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  • dimers
  • The mutants rescued at 27°C were incorporated into fibrin clots and formed factor XIII-mediated γ-γ dimers in contrast to the dysfibrinogenemia Vlissingen/Frankfurt IV mutant, a negative control for these assays. (haematologica.org)
  • plasmin
  • However, plasmin digestion analyses revealed aberrant patterns for the mutants compared to normal fibrinogen. (haematologica.org)
  • Plasmin proteolysis of fibrinogen occurs in the coiled-coil connectors, notably generating a small fragment E, corresponding to the central domain, and two fragments D, corresponding to the lateral regions, formed by the globular C-termini of the Bβ (βC) and γ chains (γC) and by a portion of the coiled-coils. (haematologica.org)
  • fibronectin
  • The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. (bioportfolio.com)
  • 6. An elastin containing composition according to claim 1, further comprising at least one additive selected from the group consisting of collagen, thiourea, cellulose derivatives, calcium alginate, sodium ethylmercrylthiosalicylate, FVIII complex (antihemophilic A), the latter containing about 10 to 15 g/l of fibrinogen and about 2 to 4 g/l of fibronectin, von Willebrand factor, thrombospondin and laminin. (google.co.uk)
  • Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. (abcam.cn)
  • Moreover
  • Moreover, the model qualitatively predicted the impact of tissue factor and tPA/tenecteplase level variations on the fibrin output. (nih.gov)
  • conclude
  • We conclude that a common network of protein interactions can account for key kinetic features characterizing fibrin accumulation and degradation in human blood plasma under diverse experimental conditions. (nih.gov)
  • collagen
  • Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage. (bioportfolio.com)
  • Fibrin itself adheres to collagen, and factor XIII stimulates increased collagen biosynthesis by activating fibroblasts. (google.com)
  • protein
  • Batroxobin obtained from certain subspecies exhibits the hemostatic efficacy, whereas the protein obtained from other subspecies exhibits the cleavage of fibrinogen. (wikipedia.org)
  • The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein which can be coagulated and/or activated by thrombin. (google.co.uk)
  • Ascites
  • Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. (abcam.cn)
  • amino
  • these include a receptor that recognizes an epitope within the E domain and another that recognizes the Bβ15-42 sequence near the amino terminus of fibrinogen. (ahajournals.org)
  • plasma
  • We then applied the model to investigate the ability of fibrinogen and a recently proposed prothrombin complex concentrate composition, PCC-AT (a combination of the clotting factors II, IX, X, and antithrombin), to restore normal thrombin and fibrin generation in diluted plasma. (nih.gov)
  • In the majority of considered cases, PCC-AT combined with fibrinogen accurately approximated both normal thrombin and fibrin generation in diluted plasma, which could not be accomplished by fibrinogen or PCC-AT acting alone. (nih.gov)
  • Heterozygosity for any of these mutations can cause hypofibrinogenemia, characterized by plasma fibrinogen levels below 1.5 g/L, which are found mostly in asymptomatic patients. (haematologica.org)
  • 12. A process according to claim 11, wherein said fibrinogen is provided by plasma. (google.co.uk)
  • levels
  • Fibrinopeptide beta 15-42 levels increased from 4.3 +/- 3 pmol/mL to 70 +/- 19 pmol/mL in group 1, but did not increase in group 2. (timi.org)
  • vitro
  • Here, we investigate the ability of the suggested molecular mechanisms to account for fibrin generation and degradation kinetics in diverse, physiologically relevant in vitro systems. (nih.gov)
  • release
  • Fibrinogen and its degradation products stimulate the release of several growth factors and urokinase plasminogen activator (uPA) from endothelial cells 7 8 and can promote an increase the vascular permeability and disorganization of the endothelium. (ahajournals.org)