Form a cytokine 2 activity of interleukin 1 receptors interleukin 1 type ii. Medical search. Frequent questions

LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
IL-33 binds to its receptor ST2 to induce type 2 cytokines and exert both pro-inflammatory and protective functions in host defense and disease. (frontiersin.org)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
Following incubation unbound samples are removed during a wash step, and then a detection antibody specific for IL-1βis added to the wells and binds to the combination of capture antibody-IL-1βin sample. (eaglebio.com)
The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (arigobio.cn)
This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. (creativebiomart.net)
The B polypeptide forms a pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3). (listlabs.com)

Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes (1, 2). (abscitech.com)
Interleukin 15 (IL-15) is a pleiotropic cytokine, which was originally discovered by Drs. Waldmann and Grabstein's groups ( 6 , 7 ). (frontiersin.org)

Stimulation of CD28 on type 1 THCs by B7 costimulatory molecules results in the secretion of interleukin (IL)-2 and interferon gamma by type 1 THCs. (medscape.com)
This might account for the link between adiposity, cytokine secretion and vascular disease. (diabetesobesity.org.uk)
Our results suggest that the NLRP3/ASC/caspase-1 axis participates in the regulation of pro-imflammatory cytokine secretion in RAW264.7 cells, particularly the generation of IL-1β and IL-18. (spandidos-publications.com)
The NLRP3 inflammasome is a multiprotein complex that activates cysteine protease caspase-1, which leads to the maturation and secretion of pro-inflammatory cytokines, such as interleukin-1β (IL)-1β and IL-18 ( 7 ). (spandidos-publications.com)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)
We further identified calpain 1 as the major intracellular protease mediating tumoral IL-1α secretion. (bvsalud.org)
Mechanistically, VGLL3 was shown to promote the expression and secretion of the potent NF-κB-activating cytokine interleukin (IL)-1α, probably through its association with TEADs. (bvsalud.org)
TGF-ß stimulation was observed to induce IL-1α secretion and NF-κB activation, and VGLL3 was associated with this phenomenon. (bvsalud.org)

ARG82842 arigoPLEX ® Mouse Proinflammatory Cytokine Multiplex ELISA Kit (IL1 beta, IFN gamma, TNF alpha, IL6) is an Enzyme Immunoassay kit for the semi-quantification of Mouse Proinflammatory Cytokine (IL1 beta, IFN gamma, TNF alpha, IL6) in serum, plasma and cell culture supernatants. (arigobio.cn)
IL1 beta: Potent proinflammatory cytokine. (arigobio.cn)
IL-10 is a multifunctional cytokine that can downregulate immune and proinflammatory responses. (bdbiosciences.com)
WBC) and proinflammatory cytokines in All PCs were obtained from healthy volc the supernatant of platelet concentrates unteer donors by apheresis (CSc3000 Plus, [ 4,5 ]. (who.int)

gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)
IL-33 is an endogenous ligand for the ST2/T1 receptor, and depending on the cellular and cytokine context, participates in many immune diseases with dual, pro-inflammatory, or protective roles. (frontiersin.org)
We used a tensor-structured dimensionality reduction scheme to decompose the responses of each cell population to each ligand over a range of time points and cytokine concentrations. (biorxiv.org)
In total, these findings represent a comprehensive analysis of how ligand properties, and their consequent effects on surface receptor-ligand interactions, translate to selective activation of immune cell populations. (biorxiv.org)
This altered selectivity is explained by altered surface receptor-ligand binding kinetics and can be quantitatively predicted using a multivalent binding model. (biorxiv.org)
The cytokine family operates through a common theme of binding private receptors for each ligand before engaging the common γ c receptor to induce signaling. (biorxiv.org)
After binding a target ligand the NK receptors can transmit an inhibitory signal that cancels a program for cytotoxic action previously triggered by contact with the target cell. (codondex.com)
The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. (sbhsciences.com)

The chromosomal arrangement of emm subfamily genes reveals 5 major emm patterns, designated as emm patterns A through E. An example of the usefulness of emm typing is described by McGregor et al. (medscape.com)
The two distinct molecular forms of IL-1 are thought to be derived from two genes. (eaglebio.com)
It is thought that IL-1 genes are induced to respond to tissue damage or in infection. (eaglebio.com)
This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. (arigobio.cn)
This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. (creativebiomart.net)
Using the network pharmacology approach, we identified two clusters of genes involved in immune response (IL1A, IL2, and IL6R) and cell proliferation (CCND1, PPARG, and EGFR) mediated by biochanin A in CRC/COVID-19 condition. (bvsalud.org)

This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)
Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
XOMA 052 is designed to inhibit the pro-inflammatory cytokine interleukin-1 beta that is believed to be a primary trigger of pathologic inflammation in multiple diseases. (biospace.com)
By attaching to interleukin‑1 beta, canakinumab blocks its activity, helping to reduce inflammation thereby relieving the symptoms of the diseases. (europa.eu)
In addition to elevated serum levels, IL-1 has been found in synovial fluids of patients with rheumatoid arthritis and in cerebrospinal fluid after neurological inflammation or insult. (eaglebio.com)
IL6: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. (arigobio.cn)
The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. (arigobio.cn)
The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome plays pivotal roles in inflammation and autoimmunity. (spandidos-publications.com)
The IL-1 family has been recognized to play important roles in inflammation with pro-inflammatory properties, associated with acute and chronic inflammation, and plays a significant role in the innate immune defense ( 12 ). (spandidos-publications.com)
Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. (aspetjournals.org)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
It is presently unknown whether peroxisome proliferator-activated receptor (PPAR) β/δ activation prevents inflammation in adipocytes. (diabetesjournals.org)
Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. (biomedcentral.com)
The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans. (biomedcentral.com)
Therefore, exclusively inhibiting the actions of interleukin-5 can suppress at least one of the alleged causes of asthma, namely tissue damage due to eosinophil accumulation during pulmonary inflammation. (biomedcentral.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. (bvsalud.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

Regulation of the immune response involves the suppression of type 2 THCs (involved in humoral immunity) by interferon gamma and the production of IL-10 by type 2 THCs, which inhibits type 1 THCs. (medscape.com)
Recent insights into the cancer development mechanisms have revealed that immune system functionally regulates development and progression of epithelial malignancies and tumor-infiltrating leukocytes may be causal players in cancer development ( 2 ). (frontiersin.org)
The common γ-chain receptor cytokines are promising immune therapies due to their central role in coordinating the proliferation and activity of various immune cell populations. (biorxiv.org)
Significance Statement Signaling in off-target immune cells has hindered the effectiveness of IL-2 as an immunotherapeutic. (biorxiv.org)
Cytokines that bind to the common γ-chain (γ c ) receptor, including interleukin (IL)-2, 4, 7, 9, 15, and 21, are a critical hub in modulating both innate and adaptive immune responses ( 1 ) . (biorxiv.org)
A prominent phenotypic outcome of γ c receptor signaling is lymphoproliferation, and so the cytokines are often observed to be an endogenous or exogenous mechanism for altering the balance of immune cell types. (biorxiv.org)
The importance of these cytokines to immune homeostasis and challenges in altering their signaling toward specific therapeutic goals have inspired a variety of engineered forms. (biorxiv.org)
These cytokines are involved in a variety of functions including the modulation of inflammatory and immune responses, heart development, fertility, and many other activities (2). (rndsystems.com)
Individual colonies reproduce asexually, but individuals from two colonies first allorecognize their compatibility via their contacted ampullae and two individual immune reactions that determines the level of fusion or rejection . (codondex.com)
NK cell lineage has been traced through the CD94 family of receptors to Urochordates (like the Sea Squirt) where transplant immunity was described after tests conducted for immune resistance between colonies. (codondex.com)
Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as innate immune receptors that play a pivotal role in initiating the inflammatory response ( 4 ). (spandidos-publications.com)
This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types. (abscitech.com)
The clinical effect of imiquimod stems from cytokine-induced activation of the immune system. (ijstd.org)
Nevertheless, it is known that imiquimod activates immune cells through the toll-like receptor 7none (TLR7), commonly involved in pathogen recognition, on the cell surface. (ijstd.org)
[2] There is evidence that imiquimod, when applied to skin, can lead to the activation of Langerhans cellsnone , which subsequently migrates to local lymph nodes to activate the adaptive immune system. (ijstd.org)
This immune modification mediates the indirect antiviral, antiproliferative and antitumor activity of imiquimod in vivo . (ijstd.org)
In general, the main difference between these two immune systems lies in the mechanisms and receptors used for immunological recognition 8 . (nature.com)
Immunonutrition refers to circumstances where feeding specific nutrients present a potential to modulate the activity of the immune system. (nature.com)
Given their central role in controlling the immune response in patients with cancer, DCs are emerging as a critical cell type that must be considered as we come to understand basic cancer immunobiology. (aacrjournals.org)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
The immune system is divided into two basic elements, a conceptual understanding that dates back to the early days of the 20th century. (aacrjournals.org)
In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. (biomedcentral.com)
A major breakthrough in cancer therapy is immune checkpoint inhibitor (CPI)-based immunotherapy which has been approved by the FDA for the treatment of multiple types of cancers ( 1 ). (frontiersin.org)
There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)
However, the immune regulatory role of secreted IL-1α in tumor development and whether it can be targeted for cancer therapy are still unclear. (bvsalud.org)

[5] Topical application of imiquimod elevates the production of cytokines, including the principal cytokine for antiviral activity, interferon-α. (ijstd.org)

This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. (arigobio.cn)
Allergic contact dermatitis (ACD), a form of delayed-type hypersensitivity, is a typical T-cell-mediated skin inflammatory response that occurs after cutaneous exposure to an allergen. (aspetjournals.org)
Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. (cdc.gov)

the second stimulus is DAMPs that induce the activation of caspase-1 ( 3 , 5 , 8 , 9 ). (spandidos-publications.com)
In addition to inhibiting protein synthesis, Shiga toxins induce cytokines such as interleukin-1, interleukin-6, and interleukin-8. (listlabs.com)
However, they have both been shown to induce apoptosis in several different cell types. (listlabs.com)

Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)
This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
The active substance in Ilaris, canakinumab, is a monoclonal antibody, a type of protein that has been designed to recognise and attach to a messenger molecule or 'cytokine' in the body called interleukin‑1 beta. (europa.eu)
To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)
Functional studies showed that sequence conservation was reflected in biochemical activity and the ability of lamprey-Mdm2 protein to function as a very effective E3 ubiquitin ligase ( that degrades p53 ) in mouse cells. (codondex.com)
IL1 beta: The protein encoded by this gene is a member of the interleukin 1 cytokine family. (arigobio.cn)
The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. (creativebiomart.net)
Cannabinoid type-2 (CB 2 ) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). (aspetjournals.org)
This activity renders the 28S rRNA unable to interact with the elongation factors EF-1 and EF-2, thus inhibiting protein synthesis. (listlabs.com)
The sequence of human IL-2 cDNA predicts a 153 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein (3). (abscitech.com)
On the contrary, systemic administration of recombinant IL-1α protein significantly inhibited tumor development by activating T cells. (bvsalud.org)
In fact, IL-1α protein could promote T cell activation and enhance the cytotoxicity of CD8+ T cells in vitro. (bvsalud.org)

This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (cancerindex.org)
The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains (7, 8). (abscitech.com)

We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
Further studies showed that tumoral-released IL-1α promoted MDSC recruitment to the tumor microenvironment through a CXCR2-dependent mechanism. (bvsalud.org)

IL-33 induces T cells to produce IL-4, IL-5, and IL-13, and potently induces pro-inflammatory cytokines and chemokines through a Th2-dependent pathway, and also promotes Th1-type responses ( 5 ). (frontiersin.org)

also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)

Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
In mammals, NK cells are large, granular lymphocytes that recognize MHC class I molecules on target cells via inhibitory NK cell receptors. (codondex.com)
IL-10 is also known as Cytokine Synthesis Inhibitory Factor (CSIF), B cell-derived T cell growth factor (B-TCGF), and T-cell growth inhibitory factor (TGIF). (bdbiosciences.com)
Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
The inhibitory effect of PAP-BALF occurred only when TF-1 cells were cultured with GM-CSF but not when cultured with IL-3, suggesting that PAP-BALF contains a factor that specifically interferes with GM-CSF function. (wiley.com)

J Clin Immunol 2009(2): 238-45 [ PubMed abstract ]. (lu.se)
Int J Mol Med 2003(2): 185-91 [ PubMed abstract ]. (lu.se)
Clin Immunol 2002(1): 25-7 [ PubMed abstract ]. (lu.se)
Cytokine Growth Factor Rev 2000(4): 321-33 [ PubMed abstract ]. (lu.se)

Clinical trials with humanized antibodies against interleukin-5 have begun. (biomedcentral.com)

Reactive oxygen species (ROS), generated as consequence of oxidative metabolism, activate signal transduction pathways, which contribute to cellular homeostasis [ 1 ]. (hindawi.com)
Inflammasomes are intracellular multiprotein complexes that regulate the activity of caspase-1 and can be activated by various cellular dangers that trigger the processing and release of pro-inflammatory cytokines to engage innate immunity ( 3 ). (spandidos-publications.com)
The cellular levels of endocannabinoids [anandamide (AEA), 2-arachidonoylglycerol] and related molecules (palmitoylethanolamide, oleoylethanolamide) were quantified in poly-(I:C)-stimulated HaCaT cells treated with CBD. (aspetjournals.org)
The findings indicate that in the CNS: (1) sgp130 is able to block IL-6 trans-signaling, (2) trans-signaling is important for IL-6 cellular communication with selective cellular and molecular targets, and (3) blocking of trans-signaling alleviates many of the detrimental effects of IL-6. (jneurosci.org)
LBH589 (25?nmol/L) as well as Dox at the number of 0.03 to 2?g/mL induced dramatic cellular number reduction, and reduced the IC50 of Dox from 0.8?g/ml to 0.08?g/ml (Fig. (immune-source.com)

Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
The ECD also contains an N terminal immunoglobulin (Ig)-like C2-type domain, followed by the cytokine receptor homology region (CHR) which is made up of two fibronectin type III-like domains and a WSXWS motif, and three additional fibronectin type III-like domains (2). (rndsystems.com)
Despite sequence homology of only 20%, both forms are thought to bind to the same receptor. (eaglebio.com)

IL-6 signals via binding to either the membrane bound IL-6Rα (classic signaling) or soluble (s)IL-6Ra (trans-signaling) that then form a complex with gp130 to activate the JAK/STAT signaling pathway. (jneurosci.org)
Interferon-gamma and interleukin-12 pathway defects and human disease. (lu.se)

Here, we systematically profiled the signaling responses to a panel of wild type and mutein IL-2 molecules in various Fc fusion configurations. (biorxiv.org)
Fatty acids are the main compound of lipids, which are a class of molecules present in animals and vegetal cell types. (nature.com)

The diagnoses were performed in accordance with the ILAR 2001 diagnostic classification criteria ( 2 2. (scielo.br)

Methylation by PRMT1 hinders methylation by PRMT5, which augments E2F-1-dependent apoptosis, whereas PRMT5-dependent methylation favors proliferation by antagonizing methylation by PRMT1. (embl.de)
The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. (embl.de)

Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. (arigobio.cn)
and induces the proliferation and differentiation of oligodendrocytes (1, 2). (abscitech.com)

This phenotype is observed most extremely from loss-of-function or reduced activity mutations in γ c which subvert T and NK cell maturation ( 2 ) . (biorxiv.org)
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. (biomedcentral.com)
IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation. (abscitech.com)
The spleen is responsible for the production and maturation of IgM, B lymphocytes, and opsonins 1 . (healthjade.net)

IFN gamma: This gene encodes a soluble cytokine that is a member of the type II interferon class. (arigobio.cn)

Deletion of IL-33/ST2 function enhances cytotoxicity of NK cells and increases levels of TNF-α, IFN-γ, and IL-17, and systemic pro-inflammatory cytokines, leading to attenuated tumor growth ( 8 ). (frontiersin.org)
Indeed, nowadays psoriasis is considered a systemic pathology, including also other conditions, from psoriatic arthritis to obesity and metabolic disease (MetS), which increased cardiovascular risk in psoriatic patients [ 2 - 4 ]. (springer.com)
Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. (frontiersin.org)
Systemic and local administration of IL-15cx shows two distinct therapeutic responses, a moderate tumor growth inhibition or heterogeneous tumor regressions with survival improvement. (frontiersin.org)
Systemic-onset juvenile idiopathic arthritis (sJIA) is a type of auto-inflammatory disease that shows clinical manifestations such as fever, rash, hepatosplenomegaly, serositis, and synovitis ( 1 1. (scielo.br)
Thus, our study demonstrated that tumoral-released IL-1α promoted tumor development through recruiting MDSCs to inhibit T cell activation, while systemic IL-1α directly promoted anti-tumor T cell responses. (bvsalud.org)

Alternative splicing generates a 90 kDa soluble form of the mouse LIF R alpha ECD (4). (rndsystems.com)
Both IL-6R and gp130 also occur in soluble form in biological fluids and has been purified from human serum and urine. (sbhsciences.com)
Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)

One of these cytokines, interleukin (IL)-2, has potential as a therapy in autoimmunity but is limited in effectiveness by its modest specificity toward regulatory T cells (T reg s). (biorxiv.org)
This specificity occurs because only those cells possess the interleukin-5 receptor. (biomedcentral.com)

RESEARCH DESIGN AND METHODS AND RESULTS- First, we examined whether the PPARβ/δ agonist GW501516 prevents lipopolysaccharide (LPS)-induced cytokine production in differentiated 3T3-L1 adipocytes. (diabetesjournals.org)

The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)
Eleven potential N-linked glycosylation sites are found within the rat gp130 ECD (1). (rndsystems.com)
Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)

These cells are fixed, permeabilized, and lyophilized PBMC that are either untreated or treated with stimulators [including phorbol 12-myristate 13-acetate (PMA), interferon-alpha (IFN-α), interleukin-2 (IL-2), IL-4, and IL-6]. (bdbiosciences.com)
Chinese patients with defective IL-12/23-interferon-gamma circuit in Taiwan: partial dominant interferon-gamma receptor 1 mutation presenting as cutaneous granuloma and IL-12 receptor beta1 mutation as pneumatocele. (lu.se)
Two patients with complete defects in interferon gamma receptor-dependent signaling. (lu.se)
The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction. (lu.se)
Disseminated Mycobacterium peregrinum infection in a child with complete interferon-gamma receptor-1 deficiency. (lu.se)
A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases. (lu.se)
Genetic basis of patients with bacille Calmette-Gu rin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. (lu.se)
561del4 defines a novel small deletion hotspot in the interferon-gamma receptor 1 chain. (lu.se)
Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor. (lu.se)
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. (lu.se)
Recurrent Mycobacterium avium osteomyelitis associated with a novel dominant interferon gamma receptor mutation. (lu.se)
Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor (IFNgammaR1) deficiency: mutational analysis and evaluation of therapeutic options. (lu.se)

IL-6 and IL-8 are cytokines secreted by adipose tissue. (diabetesobesity.org.uk)
OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)

With this therapeutic antibody designed to inhibit interleukin-1 beta we are reinforcing our strategy in the field of biologics and developing novel approaches aimed at treating severe diseases. (biospace.com)
For optimal immunofluorescent staining and flow cytometric analysis, this anti-cytokine antibody should be titrated (≤ 0.5 µg mAb/million cells). (bdbiosciences.com)
No. 554611) prior to staining, or 2) pre-block the fixed/permeabilized cells with unlabelled JES3-19F1 antibody (Cat. (bdbiosciences.com)
use at comparable concentrations to the antibody of interest (e.g., ≤ 0.5 µg mAb/1 million cells). (bdbiosciences.com)
The JES3-19F1 antibody reportedly neutralizes the biological activity of human IL-10 and ebvIL-10. (bdbiosciences.com)
Anti-Shiga Toxin Camelid Antibody, which is a heterotetramer VHH that recognizes both Shiga Toxin 1 and Shiga Toxin 2, is also available. (listlabs.com)
Anti-Shiga Toxin 1 or Anti-Shiga Toxin 2 Antibody, when paired with the Anti-Shiga Toxin Camelid Antibody, can be used in a standard sandwich ELISA. (listlabs.com)

It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)

IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)

The IL-1 Beta Human ELISA Assay (enzyme-linked immunoassay kit) is intended for the quantitative determination of human Interleukin 1 Beta (IL-1β) concentrations in cell culture supernates, serum, and plasma. (eaglebio.com)
2, 3 In these environments they are quantified in highly variable concentrations. (bmj.com)

The gene for IL-2 has been mapped to human chromosome 4q (6). (abscitech.com)

Classic signaling involves IL-6 binding to a specific transmembrane receptor termed IL-6Rα. (jneurosci.org)

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that serves as a potent extracellular sig. (listlabs.com)

The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). (rndsystems.com)

IL-6 contributes to hepatic insulin resistance development through inhibition of insulin receptor signal transduction partly by induction of suppressor of cytokine signalling-3 (SOCS-3). (diabetesobesity.org.uk)

Disruptive mutations in private receptors can lead to more selective reductions in cell types such as regulatory T cells (T reg s) with IL-2Rα or T cells with IL-7Rα ( 1 ) . (biorxiv.org)
Conversely, activating mutations in these receptors, such as IL-7Rα, promote cancers such as B and T cell leukemias ( 3 ) . (biorxiv.org)

Finally, our model shows that even more selective IL-2 therapies may be developed by designing cytokines in higher valency formats, revealing valency as an unexplored mechanism for engineering specific IL-2 responses. (biorxiv.org)
However, innate immunity is also involved in the development of inflammatory responses that occur in a sterile milieu ( 2 ). (spandidos-publications.com)
In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. (biomedcentral.com)

IL 6 reduces the activity of lipoprotein lipase (thus decreasing the availability of intracellular substrate for triglyceride synthesis). (diabetesobesity.org.uk)
What are the functional implications of IL1R2's intracellular domain, and how can engineered receptor constructs shed light on its contributions? (creativebiomart.net)

The biological effects of IL-2 are mediated by specific cell surface receptor complexes. (abscitech.com)

The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. (mdpi.com)
Two studies involving 454 patients with gouty arthritis showed that Ilaris was more effective than another anti-inflammatory medicine triamcinolone acetonide at reducing pain. (europa.eu)
Its oils are rich sources of unsaturated fatty acids, such as monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids, which are previously associated with the prevention of health disorders because of their anti-inflammatory effects and cell membrane properties and structure 2 . (nature.com)

We detected the expression of IL-33 in tumor tissue, and IL-33 and its related cytokines in serum from BC patients. (frontiersin.org)

IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. (abscitech.com)

The functional analysis of these two gene clusters further illustrated the effects of biochanin A on interleukin-6 production and cytokine-cytokine receptor interaction in CRC/COVID-19 pathology. (bvsalud.org)

We show that in poly-(I:C)-stimulated HaCaT cells, CBD elevates the levels of AEA and dose-dependently inhibits poly-(I:C)-induced release of MCP-2, interleukin-6 (IL-6), IL-8, and tumor necrosis factor- α in a manner reversed by CB 2 and TRPV1 antagonists 6-iodopravadoline (AM630) and 5′-iodio-resiniferatoxin (I-RTX), respectively, with no cytotoxic effect. (aspetjournals.org)

the latter are antigen-presenting cells (APCs) that function as memory cells interacting with type 1 THCs. (medscape.com)
DFCs activate some clones of type 1 THCs, although less potently than B cells do. (medscape.com)
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. (cancerindex.org)
One of the reasons for this is the acquisition of Gem resistance (Gem‑R). To elucidate the mechanism of Gem‑R, two Gem‑R PaCa cell lines were established from AsPC‑1 and MIA PaCa‑2 cells. (cancerindex.org)
These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. (hindawi.com)
It was shown that the gene, BsCD94-1, is differentially regulated during allorecognition and that a subpopulation of blood cells carries the corresponding receptor on its cell surface. (codondex.com)
This is a rare but aggressive form of cancer of NK cells. (codondex.com)
IL-1 has multiple immunological functions including enhancement of IL-2 production by T cells and activation of B-cells (BAF) and thymocytes. (eaglebio.com)
The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
Shiga toxins then enter the cells by receptor-mediated endocytosis. (listlabs.com)
The effects of Shiga toxin 1 and Shiga toxin 2 have been shown to vary with cell type because Gb3 receptors are present in certain tissues, particularly sensory neurons and renal cells. (listlabs.com)
Human IL-2 (also known as T-cell growth factor) is produced by T-cells in response to antigenic or mitogenic stimulation. (abscitech.com)
IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. (abscitech.com)
Whereas human IL-2 is active on mouse cells, mouse IL-2 is species-specific and is inactive on human cells. (abscitech.com)
[3] Other cell types activated by imiquimod include natural killer cells, macrophages and B-lymphocytes. (ijstd.org)
However, GFAP-IL6/sgp130 mice had decreased pY 705 -STAT3 in the brain due to a reduction in the total number of pY 705 -STAT3-positive cells and a marked loss of pY 705 -STAT3 in specific cell types. (jneurosci.org)
We found that bronchoalveolar lavage fluid (BALF) from 11 patients with idiopathic pulmonary alveolar proteinosis (IPAP) suppressed the growth of peripheral blood monocytes and TF-1 cells, a cell line dependent on either GM-CSF or interleukin-3 (IL-3). (wiley.com)
125 I-GM-CSF binding to TF-1 cells was prevented in the presence of BALF from IPAP patients. (wiley.com)
They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
Methods Since GBM neurosphere cultures from patient-derived gliomas are enriched for GBM stem-like cells (GSCs) and form highly intrusive and proliferative xenografts that recapitulate the features showed in human sufferers identified as having GBM, we set up inducible KLF9 appearance systems in these GBM neurosphere cells and looked into cell loss of life in the current presence of epigenetic modulators such as for example histone deacetylase (HDAC) inhibitors. (immune-source.com)
The normal adult spleen contributes to the homeostasis of the body by removing from the blood useless or potentially injurious materials (e.g., abnormal or "wornout" red blood cells and microorganisms) and by synthesizing immunoglobulins and properdin 2 . (healthjade.net)
The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
Tumoral-released IL-1α were found to inhibit T and NK cell activation, and the killing capacity of CD8+ T cells. (bvsalud.org)

The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. (embl.de)
Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. (embl.de)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
by normal individuals cause broncho-constriction in Cytokines often have overlapping biological activities, patients with asthma. (cdc.gov)
In addition to essential biological capabilities ac- are overweight [2]. (who.int)

Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)

It also identifies a new route toward engineering even more selective therapeutic cytokines. (biorxiv.org)
We show that bivalent IL-2 muteins exhibit more regulatory T cell-selective signaling than monovalent forms. (biorxiv.org)
In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. (biomedcentral.com)

This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). (arigobio.cn)

XOMA expects to release results from two ongoing Phase 2 studies in patients with Type 2 diabetes in the first quarter of 2011. (biospace.com)
According to the World Health Organization [ 1 ], the global prevalence of diabetes is approximately 10%, reaching up to 33% of the population in some regions. (biomedcentral.com)
Scientific evidence suggests increased inflammatory stress is related to molecular mechanisms leading to insulin resistance, and the intestinal microbiota interacts with environmental factors and susceptible genetic factors, contributing to the development of diabetes [ 2 ]. (biomedcentral.com)
Our aim is to clarify the currently described effects of probiotics in the prevention and management of type 1 (T1D) and type 2 (T2D) diabetes mellitus. (biomedcentral.com)
Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. (cdc.gov)
We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50-80 with and without type 2 diabetes mellitus. (cdc.gov)
The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB. (cdc.gov)

Innate immunity offers the first defense in mammals, depending on its capacity to rapidly detect invading pathogens and then eliminating the 'foreign danger' ( 1 ). (spandidos-publications.com)

Anatomy48

Organisms11

Diseases9

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes35

Disciplines and Occupations1

Information Science3

Health Care1

Binds8

Pleiotropic cytokine2

Secretion8

Proinflammatory4

Ligand8

Genes6

Inflammation20

Immune26

Production of cytokines1

Inflammatory response3

Induce3

Protein18

High affinity2

Microenvironment3

Chemokines1

Signal transducer1

Inhibitory5

Abstract4

Humanized antibodies1

Cellular5

Homology3

Pathway2

Molecules2

20011

Apoptosis2

Induces2

Maturation4

Encodes1

Systemic6

Soluble form3

Specificity2

Lipopolysaccharide1

Gp1304

Interferon12

Adipose tissue2

Antibody7

MRNA1

Alpha subunit1

Concentrations2

Chromosome1

Transmembrane1

Potent1

Hematopoietic1

Inhibition1

Mutations2

Responses3

Intracellular2

Cell surface1

Anti-inflammatory4

Serum1

Cancers1

Interaction1

Inhibits1

Cells27

Biological5

Bone marrow2

Selective3

Macrophages1

Diabetes7

Innate1