• Escherichia
  • The article reflects on the escherichia coli that is resistant to fluoroquinolone. (ebscohost.com)
  • A fluoroquinolone-resistant Escherichia coli strain of sequence type ST131 caused severe septic arthritis and contiguous osteomyelitis in an 8-month-old girl, and colonized the girl's healthy mother, who shared a different fecal E. coli strain with the father. (lww.com)
  • Aerobic Gram-positive microorganisms: Staphylococcus aureus (methicillin-susceptible strains) Streptococcus pneumoniae (penicillin-susceptible strains) Streptococcus pyogenes Aerobic Gram-negative microorganisms Citrobacter koseri (Citrobacter diversus) Enterobacter aerogenes Escherichia coli Haemophilus influenzae Klebsiella pneumoniae Neisseria gonorrhoeae Proteus mirabilis Pseudomonas aeruginosa Other microorganisms: Chlamydia trachomatis In general, fluoroquinolones are well tolerated, with most side-effects being mild to moderate. (wikipedia.org)
  • tendon
  • Fluoroquinolones have been associated with tendon disorders, usually during the first month of treatment, 1 - 5 but the epidemiological evidence is scanty. (bmj.com)
  • We did a nested case-control study among users of fluoroquinolones in a large UK general practice database to study the association with Achilles tendon disorders. (bmj.com)
  • We defined current use as when the tendon disorder occurred in the period between the start of the fluoroquinolone treatment and the calculated end date plus 30 days, recent use as when the calculated end date was between 30 and 90 days before the occurrence of the disorder, and past use as when the calculated end date was more than 90 days before the occurrence of the disorder. (bmj.com)
  • The adjusted relative risk of Achilles tendon disorders with current use of fluoroquinolones was 1.9 (95% confidence interval 1.3 to 2.6). (bmj.com)
  • The most severe form of tendonopathy associated with fluoroquinolone administration is tendon rupture, which in the great majority of cases involves the Achilles tendon. (wikipedia.org)
  • Tendon damage may manifest during, as well as up to a year after fluoroquinolone therapy has been completed. (wikipedia.org)
  • In 2008, the United States Food and Drug Administration (FDA) requested that all quinolone/fluoroquinolone drugs package inserts include a Black Boxed Warning concerning the risk of spontaneous tendon ruptures, which would have included flumequine. (wikipedia.org)
  • treatment
  • Because St. John's wort and dong quai may also cause this problem, taking these herbal supplements during treatment with fluoroquinolone drugs might add to the risk. (memorialhospitaljax.com)
  • Selection of a fluoroquinolone for the treatment or prevention of an infection should be limited to those conditions that are proven or strongly suspected to be caused by bacteria. (medpagetoday.com)
  • Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis and uncomplicated urinary tract infections, the FDA has determined that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options. (fluoridealert.org)
  • The label also contains new limitation-of-use statements to reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis and uncomplicated urinary tract infections. (fluoridealert.org)
  • In November 2015, an FDA Advisory Committee discussed the risks and benefits of fluoroquinolones for the treatment of acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis and uncomplicated urinary tract infections based on new safety information. (fluoridealert.org)
  • The advisory committee concluded that the serious risks associated with the use of fluoroquinolones for these types of uncomplicated infections generally outweighed the benefits for patients with other treatment options. (fluoridealert.org)
  • Individuals with FQAD are defined as "U.S. patients who were reported to be previously healthy and prescribed an oral fluoroquinolone antibacterial drug for the treatment of uncomplicated sinusitis, bronchitis, or urinary tract infection (UTI). (wikipedia.org)
  • Treatment of MDR-TB requires second-line drugs (i.e., fluoroquinolones, aminoglycosides, and others), which in general are less effective, more toxic and much more expensive than first-line drugs. (wikipedia.org)
  • drugs
  • One of the most effective second-line drugs is fluoroquinolone . (ersjournals.com)
  • In a communication dated 15 August 2013, the following warning was posted on the FDA website: "FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection. (wikipedia.org)
  • After lengthy testimony and discussion, the committees decided that the current labeling for these drugs was unacceptable, recommending additional study, discussion and action to make both patient and practitioners aware of the potential for both temporary and permanent adverse reactions to the drugs, particularly requiring physicians to be more completely informed that fluoroquinolones are not to be used as a first line of defense against the three maladies discussed. (wikipedia.org)
  • Even though this was the first fluoroquinolone, it is often overlooked when classifying the drugs within this class by generations and excluded from such a list. (wikipedia.org)
  • TB can usually be treated with a course of four standard, or first-line, anti-TB drugs (i.e., isoniazid, rifampin and any fluoroquinolone). (wikipedia.org)
  • Fluoroquinolone drugs, fluoroquinolone use has been linked to serious cases of toxic psychosis that have been reported to be irreversible and permanent, see adverse effects of fluoroquinolones The related quinoline derivative mefloquine (Lariam) has also been associated with psychosis. (wikipedia.org)
  • widely
  • After oral and parenteral administration, fluoroquinolones are widely distributed in most extracellular and intracellular fluids and are concentrated in the prostate, lungs, and bile. (merckmanuals.com)
  • In this study, regional environmental distribution simulation and risk assessment for three commonly used fluoroquinolones in the Wenyu River Catchment were conducted using a typical catchment model widely used in the Europe. (environmental-expert.com)
  • FQAD
  • Fluoroquinolone-Associated Disability ("FQAD") is an FDA formal review identification for a constellation of symptoms that have been identified in the FDA's Adverse Event Reporting System (FAERS) in review of data in the fluoroquinolone safety reports. (wikipedia.org)
  • toxic
  • Although the mechanism is unknown, the sudden onset of some tendinopathies, occasionally after a single dose of a fluoroquinolone, suggests a direct toxic effect on collagen fibres. (bmj.com)
  • drug
  • Today's action also follows a May 12, 2016, drug safety communication advising that fluoroquinolones should be reserved for these conditions only when there are no other options available due to potentially permanent, disabling side effects occurring together. (fluoridealert.org)
  • On August 15, 2013 the FDA issued a Safety Announcement where they described that they are requiring the medication guides and drug labels for all fluoroquinolones to be updated and better describe the risk for peripheral neuropathy. (wikipedia.org)
  • study showed
  • The presence of these fluoroquinolones in the catchment of this study showed significant characteristics of the occurrence of pharmaceuticals in the aquatic environment in an urban river, a typical kind of "down‐the‐drain" chemicals. (environmental-expert.com)
  • Safety
  • The patient Medication Guide that is required to be given to the patient with each fluoroquinolone prescription describes the safety issues associated with these medicines. (fluoridealert.org)