AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
CartilageCartilage, ArticularCartilage DiseasesChondrocytesNasal CartilagesOsteoarthritisEar CartilageLaryngeal CartilagesHyaline CartilageKnee JointProteoglycansCartilage Oligomeric Matrix ProteinOsteoarthritis, KneeAggrecansCollagen Type IIGlycosaminoglycansMatrilin ProteinsChondrogenesisExtracellular Matrix ProteinsGrowth PlateFractures, CartilageCollagenStiflePatellaTibiaFemurMenisci, TibialNasal SeptumEpiphysesArytenoid CartilageCricoid CartilageCattleThyroid CartilageOsteochondritisMatrix Metalloproteinase 13Weight-BearingJointsTissue EngineeringCompressive StrengthBone and BonesHyaluronic AcidFemur HeadSynovial MembraneExtracellular MatrixMagnetic Resonance ImagingSynovial FluidStress, MechanicalChondroitin SulfatesBiomechanical PhenomenaKnee InjuriesMandibular CondyleArthritis, ExperimentalLubricationSOX9 Transcription FactorProcollagen N-EndopeptidaseUronic AcidsAnterior Cruciate LigamentArthroplasty, Subchondral
ArticularLigamentsOsteoarthritisTissueConnective tissuesTissuesHyalineExtracellular matrixBonesCell-based cartilage repairDegenerationJoints and cartilageHypoplasiaOccursRegenerationMenisciInflammationArthritisMeniscusProgenitor cellsRepairPharyngealMSCsTumorsCollagen fibersInjuriesFibrousChondrocytesDifferentiationMusculoskeletal systemProteinsTherapeuticLongitudinalElasticityFacet jointsHyaluronic AcidHealthyDamageResearchersDestructionStemCells formedHealSkinSurfacesCutaneousBodyTypeProgression
Articular27
  • This procedure repairs damaged articular cartilage. (scoi.com)
  • The current work presents a tribological method for the characterization of frictional behavior of porcine articular cartilage and polyvinyl alcohol (PVA) hydrogels, with the latter as a possible replacement material for cartilage. (anton-paar.com)
  • The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells by: William Webb, et al. (swan.ac.uk)
  • In vitro growth factor-induced bio engineering of mature articular cartilage by: Ilyas Khan, et al. (swan.ac.uk)
  • This may be important for MSC-based repair of articular cartilage. (avma.org)
  • Sample Population -Articular cartilage and synovium with normal gross appearance from metacarpophalangeal and metatarsophalangeal joints of 8 horses (1 to 10 years of age). (avma.org)
  • Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
  • Native and concentrated BMA have been intensively studied in the context of articular cartilage repair. (hindawi.com)
  • Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)
  • We propose a novel, scaffold-less technique of cartilage repair in the human knee that combines arthroscopic microfracture and outpatient intra-articular injections of autologous bone marrow-derived mesenchymal stem cells (MSCs) and hyaluronic acid (HA). (nih.gov)
  • Loss of articular cartilage is the essence of what is called osteoarthritis , a common joint disorder. (eurekalert.org)
  • The pathologic changes in OA joints include degradation of the articular cartilage, especially at the superficial zones, thickening of the subchondral bone, osteophyte formation, and variable degrees of synovial inflammation 11 . (nature.com)
  • The first type is the white cartilage on the ends of the bones (articular cartilage) which allows the bones to glide and move on each other. (hopkinsmedicine.org)
  • The labrum is a second kind of cartilage in the shoulder, which is distinctly different from the articular cartilage. (hopkinsmedicine.org)
  • A surgical procedure to smooth the surface of the articular cartilage to restore movement in the knee. (cromwellhospital.com)
  • Articular cartilage surgery involves chondroplasty - where cartilage is smoothed within a joint to restore movement. (cromwellhospital.com)
  • There are two types of cartilage in the knee - the thick, rubbery pads of cartilage known as the menisci and the cartilage that coats the end surfaces of the bones in the joint, known as articular cartilage. (cromwellhospital.com)
  • Like the meniscus, articular cartilage can get damaged as a result of injury or diseases such as arthritis. (cromwellhospital.com)
  • If articular cartilage is torn or damaged, the ragged edges can catch within the joint, causing stiffness, pain and swelling, locking, and giving way. (cromwellhospital.com)
  • Chondroplasty involves smoothing the surface of the articular cartilage by either shaving the articular cartilage, making drill holes into the defect in the cartilage to generate fibrocartilage, or treating it with a radio frequency probe. (cromwellhospital.com)
  • How is articular cartilage surgery carried out? (cromwellhospital.com)
  • The articular cartilage is either cut away, shaved until the surface is smooth, or drilled with holes in order to generate fibrocartilage. (cromwellhospital.com)
  • What happens after articular cartilage surgery? (cromwellhospital.com)
  • It constitutes a fibrous connective tissue sheath that surrounds the outer cortical surface of bone, except at joints, where bone is lined by articular cartilage. (medscape.com)
  • A proteoglycan (a protein to which long carbohydrate chains are attached) is a central component of the extracellular matrix in the articular cartilage. (lu.se)
  • A fibrillar protein that is one of the body's most common proteins and an important building block in bones, articular cartilage and skin, among other things. (lu.se)
  • However, the main collagen is type II that occurs in the articular cartilage. (lu.se)
Ligaments3
  • These two bones are connected by ligaments - tough tissues forming tethers that hold the bones in relationship to each other. (hopkinsmedicine.org)
  • The connective tissues include several types of fibrous tissue that vary only in their density and cellularity, as well as the more specialized and recognizable variants-bone, ligaments, tendons, cartilage, and adipose (fat) tissue. (onteenstoday.com)
  • The skeleton (which includes bones, ligaments, tendons, and cartilage) and muscles that are attached to it make up the musculoskeletal system . (cdc.gov)
Osteoarthritis5
  • Osteoarthritis is a common form of arthritis characterized by cartilage degeneration. (forbes.com)
  • In osteoarthritis, usually the cartilage thins in response to aging or joint injury (Figure 1). (forbes.com)
  • at the Wake Forest Institute of Regenerative Medicine examined cartilage deterioration in patients with osteoarthritis. (forbes.com)
  • Cartilage degeneration resulting from injuries or wear-and-tear leads to osteoarthritis, which impacts millions and costs in excess of $65B per annum. (ca.gov)
  • Osteoarthritis (OA) is the most common form of arthritis. (cdc.gov)
Tissue24
  • Paramount for the generation of auricular structures of clinically-relevant size is the acquisition of a large number of cells maintaining an elastic cartilage phenotype, which is the key in producing a tissue capable of withstanding forces subjected to the auricle. (swan.ac.uk)
  • Recently, a subpopulation of stem/progenitor cells has been identi ed within the auricular cartilage tissue, with similarities to MSCs in terms of proliferative capacity and cell surface biomarkers, but their potential for tissue engineering has not yet been explored. (swan.ac.uk)
  • These results underscored the AuCPCs' tissue-speci c di erentiation potential, making them an interesting cell source for the next generation of elastic cartilage tissue-engineered constructs. (swan.ac.uk)
  • Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
  • Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
  • Some that are being tested now are skin cells , bone, heart tissue , and now cartilage. (zmescience.com)
  • A team of researchers at Sahlgrenska Academy has created cartilage tissue by printing stem cells with a 3D-bioprinter. (zmescience.com)
  • 2017. Cartilage Tissue Engineering by the 3D Bioprinting of iPS Cells in a Nanocellulose/Alginate Bioink . (zmescience.com)
  • That condensation event triggers the stem cells to differentiate and form cartilage tissue. (tecan.com)
  • They typically contain glucosamine, chondroitin sulfate, and MSM (Methylsulfonylmethane), which are known to help maintain healthy joints, reduce inflammation, and support cartilage and connective tissue. (entirelypets.com)
  • Cartilage is strong but flexible tissue. (healthline.com)
  • ROCHESTER, Minn. - For joints to work well, they need cartilage, a slippery tissue that covers the ends of bones, acts like a shock absorber, and helps joints move smoothly. (eurekalert.org)
  • No long-term solutions exist for cartilage degeneration, but cellular therapies hold promise toward replacing degenerated cartilage with healthy tissue. (ca.gov)
  • Toward developing a long-term solution for this vexing problem, cellular therapies hold the promise of replacing degenerated cartilage with healthy tissue. (ca.gov)
  • these are cartilage extracellular matrix component important in imparting mechanical function to the tissue. (ca.gov)
  • The labrum is a thick tissue or type of cartilage that is attached to the rim of the socket and essentially forms a bumper that deepens the socket and helps keep the ball in place. (hopkinsmedicine.org)
  • What tissue forms the ends of many long bones? (onteenstoday.com)
  • Cartilage is a type of supporting connective tissue. (onteenstoday.com)
  • Cartilage is a flexible connective tissue. (webmd.com)
  • This term refers to an inflammation of the plantar fascia, the thick, taut band of fibrous tissue that runs from the heel to the ball of the foot, and forms the arch. (healthy.net)
  • Another treatment works with tissue regeneration and stops an enzyme from breaking down cartilage in the knee, says Yusuf Yazici, MD, chief medical officer of Samumed, a medical research and development firm. (medscape.com)
  • A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (bvsalud.org)
  • These cells are classified as totipotent and they can form any of the tissue types found in the adult body, in addition to having unlimited proliferation potential 6 . (bvsalud.org)
  • Travelers who have visited tropical areas may exhibit aggressive forms of obligatory myiases, in which the larvae (maggots) invasively feed on living tissue. (cdc.gov)
Connective tissues4
  • This powerful joint supplement is intended for older or middle-aged large dogs or smaller dogs with maximum joint support needs such as lubrication, cushioning of tissues, and support of cartilage, connective tissues, and bones. (entirelypets.com)
  • Healthy connective tissues and cartilage contain proteins with flexible sulfur bonds. (entirelypets.com)
  • The key building block of connective tissues, glucosamine optimizes repair, regeneration and lubrication of cartilage. (vitacost.com)
  • Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)
Tissues8
  • However, aside from muscle development, the roles of ESRRs in other tissues including bone and cartilage have just begun to be investigated 10 . (nature.com)
  • Autoimmune disorders, which occur when the immune system malfunctions and attacks the body's tissues and organs, occur in some people with cartilage-hair hypoplasia. (medlineplus.gov)
  • Once printed, the stem cells multiplied and were given growth factors so they differentiated into cartilage tissues. (zmescience.com)
  • And cartilage piercings are no exception - they require additional care compared to other types because cartilages take longer time[s] to heal than regular soft tissues [2]. (dane101.com)
  • Engineering or creating tissues for therapeutic use, like pieces of cartilage for knee repair, is challenging. (newscientist.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Many studies have shown the utility of embryonic or adult stem cells for forming teeth and for regeneration of bone and soft tissues. (bvsalud.org)
  • Additionally, they can form specialized cell types from other tissues if they are transplanted 6 . (bvsalud.org)
Hyaline5
Extracellular matrix2
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • Cells that produce and maintain the extracellular matrix in the cartilage. (lu.se)
Bones10
  • This is the cartilage that covers and protects the ends of your bones where they meet in your body's joints. (scoi.com)
  • They typically have malformations in the cartilage near the ends of the long bones in the arms and legs (metaphyseal chondrodysplasia), which then affects development of the bone itself. (medlineplus.gov)
  • It also connects the nasal bones and the lateral cartilages. (healthline.com)
  • People may be born with abnormally shaped bones or a tendency toward weaker cartilage. (eurekalert.org)
  • More than two dozen bones stacked on top of each other form the spine. (upmc.com)
  • 5 fused bones that form the sacrum (S). (upmc.com)
  • Cartilage helps prevent the bones from rubbing against each other where they meet. (upmc.com)
  • OA is caused by damage or breakdown of joint cartilage between bones. (cdc.gov)
  • In addition to the basic structural role , the larger bones in the body contain bone marrow, where blood cells are formed. (cdc.gov)
  • A surgical procedure that involves inserting bone fragments between two bones so that the joint surfaces grow together and form a new bone. (lu.se)
Cell-based cartilage repair2
  • Most current cell-based cartilage repair techniques require some form of scaffolds and 2 separate surgical procedures. (nih.gov)
  • This Development Candidate Feasibility Award is a first step toward the overall goal of developing a cell-based cartilage repair therapy using stem cells derived from the skin. (ca.gov)
Degeneration3
  • Importantly, we do not know the precise details of cartilage degeneration. (forbes.com)
  • This is a reaction to the main underlying problem, cartilage degeneration. (eurekalert.org)
  • The research in the Alman laboratory is focused on five research projects: Wound Healing, Stem Cells and Neoplasia, Cartilage and Joint Development, Joint Degeneration and Repair, and Bone Regeneration. (duke.edu)
Joints and cartilage2
Hypoplasia19
  • People with cartilage-hair hypoplasia have unusually short limbs and short stature from birth. (medlineplus.gov)
  • Most people with cartilage-hair hypoplasia are unusually flexible in some joints, but they may have difficulty extending their elbows fully. (medlineplus.gov)
  • The extent of the immune deficiency in cartilage-hair hypoplasia varies from mild to severe. (medlineplus.gov)
  • Some people with cartilage-hair hypoplasia experience gastrointestinal problems. (medlineplus.gov)
  • Cartilage-hair hypoplasia occurs most often in the Old Order Amish population, where it affects about 1 in 1,300 newborns. (medlineplus.gov)
  • Cartilage-hair hypoplasia is caused by mutations in the RMRP gene. (medlineplus.gov)
  • Cartilage-hair hypoplasia (CHH), which is Online Mendelian Inheritance in Man (OMIM) disease number 250250, is an autosomal recessive inherited disorder that results in short-limb dwarfism associated with T-cell and B-cell immunodeficiency. (medscape.com)
  • [ 1 ] Cartilage-hair hypoplasia and other short-limb dwarfism phenotypes are associated with metaphyseal or spondyloepiphyseal dysplasia. (medscape.com)
  • Cartilage-hair hypoplasia is a variant of short-limb dwarfism in which fine sparse hair is also present. (medscape.com)
  • The immunodeficiency in cartilage-hair hypoplasia may be an isolated T-cell immunodeficiency, isolated B-cell immunodeficiency, or combined T-cell and B-cell immunodeficiency. (medscape.com)
  • Although originally described by McKusik et al in 1964 in Amish children and known as metaphyseal chondrodysplasia McKusick type, cartilage-hair hypoplasia has been described in non-Amish persons throughout the United States, Europe, and Mexico. (medscape.com)
  • [ 2 ] The genetic defect in cartilage-hair hypoplasia has been confirmed to be mutations in the RMRP gene. (medscape.com)
  • The genetic defect in cartilage-hair hypoplasia has been identified as a mutation in the gene for RNAase RMRP, mapped to 9p12. (medscape.com)
  • [ 15 ] The second consists of single nucleotide substitutions and other changes that involve at most 2 nucleotides in highly conserved regions of the gene.These are considered leaky mutations and result in variable expression of the gene, which may explain the variable phenotype seen in cartilage-hair hypoplasia. (medscape.com)
  • These latter mutations result in variable expression of the gene, which may explain the variable phenotype seen in cartilage-hair hypoplasia. (medscape.com)
  • G, which occurs in 30-50% of patients with cartilage-hair hypoplasia and causes an alteration in ribosomal processing. (medscape.com)
  • This suggests a common cell proliferation defect in cartilage-hair hypoplasia. (medscape.com)
  • Cartilage-hair hypoplasia is a rare defect. (medscape.com)
  • Cartilage hair hypoplasia affects bone metaphyses causing small stature from birth. (lu.se)
Occurs3
  • A cartilage injury often occurs in conjunction with injury to other structures in the knee such as an anterior cruciate ligament injury or a medial collateral ligament sprain. (sportsinjuryclinic.net)
  • During my PhD research, I was working on a very specific medical problem that involved repairing cartilage damage, such as occurs in injured athletes. (tecan.com)
  • The tumor (see the images below) occurs in both hereditary and sporadic forms, and approximately 6% are bilateral. (medscape.com)
Regeneration3
  • A hypothesis formed: if the membrane can successfully initiate the regeneration process, perhaps there are unknown factors in the synovial fluid that may interfere with the healing process. (forbes.com)
  • This restorative system includes four essential collagen types and hyaluronic acid, lubricating joints and bathing them in factors that promote regeneration and repair of cartilage. (vitacost.com)
  • In fighting catabolic joint destruction and encouraging cartilage regeneration, Nature's Plus AgeLoss Joint Support takes an entirely new approach to promoting youthful joint comfort and flexibility. (vitacost.com)
Menisci2
Inflammation1
  • As the knee's natural cushioning -- the cartilage -- wanes, inflammation and pain rise, and people can't get around as well. (medscape.com)
Arthritis3
  • Shark cartilage, as its name indicates, comes from the cartilage of sharks & may assist to promote wound healing & reduce the symptoms of arthritis & psoriasis. (shopnewzealand.co.nz)
  • Background Joint destruction in rheumatoid arthritis is comprised of cartilage and bone damage, which can be evaluated radiographically separately by the joint space narrowing (JSN) and erosion (ERO) scores. (bmj.com)
  • When this type of cartilage starts to wear out (a process called arthritis), the joint becomes painful and stiff. (hopkinsmedicine.org)
Meniscus2
Progenitor cells2
  • this released a flood of progenitor cells, or cells which eventually create new cartilage. (forbes.com)
  • This study compared the in vitro cartilage-forming ability of equine auricular cartilage progenitor cells (AuCPCs), bone marrow-derived MSCs and auricular chondrocytes in gelatin methacryloyl (gelMA)-based hydrogels over a period of 56 d, by assessing their ability to undergo chondrogenic di erentiation. (swan.ac.uk)
Repair10
  • With this technique, a patch of cartilage cells is used to repair the damage. (scoi.com)
  • Then an arthroscopy is performed to either repair or remove the torn cartilage. (sportsinjuryclinic.net)
  • A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
  • The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)
  • The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. (hindawi.com)
  • If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
  • In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
  • When this method is perfected, cartilage could be 3D printed from a patient's own stem cells to repair damaged cartilage or heal osteoarthiritis (cartilage decay in the joints). (zmescience.com)
  • Seventy matched (age, sex, lesion size) knees with symptomatic cartilage defects underwent cartilage repair with the proposed technique (n = 35) or an open technique (n = 35) in which the MSCs were implanted beneath a sutured periosteal patch over the defect. (nih.gov)
  • Prospective evaluation of both groups were performed using the International Cartilage Repair Society (ICRS) Cartilage Injury Evaluation Package, which included questions from the Short-Form (SF-36) Health Survey, International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee scale, and Tegner activity level scale. (nih.gov)
Pharyngeal5
  • Gene expression analysis indicates that esrra is expressed in developing pharyngeal arches where genes necessary for cartilage development are also expressed. (nature.com)
  • Loss of function analysis shows that knockdown of esrra impairs expression of genes including sox9, col2a1, sox5, sox6, runx2 and col10a1 thus induces abnormally formed cartilage in pharyngeal arches. (nature.com)
  • Expression of esrra is colocalised with genes necessary for cartilage development in pharyngeal arches during zebrafish embryogenesis. (nature.com)
  • Knockdown of esrra induces abnormally formed cartilage structure in pharyngeal arches. (nature.com)
  • They form during embryonic development from pharyngeal arches. (wikipedia.org)
MSCs1
  • Similar to MSCs and chondrocytes, AuCPCs displayed a marked ability to generate cartilaginous matrix, although, under the applied culture conditions, MSCs outperformed both cartilage-derived cell types in terms of matrix production and mechanical properties. (swan.ac.uk)
Tumors2
  • He makes extensive use of genetically modified mice to model human disease, and used this approach to identify new drug therapies for musculoskeletal tumors and to improve the outcome of related processes in cartilage, skin, and bone. (duke.edu)
  • Duke Medicine researchers have shown how gene mutations may cause common forms of cartilage tumors. (duke.edu)
Collagen fibers1
Injuries2
Fibrous1
Chondrocytes1
Differentiation5
  • To validate a technique for reproducible measurement of the osteochondroma cartilage cap with computed tomography (CT) and magnetic resonance (MR) imaging and to reevaluate the correlation of the thickness of the cartilage cap with pathologic findings to improve noninvasive differentiation of benign osteochondromas from secondary chondrosarcomas. (rsna.org)
  • In nature, the differentiation of stem cells into cartilage is a simple process, but it's much more complicated to accomplish in a test tube. (zmescience.com)
  • I was experimenting with different molecules that would stick cells together and stimulate stem cell differentiation and cartilage formation. (tecan.com)
  • They proved to be very useful at triggering stem cell differentiation into cartilage, and that was the first idea Kramer and I intended to pursue. (tecan.com)
  • This highlights a rare form of divergent differentiation and a potential diagnostic pitfall. (bvsalud.org)
Musculoskeletal system1
  • Introduction to the Biology of the Musculoskeletal System The musculoskeletal system provides form, stability, and movement to the human body. (msdmanuals.com)
Proteins2
  • This RNA attaches (binds) to several proteins, forming an enzyme complex called mitochondrial RNA-processing endoribonuclease, or RNase MRP. (medlineplus.gov)
  • The remaining 20% ​​consists of proteins, carbohydrates and cartilage cells. (lu.se)
Therapeutic1
  • These data suggest that particular attention should be given to therapeutic interference with cartilage destruction. (bmj.com)
Longitudinal1
  • There are different ways in which the cartilage can tear including longitudinal, bucket handle tears, radial tear, and degenerative. (sportsinjuryclinic.net)
Elasticity1
Facet joints1
Hyaluronic Acid1
Healthy3
  • Chondroitin is necessary for healthy cartilage as it absorbs water to keep the cartilage hydrated and cushioned. (entirelypets.com)
  • The site forms a wheal on healthy skin, but not on skin where nerve damage is present. (medscape.com)
  • In healthy cartilage the concentration of (Gd-DTPA)2- will be low, while in damaged cartilage it would be high leading to T1-contrast in MRI. (lu.se)
Damage3
  • Conclusions Cartilage damage appears to be the more clearly associated with irreversible physical disability than bony damage. (bmj.com)
  • Bone and cartilage damage occurred in animal studies on molnupiravir. (who.int)
  • Existing work has identified biomarkers of cartilage and muscle damage, and demonstrated responsiveness to various forms of physical activity and biomechanical loading. (cdc.gov)
Researchers5
  • The researchers took cartilage cells from patients who had recently had knee surgery and their cells were manipulated to become "pluriplotent", so they can develop into many different types of cells. (zmescience.com)
  • When researchers used sound to levitate stem cells, they found that the cells formed into spheres. (newscientist.com)
  • Building knee cartilage has been a dream of researchers, and now several methods are under study. (medscape.com)
  • The researchers did MRIs at the beginning of the study and at week 26 to find changes around the bone, which reflect cartilage change. (medscape.com)
  • The researchers did X-rays to see if the treatment made more space in the joint, which is a sign of more cartilage, Yazici says. (medscape.com)
Destruction2
  • Nature's Plus® AgeLoss Joint Support nutritionally promotes the anti-aging activities that rebuild and rejuvenate cartilage and joints, while countering catabolic oxidation and destruction. (vitacost.com)
  • A treatment known as MIV-711 targets an enzyme called cathepsin K that is thought to play a role in the destruction of cartilage and the breakdown of too much bone. (medscape.com)
Stem4
  • We could use the same 3D Bloom reagents we were using to make stem cells stick together to produce cartilage instead to make cancer cells stick together, forming microtumors in the lab. (tecan.com)
  • Since much of the prior work on directing stem cells from the skin to form neocartilage has been done using animal-derived stem cells, in the next project period neocartilage will be formed using human stem cells instead. (ca.gov)
  • Stem cells levitated with sound can spontaneously form spherical blobs. (newscientist.com)
  • Stem cells are defined as undifferentiated cells that have precursor properties, are capable of forming many different cell types and have the property of unlimited self-renewal 5 . (bvsalud.org)
Cells formed1
Heal2
Skin1
Surfaces1
Cutaneous1
  • This article focuses on cutaneous leishmaniasis, the more common form of the disease. (aafp.org)
Body7
  • Your body may try to compensate by growing extra bone in the form of bone spurs . (medicinenet.com)
  • The structural material needs to be able to break down and be absorbed safely by the body so only cartilage is left. (zmescience.com)
  • We took the approach to try to stimulate the body to make cartilage the way it does during embryogenesis. (tecan.com)
  • When cartilage degenerates, the body forms bone spurs ,' Dr. Sanchez-Sotelo says. (eurekalert.org)
  • Ice is one of the cheapest and most effective ways to numb any part of your body[6] - including cartilage. (dane101.com)
  • According to a research review , there are at least 28 different types of collagen, but types I, II, and III are the most common forms found in the human body. (greatist.com)
  • The facets of one vertebral body rest on the facets of the one below it, forming a joint. (msdmanuals.com)
Type1
Progression2
  • Treatment with dexamethasone stimulated ALP activity and ALP mRNA, consistent with the progression of cartilage toward bone. (avma.org)
  • The cartilage becomes thicker, and it will do a better job of shock absorption and it will slow the progression of already established knee OA," he says. (medscape.com)