Formation oxidative stress lipid peroxidation. Medical search. Frequent questions

Chromium is known to catalyze the formation of reactive oxygen species that may have a role in disease, aging, and oxidative stress. (cdc.gov)
If not for an extracellular antioxidant system to eliminate reactive oxygen and nitrogen species, lipid peroxidation and protein oxidation would become excessive, resulting in cellular damage. (go.jp)
In particular, Peroxynitrite, a powerful RNS (Reactive Nitrogen Species), exhibits a wide array of tissue-harmful effects, ranging from lipid peroxidation and DNA damage to inactivation of enzymes via protein oxidation and nitration. (lotioncrafter.com)
Some of the iron will then bind to other molecules not have transferrin's ability to protect its host from iron catalyzed lipid peroxidation and the formation of reactive oxygen species. (irondisorders.org)
After incubation for 30 min, the effect of the drugs on erythrocytes hemolysis as well as some biomarkers of oxidative stress (none protein thiols, protein carbonyl, thiobarbituric acid reactive substance) were investigated. (medsci.org)
Then, blood urea nitrogen (BUN) and creatinine (Cr) of plasma samples as well as glutathione (GSH), lipid peroxidation, reactive oxygen species, and total antioxidant capacity of kidneys were assessed in the experimental mice groups. (biomedcentral.com)
NewsTarget) Oxidative stress represents an imbalance between the production of reactive oxygen species (free radicals) and the body's ability to detoxify the reactive intermediates and repair the resulting damage. (naturalnews.com)
The hydroxyl free radical is highly reactive and is produced in abundant amounts when the body is under stress. (naturalnews.com)
There was a significant rise in the thiobarbituric acid reactive substances on day 1 indicating increased lipid peroxidation in the testis. (archive.org)
Lipid peroxidation, which is the indicator of oxidative stress was quantified by measuring the formation of thiobarbituric acid reactive substances (TBARS). (gazi.edu.tr)
These free radicals produced by iron are highly reactive and they interact with proteins, DNA and lipid inflicting severe damage to these biomolecules and subsequently tissue injury [5]. (biomedres.us)
Presence of iron is a double-edged sword, it is extremely indispensable to carry various important metabolic processes at the same time its slight excess induces oxidative stress due to production of free radicals, especially the hydroxyl radical which is highly reactive and provoke critical and even irreversible cell injury. (biomedres.us)
More recently, the factors involved in denaturating of membrane proteins and lipid peroxidation have been investigated in detail, as well as the mechanism of reactive oxygen species formation in red cells. (unisi.it)
Extensive investigations demonstrated the key role of oxidative stress and iron release in a reactive form causing membrane protein damage via the Fenton reaction and hydroxyl radical production. (unisi.it)
In the absence of efficient protection by antioxidant factors and other molecules such as flavonoids, oxidative stress is responsible for the release of iron in reactive form, predisposing red cells to hemolysis through the formation of senescence antigen. (unisi.it)
In such conditions formation of reactive oxygen species (ROS) can damage biological membranes and cell structures. (unios.hr)
respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
Further, using a model peptide we demonstrate adduct formation with Cys as the preferred nucleophilic residue and PE(26:2) +2 oxygens, as one of the most reactive truncated PE-electrophiles produced. (cdc.gov)
Lung oxidative stress was evaluated biochemically by measuring the level of reactive oxygen species (ROS), lipid peroxidation (LPO), reduced glutathione (GSH), catalase, and superoxide dismutase (SOD). (who.int)

Unlike its allozymes PON1 and PON3 are bound with HDL in circulatory vessels protecting LDL against oxidation, PON2 is ubiquitously located in subcellular structures, such as perinuclear region, endoplasmic reticulum (ER), and mitochondria, compartments that are crucial for balancing intracellular oxidative stress. (hindawi.com)
The reduction of protein oxidation and lipids peroxidation by PS is related to antioxidants effect of this statin. (medsci.org)
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates lipid uptake, advanced oxidation protein products, and immunological recognition, and has roles in lipid accumulation, apoptosis, as well as in metastatic colonization in cancer. (bvsalud.org)
It has been known for many decades that oxidative stress leads to oxidation of hemoglobin and damage to the erythrocyte membrane. (unisi.it)
NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)

AFB 1 -administered HCC-bearing rats (Group II) showed increased levels of lipid peroxides (LPOs), thiobarbituric acid substances (TBARs), and protein carbonyls (PCOs) and decreased levels of enzymic and nonenzymic antioxidants when compared to control animals (Group I). Administration of TD orally (300 mg/kg body weight/day) for 45 days to HCC-bearing animals (Group III) significantly reduced the tissue damage accompanied by restoration of the levels of antioxidants. (hindawi.com)
Many reviews have focused on the role of intracellular antioxidants in the elimination of oxidative stress, but this one will focus on the coordinated action of both intracellular and extracellular antioxidants in limiting cellular oxidant stress. (go.jp)
Single-wall nanotube has been found to cause other oxidative stresses such as free radical formation and depletion of antioxidants in cells. (edu.hk)
It states that reviewed data indicates dietary modification or supplementation with antioxidants such as vitamin C, vitamin E, coenzyme Q10, selenium, carnitine and zinc can improve markers of male fertility and reduce markers of seminal oxidative damage. (nutraingredients-usa.com)
Consumption of fruits and vegetables containing high amounts of antioxidative nutraceuticals have been associated with the balance of the free radicals/antioxidants status, which helps to minimize the oxidative stress in the body and to reduce the risk of diseases (Kaur and Kapoor, 2001). (scialert.net)
To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)

When hydroxyl free radicals interact with cell membranes they cause lipid peroxidation. (naturalnews.com)
However, recent studies found that buckyballs have considerable water solubility, and can cause lipid peroxidation in fish brain after 48 hours at a concentration of 500 parts per billion (ppb). (edu.hk)

Both hexavalent and trivalent chromium were used in increasing concentrations ranging from 0.1mM to 1.2mM to oxidize proteins under physiological conditions resulting in protein carbonyl formation. (cdc.gov)
Free radicals can cause damage in structural and metabolic components like lipids, proteins, enzymes, carbohydrates and DNA in cells and tissues. (hindawi.com)
This ultimately results in membrane damage, fragmentation, or random cross-linking of molecules like DNA, enzymes, and structural proteins and even lead to cell death induced by DNA fragmentation, lipid peroxidation and finally to cancer formation [ 15 ]. (hindawi.com)
The redox potential of the cytosolic compartment of the intracellular environment limits disulfide bond formation, whereas the oxidizing extracellular environment contains proteins rich in disulfide bonds. (go.jp)
Denaturating of membrane proteins generally precedes lipid peroxidation and consequent phagocytosis due to caspase activation. (unisi.it)
1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)
Finally, our docking simulations showed that the truncated PE species bound at least as good to several of the lantibiotic-identified proteins, as compared to the non-truncated parent molecule, stearoyl-arachidonoyl PE (SAPE), indicating that these oxidatively-truncated species favor/promote the formation of PEox-protein adducts. (cdc.gov)

The use of Lipochroman ® -6 in cosmetic formulations can significantly reduce oxidative stress. (lotioncrafter.com)

The excess of iron has been indicated in several diseases as it induces oxidative stress. (biomedres.us)

Intra-testicular levels of superoxide anion, lipid peroxidation and antioxidantssuperoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and ascorbic acid were measured. (archive.org)
The glutathione, glutathione-s-transferase, catalase, superoxide dismutase, lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels were estimated in the liver of iron treated mice after 30 days post-iron treatment. (biomedres.us)
The feeding of different concentrations of iron for 30 days led to an increase in the oxidative stress as indicated by a decline in the glutathione concentration, and glutathione-s-transferase, catalase, and superoxide dismutase activities accompanied by the rise in the lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels. (biomedres.us)
Treatment of hesperidin for 5 days before iron overload elevated the activities of glutathione-s-transferase, catalase, and superoxide dismutase and glutathione concentration, whereas the activities of lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase and lipid peroxidation declined significantly. (biomedres.us)
Our study demonstrates that pre-treatment of hesperidin for five days reduced the iron induced oxidative stress indicated by the reduction in lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase activities and a rise in the glutathione-s-transferase, catalase, and superoxide dismutase and glutathione contents in the mice liver. (biomedres.us)
The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
Environmental adaptations of the oral microbiota and effects on the divers' physiology: analysis of the metagenome and salivary stress biomarkers. (ntnu.no)
Saleh R, Betancor M, Roo J, Benitez-Santana T, Zamorano MJ & Izquierdo MS (2015) Biomarkers of bone development and oxidative stress in gilthead seabream larvae fed microdiets with several levels of polar lipids and α-tocopherol. (stir.ac.uk)

However, feeding SBL markedly increased TBARs and GPX gene expression increasing the peroxidation risk in the larvae. (stir.ac.uk)
Indeed, dietary -tocopherol decreased the oxidative stress in the larvae as denoted by the reduction in larval TBARs contents and gene expression of SOD and CAT, but not GPX. (stir.ac.uk)

Although dietary marine phospholipids are able to improve culture performance of marine fish larvae in a further extend than soybean lecithin, both types of phospholipids (PL) markedly increase oxidative risk. (stir.ac.uk)

Free" iron produces hydroxyl radicals from superoxide and hydrogen peroxide via Fenton chemistry inducing oxidative stress in the cells [4]. (biomedres.us)
Water withholding caused an increase in the concentration of lipid peroxidation, hydrogen peroxide and proline content in most genotypes. (unios.hr)

Significant exposure to Aflatoxin B 1 (AFB 1 ), a potent hepatotoxic and hepatocarcinogenic mycotoxin, plays a major role in liver carcinogenesis through oxidative tissue damage and p53 mutation. (hindawi.com)
Oxidative damage/stress results when the level of ROS overpowers the system's ability to neutralize and eliminate them. (hindawi.com)
This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)
Thus the protective effect of pravastatin (PS) against PQ induced oxidative damage to human erythrocytes was investigated in the current studies upon loading to erythrocytes. (medsci.org)
This stress arrives in the form of protein, lipid (fat) peroxidation, carb and DNA damage. (alternative-medicine-clinics.com)
The purpose of this study was to investigate the protective effects of Dunaliella salina ( D. salina ) on UVB radiation-induced corneal oxidative damage in male imprinting control region (ICR) mice. (molvis.org)
Corneal oxidative damage was induced by exposure to UVB radiation at 560 μW/cm 2 . (molvis.org)
The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)
They are a sign of excessive oxidative stress and internal damage within the body. (naturalnews.com)
Overall, the experimental findings demonstrated that cellular phone radiation may increase the oxidative damage and NOx level during epileptic activity in mouse brain. (gazi.edu.tr)
However, the physiologically relevant pathways mediating oxidative damage have not yet been identified. (scienceopen.com)
The detection of a selective increase of o,o'-dityrosine in LDL isolated from vascular lesions is consistent with the hypothesis that oxidative damage in human atherosclerosis is mediated in part by tyrosyl radical. (scienceopen.com)
This kind of oxidative stress is usually a first sign of biological damage. (edu.hk)
Research on this topic may be of great procedures were approved by the Eth- Results interest since oxidative damage has ics Review Committee of the National been proposed as a pathogenic mecha- Research Centre. (who.int)

PON2 is mainly involved in prevention of intracellular oxidative stress [ 17 - 19 ] and is an important endogenous defense mechanism against vascular oxidative stress in atherogenesis [ 16 , 20 - 22 ]. (hindawi.com)
Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)

AFB 1 induces lipid peroxidation in rat liver, and this may be an underlying mechanism of carcinogenesis [ 7 ]. (hindawi.com)

Via AT1a receptor, AngII increased oxidative stress, which is a critical regulator of VSMC proliferation and migration in hypertension and vascular remodeling [ 6 - 8 ]. (hindawi.com)

However, when the production of ROS becomes excessive, oxidative stress will develop and impose a harmful effect on the functional integrity of biological tissue. (diabetesjournals.org)
Glutathione peroxidase 4 (GPX4), a crucial ferroptosis regulator, protects cells from excessive oxidative stress by neutralizing lipid peroxidation. (bvsalud.org)

2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)

Both hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be particularly more potent in inducing oxidative stress, suggesting unique mechanisms that are activated by these viral infections. (hindawi.com)
The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)
Oxidative stress is the imbalance between cellular production of free radical species and the ability of cells to eliminate them employing endogenous antioxidant defense mechanisms. (lotioncrafter.com)
This effect has been linked to lipid peroxidation and membrane disruption, but the specific mechanisms behind these phenomena remain unclear. (sdu.dk)
Investigations into the pathophysiology of these conditions traditionally stressed dysregulation of the glutamatergic and monoaminergic systems, but the mechanisms causing these neurotransmitter abnormalities remained elusive. (biomedcentral.com)

Anti-oxidants are a primary defense against the damaging effects of oxidative stress. (naturalnews.com)

High levels of unmanaged oxidative stress accelerate aging and disease formation. (naturalnews.com)
Exercise enhances our metabolic rate and dramatically increases oxidative stress levels in our body. (naturalnews.com)
The present study was designed to investigate the effects of GS on oxidative stress, antioxidant levels, testicular structure and sperm parameters in the rat. (archive.org)
The objective of the this study was to evaluate the effects of cellular phone radiation on oxidative stress parameters and oxide levels in mouse brain during pentylenetetrazole (PTZ) induced epileptic seizure. (gazi.edu.tr)
Lipid peroxidation and NOx levels of brain tissue increased significantly in group II and III compared to group I. On the contrary, GSH levels were significantly lower in group II and III than group I. However, no statistically significant alterations in any of the endpoints were noted between group II and Group III. (gazi.edu.tr)
characterized by modified protein content and elevated levels of lipid peroxidation products, is representative of multiple oxidative processes acting on plasma lipoproteins that prevail during HD. (scienceopen.com)
The objective of this study was to determine the combined effect of graded levels of -tocopherol with different levels and sources of krill phospholipids (KPL) and soybean lecithin (SBL) on growth, survival, resistance to stress, oxidative status, bone metabolism-related genes expression and biochemical composition of sea bream larvae. (stir.ac.uk)
ing high levels of oxidative stress [1]. (who.int)

Further studies of the antioxidant system and measurements of other components of oxidative stress are needed in order to determine the relationship between the amount of ROS and the antioxidant response. (unios.hr)

Respiratory effects can occur when acidic waters are rapidly neutralized, such as when an acidic tributary enters a larger, neutral receiving stream, leading to the formation of mononuclear and polynuclear aluminum species from the dissolved ion (Gensemer and Playle 1999). (canada.ca)

The extent to which ginger extract reduced the micronuclei formation induced by TSO exposure was almost normal or less than the control values. (scialert.net)

Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)

In conclusion, GS induces an oxidative stress-status in the testis by increasing free radical formation and lipid peroxidation, and by decreasing the antioxidant reserves. (archive.org)

Based on this current study, it was evident that aluminum chloride induced oxidative stress and retarded reproduction in males whereas Ananas comosus mitigated reproduction in males by improving sperm parameters and microarchitecture of the testes. (springeropen.com)

Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)

What Can Oxidative Stress and Free Radicals Cause? (alternative-medicine-clinics.com)
In the cytoplasm, however, free DA can give rise to formation of cytotoxic free radicals. (jneurosci.org)
Thus, increase in dietary -tocopherol effectively prevented the formation of free radicals from HUFA, particularly EPA, but did not affect the incidence of bone anomalies or the expression of genes related to osteogenetic processes. (stir.ac.uk)
All of the above mentioned conditions can disturb the oxidant-antioxidant balance of the organism and can trigger the formation of free radicals. (bvsalud.org)

Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)

The mismanagement of iron in the cells is the principle cause of underlying pathogenic event in oxidative stress that is harbinger of several diseases [11,12]. (biomedres.us)

The cornea has the physiologic capacity to absorb the majority of UVB radiation, and protects the inner eye against UVB-induced oxidative damaging effects. (molvis.org)

The testes of exposed mice exhibited no evidence of gross histological change or elevated stress, irrespective of the RF-EME exposure regimen. (nature.com)

Oxidative stress is caused by exposure to heavy metals. (springeropen.com)

It is commonly believed that abnormal proliferation and migration of medial vascular smooth muscle cells (VSMCs) are the pathological causes of neointimal formation after intima injury [ 4 ]. (hindawi.com)
Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
Abnormal vascular remodeling is the core cause of neointimal formation, mediator degeneration and cell dysfunction, which leads to atherosclerosis and vascular dilatation and other diseases[ 3 ]. (ijpsonline.com)

This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)

MDMA (30 mg/kg x 3) increased the formation of 2,3-dihydroxybenzoic acid (2,3-DHBA) from salicylic acid perfused through a probe implanted in the striatum, indicating that MDMA increased free radical formation. (erowid.org)
These data suggest that MDMA-induced toxicity of dopamine neurones in mice results from free radical formation which in turn induces an oxidative stress process. (erowid.org)
The data also indicate that the free radical formation is probably not associated with the MDMA-induced dopamine release and that MDMA does not induce dopamine release via an action at the dopamine transporter. (erowid.org)
What Causes Free Radical Formation? (alternative-medicine-clinics.com)
Other well-known sources of oxidative stress in red cells are free radical production outside the red cell by activated phagocytes, endothelial metabolism, hyperoxia, ischemia-reperfusion and the arachidonic acid cascade. (unisi.it)

Macrophage-derived foam cell formation is critical for the initiation and development of atherosclerosis, which contributes to atherosclerotic cardiovascular disease (ASCVD). (bvsalud.org)
Collectively, our study lends a novel insight into the role of GPX4 in suppressing macrophage-derived foam cell formation and suggests GPX4 as a promising therapeutic target to interfere with atherosclerosis-related diseases. (bvsalud.org)

Indeed, a number of signaling functions of (phospho)lipid molecules has been discovered. (cdc.gov)

Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)

Therefore, we investigated the role of fisetin in neointimal formation in vitro and in vivo. (hindawi.com)
To address this, we have prepared α-syn oligomers (αSOs) in vitro in the presence of the lipid peroxidation product 4-oxo-2-nonenal and investigated their interaction with live cells using in-cell NMR as well as stimulated emission depletion (STED) super-resolution and confocal microscopy. (sdu.dk)

Oxidative stress depletes adenosine triphosphate (ATP) and adenine nucleotides, whereas adenosine monophosphate (AMP) deaminase seems to depress energy metabolism by blocking the salvage pathway of purine nucleotides. (unisi.it)

Iron is an essential element, which is abundant in the red blood cells and plays a key role during oxidative phosphorylation in the mitochondria of all cells. (biomedres.us)

Oxidative stress and formation of cytotoxic oligomers by the natively unfolded protein α-synuclein (α-syn) are both connected to the development of Parkinson's disease. (sdu.dk)

CONCLUSION: The recent insight into the mechanism of oxidative injury of red cells and evidence of relationships between erythrocyte oxidative stress and hypoxia suggest that increased hemolysis is induced by severe hypoxia and acidosis in the fetus as well as the newborn. (unisi.it)

Anatomy22

Organisms9

Diseases11

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes33

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science1

Health Care4

Reactive19

Oxidation5

Antioxidants6

Cause lipid peroxidation2

Proteins8

Reduce oxidative stress1

Induces oxidative stress1

Catalase7

Biomarkers3

TBARs2

Increase oxidative1

Hydrogen peroxide2

Damage14

Intracellular2

Underlying mechanism1

Receptor1

Excessive2

Concentrations1

Mechanisms5

Defense1

Levels8

Antioxidant system1

Species1

Induced by TSO expo1

Mediators2

Testis1

Parameters1

Thiols1

Radicals4

System's ability1

Pathogenic1

Protects1

Testes1

Exposure1

Vascular4

Rats1

Free5

Atherosclerosis2

Molecules1

Accumulation1

Vitro2

Adenine1

Mitochondria1

Cytotoxic1

Erythrocyte1