• Chagas
  • SEATTLE AND SAN FRANCISCO -- As an infectious disease outbreak raises public awareness and concern in the U.S., the Bill & Melinda Gates Foundation today announced two new grants totaling more than $4.6 million to the Institute for OneWorld Health (iOWH) to fund drug development that will treat two parasitic, neglected diseases - visceral leishmaniasis and Chagas. (gatesfoundation.org)
  • paromomycin
  • iOWH today announced a $4.2 million grant from the foundation to begin final testing of paromomycin, a promising new therapy to cure visceral leishmaniasis, a deadly parasitic disease threatening more than 350 million people worldwide. (gatesfoundation.org)
  • This grant will enable iOWH to partner with the World Health Organization's Special Program for Research and Training in Tropical Diseases (WHO/TDR) and the International Dispensary Association (IDA) to develop paromomycin as a new anti-parasitic drug therapy for visceral leishmaniasis. (gatesfoundation.org)
  • Some possible medications used for visceral disease include liposomal amphotericin B, a combination of pentavalent antimonials and paromomycin, and miltefosine. (wikipedia.org)
  • 60,000
  • Leishmaniasis is a neglected disease resulting in a global morbidity of 2,090 thousand Disability-Adjusted Life Years and a mortality rate of approximately 60,000 per year. (hindawi.com)
  • irregular
  • The nearest and next-nearest neighbors form an irregular octahedral complex, with the three atoms in each double layer slightly closer than the three atoms in the next. (wikipedia.org)
  • medication
  • Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis. (wikipedia.org)
  • Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. (wikipedia.org)
  • Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri. (wikipedia.org)
  • This drug is now listed as a core medication for the treatment of leishmaniasis under the WHO Model List of Essential Medicines. (wikipedia.org)
  • injectable form
  • Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems. (wikipedia.org)
  • rapidly
  • Synapses form rapidly, efficiently and selectively in this system, and are easily accessible for quantification. (jove.com)
  • antimony
  • As dosage regimens for treating leishmaniasis have evolved, the daily dose of antimony and the duration of therapy have been progressively increased to combat unresponsiveness to therapy. (wikipedia.org)
  • It is recommend treating all forms of leishmaniasis with a full 20 mg/kg/day of pentavalent antimony. (wikipedia.org)
  • Four allotropes of antimony are known: a stable metallic form and three metastable forms (explosive, black and yellow). (wikipedia.org)
  • A rare explosive form of antimony can be formed from the electrolysis of antimony trichloride. (wikipedia.org)
  • Black antimony is formed upon rapid cooling of antimony vapor. (wikipedia.org)
  • Antimony trioxide is formed when antimony is burnt in air. (wikipedia.org)
  • Antimony pentoxide (Sb 4O 10) can be formed only by oxidation with concentrated nitric acid. (wikipedia.org)
  • Antimony also forms a mixed-valence oxide, antimony tetroxide (Sb 2O 4), which features both Sb(III) and Sb(V). Unlike oxides of phosphorus and arsenic, these oxides are amphoteric, do not form well-defined oxoacids, and react with acids to form antimony salts. (wikipedia.org)
  • pathogen
  • This response occurs when the body detects a pathogen and forms an antibody specific to an identified antigen (a protein configuration) present on the surface of the pathogen. (wikipedia.org)
  • allotrope
  • Mechanistic studies demonstrate that this carbene-supported P 8 allotrope forms via a [2+cycloaddition dimerization of a transient diphosphene which has been trapped by treatment with 2,3-dimethyl-1,3-butadiene. (jove.com)
  • Treatment
  • Treatment of PCP caused by Pneumocystis jirovecii Prevention of PCP in adults with HIV who have one or both of the following: History of PCP CD4+ count ≤ 200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Pentamidine is classified as an orphan drug by the U.S. Food and Drug Administration Use as an antitumor drug has also been proposed. (wikipedia.org)
  • immune
  • Her research covers the development of diagnostic tests and attenuated vaccines, drug resistance and immune responses for patients suffering from Leishmaniasis in some form. (wikipedia.org)
  • types
  • During development, diverse types of inhibitory neurons with distinct morphological, electrophysiological and neurochemical characteristics have the ability to recognize their target neurons and form synapses which incorporate specific GABA A Rs subtypes. (jove.com)