Endothelial cellsPolypeptidesDENDRITIC CELLSRECEPTORSMacrophageIntracellularLipidsMACROPHAGESImmunologyProteinsImmuneAccumulationInhibitMetastasisTissuesMammalian cellsChainsPolysaccharidesLigandsClinicalAdhesionMetabolitesAntibodySurfaceSignificantlyDrugGeneAminoPresentationForeignGrowthRoleLinesMultipleDictionaryFormCancerHighStudyExpression
Endothelial cells2
- The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (lookformedical.com)
- Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Human cerebral endothelial cells are a potential source for bioactive BDNF. (2medicalcare.com)
Polypeptides3
- Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
- Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
- The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). (edu.au)
DENDRITIC CELLS1
- Using mouse BMDCs (bone marrow-derived dendritic cells) as langerin-expressing cells, we observed the downregulation of IL-6 and TNFa and the upregulation of IL-10 after incubation with L4. (bvsalud.org)
RECEPTORS2
Macrophage3
- N-Acylphosphatidylserine was also detected in the lipids of pig brain, mouse macrophage tumor cells, and yeast. (gerli.com)
- Moreover, this research identified DCIR (dendritic cell immunoreceptor) as a potential novel target for regulating macrophage polarization. (bvsalud.org)
- BACKGROUND: This study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric cancer (GC), and to explore the mechanism of Dectin-1 regulating tumour-associated macrophage (TAM)-mediated immune evasion in GC. (bvsalud.org)
Intracellular2
- No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
- Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
Lipids2
- It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
- 6) Lysosomes are the pools of metabolites in cells, including amino acids, sugars, lipids and nucleotides. (biomedcentral.com)
MACROPHAGES1
- The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. (edu.au)
Immunology1
- When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (lookformedical.com)
Proteins2
- They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
- Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
Immune3
- A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. (edu.au)
- 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
- CONCLUSIONS: Dectin-1 could affect T-cell anti-tumour immune response by regulating the immunosuppressive function of TAMs, leading to poor prognosis and immune evasion in GC patients. (bvsalud.org)
Accumulation2
- The storage of iron or copper can prevent their harmful accumulation in cells. (biomedcentral.com)
- Dectin-1+ cells were mainly composed of TAMs, and the accumulation of Dectin-1+ TAMs was associated with T-cell dysfunction. (bvsalud.org)
Inhibit1
- The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
Metastasis2
- The role of CS-GAGs in metastasis was tested using the 4T1 murine mammary cell line (10 mice per group). (biomedcentral.com)
- In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
Tissues2
- In addition, CSPG4 and CHST11 were over-expressed in tumor-containing clinical tissue specimens compared with normal tissues. (biomedcentral.com)
- The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
Mammalian cells1
- The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
Chains1
- The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). (lookformedical.com)
Polysaccharides1
- Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. (lookformedical.com)
Ligands2
- We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)
- Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
Clinical1
- METHODS: The association of Dectin-1+ cells with clinical outcomes was inspected by immunohistochemistry on tumour microarrays. (bvsalud.org)
Adhesion2
- Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)
- In previous studies we found that CS/DS-GAGs are expressed on the cell surface of murine and human breast cancer cell lines with high metastatic capacity and that they play a major role in P-selectin binding and P-selectin-mediated adhesion of cancer cells to platelets and endothelial cells [ 24 ]. (biomedcentral.com)
Metabolites1
- Phosphatidylserine was not shown to be involved in cell signaling through the formation of metabolites (as phosphatidylcholine or phosphatidylinositol) but is a key component in the activation of various kinases (kinase C, Raf-1 kinase) as well as the blood coagulation process. (gerli.com)
Antibody1
- Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
Surface6
- This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
- Enzymatic removal of tumor-cell surface CS-GAGs significantly inhibited lung colonization of the 4T1 murine mammary cell line ( P = 0.0002). (biomedcentral.com)
- Cell surface P-selectin binding depends on CHST11 gene expression. (biomedcentral.com)
- Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (edu.au)
- Molecules on the surface of T-lymphocytes that recognize and combine with antigens. (edu.au)
- Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)
Significantly2
- The CHST11 gene was highly expressed in aggressive breast cancer cells but significantly less so in less aggressive breast cancer cell lines. (biomedcentral.com)
- Transcriptome sequencing showed that SFE significantly upregulated the expression of dendritic cell immunoreceptor (DCIR, also known as CLEC4A2). (bvsalud.org)
Drug1
- Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. (yale.edu)
Gene1
- The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. (edu.au)
Amino1
- It is the only amino acid-containing glycerophospholipid in animal cells. (gerli.com)
Presentation1
- Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)
Foreign2
- and foreign particles by phagocytic cells (PHAGOCYTES). (lookformedical.com)
- They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (lookformedical.com)
Growth1
- Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
Role1
- Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)
Lines2
- The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)
- It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)
Multiple1
- Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. (2medicalcare.com)
Dictionary1
- from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed. (lookformedical.com)
Form1
- The process by which antigen is presented to lymphocytes in a form they can recognize. (edu.au)
Cancer1
- CSPG4 serves as a P-selectin ligand through its CS chain and participates in P-selectin binding to the highly metastatic breast cancer cells. (biomedcentral.com)
High1
- RESULTS: High infiltration of intratumoral Dectin-1+ cells predicted poor prognosis in GC patients. (bvsalud.org)
Study1
- Hung, S.-C., 2014, "Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose", Organic & Biomolecular Chemistry , 12(2), 376-382. (sinica.edu.tw)
Expression1
- Blocking the expression of CHST11 with siRNA inhibited CS-A expression and P-selectin binding to MDA-MB-231 cells. (biomedcentral.com)