• Nystatin
  • It offers an intriguing possibility for difficult-to-treat systemic infections, such as invasive aspergillosis, or infections that demonstrate resistance to amphotericin B. Cryptococcus is also sensitive to nystatin. (wikipedia.org)
  • The oral suspension form produces a number of adverse effects including but not limited to: Diarrhea Abdominal pain Rarely, tachycardia, bronchospasm, facial swelling, muscle aches Both the oral suspension and the topical form can cause: Hypersensitivity reactions, including Stevens-Johnson syndrome in some cases Rash, itching, burning and acute generalized exanthematous pustulosis Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. (wikipedia.org)
  • aqueous
  • Amphotericin B concentration in the aqueous phases was the highest with iCo-010 which also had the lowest sediment recovery. (sigmaaldrich.com)
  • Given the observation that iCo-010 had the highest aqueous micellar solubilization and the lowest sediment recovery of AmB among the tested formulations, these results could potentially be used to interpret and predict the in vivo performance of AmB- SEDDS formulations in future studies. (sigmaaldrich.com)
  • resistance
  • This is because amphotericin B resistance requires sacrifices on the part of the pathogen that make it susceptible to the host environment, and too weak to cause infection. (wikipedia.org)
  • Significance of Bioenhancers Due to an increased bioavailability, the dose and cost of active drug can be reduced, making the formulation cheaper and safer, better tolerated, having better efficacy, better compliance and having lesser risk of developing drug resistance as in case of antibiotics. (wikipedia.org)
  • vancomycin
  • It is known to interact with nephrotoxic agents (e.g. amphotericin B, foscarnet, IV aminoglycosides, IV pentamide, vancomycin, tacrolimus, non-steroid anti-inflammatory drugs, etc.) to increase their nephrotoxic potential. (wikipedia.org)
  • drug
  • Torrado-Santiago, S. "Amphotericin B formulations and drug targeting" Journal of Pharmaceutical Sciences 2008, volume 97, pp. 2405-2425. (wikipedia.org)
  • Dr.Atal also initiated the bioenhanced anti tubercular drug research project using Rifampicin which later resulted in development of world's first bioenhanced anti tubercular drug formulation. (wikipedia.org)
  • Indian
  • This DCGI approved formulation was officially released by Indian government at Anusandhan Bhawan Delhi on world tuberculosis day 2011, and also presented to Mr. Bill Gates, chairman of Microsoft same day at a function at Le Meridian in Delhi. (wikipedia.org)
  • make
  • It was created to make sure that the needs of children were systematically considered such as availability of proper formulations. (wikipedia.org)