Our findings suggest that plasma clusterin is a candidate biomarker for acute TBI diagnosis. (nature.com)
Clusterin may be a biomarker of disease, as well as a therapeutic target to potentially prevent this disease. (medicalxpress.com)
Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease. (ox.ac.uk)
Protein17
Moreover, it was proposed that Clusterin functions as an extracellular chaperon that stabilizes stressed proteins in a folding-competent state, and that the protein is involved in programmed cell death. (biovendor.com)
On this basis, we hypothesized that TBI leads to increases in the brain levels of clusterin protein, and consequently, increased plasma clusterin levels. (nature.com)
Immunohistochemistry revealed a marked increase in extracellular clusterin protein expression in the perilesional cortex and ipsilateral hippocampus (7d to 1 month post-TBI), and ipsilateral thalamus (14d to 12 months post-TBI). (nature.com)
Clusterin (apolipoprotein J) is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. (wikipedia.org)
During a study spanning nearly a decade, researchers at The Ohio State University College of Medicine, Houston Methodist Research Institute and Houston Methodist Cancer Center have linked the protein clusterin-for the first time-to many different facets of cardiometabolic syndrome risk through its actions in the liver. (medicalxpress.com)
The study found that a particular extracellular matrix protein called clusterin, which is overproduced from the fat cells of obese patients, is strongly related to insulin resistance. (medicalxpress.com)
Previously this protein clusterin has been mostly studied for its role in neurodegenerative diseases such as Alzheimer's but it now appears to have a broader role in human physiology and disease. (medicalxpress.com)
The clusterin protein is a key component of the extracellular matrix , so this work opens up a new vista to understand the role of clusterin in inter-cellular crosstalk of tissue microenvironments of various diseases, including diabetes , cancer and neurodegeneration," said the co-corresponding author, Dr. Stephen T. C. Wong, professor and chair of the Department of Systems Medicine and Bioengineering at Houston Methodist. (medicalxpress.com)
The CLU gene codes for a protein called clusterin which normally protects the brain in several ways. (medicalnewstoday.com)
Variations in CLU could remove the protective benefit of clusterin, and this could be a potential route to Alzheimer's, a disease whose features include the build up of amyloid protein plaques around brain cells. (medicalnewstoday.com)
RayBio® Human Immunoquantitative (PCR-Based) Clusterin-like protein 1 ELISA Kit for cell culture supernatants, plasma, and serum samples. (raybiotech.com)
The RayBio ® Custom Human Clusterin-like protein 1 IQELISA™ Kit is a modified ELISA assay with high sensitivity qPCR readout for the quantitative measurement of Human Clusterin-like protein 1 in serum, plasma, and cell culture supernatants. (raybiotech.com)
This assay employs an antibody specific for Human Clusterin-like protein 1 coated on a 96-well PCR plate. (raybiotech.com)
Standards and samples are pipetted into the wells and Clusterin-like protein 1 present in a sample is bound to the wells by the immobilized antibody. (raybiotech.com)
And in December of 2021, Wyss-Coray published a study in Nature, this time showing that the protein clusterin confers to sedentary mice most of the benefits seen in mice who exercise. (discovermagazine.com)
In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2. (bvsalud.org)
Glycoprotein6
Clusterin is a highly conserved glycoprotein ubiquitously expressed in the brain as well as in peripheral tissues in different species, including rodents and humans 15 . (nature.com)
Clusterin is a glycoprotein that was initially isolated from the male reproductive system. (washington.edu)
Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (sCLU), which plays important roles in cell survival and death. (biomedcentral.com)
Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (sCLU). (biomedcentral.com)
Clusterin, aka apolipoprotein J, is a glycoprotein that can be found in most fluids. (ampersandbio.com)
Clusterin (CLU) is a secreted heterodimeric glycoprotein expressed in all organism fluids as well as in the intracellular matrix that plays key roles in several pathological processes. (torvergata.it)
Alzheimer's9
Another defining prominent function of Clusterin is its induction in many severe physiological disturbances states including kidney degenerative diseases, prostate and vesicle carcinogenesis, ovarian cancer and several neurodegenerative conditions (Alzheimer's disease). (biovendor.com)
Two independent genome-wide association studies found a statistical association between a SNP within the clusterin gene and the risk of having Alzheimer's disease. (wikipedia.org)
Further studies have suggested that people who already have Alzheimer's disease have more clusterin in their blood, and that clusterin levels in blood correlate with faster cognitive decline in individuals with Alzheimer's disease, but have not found that clusterin levels predicted the onset of Alzheimer's disease. (wikipedia.org)
An international team of scientists working on the largest ever genome-wide study looking for genes linked to Alzheimer's have discovered two new genes, CLU and PICALM, are related to the disease, a finding that is being described as a "leap forward" for dementia research, especially because the last time a gene was found to be linked to the common form of Alzheimer's disease was in 1993. (medicalnewstoday.com)
However, the effect might be small but it is not insignificant, she added, explaining that while it isn't yet clear how these new genes influence Alzheimer's risk, levels of clusterin tend to rise when brain tissue is injured or becomes inflamed. (medicalnewstoday.com)
Some researchers have found increased levels of clusterin in the brain and spinal fluid of patients with Alzheimer's, said Goate. (medicalnewstoday.com)
The researchers also found 13 other genes that should be investigated further for possible links with Alzheimer's risk, so there may be more discoveries yet to come. (medicalnewstoday.com)
Eight β64N glycoforms are significantly reduced in patients with high atrophy compared with those with low atrophy, which demonstrates the utility of clusterin isoforms as diagnostic and prognostic Alzheimer's disease (AD) markers. (ox.ac.uk)
Clusterin is multifunctional with large amounts found in the central nervous system and has been associated with Alzheimer's disease. (ampersandbio.com)
Biomarkers2
These results provide a novel and robust workflow suitable for rapid verification of specific clusterin glycoforms with utility as AD biomarkers. (ox.ac.uk)
BACKGROUNDS: Due to difficulty in early diagnosis of chronic pancreatitis (CP), it is urgent to find novel biomarkers to detect CP. (bvsalud.org)
Serum5
Recent study demonstrates, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. (biovendor.com)
These data raise the possibility that elevated Clusterin levels in serum may represent a strong indication of vascular damage. (biovendor.com)
In patients with systemic lupus erythematosus (SLE), reduced serum Clusterin levels correlated inversely with disease activity. (biovendor.com)
Kropáčková T, Šléglová O, Růžičková O, Vencovský J, Pavelka K, Šenolt L. Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain. (biovendor.com)
Older humans who exercise were likewise found to have higher levels of GPLD1 than their sedentary counterparts. (discovermagazine.com)
Inhibits1
Further translational research involving mouse models is needed to learn more about how clusterin impacts each of the CMS components and whether administrating clusterin-inhibiting antibodies inhibits CMS. (medicalxpress.com)
Atrophy4
Specific glycosylated peptides of clusterin are found associated with hippocampal atrophy. (ox.ac.uk)
Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we have determined the differences in the glycoforms associated at each of the different glycosylation sites in plasma clusterin obtained from subjects of low hippocampal atrophy (n = 13) and high hippocampal atrophy (n = 14). (ox.ac.uk)
Across all participants, we found a significant association of CSF HFABP with longitudinal atrophy of the entorhinal cortex and other AD-vulnerable neuroanatomic regions. (escholarship.org)
However, we found that the relationship between CSF HABP and brain atrophy was significant only among those with low CSF Aβ1-42 and occurred irrespective of phospho-tau181p status. (escholarship.org)
Proliferation1
Additionally, when the researchers studied mice lacking revSC, they found that those mice, after irradiation, had decreased proliferation, intestinal crypt numbers and crypt length, while uninjured ones had intestines similar to wild-type mice. (genomeweb.com)
Gene1
They further found that the YAP1 gene signature - a transcriptional regulator that is a key player in intestinal regeneration - was found only among the SSC2c subgroup. (genomeweb.com)
Renal2
Another interesting observation obtained in rat model suggests that measurement of urinary Clusterin levels may be a useful clinical marker for the severity of renal tubular damage. (biovendor.com)
RESULTS: Remarkably, we found that 1400W affects the renal cortex and medulla in different ways. (uandes.cl)
Induction2
Our data strongly suggest that the signal transduction processes involved in induction of secretory clusterin (sCLU) expression after ionizing radiation (IR) exposure and during cellular replicative senescence are identical. (elsevierpure.com)
By elucidating the molecular events and signal transduction in the induction of sCLU, during cell stress (e.g., low-dose IR exposure), replicative senescence, and tumorigenesis, we theorize that we have found a common stress response pathway. (elsevierpure.com)
Assay3
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Clusterin (CLU) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Clusterin (CLU) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
This assay has high sensitivity and excellent specificity for detection of Clusterin (CLU). (biomatik.com)
Levels2
Lowered Clusterin levels could be involved in the pathogeneses of SLE on account of decreased protective effects. (biovendor.com)
Unfortunately, no functional association between CLU expression levels and the presence of CLU rs11136000 polymorphism in OP patients was found. (torvergata.it)
Proteins1
Following up on this finding, a yeast two-hybrid screen was conducted using MMP9 as the bait to identify other proteins involved. (edu.au)
Insulin3
David Bradley et al, Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk, Diabetes Care (2019). (medicalxpress.com)
In Buy Ambien Online Reviews inhibiting the patient has been found in insulin Ambien Buyers In Usa production. (lorenzopetrantoni.com)
Researchers assessed insulin sensitivity in women to find out the reason behind increased food cravings right before a period. (medicaldaily.com)
Plasma1
The glycosylation of clusterin from human plasma was comprehensively analyzed and characterized using mass spectrometry (MS)-based glycoproteomics analysis. (ox.ac.uk)
Researchers5
Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
Researchers found that women with any type of migraine are at an increased risk of developing overall breast cancer, especially estrogen-receptor breast cancer. (medicaldaily.com)
Using transgenic mice with marked endogenous Clu, the researchers found that Clu-GFP-positive cells were rare in healthy intestines, but increased in number following radiation, especially as Lgr5-GFP-positive cells are lost. (genomeweb.com)
By labeling different cell types in another mouse model, the researchers found that CLU + cells could give rise to LGR5 + CBCs as well as differentiated progeny. (genomeweb.com)
Mice1
Significantly, we found that sCLU-shRNA could exert marked inhibition of the lung metastasis of Hep-2 cells in nude mice in vivo . (biomedcentral.com)
Findings1
Why weren't the Forest Service folks who are cited as originally finding the findings not interviewed here? (portlandmercury.com)
Damage1
The SSC2 cluster, meanwhile, included cells from irradiated crypts that typically expressed genes involved in DNA damage response and cell survival like clusterin (Clu). (genomeweb.com)
Tissue1
Due to its wide breath of tissue distribution many diverse physiological functions have been attributed to Clusterin including sperm maturation, membrane recycling, lipid transportation, tissue remodelling, complement inhibition and cell-cell or cell-substratum interactions. (biovendor.com)
Specific1
Find support for a specific problem in the support section of our website. (mdpi.com)
Data1
Our previous mRNA-seq data revealed a 1.8-2.5 fold increase in clusterin mRNA expression in lesioned brain areas in rats with lateral fluid-percussion injury (FPI)-induced TBI. (nature.com)
Riaz MA, Stammler A, Borgers M, Konrad L. Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells. (biovendor.com)
Time1
At a time when we are yet to find ways of halting this devastating condition, this development is likely to spark off numerous new ideas, collaborations and more in the race for a cure," she added. (medicalnewstoday.com)
Blood1
This collaborative research is shedding new light on the importance of clusterin on "cardiometabolic syndrome," which may eventually lead to developing new treatments for this life-threatening combination of diabetes, high blood pressure and obesity," said Dr. K. Craig Kent, dean of the Ohio State College of Medicine. (medicalxpress.com)
Significant1
No significant cross-reactivity or interference between Clusterin (CLU) and analogues was observed. (biomatik.com)