• wherein said fibrinogen
  • 8. A composition comprising a scaffold which comprises a plurality of fibrinogen molecules and a plurality of synthetic polymers, each of said fibrinogen molecules being covalently attached to at least two of said synthetic polymers, wherein said synthetic polymers are crosslinked and wherein said fibrinogen is denatured using a denaturing agent, the scaffold further comprising PEGylated fibronectin, and said synthetic polymers comprise polyethylene glycol (PEG). (google.fr)
  • function of fibrinogen
  • Furthermore, bleeding may result in re-exploration, which is associated with increased morbidity and mortality.Recent studies have shown that patients and children undergoing cardiac surgery with pump often experience a significant drop in their levels and function of fibrinogen, and it would be in part responsible for the bleeding. (clinicaltrials.gov)
  • disseminated intravascul
  • Acutely low levels are often related to consumption of fibrinogen such as may be seen with disseminated intravascular coagulation (DIC) and abnormal fibrinolysis , which occurs when the body is overactive in clearing blood clots. (labtestsonline.org)
  • glycoprotein
  • Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood. (wikipedia.org)
  • blood platelets and their precursors, bone marrow megakaryocytes, while once thought to make fibrinogen, are now known to take up and store but not make the glycoprotein. (wikipedia.org)
  • The heximer is transferred to the Golgi where it is glycosylated, hydroxylated, sulfated, and phosphorylated to form the mature fibrinogen glycoprotein that is secreted into the blood. (wikipedia.org)
  • Tirofiban is a synthetic, non-peptide inhibitor of the interaction of fibrinogen with the integrin glycoprotein (GP) IIb/IIIa on human platelets. (wikipedia.org)
  • Sequence
  • An internal peptide sequence in the fibrinogen γ chain has been shown to function as the high affinity binding site for CD11b/CD18 on human neutrophils ( 3 , 4 ). (jimmunol.org)
  • genes
  • The coordinated transcription of these three fibrinogen genes is rapidly and greatly increased by systemic conditions such as inflammation and tissue injury. (wikipedia.org)
  • deposition
  • AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. (abcam.com)
  • The disorders may lead to pathological bleeding and/or blood clotting or the deposition of fibrinogen in the liver, kidneys, or other organs and tissues. (wikipedia.org)
  • subunit
  • The Merck chemistry team of George Hartman, Melissa Egbertson and Wasyl Halczenko developed tirofiban from a lead compound discovered in focused screening of small molecule replacements of the key arginine-glycine-aspartic acid (Arg-Gly-Asp) subunit of fibrinogen. (wikipedia.org)
  • During circulation, this subunit binds fibrinogen. (wikipedia.org)
  • Leukocyte
  • Leukocyte interaction with fibrinogen or its degradation products has special importance at sites of inflammation, since fibrinogen may gain access to the extravascular compartment by exudation, where it encounters migrating leukocytes ( 9 ). (jimmunol.org)
  • binds
  • Recent structural studies have identified two conformational states of the ligand binding site of CD11b/CD18 that may correspond to two functional states, one active (which binds to activation-dependent ligands such as iC3b and fibrinogen) and one inactive (which binds only to activation-independent ligands such as the neutrophil adhesion inhibitor) ( 6 ). (jimmunol.org)
  • concentration
  • Abstract -The relation between alcohol consumption and fibrinogen concentration was evaluated in a French population to investigate whether fibrinogen could explain part of the relation between alcohol consumption and cardiovascular disease. (ahajournals.org)
  • Furthermore, smoking was positively associated with fibrinogen concentration, and in men the difference between nondrinkers and drinkers with the lowest fibrinogen level was higher in nonsmokers and ex-smokers than in current smokers. (ahajournals.org)
  • 26 27 To evaluate this hypothesis, we investigated whether there was a U-shaped relation between fibrinogen concentration and alcohol consumption in a population of French men and women. (ahajournals.org)
  • Methods are provided for the stable storage of ready-to-use, biocompatible human fibrinogen, which despite its concentration, remains available in fluid form, and which will permit long-term rapid and easy processing into a tissue adhesive preparation. (google.co.uk)
  • Measurement of fibrinogen, factor VII activity, cholesterol concentration, blood pressure, and other indices of ischaemic heart disease risk. (bmj.com)
  • scaffold
  • Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue. (google.fr)
  • homology
  • sFGL2's FRED domain shares significant homology to the fibrinogen related domains of potent immunoregulatory molecules like cytotaxin and tenascin. (wikipedia.org)
  • cholesterol
  • However, many health practitioners feel that fibrinogen activity measurements give them additional information that may lead them to be more aggressive in treating those risk factors that they can treat (such as unhealthy levels of cholesterol ). (labtestsonline.org)
  • 1 2 3 4 5 Fibrinogen is also associated with major cardiovascular risk factors, such as smoking, hypertension, and total cholesterol. (ahajournals.org)
  • tissue
  • PTX3 seems to be associated with tissue destruction in earlier periods of inflammatory periodontal disease, contrary to the fibrinogen findings. (hindawi.com)
  • Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator. (wikipedia.org)
  • receptor
  • Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. (wikipedia.org)
  • levels
  • Reduced fibrinogen levels may also occur following rapid, large-volume blood transfusions and in people who are malnourished. (labtestsonline.org)
  • Drugs known to influence fibrinogen levels, such as fibric acid derivatives, also alter many other factors related to the risk of MI. (ahajournals.org)
  • An alternative approach is to study genetic markers that are associated with elevated fibrinogen levels. (ahajournals.org)
  • We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. (diva-portal.org)
  • these conditions are treated by supplementing blood fibrinogen levels and inhibiting blood clotting, respectively. (wikipedia.org)
  • evaluate
  • In some cases, fibrinogen activity testing is performed along with other tests when a health practitioner wants to evaluate an individual's risk of developing cardiovascular disease . (labtestsonline.org)
  • To evaluate the association with fibrinogen, alcohol consumption was divided into the following 6 groups: nondrinkers and those who consumed 0 to 19, 20 to 39, 40 to 59, 60 to 79, and ≥80 g/d of alcohol. (ahajournals.org)
  • The purpose of this study is to evaluate prospectively whether concentrate fibrinogen reduces blood losses, transfusion requirements and occurrence of clinical complications compared to cryoprecipitate in children after cardiac surgery with pump. (clinicaltrials.gov)
  • known
  • In a study of people without known cardiovascular disease, we estimated that under current treatment guidelines, assessment of the CRP or fibrinogen level in people at intermediate risk for a cardiovascular event could help prevent one additional event over a period of 10 years for every 400 to 500 people screened. (diva-portal.org)