Intravenous immunoglobulin (IVIG) has been used primarily for immune deficiency patients, and its greatest expansion is seen more and more in the treatment of autoimmune disorders, especially in neurology. (nursingcenter.com)
Intravenous immunoglobulin (IVIG) is a polymeric highly purified immunoglobulin fraction derived from large pools of up to 60,000 plasma donors. (nursingcenter.com)
The optimal AAVrh.10 vector was further evaluated for their immune escape potential, in animals pre-immunized with human intravenous immunoglobulin. (nih.gov)
Intravenous immunoglobulin (IVIg) is an FDA-approved therapeutic modality used for various inflammatory diseases. (scienceopen.com)
However, presently, intravenous immunoglobulin (IVIG) replacement therapy is generally accepted as the treatment of choice for selected patients with IgG subclass deficiency and persons with other immunodeficiencies. (medscape.com)
IVIG2
The action of IVIG is mediated through both the variable and the constant regions of the Fab 2 as well as the Fc portion of the immunoglobulin molecule. (nursingcenter.com)
Currently, intravenous human immunoglobulin (IVIG) treatment is being explored in multiple off-label uses other than immunotherapy, including AD. (sciencedaily.com)
Antibodies3
More importantly, the mutant AAVrh.10 vector was able to partially evade neutralizing antibodies (~27-64 fold) in pre-immunized animals. (nih.gov)
A recent clinical study showed that LifeinU BSCU1 significantly increased the level of secretory immunoglobulins A (sIgA), which the company describes as immune system antibodies that act as a first-line defense against toxins and infectious agents. (nutritionaloutlook.com)
Serological data such as seroconversion or a four-fold increase in paired sera would also be applicable to Toscana virus as well as the presence of IgM in a unique serum sample is indicative of a probable case of infection. (europa.eu)
Mice were tail bled prior to exposure and bi-weekly thereafter to obtain total and specific serum immunoglobulin levels. (cdc.gov)
A slight polyclonal increase in immunoglobulin on serum protein electrophoresis, consistent with HIV infection. (scielo.org.za)
Selective antibody deficiency with normal immunoglobulins (Ig) is characterized by deficient specific antibody response to polysaccharide antigens but not to protein antigens, despite normal or near normal serum levels of immunoglobulins, including IgG subclasses. (msdmanuals.com)
Proteins7
In the recent PNAS study, the Wiseman lab, in collaboration with Jeffery Kelly's lab at TSRI, focused on a systemic amyloid disease called light chain amyloidosis, where the unstable proteins are called light chain immunoglobulins. (scripps.edu)
In the ER, proteins, such as immunoglobulin light chains, fold into structures that are then secreted into the blood where they perform important functions in the body. (scripps.edu)
In light chain amyloidosis, mutations in immunoglobulin light chains make the proteins unstable, allowing them to unfold in the blood and form toxic clusters (aggregates) that damage the heart. (scripps.edu)
The UPR regulates ER function through the increased expression of proteins, such as "chaperones," that directly influence the folding and secretion of destabilized proteins. (scripps.edu)
Using a chemical biologic approach, the researchers showed that activation of the UPR-associated protein ATF6 increases expression of many ER proteins involved in regulating protein folding and trafficking and reduces secretion of disease-associated light chains without causing toxic consequences. (scripps.edu)
These studies demonstrated that endotoxin induced an immunoglobulin class switch whereas glutaraldehyde augmented the IgE response to NRL proteins. (cdc.gov)
These methods dramatically increase the likelihood of producing proteins that cannot fold or assemble appropriately. (cipsm.de)
Protein9
The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology, consisting of about 125 amino acids. (wikipedia.org)
Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (wikipedia.org)
Usually, protein transport occurs before the nascent protein has folded. (elifesciences.org)
This paper explores how the protein folding process per se may be exploited to drive protein translocation. (elifesciences.org)
The protein must then fold during or after the translocation process. (elifesciences.org)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
Nonetheless, nascent polypeptides with more complex tertiary structure fold close to and outside the tunnel, as found for spectrin - a three-helix bundle protein, and titin, an all beta-sheet immunoglobulin domain 10,13. (biorxiv.org)
Structural details on the organisation of FLN5 and FLN6 NC within the ribosome and the effect of the ribosome on the folding of FLN5 remains to be understood that would help to address the question on how the ribosome modulates co-translational protein folding. (biorxiv.org)
Titers3
His workup after the last case revealed an absence of immunodeficiency and a greater than 4-fold increase in coxsackievirus B titers. (medscape.com)
No serologic evidence of acute infection was identified, and titers of immunoglobulin G remained elevated for 1 year following this third episode. (medscape.com)
titers of specific immunoglobulins to Pfs 25 were approximately ten-fold higher across dose levels when the iBioModulator was used. (globenewswire.com)
Selective3
To analyze the presence of selective immunoglobulin M immunodeficiency (SIgMD) among long-term clozapine-treated outpatients in a nested case-control study. (psychiatrist.com)
Selective immunoglobulin M immunodeficiency (SIgMD) is a rare form of dysgammaglobulinemia, which is characterized by a selective low level of IgM in conjunction with normal T cell numbers and function and no other identifiable immunodeficiency. (psychiatrist.com)
However, prior to immunoglobulin treatment, repeated measurements of IgG level, specific antibody, or subclass are necessary for documentation of selective deficiencies. (medscape.com)
Antibody2
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
A clinically compatible illness occurring during a period when arboviral transmission is likely, and with the following supportive serology: a stable (less than two-fold change) elevated antibody titer to an arbovirus (e.g., greater than 320 by hemagglutination inhibition, greater than 128 by complement fixation, greater than 256 by immunofluorescence, and greater than160 by neutralization), or a positive serologic result by enzyme immunoassay (EIA). (cdc.gov)
Genes2
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. (jax.org)
Here we test this hypothesis by exploiting a Burkitt's lymphoma line (Ramos) that we have previously shown to hypermutate its immunoglobulin genes constitutively. (lu.se)
Epicanthal1
These features can include folds of skin that cover the inner corners of the eyes (epicanthal folds), a prominent nasal bridge, and abnormally shaped ears. (medlineplus.gov)
H. pylori Csd4 consists of three domains: an N-terminal D,L-carboxypeptidase domain with a typical carboxypeptidase fold, a central β-barrel domain with a novel fold and a C-terminal immunoglobulin-like domain. (rcsb.org)
Studies using cryo-EM have shown NC folding within the exit tunnel is largely limited to the formation of rudimentary secondary structure, pre-dominantly α helices within different areas of the tunnel, while β hairpins as well as the formation of small domains in the wider vestibule region of the tunnel 9-13. (biorxiv.org)
FLNa dimeric subunits have N-terminal spectrin family F-actin binding domains (ABDs) and an elongated flexible segment of 24 immunoglobulin (Ig) repeats. (rupress.org)
The ribosome-NC contacts within the vestibule define these NC pathways and modulate position of a folded immunoglobulin domain outside the ribosome. (biorxiv.org)
Amino acid1
therefore, cellular and molecular analyses of RTX and CA125 interaction were peformed, and a library of RTX variants was generated using a proprietary technology called Block‑Removed Immunoglobulin Technology that combines randomized amino acid substitutions and high‑throughput functional screenings to identify CA125‑refractory RTX variants. (spandidos-publications.com)
Levels3
Therefore, due to speculated immunosuppressive effects of clozapine as a part of its antipsychotic effect, which can alter levels of immunoglobulins and eventually may lead to SIgMD, we investigated the presence of SIgMD among clozapine-treated patients with the purpose of clinical management. (psychiatrist.com)
However, upon co-exposure to levels of glutaraldehyde in the range of the PEL a dose responsive increase in both total (3 fold) and NRL specific (>40 fold) IgE was observed. (cdc.gov)
[ 27 ] Monitoring trough immunoglobulin levels may help define the optimal time between doses because immunoglobulin clearance varies from patient to patient. (medscape.com)
Doses1
Dr. Pasinetti and his team of investigators recently found that prolonged administration of human immunoglobulin in models of Alzheimer's disease, using a dose of immunoglobulin ~5-20-fold less than equivalent doses used in Alzheimer's disease patients, is effective at attenuating Alzheimer's disease-type cognitive dysfunction while promoting synaptic plasticity. (sciencedaily.com)
Infection1
EIAs) for detection of HBoV-specific immunoglobulin other virus, 64% had a serologically verified HBoV infection. (cdc.gov)
Nascent1
Recently, it has been found that ribosomes can also play a significant role in the process of co-translational folding by modulating the folding of a nascent chain (NC) during translation 1-6. (biorxiv.org)
Gene1
Burkitt's lymphomas harbour chromosomal translocations bringing c-MYC into the vicinity of one of the immunoglobulin gene loci. (lu.se)
We then determined that the standard iron dextran treatment used to prevent iron deficiency anemia (100 mg iron given intramuscularly), was associated with a two-fold increase (P (usda.gov)
Indeed, this strategy has resulted in a 25-fold increase in cell density in cultures from 1986-2007. (genengnews.com)
DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells. (scienceopen.com)
Occurs1
Initial analyses of these RNCs revealed the transition of FLN5 to the folded state occurs when it is bound to the ribosome by a linker of approximately 45 amino acids 2, 20. (biorxiv.org)
Large1
Immunoglobulin preparations for replacement therapy are prepared from large pools of plasma obtained from thousands of donors. (medscape.com)
Source1
This is an approach to treat light chain amyloidosis that 'cuts it off at the source' by not allowing the disease-associated immunoglobulin light chain to get out of cells to aggregate," said TSRI Research Associate Christina Cooley, co-first author of the new study with Lisa M. Ryno, now an assistant professor at Oberlin College. (scripps.edu)