• human macrophage foam cells
  • The aim of the current study was to investigate whether human macrophage foam cells degrade the extracellular matrix (ECM) of atherosclerotic plaques by cathepsin K mediated processes. (pubmedcentralcanada.ca)
  • Human macrophage foam cells degrade the atherosclerotic plaques though cathepsin K mediated processes, resulting in increase in levels of CTX-I. Serum CTX-I was not elevated in women with aortic calcification, likely due to the contribution of CTX-I from osteoclastic bone resorption which involves Cathepsin-K. The human macrophage model system may be used to identify important pathway leading to excessive proteolytic plaque remodeling and plaque rupture. (pubmedcentralcanada.ca)
  • study
  • Researchers study the role of PPAR-activators in foam cell formation and cholesterol metabolism, as well as the regulation of the ABCA1 pathway in patients with Tangier disease. (readabstracts.com)