Formulation characterization drug carriers. Medical search. Frequent questions

On the other hand, he is experienced in developing nanoparticles and nanofibers to deliver drugs effectively. (upes.ac.in)
Dr. Gunjan carries expertise in the areas of pharmaceutical product development, design, and development of novel drug delivery systems like micelle, nanoparticles, nanofibres, and other nano colloidal drug delivery systems, rate-controlled and targeted approaches for cancer chemotherapy, enhancement of drug solubility and bioavailability of poorly soluble drug, pharmacokinetics and biodistribution. (upes.ac.in)
Niosoms are nanoparticles used in drug delivery systems. (scialert.net)
Tamoxifen-loaded poly(L-lactide) nanoparticles: development, characterization and in vitro evaluation of cytotoxicity. (springer.com)

Formulation development requires a deep understanding of how the physicochemical properties of an API will affect the stability, solubility and bioavailability of the molecule. (ri.se)
Methods: Sitagliptin liposomes were prepared by the ethanol injection method and were evaluated for various physicochemical properties such as visual appearance, particle size distribution, zeta potential, % drug entrapment efficiency, % drug loading capacity and in vitro drug release studies. (benthamscience.com)

The amount of released drug (48 h) from pegylated and non pegylated formulations in the presence of Spans 60 and 20 were 8, 10, 6, 7%, respectively. (scialert.net)

Drug loading, particle size, and percent drug release were used as response factors in the formulation optimization process, which took into account polymer concentration and stirring rate as independent variables.The bulk density, tapped density, flowability, and particle size of the formulation batches were all evaluated. (rjptonline.org)
9. Ray S., In vitro evaluation and optimization of controlled release drug delivery system of Metformin Hydrochloride. (rjptonline.org)

with a yield of 88.30±0.53%, an ideal drug loading of 85.50±0.55%, and a preferred buoyancy of 91.93±0.61%, tiny to big and spherical microspheres were created at 40°C using a 1:6 polymer, 2% Tween 80, and that temperature. (rjptonline.org)
3. Kawashima Y., Niwa T., Takeuchi H., Hino T., Ito Y., Preparation of multiple unit hollow microspheres (microballoons) with acrylic resins containing tranilast and their drug release characteristics (in vivo). (rjptonline.org)
8. Shrivastava A. K., Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. (rjptonline.org)
Recently calcium silicate based porous carrier based floating orlistat microspheres for gastric emptying was carried out by Jain et al [ 12 ]. (jbclinpharm.org)

Excipient screening/formulation strategy for increased stability and solubility. (ri.se)
Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. (herts.ac.uk)
The drug-excipient compatibility is confirmed using (FTIR, DSC and PXRD) analyses. (iqnjm.com)

In this chapter, we have covered various aspects of hyaluronic acid-modified delivery systems including strategies for synthesis, characterization, and biocompatibility. (intechopen.com)
The synthesis process was optimised by varying both liposome formulation and the operating fluidic parameters, including the ratio between inlet flow rates (or flow rate ratio) and the total flow rate. (ox.ac.uk)
8. Kucinska-Lipka J, Gubanska I, Strankowski M, Cieśliński H, Filipowicz N, Janik H. Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with L-ascorbic acid, as materials for soft tissue regeneration. (iqnjm.com)

Niosomes entrap soluble material as do liposomes but the former is more stable at laboratory's atmosphere so they can increase the stability of the drugs. (scialert.net)
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology, such as niosomes, liposomes and proniosomes. (innovareacademics.in)
Mice that had received the drug with one of the liposomes were healthy and tumor-free for the nearly 100-day run of the experiment. (medgadget.com)
Liposomes serve as promising active carriers of drugs to posterior segment eye disorders due to improvement in intravitreal half-life and targeted sustained drug delivery to the retina. (benthamscience.com)
Liposomes act as drug carriers for entrapment of hydrophilic and hydrophobic drugs. (benthamscience.com)
Recent applications of liposomes in ophthalmic drug delivery. (benthamscience.com)
These drawbacks could be mitigated by employing liposomes as carriers for AgNPs. (ox.ac.uk)

Formulation and Evaluation of Gastro-Retentive Tinidazole Loaded Floating Microsphere for Sustained Release, Materials Today: Proceedings (In Press) DOI:10.1016/j.matpr.2021.05.616. (upes.ac.in)
Formulation and evaluation of ibuprofen transdermal patches. (isca.me)
Formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate. (isca.me)
In-vitro and In-vivo evaluation of transdermal prolonged release proniosomal gel formulations of propranolol HCL. (isca.me)
Formulation and evaluation of gliptin loaded polymeric nanomicelles for controlled drug delivery. (benthamscience.com)
10. Ozdemir N., Ordu S., Ozkan Y., Studies of floating dosage forms of furosemide: in vitro and in vivo evaluation of bilayer tablet formulation. (rjptonline.org)
What follows is a summary and evaluation of the state of the art of both bacterial permeation models and advanced anti-infective formulation strategies, together with an outlook for future directions in these fields. (ljmu.ac.uk)

Diversity, Antibacterial Activity And Molecular Characterization of Actinomycetes Isolated From Salt Pan Region of Kodiakarai, Nagapattinam DT. (ajptonline.com)
Isolation, Identification and Molecular Characterization of Phosphate Solubilizing Actinomycetes Isolated From The Coastal Region of Manora, Thanjavur (Dt. (ajptonline.com)

We also have the ability for specific analysis development for the API to ensure that the right formulation strategy is being developed that maximizes the stability, solubility and bioavailability of the drug. (ri.se)
Results: The optimized formulation (L-3) showed round-shaped distinct particles with good stability. (benthamscience.com)
Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
Thanks to high binding affinity with biotin, streptavidin was used as linker to conjugate the synthetized peptide to the entire systems, using a decoration strategy, while keeping nano-carrier stability. (unina.it)
Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. (sharif.edu)
This presentation will focus on some pharmaceutical development key issues including drug product performance and physical stability and how to use novel material technologies to mitigate the risks, illustrated by nano material and SDD product development case study examples. (ddfsummit.com)

A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization. (ljmu.ac.uk)
Non-ionic surfactant-based vesicles (niosomes) in drug delivery. (innovareacademics.in)
Vesicles size and entrapment efficiency of stable formulations (F2-F6) was varied from 71.2±14.16 to 199.3±26.03 nm and 72.98 % to 77.44 % respectively. (ijpsonline.com)

This review focuses on different aspects of proniosomes such as preparation, characterization, in vitro drug release, entrapment efficiency, applications in the present scenario in the market and future trends. (innovareacademics.in)
This article reviews various aspect of ethosomes including their preparation, characterization, potential advantages and their applications in drug delivery. (ajptonline.com)
Preparation and characterization of ibuprofen loaded transferosome as a novel carrier for transdermal drug delivery system. (isca.me)
Therefore, based on the characteristics of black phosphorus two-dimensional nanomedicine, experimental designs were conducted on its nanosheet preparation, polyethylene glycol modification, and anti-tumor drug loading. (frontiersin.org)
11. Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. (rjptonline.org)

TW001 is an oral formulation with the radical scavenger edaravone as its active ingredient, targeting oxidative stress. (bvsalud.org)

Objective: The study aimed to formulate and evaluate sitagliptin liposomal formulation for sustained effect in individuals suffering from neurodegeneration owing to high patient compliance, especially in geriatric patients. (benthamscience.com)

Analysis of compressibility particle size, drug entrapment effectiveness, surface topography (SEM), and an in vitro release research. (rjptonline.org)
After 2 months, the most stable formulation in terms of size, PDI, zeta potential, and entrapment efficiency was used to study the secondary structures of lysozyme in niosomal and free forms. (sharif.edu)

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
Further use of zaltoprofen limits because of its poor aqueous solubility and poor oral bioavailability as it belongs to BCS Class II drug. (ijpsr.com)
Dissolution and bioavailability of lipophilic drugs can be enhanced by Lipid-based drug delivery systems. (ijpsr.com)
SNEDDS increases the bioavailability of drug by increasing its solubility, intestinal wall permeability and reducing the first-pass metabolism of drugs 7-10 . (ijpsr.com)
Different surfactants such as phospholipids, labrasol, cremophore, tween 80 can also enhance the bioavailability of drugs by facilitating transcellular and paracellular absorption and can also act as p-glycoprotein and/ or CYP450 enzyme inhibitors, decreasing the intestinal efflux and drug biotransformation 11, 14 . (ijpsr.com)
Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine. (omicsonline.org)
Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. (omicsonline.org)
Conventional ophthalmic formulations exhibit poor bioavailability. (benthamscience.com)
The area under the curve of optimized formulation (F2) was 3.98 and 1.53 times more than oral drug solution and intranasal gel respectively, confirming improvement in bioavailability. (ijpsonline.com)
Advantages of nanoemulsions include increased drug loading and enhanced bioavailability. (rroij.com)
Nanotechnology-based drug delivery systems are able to incorporate drugs or gene products with active anti-cancer activity but poor solubility, low bioavailability, or inadequate toxicological profile. (oaepublish.com)

On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. (mdpi.com)
Dermal/transdermal delivery of drugs represents an effective method to deliver drugs directly to the site of action or to enhance treatment activity noninvasively. (mdpi.com)
A review on: proniosomes-A surrogate carrier for improved transdermal drug delivery system. (innovareacademics.in)
Mishra A, Kapoor A, Bhargava S. A review on: proniosomal gel as a carrier for improved transdermal drug delivery. (innovareacademics.in)
Ethosomes: Novel noninvasive carrier for Transdermal Drug Delivery. (ajptonline.com)
The buccal and transdermal routes are capable of avoiding FPM, but they lack drug targeting potential. (ijpsonline.com)
4. Maxwell A, Priya S. Nanosized ethosomes - a promising vesicular drug carrier for transdermal drug delivery. (iqnjm.com)
6. Abdel Messih HA, Ishak RAH, Geneidi AS, Mansour S. Nanoethosomes for transdermal delivery of tropisetron HCl: multi-factorial predictive modeling, characterization, and ex vivo skin permeation. (iqnjm.com)
12. Sakdiset P, Amnuaikit T, Pichayakorn W, Pinsuwan S. Formulation development of ethosomes containing indomethacin for transdermal delivery. (iqnjm.com)

Vesicular system is a good approach to improve hydrophilic drug permeability using phospholipids as Nanocarriers to increase lipophilicity and reduce vesicle size. (iqnjm.com)
Ethosomes as nanocarriers for the development of skin delivery formulations. (iqnjm.com)
Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. (iqnjm.com)

Drug Dev Ind Pharm. (innovareacademics.in)

Feroz joined Gilead sciences in January 2021 and was the Director and head of the commercial drug product and formulation. (whsmith.co.uk)

Hydrophilic polymers are widely investigated and found to be the most apposite in controlling the release of drug in floating drug delivery systems. (jbclinpharm.org)

Fabrication and characterization of boric acid-crosslinked ethyl cellu" by NASRIN ALIASGHARLOU, FARZIN ASGHARI SANA et al. (tubitak.gov.tr)

Prepared formulations were also evaluated for % drug permeation using non-everted rat intestinal sac method which showed that Pluronic was not involved in permeability enhancement of Cefixime. (omicsonline.org)
The improved drug permeation and higher flux across nasal mucosa with enhancement ratio of 2.75 was observed for flexible liposomal thermoreversible gel F2 compared to normal thermoreversible hydrogel of drug. (ijpsonline.com)

pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. (scialert.net)
The improvement of therapeutic formulation efficacy is correlated to its ability to selectively target, with specific moieties, diseased tissue without affecting healthy sites. (unina.it)
Concomitantly, substantial progress was made in pharmaceutical formulation development of peptides and proteins, inasmuch as many challenges in formulating these compounds in products with optimal therapeutic effects and shelf life were successfully approached. (uni-muenchen.de)
Perspective drug delivery systems can be defined as mechanisms to introduce therapeutic agents into the body. (rroij.com)
Moreover, a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents, which cause high toxicity, in order to reach effective therapeutic dose. (oaepublish.com)
The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. (whsmith.co.uk)
It also justifies the folklore medicinal uses and claims about the therapeutic values of this plant as curative agent against tumor and we therefore, suggest further, the purification and characterization of the phytochemicals along with investigations needed to provide some additional insight into the in vivo cytotoxicity activity of the plants with a view to obtaining useful chemotherapeutic agent. (iajpr.com)
The key challenge in the oral delivery of drugs acting locally in the stomach or having narrow absorption window in the gastrointestinal tract is the retention of the dosage form in the upper gastrointestinal tract for lingering therapeutic effect. (jbclinpharm.org)

Aceclofenac topical dosage forms: in vitro and in vivo characterization. (isca.me)
In vitro and in vivo investigation of topical formulations of erythromycin. (isca.me)
The ex vivo permeation of drug through goat nasal mucosa was studied. (ijpsonline.com)
Additionally, the Ex-vivo drug permeation investigation demonstrated that the prepared formula of LAA had flux and permeability coefficients that were two times higher than the control. (iqnjm.com)

Without any liposome, the drug showed some tumor suppression, but the mice that had received the drug alone had to be euthanized after 70 days because of tumors that were no longer being controlled. (medgadget.com)
Thus present study concludes that flexible liposome enriched thermoreversible, mucoadhesive in situ intranasal gel of rizatriptan benzoate is a safe and effective drug delivery system for treatment of migraine. (ijpsonline.com)

Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional drug formulations. (scialert.net)
Although the semisolids and liquids remains the choice of dosage forms, there is need of improved drug delivery systems which can be easily applied to areas where application of conventional dosage forms is difficult. (volksonpress.com)

The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 °C. Further, the developed formulations are stable for 75 days. (tubitak.gov.tr)
Typically, the ionized drug and the ion-exchanger form a stable complex for the relatively short period of exposure, making the drug unavailable for taste sensation. (sld.cu)
Topical foams are novel carriers for such applications and gaining popularity due to their stable, non-toxic, non-irritant nature and ease of application. (volksonpress.com)

Formulation development is an important part of the product development of new medicines. (ri.se)
Our formulation scientists have good knowledge of the drug development process and can help from early preformulation to production of GMP classed trial material. (ri.se)
There can be several reasons to outsource the formulation development externally, such as time limitations internally or the need to quickly recruit the right expertise and analytical capacity when needed during the development process. (ri.se)
We at RISE can help solve an existing formulation problem or have a larger active role during the formulation development of a new drug candidate and involve an expert team to work as an extension of the own company. (ri.se)
The development of a new drugs may require that the formulation is being adjusted and optimized during the preclinical phase and initial animal studies, and further developed before clinical testing and finalized drug product. (ri.se)
Pre-formulation (and development of adjusted analytical methods and characterization). (ri.se)
In the development of new dosage forms, drug delivery using nanotechnology is playing a vital role. (innovareacademics.in)
Enhanced delivery of bioactive molecules through the skin and cellular membranes by means of an ethosomal carrier opens numerous challenges and opportunities for the research and future development of novel improved therapies. (ajptonline.com)
In addition, the controlled drug delivery area needs further development of techniques for delivery of peptide and protein drugs. (scialert.net)
Pokharkar, B.V. Development and characterization of liposomal drug delivery system for nimesulide. (benthamscience.com)
The development of bioinformatics technology has enabled nanomedicine to play a significant role in drug delivery systems. (frontiersin.org)
This led to the development of different drug delivery methods in the later part of the eighteenth and early nineteenth century. (rroij.com)
Apart from this, the nanoemulsions with pharmaceutically accepted ingredients are utilized in the development of drug formulations for oral drug delivery. (rroij.com)
This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. (whsmith.co.uk)
After graduating from University of Connecticut with a Ph.D in Pharmaceutical sciences, Feroz started his carrier with Baxter Biosciences where he was involved in the end-to-end development and tech transfer of lyophilized dosage form of recombinant Factor VIII (RecombinateTM). (whsmith.co.uk)
In 2002, Feroz joined Amgen where he had the opportunity to work on all aspects of drug product development and manufacturing of various modalities including Enbrel (R), Nplate (R), Repatha (R) and Blincyto (R). In 2016 Feroz joined AbbVie heading the formulation development function of New Biological Entities, Lake County, IL, where he was involved in early and late-stage development of parenteral products. (whsmith.co.uk)
Thus, new approaches which allow for more comprehensive characterization of anti-infective permeation processes (and as such, would be usable as screening methods in early drug discovery and development) are desperately needed. (ljmu.ac.uk)
This is a significant paradigm shift for pharmaceutical industry which aims to improve efficiency, quality and patient outcomes by utilizing digital solutions and data driven approaches in drug discovery, development, manufacturing, supply chain management and personalized medicine. (ddfsummit.com)
Physiologically based biopharmaceutics models (PBBM) have been playing an increased role in development decisions as related to formulation changes, spanning both clinical development aspects and drug product quality. (ddfsummit.com)

The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters. (mdpi.com)
In addition, formulations combining efflux pump inhibitors or antimicrobial peptides with anti-infectives show promise in the restoration of antibiotic activity in resistant bacterial strains. (ljmu.ac.uk)

Tablets were formulated of selected batches and evaluated for drug release and physical parameters. (sld.cu)
Modification of the dosage form has been also attempted by formulating floating device consisting of two drug coated HPMC matrix tablets within an impermeable hollow polypropylene cylinder open at both ends [ 10 ]. (jbclinpharm.org)

Proniosomes are water-soluble carrier particles that are coated with surfactant so these are dry formulations. (innovareacademics.in)

Among these, FDDS or hydrodynamic balanced systems (HBS) have demonstrated to be the promising method due to its capacity to retain the dosage form in the stomach for a predetermined time [ 1 ] .Several parameters such polymers, dosage form density, formulation and processing variables, addition of gas forming agents etc affects the successful delivery of a floating drug delivery systems, and needs prime consideration. (jbclinpharm.org)

Depending on the API (small molecules or biologics, such as peptides, proteins, enzymes, nucleotides and antibodies), specific expertise and an adjusted formulation strategy is needed to guide in the right choice of excipients/carriers and dosage form. (ri.se)

Carriers injection at nano scale are used with the aim of passing through biological barriers, drug protection and release of optimum dose of drugs ( Costantino and Boraschi, 2012 ). (scialert.net)
Excipients are pharmacologically inactive substances used as carrier and release controllers for active drug ingredients. (chromatographyonline.com)
If symptoms of a disease display circadian variation, drug release should also vary over time. (scialert.net)
PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
It would be highly beneficial if the active agents were delivered by a system that sensed the signal caused by disease, judged the magnitude of signal and then acted to release the right amount of drug in response. (scialert.net)
The pH range of fluids in various segments of the gastrointestinal tract may provide environmental stimuli for responsive drug release. (scialert.net)
Thus, drug release from devices made from these polymers will display release rates that are pH sensitive. (scialert.net)
L-3 followed Korsmeyer- Peppas model with fickian diffusion transport of drug release giving n' (0.3094), r2 (0.9753), with 83.78 ± 0.97% of sustained drug release. (benthamscience.com)
Prolonged (upto 5 h) and slow drug release was observed with resin 214 at higher concentration. (sld.cu)
out of three resins chosen, Indion ® 214 at higher concentration exhibit excellent taste masking as well as sustained drug release action. (sld.cu)
Its low toxicity, high efficiency, and controllable drug release advantages make it have good application effects. (frontiersin.org)
Experimental analysis was also conducted on the characterization ability, drug release, and targeted therapy of nanomedicine. (frontiersin.org)
The maximum drug release rates of BP-PEG-DOX-NIR reached 33.23% and 28.67% at temperatures of 35°C and 45°C, with differences of over 10% compared to the non laser group. (frontiersin.org)
Its drug release characteristics perform well in photothermal therapy, indicating that black phosphorus nano drugs can improve the biological safety and applicability of drugs in new tumor targeted therapy. (frontiersin.org)
Drug delivery systems seem to be a new method for improving drug targeting and release into cells, bringing new opportunities for improving drug efficiency and avoiding potential side effects. (frontiersin.org)
6. A. A. Deshpande, C.T. Rhodes, N.H. Shah and A.W. Malick, Controlled release drug delivery system for prolonged gastric residence an overview. (rjptonline.org)
A second objective was to study erosion/dispersion behavior of the formulations because it would condition release of any drug. (fhnw.ch)
An inert hydrophobic buoyant coated-core was developed as floating drug delivery system (FDDS) for sustained release of cisapride using direct compres-sion technology. (jbclinpharm.org)
Sustained release of cisapride was achieved with HPMC K4M in the outer drug layer. (jbclinpharm.org)
The choice of the polymer is based on its bulk density, ability to form a cohesive gel barrier, and capability to control the release of the drug over a period of time [ 2 , 3 ]. (jbclinpharm.org)

1 Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona , Barcelona 08035, Spain . (oaepublish.com)

Sadanandan A, Boby Johns G, Samuel J, Raj P, Thomas N, Daisy PA, Carla B. A review on: proniosomes-An innovative approach to vesicular drug delivery system. (innovareacademics.in)
The objective of the work was to formulate a self-nanoemulsifying drug delivery system (SNEDDS) of zaltoprofen and to study the impact and interaction of various formulation variables on the formulation by the design of the experiment. (ijpsr.com)
It can be concluded that the hydrophobic coated buoyant core could be used as FDDS for gastroretentive delivery system of cisapride or other suitable drugs. (jbclinpharm.org)

Various approaches have been tried to develop an effective formulation for rizatriptan benzoate. (ijpsonline.com)
As the technological advancements been made some new formulation approaches have been devised by the scientists. (rroij.com)

Chewing leaves and roots of medical plants and inhalation of soot from the burning of medical substances are examples of drug delivery from the earliest times. (rroij.com)

Self-nano emulsifying drug delivery systems (SNEDDS) is one of the approach that are used to enhance the drug dissolution by dissolving the drug in a mixture of oil, surfactant, and co-surfactant which gets disperse in small oil droplets throughout the GI tract when administered orally. (ijpsr.com)

Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC® 25923TM and ATCC® 29213TM). (tubitak.gov.tr)
After prophylactic antibacterial drugs were administered to close contacts of infected children, no further cases of disease were detected in the facilities, although test results showed that some children still carried the bacterium. (cdc.gov)

Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. (ajptonline.com)
Because of their unique structure, ethosomes are able to encapsulate and deliver through the skin highly lipophilic molecules such as cannabinoids, testosterone, and minoxidil, as well as cationic drugs such as propranolol, trihexyphenidil, Cyclosporine A, insulin, Salbutamol etc. (ajptonline.com)
The purpose of this work is to prepare LAA-containing ethosomes formulations utilizing a modified thin film hydration approach. (iqnjm.com)

Niosomes are one of these carriers. (scialert.net)
Review on: niosomes-targeted and controlled drug delivery novel carrier system, C.B.S [publication]. (innovareacademics.in)
Lysozyme loaded niosomes containing various molar ratios of two kinds of surfactants were prepared and the properties of these niosomal formulations were studied. (sharif.edu)

In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. (tubitak.gov.tr)
Additionally, new drug delivery systems - e.g., based on polymeric materials - will most likely enlarge the spectrum of future proteinic dosage forms, where today solutions and lyophilized products take center stage. (uni-muenchen.de)

In this study formulations were prepared by reverse phase evaporation employing Spans 60 and 20. (scialert.net)
Comparative study was carried out using Pluronic as solid dispersion and beta cyclodextrin as inclusion complexation in different drug to polymer ratios through physical mix, kneading, solvent evaporation and spray drying technique. (omicsonline.org)

Methods Different formulations containing a lipid, a polymer and different silica based inorganic carriers were produced by hot-melt extrusion at various screw speeds. (fhnw.ch)

Two factors govern the total oral absorption of drug i.e. drug's solubility and permeability across intestine. (omicsonline.org)
For usual absorption of drug it is soluble then it will reach intestinal wall in dissolved state and later absorbed in gut membranes combining all above transport mechanisms. (omicsonline.org)
The enhanced light absorption and scattering capacity of SNPs, make them a promising candidate system for non-invasive imaging and drug delivery in nanoparticle-assisted diagnostics and therapy. (ox.ac.uk)
The drug content uniformity was in between 97.90 to 99.90 %, water absorption ration were found between 51 to 80% and wetting time between 13 to 61 sec. (iajpr.com)

Their vesicular system can be used as carriers of lipophilic and amphiphilic drugs. (scialert.net)
Among the vesicular carriers, proniosomes are superior. (innovareacademics.in)
Rao R, Kakar R, Anju G, Sanju N. Review on proniosomes: an emerging vesicular system in drug delivery and cosmetics. (innovareacademics.in)
Kakr R, Rao R, Goswami A, Nanda S, Saroha K. A review on: proniosmes-An emerging vesicular system in drug delivery and cosmetics. (innovareacademics.in)
Vesicular system-carrier for drug delivery. (innovareacademics.in)
A review on: proniosomes-A novel approach to vesicular drug delivery systems. (innovareacademics.in)

Objectives This study investigates a new nanoparticulate (NP) formulation for local buccal administration of pilocarpine (PIL) to treat xerostomia, aiming to improve patient compliance and reduce side effects. (researchgate.net)

Multi-functional oil in water nanoemulsions (O/W NEs) are an ideal carrier for drug delivery thanks to their ability to dissolve hydrophobic drugs and natural substances like curcumin and coenzyme Q10 (CoQ10), and protect their cargo from hydrolysis and enzymatic degradation under physiological conditions. (unina.it)

Inverse gas chromatography is a physical characterization analytical technique that is used in the analysis of the surfaces of solids. (wikipedia.org)
IGC is considered a materials characterization technique (of the solid) rather than an analytical technique (of a gas mixture). (wikipedia.org)

When those data were "very encouraging," Alani's team assessed the efficacy of the formulations in mice that had tumors grafted into them. (medgadget.com)

The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications. (tubitak.gov.tr)
Topical drug delivery remains the popular choice of treatment for most of the dermatological diseases. (volksonpress.com)

The system is having donar and receiver compartment for studying permeation of drug across the membrane. (omicsonline.org)

During an IGC experiment a pulse or constant concentration of a known gas or vapor (probe molecule) is injected down the column at a fixed carrier gas flow rate. (wikipedia.org)
Measuring how the retention time changes as a function of probe molecule chemistry, probe molecule size, probe molecule concentration, column temperature, or carrier gas flow rate can elucidate a wide range of physico-chemical properties of the solid under investigation. (wikipedia.org)
therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose. (scialert.net)
Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
Results Multifractal analysis indicated that inorganic carrier type and concentration as well as the screw speed affected the microstructure of the extrudates. (fhnw.ch)
The aqueous erosion/dispersion study showed that only the type and concentration of inorganic carrier were important. (fhnw.ch)

Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs. (isca.me)

Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor Kunda NK. (ljmu.ac.uk)
This microstructural analysis was complemented with dynamic optical imaging of formulation erosion/dispersion behavior. (fhnw.ch)
Conclusions The use of microstructural and dispersion analysis appeared to be complementary to better characterize and understand complex formulations obtained by hot-melt extrusion. (fhnw.ch)

However, the problem associated with nasal drug delivery is lower penetrability of drug through nasal mucosa and drainage of formulation into oral cavity. (ijpsonline.com)

Anatomy2

Organisms3

Diseases1

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes22

Disciplines and Occupations5

Technology, Industry, Agriculture19

Health Care5

Nanoparticles4

Physicochemical2

Pegylated and non pegylated1

Optimization2

Microspheres4

Excipient3

Synthesis3

Liposomes7

Evaluation7

Molecular Characterization2

Stability6

Vesicles3

Preparation5

Oral formulation1

Liposomal formulation1

Entrapment2

Bioavailability11

Transdermal9

Nanocarriers3

Pharm1

20211

Hydrophilic1

Fabrication1

Enhancement2

Therapeutic8

Vivo4

Liposome2

Conventional2

Stable3

Development19

Efflux2

Tablets2

Particles1

Parameters1

Peptides1

Release20

Nanomedicine1

Delivery system3

Approaches2

Inhalation1

Dissolution1

Antibacterial2

Ethosomes3

Niosomes3

Polymeric2

Evaporation2

Polymer1

Absorption4

Vesicular6

Buccal1

Hydrophobic drugs1

Analytical2

Efficacy1

Topical drug delivery2

Permeation of drug1

Concentration6

Soluble1

Dispersion3

Nasal drug delivery1