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FluorouracilLeucovorinAntimetabolites, AntineoplasticChemistry, PharmaceuticalAntineoplastic Combined Chemotherapy ProtocolsDihydrouracil Dehydrogenase (NADP)Organoplatinum CompoundsDrug Administration ScheduleDelayed-Action PreparationsColorectal NeoplasmsCisplatinThymidylate SynthaseInfusions, IntravenousDrug CompoundingExcipientsCamptothecinMethotrexateTabletsUracilFloxuridineChemotherapy, AdjuvantTreatment OutcomeAdenocarcinomaEpirubicinDrug CarriersFluorodeoxyuridylateDosage FormsColonic NeoplasmsCombined Modality TherapyCyclophosphamideTegafurTechnology, PharmaceuticalAntimetabolitesMitomycinSurvival AnalysisAdministration, OralDoxorubicinAntineoplastic AgentsDisease-Free SurvivalSemustineStomach NeoplasmsEmulsionsDrug StabilityDrug Delivery SystemsCapsulesParticle SizeDeoxycytidineDose-Response Relationship, DrugRectal NeoplasmsLevamisoleBiological AvailabilityNeoplasm MetastasisTherapeutic EquivalencyBreast NeoplasmsSurvival RateProdrugsStomatitisInfusions, Intra-ArterialSolubilityPowdersNanoparticlesInjections, IntravenousDrug SynergismLiver NeoplasmsAdministration, TopicalLevoleucovorinLiposomesBromouracilPharmaceutical SolutionsTaxoidsAntidotesDrug CombinationsFlucytosineSkin AbsorptionChronotherapyMethylcelluloseLeukopeniaTime FactorsCarcinoma, Squamous CellHead and Neck NeoplasmsEsophageal NeoplasmsPhosphoribosyl PyrophosphateNeoplasm StagingPharmaceutical VehiclesPaclitaxelNeutropeniaDrug Resistance, NeoplasmDrug EvaluationMucositisNeoadjuvant TherapyCell Line, TumorSuspensionsNauseaPancreatic NeoplasmsThymidine PhosphorylaseCytosine DeaminaseArea Under CurveOxonic AcidPoloxamerFreeze Drying
CapecitabineLiposomal formulationChemotherapeuticOral formulationCisplatinLeucovorinIrinotecanAnticancer drugMetastaticDosageToxicityTopical formulationsSignificantlyGemcitabineInflammationDecreasesSynthesisTolerabilityNanoparticlesPaclitaxelIntravenousAlopeciaTumorConcentrationsCardiacAdverse eventsCreamStrengthDrugCreamsDosesConventionalGenericTreatmentExperimentsMedicationPatientsDerivativesStudyTypes of cancerDemonstrateResultsDrugsProductsWeeksQuality ControlTreatCaseTraditionalLiquidAgentDeliveryClassSection
Capecitabine6
  • Capecitabine is a prodrug of fluorouracil that undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)
  • The cardiac symptoms subsided after initiation of capecitabine, the oral formulation of 5-fluorouracil. (elsevierpure.com)
  • To our knowledge, this is only the second reported case where 5-fluorouracil was successfully replaced by capecitabine without recurrence of cardiac symptoms. (elsevierpure.com)
  • Capecitabine may be a viable option for patients who develop 5-fluorouracil-induced chest pain. (elsevierpure.com)
  • Saneeymehri, SS, Markey, KR & Mahipal, A 2016, ' Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review ', Journal of Oncology Pharmacy Practice , vol. 22, no. 3, pp. 552-555. (elsevierpure.com)
  • 7. Hypersensitivity to capecitabine, fluorouracil, or any component of the formulation and or a known deficiency of dihydropyrimidine dehydrogenase. (stanford.edu)
Liposomal formulation6
  • The results showed liposomal formulation increases the penetration of the 5-Fluorouracil in biological membrane. (repository-tnmgrmu.ac.in)
  • Irinotecan sucrosofate salt in a pegylated liposomal formulation. (medscape.com)
  • As pegylated liposomal formulation: In patients who failed 1st-line platinum-based chemotherapy regimen: 50 mg/m 2 via infusion over 60 minutes once every 4 weeks. (azurewebsites.net)
  • As pegylated liposomal formulation: In patients with low CD4 counts and extensive visceral or mucocutaneous disease, or after failure of or intolerance to previous systemic chemotherapy: 20 mg/m 2 via infusion over 30 or 60 minutes once every 2-3 weeks. (azurewebsites.net)
  • As pegylated liposomal formulation: In combination with bortezomib for the treatment of progressive cases in patients who have undergone or are unsuitable for a bone marrow transplant and who have received at least 1 prior therapy: 30 mg/m 2 on day 4 of the bortezomib 3 week regimen given via infusion over 60 minutes immediately after bortezomib infusion. (azurewebsites.net)
  • As pegylated liposomal formulation: Monotherapy in patients with increased cardiac risk: 50 mg/m 2 via infusion over 60 minutes once every 4 weeks. (azurewebsites.net)
Chemotherapeutic2
  • 5-fluorouracil is a chemotherapeutic agent that plays an important role in the treatment of various cancers including head and neck and gastrointestinal malignancies. (elsevierpure.com)
  • In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. (emerginginvestigators.org)
Oral formulation3
  • No significant bone marrow or hepatotoxicity was seen, there was no detectable difference in bone marrow toxicity between patients on intravenous and those on oral formulation, and no patients discontinued treatment. (tropmedres.ac)
  • The bioavailability of the oral formulation may be reduced in late-stage HIV-infected patients in Thailand. (tropmedres.ac)
  • Pharmaceutical Oral Formulation of Methionine as a Pediatric Treatment in Inherited Metabolic Disease. (stabilis.org)
Cisplatin2
  • A total of 95 patients received front-line therapy with 20 mg/m 2 of cisplatin, 350 mg/m 2 of 5-fluorouracil, and 20 mg/m 2 of docetaxel administered once weekly for 6 consecutive weeks followed by a 2-week break. (elsevierpure.com)
  • 1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. (sigmaaldrich.com)
Leucovorin4
Irinotecan1
Anticancer drug1
  • 5-Fluorouracil (5-FU) being a mainstream anticancer drug is under keen and detailed investigation for prodrugs formulations in order to minimize the associated side effects. (ntu.ac.uk)
Metastatic1
Dosage1
  • The results suggest that either formulation can be used safely at this dosage in a developing country setting, without drug concentration monitoring. (tropmedres.ac)
Toxicity4
  • CONCLUSIONS: In patients with advanced gastric and esophageal cancer who were not candidates for every-3-week DCF, a weekly formulation of DCF demonstrated modest activity with minimal hematologic toxicity, suggesting that weekly DCF is a reasonable treatment option for such patients. (elsevierpure.com)
  • Moreover, Emtricitabine IP Impurity F is also used in the process of Abbreviated New Drug Application (ANDA) filing to FDA and toxicity study of respective drug formulation. (synthinkchemicals.com)
  • This product provided by SynThink is generally used for Abbreviated New Drug Application (ANDA) filing to FDA, toxicity study of respective drug formulation, Quality Control (QC) and analytical studies during commercial production of the API]. (synthinkchemicals.com)
  • This novel co-formulation offers significantly reduced toxicity, enhanced safety, and improved tolerability of greater 5-FU doses compared to SOC formulations. (fivephusion.com)
Topical formulations2
  • The 5% strength topical formulations are also useful in the treatment of superficial basal cell carcinomas. (rxwiki.com)
  • This technology provides a unique base for topical formulations, permitting a concentrated delivery of the active ingredient and potentially allowing less systemic absorption, which may lead to reduced systemically associated adverse effects. (shopwestcomb.com)
Significantly1
  • Prepared formulation significantly altered the follicular response in 5-Fluorouracil induced alopecia model. (edu.sa)
Gemcitabine1
  • The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
Inflammation1
Decreases1
  • The Buccal film formulation decreases dosing frequency, avoids gastric irritation, reduces cytotoxicity, avoids first pass metabolism and improve bioavailability of the drug. (repository-tnmgrmu.ac.in)
Synthesis1
  • Paclitaxel protein bound is a microtubular inhibitor (albumin-conjugated formulation) and a natural taxane that prevents depolymerization of cellular microtubules, which results in DNA, RNA, and protein synthesis inhibition. (medscape.com)
Tolerability3
  • The objective of the current study was to evaluate the efficacy and tolerability of a weekly formulation of DCF. (elsevierpure.com)
  • The FP101A data reaffirms the superior safety and tolerability of Deflexifol™ over SOC 5-FU formulations in end stage solid tumour patients, as observed in the previously completed forty patient phase 1b/2a clinical study, FP101. (fivephusion.com)
  • Current formulations of 5-FU and LV suffer from limitations in their safety, tolerability, effectiveness and pharmacological compatibility. (fivephusion.com)
Nanoparticles2
  • In-vitro and in-vivo assessment of dextran-appended cellulose acetate phthalate nanoparticles for transdermal delivery of 5-fluorouracil. (bvsalud.org)
  • The main objective of the study is to formulate 5 Fluorouracil loaded sustained release nanoparticles with the size of around 250 nm and to increase the encapsulation efficiency of the drug. (ajrbps.com)
Paclitaxel1
  • In the animal portion of the new study, Sukumar's lab examined the intraductal effectiveness of four standard anticancer drugs, 5-fluorouracil (5FU), carboplatin, methotrexate and paclitaxel, all compared with PLD. (futurity.org)
Intravenous1
  • Concentrations of flucytosine with intravenous formulation at 100 mg/kg/day may be in excess of those required for maximal fungicidal activity. (tropmedres.ac)
Alopecia1
  • Our compounds formulations are designed to treat and correct a variety of dermatological conditions like eczema , psoriasis , rosacea , acne , warts and alopecia . (townelakepharmacy.com)
Tumor3
  • Fluorouracil is used in combination with other medications to treat certain types of breast cancer after surgery to remove the tumor or radiation therapy. (rxwiki.com)
  • Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil. (greenmedinfo.com)
  • Intraperitoneal administration of bromelain (1, 12.5, 25 mg/kg), began 24 h after tumor cell inoculation in experiments in which 5-fluorouracil (5-FU, 20 mg/kg) was used as positive control. (greenmedinfo.com)
Concentrations2
Cardiac2
  • Therapy with 5-fluorouracil is rarely associated with cardiotoxic effects including angina, heart failure, myocardial infarction and cardiac arrest, resulting in discontinuation at the expense of sub-optimal treatment of the targeted malignancy. (elsevierpure.com)
  • Currently, there is insufficient evidence to recommend an optimal approach for safe and effective alternative treatment for patients who experience 5-fluorouracil-induced cardiac adverse events. (elsevierpure.com)
Adverse events1
  • Although newer formulations can reduce the risk for adverse events to patients, the majority of IV chemotherapies are packaged such that they require pharmacists to manipulate these drugs before administration. (valuebasedcancer.com)
Cream8
  • Fluorouracil cream and topical solution are prescription medications used to treat a skin condition on the face and front part of the scalp known as actinic keratosis (also called solar keratosis). (rxwiki.com)
  • Common side effects of fluorouracil cream and topical solution include skin and eye irritation. (rxwiki.com)
  • Safely Buy Efudex Cream ( Fluorouracil ) from Canada Prescriptions Plus. (canadaprescriptionsplus.com)
  • In dermis , concentration of 5-FU was found higher in case of FDCN formulation than plain FU cream. (bvsalud.org)
  • Information is also available online at https: Continue typing to refine, 5 fluorouracil cream. (shopwestcomb.com)
  • Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types cream treatment cannot be used. (shopwestcomb.com)
  • If you have concerns about the fluorouracil of your reaction to 5-FU cream, get in touch with your doctor. (shopwestcomb.com)
  • The total area of skin being treated with Efudix at any one time should not exceed cm 2 approximately 23 x 23 cm, 5 fluorouracil cream. (shopwestcomb.com)
Strength1
  • Fluorouracil ( Efudex ) 5% strength topical formulation is also useful in the treatment of superficial basal cell carcinomas. (rxwiki.com)
Drug4
  • The Jss o 5-Fluorouracil from F4 was found 9.4802 mg cm-2 h-1, the result indicates 8.53 times higher than compared to free drug. (repository-tnmgrmu.ac.in)
  • The F4 formulation shows satisfactory results in the parameters such as Weight, thickness, Surface pH, percentage moisture absorption and loss, folding endurance, drug content and diffusion studies. (repository-tnmgrmu.ac.in)
  • These high in situ gelling properties can also be used for numerous further reasons such as for parenteral formulations, as coating material or for food additives Due to a sustained drug release, a prolonged therapeutic level of drugs exhibiting a short elimination half-life can be maintained. (wikipedia.org)
  • The amount of released drug (48 h) from pegylated and non pegylated formulations in the presence of Spans 60 and 20 were 8, 10, 6, 7%, respectively. (scialert.net)
Creams1
  • The hematological data recommended that FDCNs formulation was less immunogenic compared to FU creams formulation. (bvsalud.org)
Doses1
  • Starting first with dextrose-essentially sugar water-and later using escalating doses of the same formulation administered to Sukumar's rats, she infused patients' breast ducts via a small catheter placed into the nipple. (futurity.org)
Conventional6
  • As conventional formulation: As a single agent: 60-75 mg/m 2 once every 3-4 weeks or 1.2-2.4 mg/kg once every 3 weeks. (azurewebsites.net)
  • As conventional formulation: Dose reduction or longer intervals between cycles may be needed. (azurewebsites.net)
  • As conventional formulation: Dose reduction may be needed. (azurewebsites.net)
  • As conventional formulation: As a component of adjuvant therapy (multi-agent) in women with axillary lymph node involvement following resection of primary breast cancer: In combination with cyclophosphamide: 60 mg/m 2 on day 1 of each 21-day treatment cycle, for a total of 4 cycles. (azurewebsites.net)
  • Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
  • It has been reported that plasma Cur levels are quite low after oral administration of conventional formulations [7, 8,10]. (researchgate.net)
Generic1
  • The Actikerall medication you purchase is manufactured by Almirall Ltd. Fluorouracil/Salicylic Acid is the generic alternative to Actikerall. (pharmapassport.com)
Treatment2
  • Its main medicinal use is recognized as digestive, in vaccine formulation, antitumoral and skin debrider for the treatment of burns. (greenmedinfo.com)
  • Optimal treatment of AK lesions in the elderly depends on several factors, including adherence to treatment regimens fluorouracil modification of regimens to adjust to pharmacokinetic and pharmacodynamic changes that occur. (shopwestcomb.com)
Experiments1
  • Experiments in various species revealed an impairment of fluorouracil fertility and reproductive performance of systemic 5-fluorouracil. (shopwestcomb.com)
Medication2
  • Fluorouracil injectable is a prescription medication used to treat certain types of cancer. (rxwiki.com)
  • Fluorouracil is a prescription medication used in combination with other medications to treat colon cancer or rectal cancer (cancer that begins in the large intestine) that has gotten worse or spread to other parts of the body. (rxwiki.com)
Patients3
  • Fluorouracil has some effect on DNA and is useful in symptom palliation for patients with progressive disease. (medscape.com)
  • METHODS: Data from 117 patients treated at The University of Texas M. D. Anderson Cancer Center from 2002 to 2006 with a weekly formulation of DCF were retrospectively collected. (elsevierpure.com)
  • The present invention provides an enteral nutritional formulation that meets the nutrient requirements of patients with wounds. (everypatent.com)
Derivatives1
  • A pharmacokinetic study after oral administration of the Cur ester derivatives was performed in rats and compared to the administration of suspended or dissolved Cur formulation. (researchgate.net)
Study3
  • The study confirms that amount of polymers in buccal film formulation plays an essential role in the physicochemical properties and permeability through Goat buccal skin. (repository-tnmgrmu.ac.in)
  • In this study formulations were prepared by reverse phase evaporation employing Spans 60 and 20. (scialert.net)
  • Herbal formulation, HF1 diminishes tumorigenesis: a cytokine study between MCF-7 and BM-MSCs. (emerginginvestigators.org)
Types of cancer1
  • Fluorouracil treats certain types of cancer. (rxwiki.com)
Demonstrate1
  • These results demonstrate that the possibility of delivering 5 Fluorouracil to colorectum with enhanced encapsulation efficiency. (ajrbps.com)
Results1
  • The results showed the formulation prepared with Span 60 is more effective than that of Span 20 and the IC 50 of the former was decreased twice while IC 50 of the later decreased 1.5 times. (scialert.net)
Drugs2
  • Fluorouracil is in a class of drugs known as antimetabolites. (rxwiki.com)
  • Along with new agents in the pipeline for prostate cancer arenew applications and different formulations of older drugs, saidmedical oncologist Gene Resnick, MD, vice president for clinicalresearch, Schering-Plough Research Institute. (cancernetwork.com)
Products1
  • Our SAFC ® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines. (sigmaaldrich.com)
Weeks1
Quality Control1
  • This compound is generally used for Quality Control (QC), Quality Assurance (QA) during commercial production of Emtricitabine and its related formulations. (synthinkchemicals.com)
Treat1
  • Fluorouracil is also used to treat cancer of the pancreas and stomach cancer. (rxwiki.com)
Case1
  • In this article, we review the literature reported on 5-fluorouracil-associated cardiotoxicity and present a case of a patient who experienced chest pain on 5-fluorouracil. (elsevierpure.com)
Traditional1
  • The unique formulation of this formula targets the middle how to get prescribed to promethazine of the eye and so is less likely to interfere with vision than traditional formulations. (ampaperu.info)
Liquid1
  • Because of these properties they can be administered as liquid formulations forming stable gels once having reached their site of application. (wikipedia.org)
Agent1
Delivery1
  • The aim of this research was transdermal delivery of 5-fluorouracil ( 5-FU ) using dextran -coated cellulose acetate phthalate (CAP) nanoparticulate formulation. (bvsalud.org)
Class1
Section2