• A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
  • We have previously shown that tumor founding clone mutations are able to predict tumor recurrence. (nature.com)
  • Studies have shown that by treating the area of the breast in the vicinity of the original tumor, APBI can reduce recurrences . (cancer.gov)
  • Both treatment groups had low rates of tumor recurrence: In the APBI group, the 5-year and 8-year cumulative rates of recurrence were 2.3% and 3.0%, respectively, whereas the corresponding rates for the WBI group were 1.7% and 2.8%, respectively. (cancer.gov)
  • Tumor recurrence, disease-free survival (DFS), and side-effects were recorded and compared between the 2 groups. (spandidos-publications.com)
  • Numerous clinical trials have shown that combining MMC administration with hypothermia can improve tumor ablation and prevent recurrence post-TUR. (spandidos-publications.com)
  • In a ease-cohort study of 78 patients with favorable histology Wilms' tumor, we compared tumor telomerase levels in patients with and without eventual recurrence. (northwestern.edu)
  • The study concluded that in completed phase 1/2 trials of NeuVax, patients who exhibit robust in vitro IR have lower recurrence rates. (her2support.org)
  • Healthy young adults showed the best homeostasis (lower recurrence). (bvsalud.org)
  • Evidence supporting similar recurrence rates between video-assisted and open surgery for the treatment of recurrent pneumothorax is questionable, because the number of randomised trials is sparse and they are underpowered to detect any meaningful difference. (nih.gov)
  • The NIOSH investigator offers the following recommendations to possibly prevent a similar recurrence and to address general safety and health issues. (cdc.gov)
  • The recurrence rate of CSNG-treated patients after a follow-up period of up to 7 years was low (6.1%, 95% confidence interval [CI] 2.0-15.6). (cdc.gov)
  • Follow-up data on the rate of recurrence in hospital-treated Buruli ulcer patients are rarely reported. (cdc.gov)
  • This study reports the recurrence rate of CSNG-treated patients after up to 7 years of follow-up. (cdc.gov)
  • VANCOUVER, British Columbia - An 11 C-choline PET/MR protocol for the restaging of prostate cancer was well tolerated by patients and detected significantly more recurrences than PET/CT, according to new research. (medscape.com)
  • Patients are monitored for levels of prostate-specific antigen, and when the levels rise, physicians suspect a recurrence. (medscape.com)
  • After a median follow-up of 10.2 years, 161 patients had a breast cancer recurrence: 90 patients who received APBI and 71 who received WBI. (cancer.gov)
  • For cancer patients, cancer recurrence is often one of the biggest fears. (cancercenter.com)
  • Patients should be aware of these potential developments to look for signs of recurrence so it may be diagnosed as early as possible. (cancercenter.com)
  • If treatment for cancer recurrence leads to tests that show no evidence of disease, patients may want to know how many more times it may come back. (cancercenter.com)
  • As an example of how staging affects recurrence rate, a large study of Swedish colon cancer patients, published in the Diseases of the Colon & Rectum journal, found that within five years after initial treatment, the recurrence rates were 5 percent for stage 1, 12 percent for stage 2, and 33 percent for stage 3. (cancercenter.com)
  • The NeuVax poster presentation entitled: 'Biomarker Correlation to Clinical Response in Phase I/II Trials of the Adjuvant Breast Cancer Vaccine, NeuVax (nelipepimut-S or E75)' examined the relationship between in vitro immunologic response (IR) and clinical recurrence (CR) after five years of follow-up in patients with breast cancer. (her2support.org)
  • The vaccine was administered in the adjuvant setting to prevent recurrence in breast cancer patients rendered disease-free following standard-of-care therapy. (her2support.org)
  • The patients with NMIBC may be categorized in three risk groups according to the risk of recurrence and progression characterized by the disease. (bcan.org)
  • 184 patients) reported nonclinical fear of cancer recurrence. (oncologynurseadvisor.com)
  • Doctors typically treat patients in full or partial remission as though they have a chronic illness due to the risk of recurrence. (mesotheliomahope.com)
  • Patients in remission should attend regular follow-up appointments and watch for any symptoms of mesothelioma recurrence. (mesotheliomahope.com)
  • This has implications for not only designing clinical trials, but also for evaluating the benefit of various forms of treatment intensification and for counseling patients. (news-medical.net)
  • However, previous analyses have yielded conflicting conclusions about whether or not biochemical recurrence could be a reliable predictor of overall survival for patients treated for prostate cancer. (news-medical.net)
  • Despite the potential of using biochemical recurrence as a potential marker to predict overall survival in patients with prostate cancer, the results of the study indicates that it should not be the main focus or primary measure in future clinical trials for localized prostate cancer. (news-medical.net)
  • The authors say the next step is a new clinical study expected to begin in early 2020, which utilizes this discovery to enroll patients who are at high risk for recurrence and evaluates new treatment options for them. (iu.edu)
  • Meta-analysis was done by combining the results of reported recurrence rates in patients undergoing video-assisted thoracoscopic surgery compared with those having open surgery. (nih.gov)
  • Measurement of hTERT mRNA level may, therefore, enable clinicians to identify a population of patients at high risk for recurrence and to adjust their therapy accordingly. (northwestern.edu)
  • Thus, there is a significant unmet need for both reducing the risk of recurrence and providing a tolerable treatment option that keeps patients cancer-free without disrupting their daily life. (yahoo.com)
  • Sur 93 patients atteints d'une insuffisance rénale chronique, âgés en moyenne de 57,0 ans (ET 18,5), 25 patients (26,9 %) étaient positifs pour les anticorps anti-VHE. (who.int)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • The authors note that UBC is associated with a high risk for recurrence, and although cystoscopy and urine cytology are the current gold standards for monitoring patients, they have low sensitivity in NMIBC. (medscape.com)
  • Il s'agit d'une étude transversale, monocentrique et descriptive, durant 12 mois, incluant les patients âgés d'au moins 18 ans admis en réanimation polyvalente pour un sepsis ou choc septique. (bvsalud.org)
  • In general, cancer recurrence and metastasis are the result of the interactions of multiple mutated genes. (nature.com)
  • But the recurrence could be local, in the lymph nodes, or a bone metastasis. (medscape.com)
  • There was no significant relationship between the DNA ploidy status and histopathological grading, lymph node metastasis and local recurrence development, respectively. (researchgate.net)
  • The treatment of high risk NMIBC includes a transurethral resection of the tumour(s), which is followed by an adjuvant instillation therapy, aiming to reduce the risk of recurrence and progression. (bcan.org)
  • Preventing the recurrence of non-muscle invasive bladder cancer (NMIBC) post-transurethral resection (TUR) remains challenging. (spandidos-publications.com)
  • The aim of the present study was to investigate the effectiveness and safety of bladder intracavitary hyperthermic perfusion chemotherapy (BHPC) for prevention of NMIBC recurrence post-TUR. (spandidos-publications.com)
  • Although, the recurrence rate of NMIBC is significantly decreased by TUR in combination with intravesical chemotherapy, the rate of cancer progression is not diminished ( 7 - 12 ). (spandidos-publications.com)
  • Preventing recurrence of NMIBC after TUR remains challenging ( 13 - 15 ). (spandidos-publications.com)
  • Bladder intracavitary hyperthermic perfusion chemotherapy (BHPC), the combination of local hyperthermia with chemotherapy, can significantly improve the effect of intracavity chemotherapy, and is reported to have an additive or supra-additive effect, preventing NMIBC recurrence post-TUR ( 13 - 16 , 18 - 20 ). (spandidos-publications.com)
  • Disease recurrence and progression is a major issue in high risk non-muscle-invasive bladder cancer (NMIBC). (bcan.org)
  • Results from a prospective randomized trial suggested, that sequential EMDA-MMC and BCG treatment might be even more effective against NMIBC than BCG therapy alone in terms of recurrence, progression and overall survival. (bcan.org)
  • The aim of the study is to compare effectiveness and tolerability of the two treatment regimens in preventing recurrence and progression of high risk NMIBC. (bcan.org)
  • Clinical outcome was relapse or recurrence of major depressive disorder (SCID-I). We tested the moderating effects on relapse or recurrence of age, gender, education level, residual depressive symptoms, number of previous episodes, age of onset, antidepressant medication, somatization, and self-efficacy with logistic regression analyses adjusted for baseline values of depressive symptoms. (vu.nl)
  • The study looked at the levels of E75 specific T-cells as measured by the dimer assay and correlated the IR with clinical benefit, or lack of recurrence. (her2support.org)
  • A cross-sectional survey of breast cancer survivors showed that women who experienced clinical and subclinical fear of cancer recurrence also experienced higher supportive care needs across 5 different domains. (oncologynurseadvisor.com)
  • This cross-sectional study aimed to evaluate the supportive care needs of breast cancer survivors in the context of nonclinical, subclinical, and clinical fear of cancer recurrence. (oncologynurseadvisor.com)
  • Subclinical fear of cancer recurrence occurred in 38.2% (147) of participants, and clinical fear of cancer recurrence occurred in 14.0% (54) of participants. (oncologynurseadvisor.com)
  • In participants with subclinical and clinical fear of recurrence, the most common needs were in the "Psychological" domain, occurring in 85.7% of subclinical fear of recurrence and 96.3% of clinical fear of recurrence. (oncologynurseadvisor.com)
  • This study emphasizes the importance of timely psychological support for breast cancer survivors experiencing subclinical and clinical fear of cancer recurrence. (oncologynurseadvisor.com)
  • These results imply that timely psychological support should be provided to women with subclinical or clinical FCR [fear of cancer recurrence] to meet their needs in helping to cope with the uncertainty, fear, and worry caused by the possibility of recurrence," stated the authors. (oncologynurseadvisor.com)
  • One of the most surprising results of my research was the impact of vitamin D on colorectal cancer recurrence and mortality. (cancer.org)
  • So far, the studies I have mentioned deal with the recurrence of colorectal cancer. (cancer.org)
  • Unfortunately, I could not find any that dealt with recurrence with these supplements, but there are studies dealing with the initial occurrence of colorectal cancer, plus what I call "test-tube" studies that were generally favorable. (cancer.org)
  • In the study, the majority of the recurrences occur in women that had lower absolute levels of NeuVax-specific T cells or more modest increases in their NeuVax-specific T cells. (her2support.org)
  • This can help treat recurrence early if it does occur. (mesotheliomahope.com)
  • Biochemical recurrences occur much earlier in the disease course than metastases or survival, and could potentially be the ideal surrogate endpoint for prostate cancer. (news-medical.net)
  • If a recurrence does occur, it is often at a more advanced stage. (yahoo.com)
  • A UCLA-led study found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising prostate-specific antigen (PSA) levels after radiotherapy, commonly referred to as biochemical recurrence, do not necessarily improve a patient's long-term overall survival. (news-medical.net)
  • The team of investigators found that while biochemical recurrence was associated with a higher risk of death, it still did not meet the criteria to be a reliable surrogate endpoint for overall survival. (news-medical.net)
  • The strength of the correlation between biochemical recurrence and overall survival varied depending on how deaths from non-cancer-related causes were accounted for. (news-medical.net)
  • The researchers collected and analyzed data from 11 different studies evaluating radiation therapy dose escalation, the use of androgen deprivation therapy and androgen deprivation therapy prolongation to evaluate the potential of biochemical recurrence as a predictor of survival. (news-medical.net)
  • Ribociclib also showed more favourable outcomes in overall survival, recurrence-free survival, and distant disease-free survival, according to the researchers. (yahoo.com)
  • RESULTS: TLS+ cases had better recurrence-free-survival (RFS) (p (bvsalud.org)
  • A new noninvasive test may be able to detect bladder cancer recurrence earlier than standard cytology and cystoscopy, according to new findings published online July 7 in the British Journal of Cancer . (medscape.com)
  • After 10 years from the diagnosis, the research team found no difference in recurrence rate between women who became pregnant and those who did not. (pabreastcancer.org)
  • And for people who have cancer, exercise reduces the rate of recurrence, especially when it comes to things like certain types of breast cancer. (upstate.edu)
  • found a local recurrence rate of 16% at the same site within a year of follow-up ( 5 ). (cdc.gov)
  • COPENHAGEN - Cold snare endoscopic mucosal resection (CS-EMR) is safer than hot snare (HS)-EMR for the removal of large, non-pedunculated colorectal polyps, but the general recurrence rate after cold snare is higher, the first data from a prospective, multi-center, randomized controlled trial (RCT) show. (medscape.com)
  • But because the general recurrence rate [residual neoplasia] is higher after cold snare, careful selection of the target lesion should be made," he said. (medscape.com)
  • In another abstract in the same session, presented by Óscar Nogales, MD, gastroenterologist from the Hospital General Universitario Gregorio Marañón, Spain, the data showed that the recurrence rate of large non-pedunculated colonic lesions was significantly higher after CS-EMR, compared with the standard technique (conventional EMR), although there was also a trend toward fewer adverse effects. (medscape.com)
  • Secondary endpoints were intraprocedural bleeding, post-polypectomy syndrome, technical success, resection speed, and recurrence rate after 4 months. (medscape.com)
  • According to older research that set the standard for treatment recommendations, the rate of recurrence for people who chose a lumpectomy is about the same as the rate of recurrence for people who undergo a mastectomy. (medicalnewstoday.com)
  • The type of breast cancer can affect the recurrence rate. (medicalnewstoday.com)
  • Which cancer has the highest recurrence rate? (cancercenter.com)
  • Glioblastoma , the most common type of brain cancer , has a near 100 percent recurrence rate, according to a study published in the Journal of Neuro-Oncology . (cancercenter.com)
  • Epithelial ovarian cancer has an 85 percent recurrence rate, according to a study published in Expert Review of Anticancer Therapy . (cancercenter.com)
  • Incomplete ablation rate was 2.5% (1/40), local recurrence rate 10% (4/40). (nature.com)
  • The recurrence rate is similar to that of primary spontaneous pneumothorax. (msdmanuals.com)
  • This study was conducted to determine a simple method of detecting homeostasis impairment based on heart rate variability and recurrence plots. (bvsalud.org)
  • Failure to implement recommended prevention measures might have contributed to recurrence of the outbreak. (cdc.gov)
  • Having a child after breast cancer treatment does not make you more likely to have a recurrence, researchers say. (pabreastcancer.org)
  • Many survivors with ER-positive cancer are concerned with the need to stop post-surgery hormone therapy before they try to get pregnant (therapy that helps to prevent recurrence). (pabreastcancer.org)
  • Oncotype DX breast cancer recurrence score) and outperformed prediction for both high- and low-risk groups. (nature.com)
  • In the case of prostate cancer recurrence, PET/MR has clear value, he noted. (medscape.com)
  • What are the chances of breast cancer recurrence? (medicalnewstoday.com)
  • According to the breast cancer charity Susan G. Komen , everyone who has had breast cancer has a risk of recurrence. (medicalnewstoday.com)
  • If a person has a lumpectomy and develops local or regional recurrence of breast cancer, a doctor may suggest a mastectomy and radiation therapy. (medicalnewstoday.com)
  • In a 2017 study , researchers found that people with estrogen-receptor (ER)-positive breast cancer had a persistent risk of recurrence for at least 20 years after their original diagnosis. (medicalnewstoday.com)
  • A local recurrence happens if new cancer cells grow in the same breast the cancer originally affected. (medicalnewstoday.com)
  • Optimizing the odds of avoiding cancer recurrence: Go jogging in your Speedo or bikini! (cancer.org)
  • I have been looking around, mostly on pubmed ( https://www.ncbi.nlm.nih.gov/pubmed/ ), for non-chemotherapy strategies to reduce cancer recurrence and mortality. (cancer.org)
  • The FDA has recently approved cyclosporine A 0.1%, a mild form of the anti-cancer drug for acute episodes of vernal conjunctivitis. (medlineplus.gov)
  • What is cancer recurrence? (cancercenter.com)
  • Doctors call this a cancer recurrence. (cancercenter.com)
  • Regional recurrence refers to the original cancer showing up in tissue or lymph nodes near the original site. (cancercenter.com)
  • Recurrence differs from developing a second form of cancer, which is far less common. (cancercenter.com)
  • While cancer doesn't always return, recurrence is common for some hard-to-treat forms of cancer. (cancercenter.com)
  • That said, recurrences are less likely the more time has passed from the original cancer. (cancercenter.com)
  • Even after a patient undergoes treatment for a recurrence, there's no guarantee that the cancer won't recur again, nor is it possible to tell how many times it may recur. (cancercenter.com)
  • The higher the level of fear of cancer recurrence, the higher the levels of supportive care needs across 5 different domains after statistically adjusting for several factors. (oncologynurseadvisor.com)
  • On the other hand, in participants with nonclinical fear of cancer recurrence, the most common supportive care needs were in the domain of "Health care system/Information. (oncologynurseadvisor.com)
  • A total of 385 breast cancer survivors completed a series of online questionnaires: supportive care needs were evaluated via the 34-item Supportive Care Needs Survey and fear of cancer recurrence was measured via the Fear of Cancer Recurrence Inventory. (oncologynurseadvisor.com)
  • The most common domain in participants with nonclinical fear of cancer recurrence occurred in 50.5% of these women and was in the "Health care system/Information" domain. (oncologynurseadvisor.com)
  • Mesothelioma recurrence occurs when signs of cancer return after the patient has achieved full or partial remission . (mesotheliomahope.com)
  • In cases of local mesothelioma recurrence , signs of cancer reappear in the same area where they first began, whether in the lining of the lungs (pleura), abdomen (peritoneum), heart (pericardium), or testicles (tunica vaginalis). (mesotheliomahope.com)
  • Biochemical recurrence develops in almost one-third of men with prostate cancer after treatment with prostatectomy or radiation therapy for localized prostate cancer. (news-medical.net)
  • Thousands of women with the world's most common form of breast cancer could benefit from a blockbuster drug that helps them live longer and cuts the risk of the disease returning by a quarter. (yahoo.com)
  • About one-third of those with stage two hormone receptor-positive, HER2-negative disease experience a recurrence after standard treatment and more than half of people with stage three disease will see their cancer return, said Slamon. (yahoo.com)
  • Anxiety is often manifested at various times during cancer screening, diagnosis, treatment, and recurrence. (cancer.gov)
  • Of the different types of cells that form the bladder, the cells lining the inside of the bladder wall are the most likely to develop cancer. (emedicinehealth.com)
  • The authors also assessed the use of the TERT test for detecting cancer recurrence. (medscape.com)
  • Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
  • Supported self-help to prevent relapse or recurrence of depression: Who benefits most? (vu.nl)
  • Background: This study aimed to identify subgroups for whom supported self-help preventive cognitive therapy (S-PCT) is more (cost)effective than treatment as usual (TAU) in preventing relapse and recurrence of major depression. (vu.nl)
  • Results: We found no moderating effect on relapse or recurrence for any of the potential moderators. (vu.nl)
  • Conclusions: S-PCT was effective in preventing relapse or recurrence of depressive disorders in a broad range of participants, but is more likely to be cost-effective in participants with 2-3 episodes than ≥4 episodes. (vu.nl)
  • Both randomised and non-randomised trials are consistent in recurrence of pneumothoraces and show a four-fold increase when a similar pleurodesis procedure is done with a video-assisted approach compared with an open approach. (nih.gov)
  • A 2021 study found a 6.7% chance of females aged 35 and younger having a local recurrence within 5 years of their initial diagnosis and treatment. (medicalnewstoday.com)
  • We present our experience with percutaneous stereotactic image-guided microwave ablation (SMWA) for non-colorectal liver metastases (NCRLM), in form of a retrospective study including all SMWA for NCRLM from 2015 to 2017. (nature.com)
  • The purpose of this study is to evaluate the safety and effectiveness of CP101 treatment in adults who had a Clostridum difficile Infection (CDI) recurrence within 8 weeks of receiving CP101 or placebo. (mayo.edu)
  • The research on vitamin D levels is solid, but there are some indications that the vitamin D levels may be protective, rather than a form of treatment. (cancer.org)
  • In the US study , for instance, more than 95% of participants in each treatment group-those receiving either WBI or APBI-did not have a recurrence at a median follow-up of 10 years after their treatments ended. (cancer.gov)
  • MWA is well recognized for hepatocellular carcinoma (HCC), where it has been shown to be a safe, effective and minimally-invasive treatment option, that can be repeated in case of local recurrence 3 . (nature.com)
  • In general, for newly diagnosed CNS lymphoma, HD-MTX based chemotherapy forms the backbone of treatment. (dana-farber.org)
  • Even in the case of NED status, new symptoms or routine follow-up testing may suggest a recurrence. (cancercenter.com)
  • The purpose of this booklet is to give you some information about the many symptoms of postnatal depression, ranging from the mildest to the most severe forms. (apni.org)
  • The median hTERT mRNA level in tumors with recurrence was higher than that in tumors without recurrence (1.42 versus 0.97 units, P = 0.023, Wilcoxon). (northwestern.edu)
  • Cells that transform in a less dangerous fashion may still multiply and form masses or tumors. (emedicinehealth.com)
  • ABSTRACT Hepatitis E virus (HEV) infection is the most common form of acute hepatitis in adults in endemic regions of Asia. (who.int)
  • It may also help prevent recurrences. (medlineplus.gov)
  • Most often, this response lacks a coordinated and multisectoral approach, fails to prevent occurrence or recurrence of outbreaks and can result in many deaths. (who.int)
  • Can I create a formula in Excel that evaluates form information? (excelbanter.com)
  • If the problem is not addressed promptly and appropriately, anterior synechiae may form, increasing the risk of graft rejection, glaucoma, or graft failure. (aao.org)
  • The late-stage trial of the drug showed it cut the risk of recurrence by 25% when used with standard hormone therapy, rather than hormone therapy alone, after traditional treatments. (yahoo.com)
  • These cancers are comprised of cells that typically form as a result of bladder inflammation or irritation that has taken place for many months or years. (emedicinehealth.com)
  • These cancers form from cells that make up glands. (emedicinehealth.com)
  • Previously enrolled in PRISM3: Subjects who had a CDI recurrence within 8 weeks of receiving CP101 or placebo and have completed their PRISM3 end of study visit. (mayo.edu)
  • Copies of all pertinent study materials (tracing materials, questionnaires, authorization forms, and health facility data collection forms) can be found in Appendix VI of the Plan and Operation of the NHANES I Epidemiologic Followup Study 1982-84. (cdc.gov)
  • Together they form a unique fingerprint. (vu.nl)
  • From March 2000 to February 2001, field trips in villages of the Atlantique and Zou regions were organized to collect data on rates of recurrence of disease and inform the population of the Buruli ulcer public health problem. (cdc.gov)
  • Our aim was to do a systematic review of randomised and non-randomised studies to compare recurrence rates between the two forms of surgical access. (nih.gov)
  • Healthy newborns and individuals with declared brain death or in a state of imminent death had higher recurrence values. (bvsalud.org)
  • The quantitative and qualitative evaluation of recurrence plots allowed the selection of two variables (standard deviation of the RR normal intervals (SDNN) and the average length of the vertical lines (trapping time)), that when correlated in a phase space, discriminate individuals with adequate autonomic control (healthy children and adults), from those with autonomic systems compromised by immaturity or progressive loss of function. (bvsalud.org)
  • The sample teaches you how to show the predefined Appointment and Recurrence form when the user selects cells in order to create an event or clicks an existing event to modify it. (mindfusion.eu)
  • People who actually use most of those forms were never as fussy about them as later musicologists have become and very often the forms get mixed, and you can't distinguish one from another [laughter] -some ricerari are actually chaconne. (conjunctions.com)
  • It is basically the idea behind the annihilator method $-$ which is more famous for solving differential equations, but nothing prevents you from adapting it to a discrete context such as recurrence relations. (stackexchange.com)
  • Recurrence plots have been increasingly used to evaluate complex dynamic systems of which the human body is an excellent model. (bvsalud.org)
  • To get at the question of self-organization, reaction times were submitted to a detrended fluctuation analysis and a recurrence quantification analysis. (frontiersin.org)