• severe pneumococcal
  • Whilst this covers only seven strains out of more than ninety strains, these seven strains cause 80% to 90% of cases of severe pneumococcal disease, and it is considered to be nearly 100% effective against these strains. (wikipedia.org)
  • meninges
  • Meningitis is most commonly caused by infection by bacteria, viruses, or fungi, although it can also be caused by bleeding into the meninges, cancer , diseases of the immune system, and an inflammatory response to certain types of chemotherapy or other chemical agents. (encyclopedia.com)
  • The organism spreads to the blood stream (where it can cause bacteremia) and is carried to the meninges, joint spaces, bones, and peritoneal cavity, and may result in meningitis, brain abscess, septic arthritis, or osteomyelitis. (wikipedia.org)
  • septicaemia
  • Meningitis is often associated with septicaemia, otherwise known as blood poisoning, which can also be extremely serious. (netdoctor.co.uk)
  • Research has found that key early warning signs of meningitis and septicaemia in children under 17 years old often include cold hands and feet, abnormal skin colour (pale, bluish or mottled), and leg pains. (netdoctor.co.uk)
  • If your child has these early warning signs and you suspect they have septicaemia or meningitis, do not wait for a rash to appear but seek medical advice immediately. (netdoctor.co.uk)
  • Ben died from the group B strain of meningitis and meningococcal septicaemia, which occurs when meningococcal bacteria enter the blood strain and multiply uncontrollably, poisoning the blood and completely overwhelming the immune system damaging the blood vessels, tissues and organs. (heart.co.uk)
  • Meningitis UK was originally called the Spencer Dayman Meningitis Laboratories in memory of founder and chief executive Steve Dayman's son, who died of meningitis and meningococcal septicaemia in 1982, aged 14-months. (wikipedia.org)
  • infections
  • Children with pneumococcal meningitis were identified from among a group of patients with systemic infections caused by S pneumoniae who were enrolled prospectively in the United States Pediatric Multicenter Pneumococcal Surveillance Study at eight children's hospitals in the United States. (aappublications.org)
  • The World Health Organization estimate that in 2005 pneumococcal infections were responsible for the death of 1.6 million children worldwide. (wikipedia.org)
  • S. pneumoniae is responsible for 15-50% of all episodes of community acquired pneumonia, 30-50% of all cases of acute otitis media, and a significant proportion of bloodstream infections and bacterial meningitis. (wikipedia.org)
  • In the United States, vaccination with Prevnar is recommended for all children younger than 2 years, and for unvaccinated children between 24 and 59 months old who are at high risk for pneumococcal infections. (wikipedia.org)
  • Adjuvant
  • We tested the adjuvant administration of paquinimod and the anti-HMGB1 antibody in our pneumococcal meningitis mouse model assessing clinical (clinical score, open-field-test, temperature) and pathophysiological parameters (intracranial pressure, white blood cell count in CSF, bleeding area) as well as bacterial titers in blood and brain 24 h after administration and 48 h after infection. (biomedcentral.com)
  • Furthermore, we explored the interactions of these two agents with dexamethasone, the standard adjuvant treatment in pneumococcal meningitis (PM), and daptomycin, a non-bacteriolytic antibiotic preventing pathogen-associated molecular pattern (PAMP) release. (biomedcentral.com)
  • strains
  • Children with pneumococcal meningitis caused by penicillin- or ceftriaxone-nonsusceptible organisms and those infected by susceptible strains had similar clinical presentation and outcome. (aappublications.org)
  • The original seven-valent formulation contains serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F, and results in a 98% probability of protection against these strains, which caused 80% of the pneumococcal disease in infants in the US. (wikipedia.org)
  • Outcome
  • In bacterial meningitis, a decreased level of consciousness is predictive for unfavorable outcome, but the clinical features and outcome in patients presenting with a minimal score on the Glasgow Coma Scale are unknown. (jove.com)
  • dexamethasone
  • Only a well-designed, prospective, randomized, placebo-controlled study, conducted in centers where optimal supportive care can be provided, will determine the potential benefit, if any, of dexamethasone in patients with pneumococcal meningitis. (aappublications.org)
  • fever
  • In babies and young children meningitis can cause fever , vomiting, refusal to feed, a high-pitched or moaning cry and irritability. (netdoctor.co.uk)
  • 1999
  • It was established in 1999 to fund a £500,000 dedicated meningitis research laboratory in the School of Medical Sciences at University of Bristol. (wikipedia.org)
  • lethal
  • In 1928 Frederick Griffith demonstrated transformation of life turning harmless pneumococcus into a lethal form by co-inoculating the live pneumococci into a mouse along with heat-killed virulent pneumococci. (wikipedia.org)
  • proteins
  • It has pneumococcal surface proteins that inhibit complement-mediated opsonization, and it secretes IgA1 protease that will destroy secretory IgA produced by the body and mediates its attachment to respiratory mucosa. (wikipedia.org)