• organs
  • Mammalian target of rapamycin (mTOR) is a key player in pathways involved for cellular growth, proliferation, and survival via a cytoplasmic serine/threonine kinase .In cells that lack either TSC1 or TSC2, mTOR activity is increased many-fold, and this would cause uninhibited growth and subsequent hamartomas in various organs. (medscape.com)
  • Tuberous sclerosis complex (TSC), neurofibromatosis type I (NF1), and Sturge-Weber syndrome (SWS) are prototypical neurocutaneous disorders in which genetic mutations in pathways regulating cell growth cause developmental dysfunction of the brain, skin, and other organs. (frontiersin.org)
  • Cowden's
  • In patients with Cowden's syndrome , retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's thyroiditis, and inflammatory pseudotumor of the orbit can all manifest, either alone or in combination. (thefreedictionary.com)
  • cancers
  • These conditions are characterized by the growth of multiple hamartomas and an increased risk of developing certain cancers, particularly breast cancer, thyroid cancer, and cancer of the uterine lining (endometrial cancer). (nih.gov)
  • blood vessels
  • One general danger of hamartomas is that they may impinge into blood vessels, resulting in a risk of serious bleeding. (wikipedia.org)
  • Evidence suggests that this enzyme also helps control cell movement (migration), the sticking (adhesion) of cells to surrounding tissues, and the formation of new blood vessels (angiogenesis). (nih.gov)
  • occur
  • Hamartomas occur in many different parts of the body, and are most often asymptomatic incidentalomas (undetected until they are found incidentally on an imaging study obtained for another reason). (wikipedia.org)
  • citation needed] The most common hamartomas occur in the lungs. (wikipedia.org)
  • Somatic mutations are not inherited and do not occur as part of a familial cancer syndrome. (nih.gov)
  • epilepsy
  • Many causes of the epilepsy have been theorized, with EEG often finding the hamartoma itself as the source of electrical activity, or epileptogenic focus. (wikipedia.org)
  • An epilepsy syndrome involves a specific seizure type(s) plus other features such as age of onset, electroencephalographic (EEG) findings, genetics/natural history, and responsiveness to particular drugs. (frontiersin.org)
  • cells
  • An X-ray will often not provide a definitive diagnosis, and even a CT scan may be insufficient if the hamartoma lacks the typical cartilage and fat cells. (wikipedia.org)
  • skin
  • The two can be differentiated as follows: a hamartoma is an excess of normal tissue in a normal situation (e.g., a birthmark on the skin), while a choristoma is an excess of tissue in an abnormal situation (e.g., pancreatic tissue in the duodenum). (wikipedia.org)
  • sometimes
  • They can be worrisome, especially if situated deep in the lung, as it is sometimes difficult to make the important distinction between a hamartoma and a lung malignancy. (wikipedia.org)
  • combination
  • Our patient appeared to have a combination of fibrolipomatous hamartoma (FLH) and macrodystrophia lipomatosa, though it is very difficult to separate these two entities, as detailed in the underlying discussion. (springeropen.com)