Forms of urticaria urticaria. Medical search. Frequent questions

Autoimmune urticaria, also known as chronic autoimmune urticaria, is a type of chronic urticaria characterized by the presence of autoantibodies in the patient's immune system that target the body's own mast cells, leading to episodes of hives (urticaria). (wikipedia.org)
Urticaria, commonly known as hives, has been recognized as a medical condition for centuries, with descriptions of the characteristic skin lesions appearing in ancient medical texts. (wikipedia.org)
These autoantibodies were found to be capable of activating mast cells and basophils, the key effector cells in urticaria, leading to the release of histamine and other inflammatory mediators that cause the characteristic hives and itching. (wikipedia.org)
This is known as hives (urticaria). (medlineplus.gov)
Cold urticaria can become dangerous in rare cases , such as when hives appear all over the body after jumping into cold water. (ecarf.org)
Cold Urticaria - Also known as hives. (sportsinjuryclinic.net)
Sometimes, doctors don't know exactly why hives have formed. (webmd.com)
Hives that form after firmly stroking or scratching the skin. (webmd.com)
You may also have other forms of hives. (webmd.com)
Epinephrine is under clinical development by ARS Pharmaceuticals and currently in Phase II for Chronic Urticaria Or Hives. (pharmaceutical-technology.com)
According to GlobalData, Phase II drugs for Chronic Urticaria Or Hives have a 52% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
Hives or the Latin term "urticaria" refers to an acutely occurring and misdirected skin reaction. (derma-wien.at)
Certain forms of hives are based on genetic causes. (derma-wien.at)
Urticaria involves hives, angioedema, or both. (mhmedical.com)
Chronic urticaria causes skin welts or hives that last more than 6 weeks. (medicalnewstoday.com)
There was also backing for Novartis' asthma drug Xolair (omalizumab) to be used as a treatment for chronic spontaneous urticaria, a severe form of hives. (pharmatimes.com)
Urticaria is a group of diseases characterized by the development of wheals (hives), angioedema (see chapter 1.1.2), or both. (cyberderm.net)
XOLAIR ® (omalizumab) for subcutaneous use is an injectable prescription medicine used to treat chronic spontaneous urticaria (CSU, previously referred to as chronic idiopathic urticaria (CIU), chronic hives without a known cause) in people 12 years of age and older who continue to have hives that are not controlled with H1 antihistamine treatment. (xolair.com)
XOLAIR is not used to treat other forms of hives. (xolair.com)
Warwick is one of the few people in the world known to have something called aquagenic urticaria (urticaria being the medical term for hives). (gizmodo.com)
Aside from hives, sufferers of vibratory urticaria can experience flushing, headaches, and a metallic taste in the mouth following exposure. (gizmodo.com)

In general, patients with urticaria do not require further inpatient care unless their urticaria is severe and does not respond to antihistamine therapy or unless they progress to laryngeal angioedema and/or anaphylactic shock or have comorbidities that necessitate inpatient therapy. (medscape.com)
A form of angioedema runs in families and has different triggers, complications, and treatments. (medlineplus.gov)
Urticaria, angioedema, and pruritus. (medlineplus.gov)
Urticaria and angioedema. (medlineplus.gov)
2024). Urticaria & angioedema. (mhmedical.com)
Angioedema is no more likely than urticaria to be associated with systemic complications, such as laryngeal edema or hypotension. (mhmedical.com)
Urticaria is the development of transient localised oedema in the dermis , characterised by wheals and often co-exists with angioedema. (dermnetnz.org)
an estimated 40% of patients with chronic urticaria (lasting over 6 weeks) have associated angioedema. (dermnetnz.org)
Angioedema with urticaria tends to suggest a histaminergic form, which includes acute allergic angioedema and histaminergic idiopathic angioedema. (dermnetnz.org)
Urticaria needs to be differentiated from other medical conditions where wheals, angioedema, or both can occur, e.g. anaphylaxis, autoinflammatory syndromes, urticarial vasculitis, orbradykinin-mediated angioedema including hereditary angioedema (HAE). (cyberderm.net)
Urticaria may be associated with angioedema: Pronounced erythematous or skin colored swelling of the lower dermis and subcutis or mucous membranes. (cyberderm.net)
Acute spontaneous urticaria: Occurrence of spontaneous wheals, angioedema or bothfor less than 6 weeks. (cyberderm.net)
Angioedema is a rather common form of edema occurring in both hereditary and non-hereditary form. (bvsalud.org)
Urticaria and angioedema are important components of systemic anaphylaxis which is an acute life threatening condition 2 . (bvsalud.org)

Acute inflammatory dermatosis conditions include erythema multiforme (EM), pruritus (urticaria), and eczema ( TABLE 1 ). (uspharmacist.com)
The intense pruritus of urticaria is a result of histamine released into the dermis. (medscape.com)
and positive anti-HCV an- skin disorders, such as pruritus, urticaria, tibodies detected using IgG 3rd-generation erythema multiforme and nodosum, may commercial enzyme-linked immunosorbent also be linked to HCV [ 2 ]. (who.int)

The wheals of cholinergic urticaria are 2-3 mm in diameter with a large surrounding red flare. (mhmedical.com)
In some forms of urticaria the lesions may be papular (e.g. cholinergic urticaria). (cyberderm.net)
The Greater Manchester Clinical Reference Group reviewed a request to add omalizumab to formulary for the unlicensed indications of severe chronic inducible urticarias (solar urticaria, cold and heat urticaria, symptomatic dermographism, delayed pressure urticaria and cholinergic urticaria). (gmmmg.nhs.uk)

How does Xolair (Novartis / Genentech), approved for chronic idiopathic urticaria in the United States, perform, and how will emerging biologics compare? (clarivate.com)
The efficacy of rupatadine as treatment for allergic rhinitis (AR) and chronic idiopathic urticaria (CIU) has been investigated in adults and adolescents (aged over 12 years) in several controlled studies, showing a rapid onset of action and a good safety profile even in prolonged treatment periods of a year. (wikidoc.org)

The lesions of IgE-mediated urticaria usually last less than 24 hours and are often migratory and leave no residual skin abnormalities. (medscape.com)
Individual lesions in true urticaria last less than 24 hours and often only 2-4 hours. (mhmedical.com)

The most common form of mastocytosis. (dermis.net)
The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in children. (curehunter.com)
Rare and severe form of cutaneous mastocytosis. (dermnetnz.org)
Urticaria pigmentosa rarely progresses to systemic mastocytosis in children but may do so more often in adults. (msdmanuals.com)

Urticaria results from the release of histamine, bradykinin, leukotriene C4, prostaglandin D2, and other vasoactive substances from mast cells and basophils in the dermis. (medscape.com)

More commonly, mast cells congregate in many areas of the skin, forming small reddish brown spots or bumps (called urticaria pigmentosa). (msdmanuals.com)
Urticaria pigmentosa may occur as reddish bumps on the skin. (msdmanuals.com)

Urticaria appears as raised, well-circumscribed areas of erythema and edema, often with central pallor, that involve the dermis and epidermis and are usually very pruritic. (medscape.com)
Phosgene oxime is an urticant or nettle agent capable of producing erythema, wheals, and urticaria. (cdc.gov)

True urticaria should be differentiated from diseases that present with similar lesions that are not true urticaria (eg, adult-onset Still disease, urticarial vasculitis, and cryopyrin-associated periodic syndromes). (mhmedical.com)
Because of the similarities between childhood Still's disease and the adult form (adult-onset Still's disease, AOSD), Ilaris is expected to have similar benefits in adults. (europa.eu)

in 1999 showed that intradermal injection of [autologous serum caused a wheal and flare reaction (a hallmark of urticaria) in a majority of patients with CSU, providing further evidence of the role of autoantibodies in this condition. (wikipedia.org)
Autoimmune urticaria is characterized by the presence of autoantibodies, which are antibodies that the immune system mistakenly produces against the body's own cells. (wikipedia.org)
In the case of autoimmune urticaria, these autoantibodies primarily target the high-affinity IgE receptor (FcεRI) on mast cells and basophils, or less commonly, IgE itself. (wikipedia.org)
Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. (scielo.br)
Some patients with chronic spontaneous urticaria demonstrate autoantibodies directed against mast cell IgE receptors. (mhmedical.com)

Unlike aquagenic urticaria, researchers have been able to discover an inherited mutation that explains at least some cases. (gizmodo.com)

Autoimmune urticaria is a relatively rare condition, affecting a small percentage of the population. (wikipedia.org)
The exact cause of autoimmune urticaria is not fully understood, but it is believed to involve a complex interplay of genetic and environmental factors. (wikipedia.org)
Despite ongoing research, many aspects of autoimmune urticaria remain poorly understood, and it continues to be a challenging condition to manage. (wikipedia.org)
The term "autoimmune urticaria" refers to a subset of chronic spontaneous urticaria (CSU) cases where the immune system appears to play a significant role. (wikipedia.org)
One of the key studies that shaped the current understanding of autoimmune urticaria was published by Hide et al. (wikipedia.org)
Subsequent research has further refined our understanding of autoimmune urticaria. (wikipedia.org)
Despite these advances, many questions remain about the precise mechanisms underlying autoimmune urticaria, and research in this area is ongoing. (wikipedia.org)
However, in autoimmune conditions like autoimmune urticaria, the immune system mistakenly identifies its own cells as foreign and produces antibodies against them. (wikipedia.org)

Solar Urticaria. (uslegalforms.com)
We report on a case of solar urticaria with elevated protoporphyrin in the stool. (karger.com)
Other kinds of physical urticaria tend to involve an overreaction by certain immune cells to a stimulus like cold or vibration, but solar urticaria might be caused when photosensitive chemicals in the body are created in response to UV radiation, which then somehow trigger an unwarranted antibody response. (gizmodo.com)

Epinephrine (ARS-1) is under development for the treatment of anaphylaxis caused by severe allergic reactions to medications, insect bites, asthma, urticaria, seasonal allergic rhinitis, food allergy and infectious rhinitis. (pharmaceutical-technology.com)
Schubert and Goetz noted no adverse effects in their series of 67 patients with allergic fungal sinusitis (AFS) who were treated for up to 1 year with systemic corticosteroids, but long-term follow-up study for this form of therapy is lacking. (medscape.com)
Rupatadine fumarate has been approved for the treatment of allergic rhinitis and chronic urticaria in adults and children over 12 years. (wikidoc.org)
Respiratory and skin signs and at work and was transported by emergency medical services symptoms, including asthma, allergic rhinitis, and urticaria, (EMS) to a local emergency department (Figure). (cdc.gov)

Therefore, the clinician must rule out these more severe syndromes of anaphylaxis in patients presenting with urticaria. (medscape.com)
EM is classified into two forms: a mild or minor form (about 80% of cases) and a major form (rarer and severe). (uspharmacist.com)
they are more widespread and severe than in the minor form, and it is painful for the patient to eat and urinate. (uspharmacist.com)
It is advisable to reserve the parenteral form of this drug for moderately severe and severe infections and for patients who are unable to take the oral forms. (nih.gov)
severe forms of familial cold auto-inflammatory syndrome (FCAS) / familial cold urticaria (FCU) presenting with signs and symptoms beyond cold-induced urticarial skin rash. (europa.eu)

The etiologies of both acute and chronic urticaria are numerous. (medscape.com)
Urticaria is divided into acute and chronic forms. (mhmedical.com)

Doctors generally use a provocation test to confirm a diagnosis of cold urticaria. (ecarf.org)
Standardized provocation testing to diagnose chronic inducible urticaria are required for an accurate diagnosis. (cyberderm.net)

The fluid pools within the skin to form spots and large welts. (kidshealth.org)

Dermatology referral is mandatory if vasculitic urticaria is suspected. (medscape.com)
Background: Despite the existence of numerous dermatology-specific quality-of-life questionnaires, there exists a need for a well-validated instrument to evaluate and monitor patients with chronic urticaria. (elsevierpure.com)

Acute urticaria is better managed with oral antihistamines but if they are not effective many practitioners prescribe systemic steroids to provide the patient with short-term reliefif the rash recurs. (klobasgrumble.com)
If this occurs, the patient should be observed for a few days (12-14 days) because it increases the risk of progression from pulmonary hypertension to sudden death [28], for steroids urticaria topical. (klobasgrumble.com)
The urticaria drug market is dominated by oral medications, including steroids and second-generation, nondrowsy antihistamines, prescribed for both chronic inducible and chronic spontaneous urticaria. (clarivate.com)
What is the physician perspective on steroids and antihistamines for chronic urticaria? (clarivate.com)

This immunologically distinct type of urticaria is considered autoimmune because the immune system, which normally protects the body from foreign organisms, mistakenly attacks the body's own cells, causing inflammation and other symptoms. (wikipedia.org)
What are the symptoms of chronic urticaria? (kyoto2.org)

The first article that discussed urticaria as a type I hypersensitivity was in 1962. (wikipedia.org)

Urticaria associated with a drug reaction. (medscape.com)
The mast cell-activating signals in urticaria are ill defined and likely to be heterogeneous and diverse (IgE-mediated Type I-reaction, non specific histamine liberators, activation of complement, autoimmune mediated urticaria - IgG against IgE or against high affinity IgE-receptor and IgE against autoantigens, as well as other poorly understood mechanisms). (cyberderm.net)
IgE-mediated (Type I Reaction) foods, medications, bee or wasp toxins, foreign proteins and other exogenous materials such as latex or plant products (contact urticaria). (cyberderm.net)

For people 12 years of age and older with chronic spontaneous urticaria (CSU) not controlled by H1 antihistamines. (xolair.com)

Physical forms (pressure, heat, vibration). (cyberderm.net)

Several conditions can cause the skin to be prone to varying degrees of itching: contact eczema, lichen planus, urticaria, dryness in mature skin, etc. (aveneusa.com)

Usually, however, the experienced clinician is able to distinguish these other diseases from urticaria because of the latter's distinctive appearance (see the images below), because it is intensely pruritic, and because it blanches completely with pressure. (medscape.com)
The type III immune-complex disease is associated with systemic lupus erythematosus and other autoimmune diseases that cause urticaria. (medscape.com)

Acute urticaria: Does not require a diagnostic workup, as it is usually self-limiting. (cyberderm.net)

Various medications are available for the treatment of cold urticaria. (ecarf.org)
The most common causes of acute urticaria are foods, upper respiratory infections, and medications. (mhmedical.com)

For patients who come to our office and suffer from urticaria for more than 6 weeks, we offer a detailed medical history and examination . (derma-wien.at)
The USS was pilot tested on 28 patients with symptomatic chronic urticaria, and a modified version was tested in 80 patients. (elsevierpure.com)
As with individuals on any form of long-term therapy, patients using topical corticosteroid sprays should be monitored. (medscape.com)
A XOLAIR prescription is required for patients with chronic spontaneous urticaria (CSU). (xolair.com)

4 Herein, we present a 7-year-old boy and a 6-year-old boy with giant urticaria in whom the disease appeared due to insect bite on their forehead followed by swelling of face. (bvsalud.org)

How do allergists and dermatologists diagnose and treat chronic urticaria, and how does treatment differ between specialists? (clarivate.com)

ECARF spoke to Dr Markus Magerl of Allergie-Centrum-Charité in Berlin about the strange phenomenon of cold urticaria. (ecarf.org)
Urticaria can also cause difficulties for people whose mucous membranes react to the cold. (ecarf.org)
The body cannot form antibodies against the cold as a physical stimulus and therefore cannot develop an allergy . (ecarf.org)

By submitting this form, I am requesting disease education and other materials from and on behalf of Genentech, its affiliates, and Novartis. (xolair.com)

Diseases8

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Hives21

Angioedema14

Pruritus3

Cholinergic urticaria3

Chronic idiopathic urticaria2

Last less than 24 hours2

Mastocytosis4

Release of histamine1

Pigmentosa2

Erythema2

Adult-onset2

Autoantibodies5

Aquagenic urticaria1

Autoimmune urticaria8

Solar3

Allergic4

Severe5

Acute and chronic2

Diagnosis2

Welts1

Dermatology2

Steroids4

Symptoms2

Hypersensitivity1

Reaction3

Antihistamines1

Vibration1

Eczema1

Diseases2

Workup1

Medications2

Patients4

Insect1

Treat chronic1

Cold3

Genentech1