• The latter enzyme, called Sc LPMO10D, and most of the enzymes found in this subclade are unique, not only because of variation in the catalytic domain, but also as their C-terminus contains a cell wall sorting signal (CWSS), which flags the LPMO for covalent anchoring to the cell wall. (nature.com)
  • This gene encodes both forms of the enzyme which arise from tissue-specific alternative transcripts that differ in the first exon. (wikipedia.org)
  • We study MTHFR from Escherichia coli as a model for the catalytic domain of the human enzyme. (carleton.edu)
  • The enzyme consists of the catalytic domain of human MMP-1 (Phe 100 -Gln 268 ) with a C-terminal purification tag. (enzolifesciences.com)
  • The enzyme consists of residues Phe 107 -Pro 449 (NM_004994), which comprises the catalytic/fibronectin domain of human MMP-9, with a C-terminal purification tag. (enzolifesciences.com)
  • In X-ray crystallographic studies, we have determined the structures of the catalytic portions of the enzyme in complex with statin molecules. (nih.gov)
  • These studies show that the HMG-like moiety of statin molecules occupy the HMG binding site of the enzyme, with the hydrophobic groups of the statins occupying a binding site exposed by movement of flexible helices in the enzyme catalytic domain. (nih.gov)
  • Proteolysis of MutY with trypsin indicated that this DNA mismatch repair enzyme could exist as two modules and that the N-terminal domain (Met1- Lys225), designated as p26, could serve as the catalytic domain [Manuel et al. (elsevierpure.com)
  • We find that nafamostat has a higher MC population than camostat and GBPA, suggesting that nafamostat is more readily available to form the stable covalent enzyme-substrate intermediate, effectively explaining its high potency. (rsc.org)
  • These heterodimers, however, show no enzyme activity and, like mammalian β2 subunits, act in a dominant negative manner when combined with the NO-sensitive subunits to disrupt their activation by NO. In addition,we show that the unique C-terminal domain of MsGC-β3 is not necessary for enzyme activity and might act as an auto-inhibitory domain. (biologists.com)
  • In addition to their role in assembling activated complexes, particular SH2 domains also form intramolecular interactions that regulate enzyme activity. (lu.se)
  • 1998). The Src SH2 domain has been shown to bind a phosphorylated tyrosine at the C-terminus of the same molecule resulting inactivation of enzyme activity by rearrangement of catalytic center in the kinase domain (reviewed in Hubbard et al. (lu.se)
  • then this catalytic domain binds to and cleaves a nerve-cell protein, making it impossible for the nerve cell to "fire," or send signals. (bnl.gov)
  • This study looked specifically at how the catalytic domain of one type of neurotoxin, neurotoxin F, recognizes and binds to its target nerve-cell protein to perform this final, paralyzing step," said Brookhaven Lab biologist Subramanyam Swaminathan, who led the research team. (bnl.gov)
  • It has a typical right-hand DNA polymerase fold, with an active site formed by a palm holding the catalytic residues, a thumb that binds the primer:template DNA and fingers interacting with incoming nucleotide, and the N and Exo domains extend from the finger toward the thumb. (cathdb.info)
  • upon elevation of Ca2+ and IP4 concentrations, the PH domain binds to IP4 thereby stimulating catalytic activity, while at the same time the C2a domain takes over the role of membrane tether. (sdbonline.org)
  • It has two domains, one that binds protective antigen and another that has ADP-ribosyltransferase activity [ 5 ]. (expasy.org)
  • In contrast, the CXXC domain of Dnmt1 selectively binds DNA substrates containing unmethylated CpG sites. (cipsm.de)
  • A loop from the N-terminal SH2 domain binds to the catalytic cleft of the phosphatase domain in the same SHP-2 molecule leading to an autoinhibited configuration (Hof et al. (lu.se)
  • Oxr1p belongs to the group of TLDc domain containing proteins that are highly conserved in higher eukaryotes. (upstate.edu)
  • Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
  • The MARCKS domain regulates the nuclear localizations of type IV DGKs while the PDZ-binding and ankyrin domains regulate interactions with several proteins. (nih.gov)
  • There are 37989 PTPc domains in 29134 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing PTPc domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with PTPc domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing PTPc domain in the selected taxonomic class. (embl.de)
  • The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)
  • The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. (embl.de)
  • There are 171652 RHOD domains in 136038 proteins in SMART's nrdb database. (embl.de)
  • Transglutamina-se(TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. (biovendor.com)
  • Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. (cipsm.de)
  • Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. (embl-heidelberg.de)
  • There are 6745 Hr1 domains in 3157 proteins in SMART's nrdb database. (embl-heidelberg.de)
  • Percentage points are related to the number of proteins with Hr1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Hr1 domain. (embl-heidelberg.de)
  • Tyrosine phosphorylated regions in proteins function as specific binding sites for the SH2 domains containing cellular signalling proteins. (lu.se)
  • Two sequence motifs, residues 1074-1077 in the long segment of the L-shaped thumb, and residues 1130-1150 in the tip of the thumb, form a continuous protein interface that tracks the position of the phosphodiester backbone of the RNA primer. (cathdb.info)
  • Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites. (nih.gov)
  • Those which bind phosphorylated tyrosine residues may recruit multi-phosphorylated substrates for the adjacent active domains and are more conserved, while the other class have accumulated several variable amino acid substitutions and have a complete loss of tyrosine binding capability. (embl.de)
  • Catalytically active TR mART domains hallmark catalytic residues in the active site. (expasy.org)
  • The selectivity of an individual SH2 domain is not sharply defined, and a range of residues is typically tolerated at each site following the phosphotyrosine. (lu.se)
  • This arrangement allows PCNA to thread and stabilize the DNA exiting the catalytic cleft and recruit FEN1 to one unoccupied monomer in a toolbelt fashion. (nature.com)
  • The epidermal growth factor domain has a calcium ion - binding site that to some degree mediates interaction with the tissue factor exposed at the site of vessel injury. (medscape.com)
  • Pol δ is anchored to one of the three PCNA monomers through the C-terminal domain of the catalytic subunit. (nature.com)
  • Mammalian Pol δ consists of a catalytic subunit and three regulatory subunits (Fig. 1a ). (nature.com)
  • The catalytic subunit (p125) harbours the polymerase and exonuclease activities, and a metal-binding C-terminal domain (CTD). (nature.com)
  • Each subunit has a region called a motor domain (also known as its 'head') that can bind to the microtubule and to a molecule called ATP, which provides the energy required for the motor to step forward. (elifesciences.org)
  • The catalytic domain of this dual-specificity phosphatase has recently been mapped to the 180 most C-terminal amino acids. (embl.de)
  • non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases. (embl.de)
  • Using domain shuffling experiments, we present evidence showing that a central domain upstream of the conserved catalytic cysteine residue determines HopZ1 recognition specificity. (uea.ac.uk)
  • This entry represents the PTPase domain found in several tyrosine-specific protein phosphatases (PTPases). (embl.de)
  • Based on the results of this analysis, we also predict that the budding yeast arsenate resistance protein Acr2 and the ORF Ygr203w encode protein phosphatases with catalytic properties similar to that of the Cdc25 family. (embl.de)
  • is inclusive of papers focused on stucture, function, and properties of enzymes as well as catalytic and inhibition mechanisms of enzymes, mechanisms of drug action, and related advances on enzymes. (mdpi.com)
  • As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
  • Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. (dundee.ac.uk)
  • The CAZy database describes the families of structurally-related catalytic and carbohydrate-binding modules (or functional domains) of enzymes that degrade, modify, or create glycosidic bonds. (lu.se)
  • non-catalytic domains of mammalian Ubp-Y. (embl.de)
  • Thus we predict that both MsGC-β3 and mammalianβ2 subunits should form active homodimers. (biologists.com)
  • However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
  • All sequences in the B family contain a characteristic DTDS motif, and possess many functional domains, including a 5'-3' elongation domain, a 3'-5' exonuclease domain, a DNA binding domain, and binding domains for both dNTP's and pyrophosphate. (cathdb.info)
  • Thus, we have shown for the first time that deletion of 125 amino acids at the C-terminus of MutY generates a stable catalytic domain which retains the functional identity of the intact protein. (elsevierpure.com)
  • Functional diversity between PTPases is endowed by regulatory domains and subunits. (embl.de)
  • The short form, HisG S , lacks a regulatory domain and cannot bind histidine. (rcsb.org)
  • They then allowed each to bind to the catalytic domain of the toxin, and analyzed the structures using high-intensity x-rays at Brookhaven's National Synchrotron Light Source (NSLS). (bnl.gov)
  • The N-terminal C2a domain has been shown to bind phospholipids in a Ca2+-dependent manner (Fukuda, 1996 and Fukuda, 1997), while the role of the C2b domain remains unclear. (sdbonline.org)
  • XopAI uses an altered mART domain to bind its own N-terminal peptide containing a conserved Arg residue [ 8 ]. (expasy.org)
  • The first two of these repeats were later shown to bind the small G protein rho [ ( PUBMED:8647255 ) ( PUBMED:9446575 ) ] known to activate PKN in its GTP-bound form. (embl-heidelberg.de)
  • 1993). Based on these results, together with structural analyses of different ligand-binding models, it is apparent that SH2 domains bind distinct but overlapping sequence motifs. (lu.se)
  • Some of the receptor PTPases contain fibronectin type III (FN-III) repeats, immunoglobulin-like domains, MAM domains or carbonic anhydrase-like domains in their extracellular region. (embl.de)
  • We have gone on to determine crystal structures of these compounds bound to a 'humanized' form of murine TDP2. (rcsb.org)
  • High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin. (expasy.org)
  • Furthermore, after superposition of the palm domains of Pol II and gp43, the DNAs of the two ternary complexes have nearly identical structures. (cathdb.info)
  • We then survey alternative DNA structures that are formed by expandable repeats and review the evidence that formation of these structures is at the core of repeat instability. (stanford.edu)
  • Structures of a significant number of SH2 domains both in isolation and bound to various target molecules have been determined by X-ray crystallography and NMR spectroscopy. (lu.se)
  • The βD', βE and βF strands form an additional β-sheet that closes off one part of this side (Figure 2 and the notation used for describing the secondary structures). (lu.se)
  • Because the reaction has a ping pong kinetic mechanism, it can be divided into two half-reactions: a reductive half-reaction where NADH reduces the FAD and an oxidative half-reaction where CH 2 -H 4 folate returns the FAD to its oxidized form. (carleton.edu)
  • During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (joplink.net)
  • This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). (babraham.ac.uk)
  • By analyzing the single-molecule properties of engineered motors, we demonstrate that the non-catalytic domain has a key role in the motility mechanism by acting as a 'foothold' that allows Kar3 to bias translocation towards the minus end. (elifesciences.org)
  • HisZ triggers HisG S catalytic activity while rendering it sensitive to allosteric inhibition by histidine. (rcsb.org)
  • When mediated by nutrient levels, the process is reversible and catalytic-activity dependent. (upstate.edu)
  • PKM is rare in that while most protein kinases have both a catalytic domain, which is the part of the molecule that does its work, and a regulatory domain, akin to an on - off switch that can be used by other signaling pathways to shut off the activity of the kinase, PKM has only the catalytic domain - not the regulatory domain. (scienceblog.com)
  • Glanzman decided to study PKM in the marine snail, which has simple forms of learning and a simple nervous system, so that he could understand in precise detail how PKM's activity maintains a long-term memory, a process that is not well understood. (scienceblog.com)
  • Biochemical and activity-based probe analyses identify a non-canonical zinc finger domain as the E3 active site, which utilizes the strictly conserved Cys4462, not involved in zinc coordination, as the reactive nucleophile. (biorxiv.org)
  • The Gap1 catalytic domain alone is insufficient for in vivo activity of Gap1, indicating a requirement for the additional domains. (sdbonline.org)
  • An inositol-1,3,4,5-tetrakisphosphate (IP4)-sensitive extended PH domain is essential for Gap1 activity, while Ca2+-sensitive C2 domains and a glutamine-rich region contribute equally to full activity in vivo. (sdbonline.org)
  • We show that the CXXC domain of Tet1 has no DNA binding activity and is dispensable for catalytic activity in vivo. (cipsm.de)
  • Interestingly, neither wild type nor ΔCXXC Dnmt1 re-methylated imprinted CpG sites of the H19a promoter in dnmt1−/− ESCs, arguing against a role of the CXXC domain in restraining Dnmt1 methyltransferase activity on unmethylated CpG sites. (cipsm.de)
  • The fusion transcript encodes a chimeric protein that couples a segment of the heat shock protein, DNAJB1, with the catalytic domain of protein kinase A (PKA) and exhibits full retention of PKA activity. (medscape.com)
  • Warfarin inhibits the activity of vitamin K epoxide reductase and prevents recycling of vitamin K back to the reduced form, thus interfering with the synthesis of factor VII and other vitamin K-dependent factors. (medscape.com)
  • Among the mAbs, there were significant differences in extraction efficiency, ability to extract BoNT/A subtypes, and inhibitory effect on BoNT catalytic activity. (cdc.gov)
  • Structurally, all known receptor PTPases, are made up of a variable length extracellular domain, followed by a transmembrane region and a C-terminal catalytic cytoplasmic domain. (embl.de)
  • 10-13 TMPRSS2 contains an extracellular trypsin-like serine-protease domain that can proteolytically activate the spike (S) protein on the surface of SARS-CoV-2 viral particles 14 ( Fig. 1 ). (rsc.org)
  • its intracellular (COOH-terminal) region contains two PTP catalytic domains while the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), and differing levels of glycosylation. (bdbiosciences.com)
  • However, the physiological relevance of any of these domains for Gap1 in vivo function has not been established. (sdbonline.org)
  • Surprisingly, a Dnmt1 mutant construct lacking the CXXC domain formed covalent complexes with cytosine bases both in vitro and in vivo and rescued DNA methylation patterns in dnmt1−/− embryonic stem cells (ESCs) just as efficiently as wild type Dnmt1. (cipsm.de)
  • Binding of SH2 domains to their in vivo targets recruits the SH2 domain-containing protein to its proper signalling complex and thereby initiates or regulates downstream signalling cascades (reviewed in Schlessinger and Lemmon, 2003). (lu.se)
  • 1998). In both examples, the high affinity ligands can compete with the intramolecular interactions and release the catalytic domains for their in vivo targets. (lu.se)
  • Supporting these findings, different SH2 domains have been shown to compete for same binding target in vivo (e.g. (lu.se)
  • A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain. (embl.de)
  • Cdc25 phosphatase catalytic domain. (embl.de)
  • The relationship of Cdc25 to the structurally well-characterized rhodanese spans the entire catalytic domain and served as template for a structural model for human Cdc25a, which is fundamentally different from previously suggested models for Cdc25 catalytic domain organization. (embl.de)
  • In addition to bonds formed by the HMG-like moiety, statins exhibit different types and numbers of binding interactions in association with structural differences. (nih.gov)
  • The structure of Pol alpha bound to RNA primer/DNA template shows that, although the palm domain makes a canonical set of interactions with the first 3 bp of the primer-template helix, the thumb domain engages almost exclusively with the RNA primer strand. (cathdb.info)
  • The interactions between the thumb domain and the RNA primer are concentrated in a contiguous region of five nucleotides, from position two to six of the RNA primer and involve solely the ribose and phosphate moieties of the RNA backbone. (cathdb.info)
  • A large proportion of these interactions involves the binding of short linear motifs (SLiMs) by folded globular domains. (sciencegate.app)
  • The catalytic domain of Clostridium botulinum neurotoxin type F (represented as a molecular surface, gray) bound to an inhibitor molecule (colored ribbon) designed to mimic the nerve-cell protein the toxin cleaves. (bnl.gov)
  • Apart from the catalytic domain in the middle of the molecule, all Gap1 family members share two N-terminal C2 domains and a C-terminal extended PH domain. (sdbonline.org)
  • Negative stain TEM and image averaging showed the triangularity of a recombinant CESA cytosolic domain, consistent with previous modeling of its trimeric nature from small angle scattering (SAXS) data. (osti.gov)
  • The catalytic core of DNA polymerase is formed from the thumb, palm and finger domains. (cathdb.info)
  • This superfamily entry represents the palm domain of DNA polymerases B. Members of this superfamily include: DNA Polymerase alpha, delta, epsilon, zeta, DNA polymerase II (Pol II) in E. coli, yeast and Archaea. (cathdb.info)
  • The heavy chain is responsible for both receptor some species of the genus Clostridium, in particular, Clostridium binding via its C-terminal (CT) binding domain [4,5] (HC) and botulinum, C. butyricum, C. baratii, and C. argentinense. (cdc.gov)
  • Family B DNA polymerases consist of five main structural domains: the N domain, the 3' - 5' Exo (exonuclease) domain, the palm domain, the finger domain and the thumb domain. (cathdb.info)
  • F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. (joplink.net)
  • Whenever each glutamyl residue is carboxylated, the reduced vitamin K is converted to the epoxide form. (medscape.com)
  • a Domain organization of the four subunits of human Pol δ and amino acid sequence of PCNA-interacting (PIP-box) motifs. (nature.com)
  • Sequence alignment showed that both CXXC domains have a very similar framework but differ in the central tip region. (cipsm.de)
  • This domain contains two long alpha helices forming a left-handed antiparallel coiled-coil fold termed the antiparallel coiled- coil (ACC) finger domain. (embl-heidelberg.de)
  • All the analysed SH2 domains have a typical SH2 domain fold consisting of a large anti-parallel β-sheet sandwiched between two α-helices The central β-sheet divides the domain into two functionally separate sides. (lu.se)
  • The knowledge gained from these investigations prove that the self-organized phases with aggregated non-polar and charged domains of ILs are the choice of sensing materials for EC and QCM based methane sensors which form the foundation to develop commercial methane sensors for mine safety application using the results obtained from this study. (cdc.gov)
  • The long form, HisG L , is a single polypeptide chain with catalytic and regulatory domains. (rcsb.org)
  • The catalytic core sits on top of PCNA in an open configuration while the regulatory subunits project laterally. (nature.com)
  • The endo-mannanase from T. reesei has a small polysaccharide binding domain, separated from the catalytic domain by a highly glycosylated linker peptide. (lu.se)
  • PTPase domains consist of about 300 amino acids. (embl.de)
  • non-catalytic domains of yeast PTP-type MAPK-phosphatases. (embl.de)
  • non-catalytic domains of yeast Ubp4, Ubp5, Ubp7. (embl.de)
  • In contrast to the continuous leading strand synthesis, the lagging strand is synthesized discontinuously in ~200 nucleotide (nt)-long Okazaki fragments, which are then ligated to form the contiguous lagging strand 2 . (nature.com)
  • Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
  • Two forms of ATPPRT, encoded by the hisG gene, exist in nature, depending on the species. (rcsb.org)
  • [ 3 ] Mutations have been identified throughout the gene, affecting all domains of the transcribed protein, most frequently the catalytic domain. (medscape.com)
  • Subunits alpha and beta form the catalytic core in F1. (joplink.net)
  • Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core and two C-terminal β-barrel domains. (biovendor.com)
  • Each domain core is formed mainly by perpendicular packing of a five-stranded mixed β-sheet against a three-stranded antiparallel β-sheet. (expasy.org)
  • The profile we developed covers the entire TR mART core domain. (expasy.org)
  • In this project the core skills of MIP Technologies and Physical Chemistry in polymer design and studies of the colloidal domain have signifi cant overlap and complementarity. (lu.se)
  • The inactive domains of tandem phosphatases can be divided into two classes. (embl.de)
  • In this study we demonstrate that MsGC-β3 does form active homodimers and also show that it is capable of forming heterodimers with the NO-sensitive subunits, although these heterodimers are inactive. (biologists.com)
  • Some enzymatically inactive mART domains, for example, the N-terminal domains of C2 and VIP2 toxins, have acquired a new, protein-binding function. (expasy.org)
  • Intoxication with delivering the catalytic light chain (LC) to its target via its N- one of the seven distinct serotypes of BoNT (A-G) causes botulism, terminal translocation domain (HN) [6]. (cdc.gov)
  • CTD C-terminal domain, OB oligonucleotide binding domain, PDE phosphodiesterase domain. (nature.com)
  • In the blood coagulation cascade, factor X is cleaved to form factor Xa, an active serine protease. (medscape.com)
  • The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
  • We compared the structure and function of the CXXC domains in the DNA methyltransferase Dnmt1 and the methylcytosine dioxygenase Tet1. (cipsm.de)
  • Exon 2 contains the junction of the membrane-binding domain and the catalytic domain of b5R, which shows that there are two forms of b5R: a soluble form and a membrane-bound form. (wikipedia.org)
  • this isoform has one hydrophobic membrane-anchoring domain and one catalytic domain that is hydrophilic. (wikipedia.org)
  • The NH2-terminal structure of the membrane-binding domain is CH3(CH2)12-CO-Gly-Ala-Gln-Leu-Ser-Thr-Leu-Gly-His-Met-Val-Leu-Phe-Pro-Val-Trp-Phe-Leu-Tyr-Ser-Leu-Leu-Met-Lys. (wikipedia.org)
  • Two forms of NADH-cytochrome b5 reductase are known, a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondria and other membranes) and a soluble form in erythrocytes. (wikipedia.org)
  • The membrane-bound form has both membrane-binding and catalytic domains. (wikipedia.org)
  • Of the two forms of NADH-cytochrome b5 reductase, the membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. (wikipedia.org)
  • Cullen, 1997), suggesting that an increase in intracellular IP4 levels leads to the release of the PH domain from the membrane. (sdbonline.org)
  • Fukuda, 1996), implying that release of the PH domain from the membrane is accompanied by activation of the catalytic domain. (sdbonline.org)
  • Furthermore, galactomannans are very interesting substrates due to their gel-forming properties. (lu.se)
  • The major proportion of factor VII circulates in plasma in zymogen form, and activation of this form results in cleavage of the peptide bond between arginine 152 and isoleucine 153. (medscape.com)
  • Based on the known structure of a similar MLL1 domain we developed homology models and designed expression constructs for the isolated CXXC domains of Dnmt1 and Tet1 accordingly. (cipsm.de)
  • The mART domain adopts a mixed α/β-fold with a characteristic β-sandwich structure. (expasy.org)