• Chagas
  • SEATTLE AND SAN FRANCISCO -- As an infectious disease outbreak raises public awareness and concern in the U.S., the Bill & Melinda Gates Foundation today announced two new grants totaling more than $4.6 million to the Institute for OneWorld Health (iOWH) to fund drug development that will treat two parasitic, neglected diseases - visceral leishmaniasis and Chagas. (gatesfoundation.org)
  • vaccine
  • A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins. (wikipedia.org)
  • irregular
  • The nearest and next-nearest neighbors form an irregular octahedral complex, with the three atoms in each double layer slightly closer than the three atoms in the next. (wikipedia.org)
  • injectable form
  • Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems. (wikipedia.org)
  • rapidly
  • Synapses form rapidly, efficiently and selectively in this system, and are easily accessible for quantification. (jove.com)
  • antimony
  • As dosage regimens for treating leishmaniasis have evolved, the daily dose of antimony and the duration of therapy have been progressively increased to combat unresponsiveness to therapy. (wikipedia.org)
  • It is recommend treating all forms of leishmaniasis with a full 20 mg/kg/day of pentavalent antimony. (wikipedia.org)
  • Four allotropes of antimony are known: a stable metallic form and three metastable forms (explosive, black and yellow). (wikipedia.org)
  • A rare explosive form of antimony can be formed from the electrolysis of antimony trichloride. (wikipedia.org)
  • Black antimony is formed upon rapid cooling of antimony vapor. (wikipedia.org)
  • Antimony trioxide is formed when antimony is burnt in air. (wikipedia.org)
  • Antimony pentoxide (Sb 4O 10) can be formed only by oxidation with concentrated nitric acid. (wikipedia.org)
  • Antimony also forms a mixed-valence oxide, antimony tetroxide (Sb 2O 4), which features both Sb(III) and Sb(V). Unlike oxides of phosphorus and arsenic, these oxides are amphoteric, do not form well-defined oxoacids, and react with acids to form antimony salts. (wikipedia.org)
  • pathogen
  • This response occurs when the body detects a pathogen and forms an antibody specific to an identified antigen (a protein configuration) present on the surface of the pathogen. (wikipedia.org)
  • treatment
  • Morbidity takes the form of deformity, disability, and skin lesions, which can be prevented through early treatment and treated with antibiotics and surgery. (wikipedia.org)
  • Mechanistic studies demonstrate that this carbene-supported P 8 allotrope forms via a [2+cycloaddition dimerization of a transient diphosphene which has been trapped by treatment with 2,3-dimethyl-1,3-butadiene. (jove.com)
  • Treatment of PCP caused by Pneumocystis jirovecii Prevention of PCP in adults with HIV who have one or both of the following: History of PCP CD4+ count ≤ 200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Pentamidine is classified as an orphan drug by the U.S. Food and Drug Administration Use as an antitumor drug has also been proposed. (wikipedia.org)
  • immune
  • Her research covers the development of diagnostic tests and attenuated vaccines, drug resistance and immune responses for patients suffering from Leishmaniasis in some form. (wikipedia.org)
  • develop
  • DNDi was awarded USD 9 million over four years by the Bill & Melinda Gates Foundation, forming part of the consortium's USD 16.1 million project to develop new VL treatments in South Asia. (bio-medicine.org)
  • types
  • During development, diverse types of inhibitory neurons with distinct morphological, electrophysiological and neurochemical characteristics have the ability to recognize their target neurons and form synapses which incorporate specific GABA A Rs subtypes. (jove.com)