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  • incidence
  • The intake of 400-600 g/d of fruits and vegetables is associated with reduced incidence of many common forms of cancer, and diets rich in plant foods are also associated with a reduced risk of heart disease and many chronic diseases of ageing. (jpgmonline.com)
  • parasite
  • There are some 10+ million people currently infected with the parasite worldwide, and leishmaniasis threatens 350 million people in 88 countries. (idri.org)
  • Current treatment for leishmaniasis is based on chemotherapy, which relies on a handful of drugs that are associated with serious limitations such as high cost, toxicity and lack of efficacy in endemic areas where the parasite is transmitted. (idri.org)
  • The first stages of development are similar between all Leishmania species, with the sandfly taking up the amastigote form of the parasite following a bite of an infected host. (wikipedia.org)
  • infections
  • Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri. (wikipedia.org)
  • It is an antibiotic used to treat intestinal infections such as cryptosporidiosis and amoebiasis, and other diseases such as leishmaniasis. (wikipedia.org)
  • irregular
  • The nearest and next-nearest neighbors form an irregular octahedral complex, with the three atoms in each double layer slightly closer than the three atoms in the next. (wikipedia.org)
  • deadly
  • With funding from the National Institutes of Health and the Bill & Melinda Gates Foundation, researchers are actively developing diagnostics and vaccines for both the cutaneous and visceral forms of this deadly and disfiguring disease. (idri.org)
  • medication
  • Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis. (wikipedia.org)
  • Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. (wikipedia.org)
  • This drug is now listed as a core medication for the treatment of leishmaniasis under the WHO Model List of Essential Medicines. (wikipedia.org)
  • injectable form
  • Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems. (wikipedia.org)
  • species
  • Such procedures have identified all recognized groups and confirmed the separation of New World leishmaniasis agents into two species complexes, Leishmania mexicana and Leishmania braziliensis . (thefreedictionary.com)
  • Treatment
  • Treatment of PCP caused by Pneumocystis jirovecii Prevention of PCP in adults with HIV who have one or both of the following: History of PCP CD4+ count ≤ 200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Pentamidine is classified as an orphan drug by the U.S. Food and Drug Administration Use as an antitumor drug has also been proposed. (wikipedia.org)
  • rapidly
  • Synapses form rapidly, efficiently and selectively in this system, and are easily accessible for quantification. (jove.com)
  • antimony
  • As dosage regimens for treating leishmaniasis have evolved, the daily dose of antimony and the duration of therapy have been progressively increased to combat unresponsiveness to therapy. (wikipedia.org)
  • It is recommend treating all forms of leishmaniasis with a full 20 mg/kg/day of pentavalent antimony. (wikipedia.org)
  • Four allotropes of antimony are known: a stable metallic form and three metastable forms (explosive, black and yellow). (wikipedia.org)
  • A rare explosive form of antimony can be formed from the electrolysis of antimony trichloride. (wikipedia.org)
  • Black antimony is formed upon rapid cooling of antimony vapor. (wikipedia.org)
  • Antimony trioxide is formed when antimony is burnt in air. (wikipedia.org)
  • Antimony pentoxide (Sb 4O 10) can be formed only by oxidation with concentrated nitric acid. (wikipedia.org)
  • Antimony also forms a mixed-valence oxide, antimony tetroxide (Sb 2O 4), which features both Sb(III) and Sb(V). Unlike oxides of phosphorus and arsenic, these oxides are amphoteric, do not form well-defined oxoacids, and react with acids to form antimony salts. (wikipedia.org)
  • pathogen
  • This response occurs when the body detects a pathogen and forms an antibody specific to an identified antigen (a protein configuration) present on the surface of the pathogen. (wikipedia.org)
  • human
  • IDRI's scientists were the first to identify rK39, a recombinant antigen that can be used to diagnose more than 98% of human visceral leishmaniasis cases with only a drop of blood. (idri.org)
  • diagnostic
  • IDRI was actually founded based on the need to develop a diagnostic for leishmaniasis. (idri.org)
  • Our diagnostic is simple and easy to use in the field, requiring a single drop of blood to quickly diagnose leishmaniasis, rather than the previous method of diagnosis which was invasive and painful. (idri.org)
  • Her research covers the development of diagnostic tests and attenuated vaccines, drug resistance and immune responses for patients suffering from Leishmaniasis in some form. (wikipedia.org)
  • control
  • The resting behaviour of Lutzomyia sand flies, like many other aspects of their biology, is important to understand for targeted, vector-based control methods to reduce transmission of Leishmaniasis. (wikipedia.org)