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  • Nystatin
  • Liposomal nystatin is not commercially available, but investigational use has shown greater in vitro activity than colloidal formulations of amphotericin B, and demonstrated effectiveness against some amphotericin B-resistant forms of fungi. (wikipedia.org)
  • It offers an intriguing possibility for difficult-to-treat systemic infections, such as invasive aspergillosis, or infections that demonstrate resistance to amphotericin B. Cryptococcus is also sensitive to nystatin. (wikipedia.org)
  • Additionally, liposomal nystatin appears to cause fewer cases of and less severe nephrotoxicity than observed with amphotericin B. In the UK, its license for treating neonatal oral thrush is restricted to those over the age of one month. (wikipedia.org)
  • The oral suspension form produces a number of adverse effects including but not limited to: Diarrhea Abdominal pain Rarely, tachycardia, bronchospasm, facial swelling, muscle aches Both the oral suspension and the topical form can cause: Hypersensitivity reactions, including Stevens-Johnson syndrome in some cases Rash, itching, burning and acute generalized exanthematous pustulosis Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. (wikipedia.org)
  • aqueous
  • Amphotericin B concentration in the aqueous phases was the highest with iCo-010 which also had the lowest sediment recovery. (sigmaaldrich.com)
  • Given the observation that iCo-010 had the highest aqueous micellar solubilization and the lowest sediment recovery of AmB among the tested formulations, these results could potentially be used to interpret and predict the in vivo performance of AmB- SEDDS formulations in future studies. (sigmaaldrich.com)
  • vancomycin
  • It is known to interact with nephrotoxic agents (e.g. amphotericin B, foscarnet, IV aminoglycosides, IV pentamide, vancomycin, tacrolimus, non-steroid anti-inflammatory drugs, etc.) to increase their nephrotoxic potential. (wikipedia.org)
  • aspergillosis
  • Tuftsin enhances the action of rifampin-bearing liposomes in the treatment of tuberculosis, and that amphotericin B - bearing liposomes in the treatment of human aspergillosis in mice. (wikipedia.org)
  • severe
  • In very severe cases, combination therapy with amphotericin B and an azole have been postulated, although no trials have been conducted. (wikipedia.org)
  • drug
  • Torrado-Santiago, S. "Amphotericin B formulations and drug targeting" Journal of Pharmaceutical Sciences 2008, volume 97, pp. 2405-2425. (wikipedia.org)
  • Dr.Atal also initiated the bioenhanced anti tubercular drug research project using Rifampicin which later resulted in development of world's first bioenhanced anti tubercular drug formulation. (wikipedia.org)
  • Indian
  • This DCGI approved formulation was officially released by Indian government at Anusandhan Bhawan Delhi on world tuberculosis day 2011, and also presented to Mr. Bill Gates, chairman of Microsoft same day at a function at Le Meridian in Delhi. (wikipedia.org)
  • make
  • It was created to make sure that the needs of children were systematically considered such as availability of proper formulations. (wikipedia.org)