SituTumorMetastasisTumorsKidney NeoplasmsTransitional Cell CarcMuscle-invasive bladder cancerMalignancyRenalPapillaryUrothelial carcinomaPathologyBenignSingle Nucleotide PBiopsyLower urinary tractDiagnosisHematuriaDiagnosticCystoscopyProstate cancerOvarianUrotheliumMalignant potentialPatientsResectionUreterMetastaticSensitivityCellsDetectionTURBTEpidemiologyIncidencePediatricCell CycleAbnormalitiesUpper tractLesionsEvaluationImmatureExcision
Situ14
- Objectives: To determine the sensitivity and specificity of combining fluorescence in situ hybridization (FISH) measurement of chromosome 9 and DNA cytometry of bladder irrigation specimens in the detection of bladder cancer. (johnshopkins.edu)
- We determined the cost-effectiveness of using fluorescence in situ hybridization assays to determine the need for biopsy in patients with atypical cytology and equivocal or negative cystoscopy. (elsevierpure.com)
- Materials and Methods Data from 2 large prospective studies evaluating the usefulness of fluorescence in situ hybridization in the setting of atypical cytology to detect urothelial carcinoma were combined. (elsevierpure.com)
- The data were used to calculate sensitivity and specificity for the UroVysion® fluorescence in situ hybridization assay in various clinical scenarios. (elsevierpure.com)
- In patients with equivocal cystoscopy (assuming biopsy was performed in the operating room) biopsy based on fluorescence in situ hybridization results saved $1,740 per patient ($3,267 vs $1,527 per patient) and avoided 42 biopsies compared to biopsy in all patients. (elsevierpure.com)
- If office based biopsies were used then cost savings using fluorescence in situ hybridization results were $95 per patient. (elsevierpure.com)
- Among patients with negative cystoscopy biopsy based on fluorescence in situ hybridization resulted in costs savings of $2,241 per patient, avoiding 167 biopsies, compared to biopsy in all patients. (elsevierpure.com)
- Conclusions The decision to perform biopsy based on fluorescence in situ hybridization assay in patients with atypical cytology and equivocal or negative cystoscopy was associated with a significant decrease in bladder cancer associated costs. (elsevierpure.com)
- Gayed, BA , Seideman, C & Lotan, Y 2013, ' Cost-effectiveness of fluorescence in situ hybridization in patients with atypical cytology for the detection of urothelial carcinoma ', Journal of Urology , vol. 190, no. 4, pp. 1181-1186. (elsevierpure.com)
- [ 13 ] In contrast, the study reported that chromosomal abnormalities detected by UroVysion fluorescence in situ hybridization are sometimes present in patients older than 19-20 years. (medscape.com)
- Value of multicolour fluorescence in situ hybridisation (UroVysion) in the differential diagnosis of flat urothelial lesions. (nih.gov)
- RNA pull down assay, luciferase reporter assay and fluorescence in situ hybridization were applied to verify the interaction between BCRC-3 and microRNAs. (biomedcentral.com)
- The treatment of non-muscle-invasive (Ta, T1, carcinoma in situ [CIS]) and muscle-invasive bladder cancer should be differentiated. (medscape.com)
- The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
Tumor5
- Bladder cancer patients were sampled in the absence of observable tumor (256 specimens) and concurrently with tumor (204 specimens). (johnshopkins.edu)
- Often the tumor will regrow from those resistant cells, the patient will relapse, and the therapy that had been previously used will no longer kill the cancer cells. (wikipedia.org)
- Most benign spindle cell tumors of the urinary bladder are an inflammatory myofibroblastic tumor (IMT). (medscape.com)
- Microscopic findings of inflammatory myofibroblastic tumor of the bladder. (medscape.com)
- The two principal treatment choices in muscle-invasive bladder cancer are radical cystectomy and transurethral resection of bladder tumor (TURBT) followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy). (medscape.com)
Metastasis2
- Our previous study had identified the negative correlation between circHIPK3 and bladder cancer grade, invasion, as well as lymph node metastasis. (biomedcentral.com)
- Bladder cancer (BC) is the number one malignancy of urinary system with an estimated over 79,030 deaths predicted in 2017 in the United State [ 1 ].The high rate of recurrence and distant metastasis of BC created a huge economic burden in EU [ 2 ]. (biomedcentral.com)
Tumors7
- Cells in pre-malignant and malignant neoplasms (tumors) evolve by natural selection. (wikipedia.org)
- Urothelial papilloma has a low incidence, representing 1%-4% of bladder tumors. (medscape.com)
- According to the authors, the molecular characteristics and clinical behavior of pediatric bladder tumors are, with the exception of rhabdomyosarcoma, less well understood than those in adults. (medscape.com)
- 11] The oldest large series of 38 spindle cell tumors in the urinary bladder included 17 pseudotumors, 4 postoperative spindle cell nodules (PSCNs), and 13 sarcomas. (medscape.com)
- In the future, treatment selection for muscle-invasive bladder cancer is likely to be based on testing of tumors for biomarkers that indicate treatment sensitivity. (medscape.com)
- Patients with resistant tumors would be offered upfront cystectomy, while those with chemoradiation-sensitive tumors would be offered bladder-preserving therapy, with regimens selected on the basis of genetic analysis. (medscape.com)
- Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
Kidney Neoplasms1
- Renal cell carcinoma (RCC) originates from either the cancerous renal cortex or renal tubular epithelial cells, and is the second most lethal urological malignancy, accounting for 90-95% of kidney neoplasms. (biomedcentral.com)
Transitional Cell Carc1
- The choice of VOCs for the initial part was based on an extensive systematic search of the literature and then followed up using urinary samples from patients with urinary bladder transitional cell carcinoma. (dundee.ac.uk)
Muscle-invasive bladder cancer2
- Chedgy and Black propose that radical cystectomy should be considered the gold-standard treatment for muscle-invasive bladder cancer. (medscape.com)
- In contrast, Mitin recommends considering trimodality therapy as the first option for patients with muscle-invasive bladder cancer, with cystectomy reserved for patients who are unable or unwilling to undergo bladder preservation or for salvage in the case of local recurrence. (medscape.com)
Malignancy3
- Kalra S , Manikandan R, Dorairajan LN, Badhe B. Synchronously detected secondary signet ring cell urinary bladder malignancy from the stomach masquerading as genitourinary tuberculosis. (edu.in)
- Indocyanine green cannot predict malignancy in partial nephrectomy: histopathologic correlation with fluorescence pattern in 100 patients. (wakehealth.edu)
- Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)
Renal1
- TCC can arise anywhere in the urinary tract, including the renal pelvis, ureter, bladder, and urethra, but it is usually found in the urinary bladder. (medscape.com)
Papillary6
- the endoscopic appearance is identical to that of low-grade papillary neoplasms. (medscape.com)
- In a study of the immunohistochemical expression of cytokeratin 20, p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder, Alrashidy et al concluded that the intense positivity of suspicious cells for at least one of these markers would confirm the presence of malignant changes and favors the diagnosis of carcinoma. (medscape.com)
- One study found a comparable percentage of FGFR3 mutations in cases of papillary urothelial neoplasm of low malignant potential (PUNLMP) and low-grade papillary urothelial carcinoma. (medscape.com)
- A type of hyperplasia that is characterized by variable thickening of the urinary tract epithelium and a slight papillary growth. (nih.gov)
- Papillary urothelial hyperplasia: relationship to urothelial neoplasms. (nih.gov)
- A precursor to papillary neoplasms. (nih.gov)
Urothelial carcinoma5
- Primary upper urinary tract (UT) urothelial carcinoma (UC) is rare. (cytojournal.com)
- Urothelial carcinoma (UC) is one the most common malignancies derived from the urothelium of the lower urinary tract. (medsci.org)
- Perioperative outcomes of robot-assisted nephroureterectomy for upper urinary tract urothelial carcinoma: a multi-institutional series. (wakehealth.edu)
- Oncologic Outcomes Following Robot-Assisted Laparoscopic Nephroureterectomy with Bladder Cuff Excision for Upper Tract Urothelial Carcinoma. (wakehealth.edu)
- Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. (biocare.net)
Pathology1
- Corresponding author: Dr. Maria Gabriella Malzone, Pathology and Cytopathology Unit, National Cancer Institute "Fondazione G. Pascale", via Mariano Semmola, 80131 Napoli, Italy. (medsci.org)
Benign2
- Urothelial papilloma is an uncommon benign exophytic neoplasm composed of a delicate fibrovascular core covered by normal-appearing urothelium. (medscape.com)
- The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
Single Nucleotide P1
- [ 80 ] For example, presence of the MRE11A single-nucleotide polymorphism rs1805363 has been associated with worse cancer-specific survival after radiation therapy, with a gene-dosage effect observed, but not after cystectomy. (medscape.com)
Biopsy1
- Evaluations with or without bladder biopsy and with or without upper tract evaluation were considered. (elsevierpure.com)
Lower urinary tract1
- Brucker BM, Nitti VW, Kalra S , Herbert J, Sadiq A, Utomo P, Aponte MM. Barriers experienced by patients with multiple sclerosis in seeking care for lower urinary tract symptoms. (edu.in)
Diagnosis2
- Overall, the experiments in this study describe a real-time platform for non-invasive bladder cancer diagnosis using fluorescence-based gassensor arrays. (dundee.ac.uk)
- It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
Hematuria1
- The most common presenting symptom is hematuria, followed by bladder outlet obstruction and dysuria. (medscape.com)
Diagnostic2
- Herein, we demonstrate a novel diagnostic platform based on an optic fluorescence sensor array for detecting urinary bladder cancer VOCs biomarkers. (dundee.ac.uk)
- Diagnostic pitfalls and review of literature, International Journal of Gynaecological Cancer, 2006, 16 (1) 319-321. (manipal.edu)
Cystoscopy1
- Purpose Patients with atypical cytology and equivocal or negative cystoscopy pose a challenge due to uncertainty about the presence of cancer. (elsevierpure.com)
Prostate cancer3
- Is it possible to predict low-volume and insignificant prostate cancer by core needle biopsies? (regionh.dk)
- Prostate Cancer and Prostatic Diseases. (elsevierpure.com)
- doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al. (dieselok.md)
Ovarian3
- This review was conducted to summarize, in a concise and systematic manner, the available scientific data relating endometriosis to ovarian cancer, published in the past five years. (endometriosi.it)
- Endometriosis is associated with an increased risk of developing epithelial ovarian cancer (EOC), mainly of endometrioid and clear cell subtypes. (endometriosi.it)
- in 25% of patients a neoplasm is detected after neurologic symptoms onset (most common being ovarian teratoma). (medlink.com)
Urothelium1
- Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
Malignant potential1
- Urothelial Proliferation of Unknown Malignant Potential Involving the Bladder: Histopathologic Features and Risk of Progression in De Novo Cases and Cases With Prior Neoplasia. (nih.gov)
Patients10
- Methods: Bladder irrigation specimens were obtained from 37 normal control patients and 317 bladder cancer patients during cystoscopic examinations. (johnshopkins.edu)
- Conclusions: The lack of increase with grade in the percentage of positive specimens by FISH supports the hypothesis that chromosome 9 aberrations are critical events in bladder tumorigenesis for many patients. (johnshopkins.edu)
- These neoplasms tend to occur in younger patients and may be seen in children. (medscape.com)
- [ 5 ] Urothelial papilloma may arise as a de novo neoplasm, or it may occur as a secondary papilloma in patients with a history of bladder cancer. (medscape.com)
- Williamson et al reported results that support the idea that mutations of the FGFR3 and TP53 genes are rare or absent in urothelial neoplasms of young patients. (medscape.com)
- All five urine samples from bladder cancer patients and five healthy controls were successfully identified with the same sensor arrays. (dundee.ac.uk)
- Pseudocarcinomatous urothelial hyperplasia of the bladder: clinical findings and followup of 70 patients. (nih.gov)
- Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer? (wakehealth.edu)
- Predictors of Medical and Surgical Complications After Robot-Assisted Partial Nephrectomy: An Analysis of 1139 Patients in a Multi-Institutional Kidney Cancer Database. (wakehealth.edu)
- They cite recommendations from European and United States guidelines, as well as published literature showing a 75% 5-year cancer-specific survival for all stages of bladder cancer treated with cystectomy, while noting that the published literature on trimodality therapy shows evidence of inferior survival and frequent treatment failure, with almost one-third of patients eventually requiring a salvage cystectomy. (medscape.com)
Resection1
- While chemotherapy is generally a standalone treatment or used in conjunction with radiation following surgical resection, adjuvant chemotherapy describes the use of chemotherapy in comparison to other cancer treatments. (lab-ally.com)
Ureter2
- 1, 2, 3] Although the urinary bladder and rarely, the ureter, are affected, this lesion has been described in numerous other locations. (medscape.com)
- Laparoscopic Mainz II Approach for Single System Ectopic Ureter with Bladder Agenesis. (edu.in)
Metastatic1
- Metastatic or Stage IV breast cancer. (lab-ally.com)
Sensitivity1
- Canonical discriminant analysis (CDA) and partial least squares discriminant analysis (PLS-DA) was employed and correctly detected 31/48 urinary bladder cancer VOC biomarkers and achieved an overall 77.75% sensitivity and 93.25% specificity by PLS-DA modelling. (dundee.ac.uk)
Cells16
- Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal cells. (wikipedia.org)
- When a cancer cell divides, both daughter cells inherit the genetic and epigenetic abnormalities of the parent cell, and may also acquire new genetic and epigenetic abnormalities in the process of cellular reproduction. (wikipedia.org)
- While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution, many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death (apoptosis). (wikipedia.org)
- See Hallmarks below) Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. (wikipedia.org)
- In this way, a population of mutant cells, called a clone, can expand in the neoplasm. (wikipedia.org)
- Cancer therapies act as a form of artificial selection, killing sensitive cancer cells, but leaving behind resistant cells. (wikipedia.org)
- At the level of the cell, there is selection for increased cell proliferation and survival, such that a mutant cell that acquires one of the hallmarks of cancer (see below), will have a competitive advantage over cells that have not acquired the hallmark. (wikipedia.org)
- 2, 4, 5, 6] Postoperative spindle cell nodule (PSCN) is usually described as histologically identical to IMT, except that a history of instrumentation or trauma to the bladder can be elicited, and plasma cells are often less prominent. (medscape.com)
- The effects of BCRC-3 on cancer cells were explored by transfecting with plasmids in vitro and in vivo. (biomedcentral.com)
- Cancer stem cells (CSCs) represent a distinct group of cells within cancerous tissue that possess the ability to initiate tumorigenesis and exhibit potency, self-renewal, and drug resistance. (bmrat.org)
- Cancer cells that proliferate quickly and unlike normal cells. (lab-ally.com)
- This is a cancer that usually affects the skeletal cells in the trunk, arms, and legs. (lab-ally.com)
- BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis. (lab-ally.com)
- and may aid in the distinction of terminally differentiated smooth muscle cells, smooth muscle neoplasms of the gastrointestinal tract and the staging of bladder carcinoma. (biocare.net)
- 2002). The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. (dieselok.md)
- Combination of analysis of fluorescence labeling and light scatter properties of cells allows rapid and better determination of target cell antigens. (ijpmonline.org)
Detection1
- Non-invasive detection of urinary bladder cancer remains a significant challenge. (dundee.ac.uk)
TURBT1
- Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)
Epidemiology1
- Urothelial carcinomas (UCs) of the upper tract (UT) have an epidemiology similar to those of the bladder. (cytojournal.com)
Incidence1
- Armitage and Doll explained the cancer incidence data, as a function of age, as a process of the sequential accumulation of somatic mutations (or other rate limiting steps). (wikipedia.org)
Pediatric1
- This disease is characterized by a greater presence of immature lymphocytes (lymphoblasts) than normally needed in the blood and bone marrow, and is the most common of pediatric cancers. (lab-ally.com)
Cell Cycle1
- Cell cycle involvement in cancer treatment with carvacrol and thymol. (dieselok.md)
Abnormalities1
- Advances in cytogenetics facilitated discovery of chromosome abnormalities in neoplasms, including the Philadelphia chromosome in chronic myelogenous leukemia and translocations in acute myeloblastic leukemia. (wikipedia.org)
Upper tract1
- The Johns Hopkins template for upper tract urinary cytology. (cytojournal.com)
Lesions1
- Tumour-like lesions of the urinary bladder. (nih.gov)
Evaluation1
- No blood tests are specific for bladder cancer, but a general evaluation is necessary prior to initiating therapy with intravesical bacillus Calmette-Guérin (BCG) vaccine. (medscape.com)
Immature1
- A form of cancer characterized by the presence of too many immature granulocytes in the bone marrow and blood. (lab-ally.com)
Excision2
- 1 ] The standard management of high-grade UTUC is nephroureterectomy, either open or laparoscopic, with excision of a cuff of the bladder mucosa. (cytojournal.com)
- Robotic-assisted nephroureterectomy and bladder cuff excision without intraoperative repositioning. (wakehealth.edu)