhydride. (sigmaaldrich.com)
  • In addition, estropipate has been found to act as an inhibitor of SLCO1B1 (OATP1B1) (IC50 = 70 nM). (wikipedia.org)