• Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. (wikipedia.org)
  • Fibrillin is important for the assembly of elastin into elastic fibers. (github.io)
  • Elastic fibers are predominantly composed of elastin, a highly hydrophobic protein (≈750 amino acids long). (github.io)
  • Soluble tropoelastin is secreted into the extracellular space, where it forms lysine cross-links to other tropoelastin molecules to generate a large network of elastin fibers and sheets. (github.io)
  • Elastin is a resilient connective tissue protein found in the ECM of most vertebrate tissues, and it is an important part in the interstitium of tissues that undergo repeated physical deformations in the human body (Swee et al. (github.io)
  • Elastin is a protein that gives skin its snap and elasticity. (skintypesolutions.com)
  • Oxytalan fibers contain the microfibrillar protein fibrillin but no elastin. (skintypesolutions.com)
  • The deeper reticular dermis houses thicker elastic fibers composed of both elastin and fibrillin called elaunin fibers running parallel to the surface. (skintypesolutions.com)
  • Within the extracellular matrix, elastin functions as a protein that provides elastic connective tissue, allowing our bodies greater flexibility and range of motion. (lionhearthealthstim.com)
  • Elastin is made up of other components such as tropoelastin - and studying tropoelastin will give us a better idea of how to potentially improve the elastic assembly. (lionhearthealthstim.com)
  • About 90% of the elastic fibers are made up of elastin, while the remaining components are made up of fibrillin glycoproteins. (lionhearthealthstim.com)
  • Both tropoelastin and elastin work toward forming biomaterials used for tissue engineering and regenerative medicine. (lionhearthealthstim.com)
  • Elastic fibres are made up of elastin and microfibrils which are made up of a mixture of elastin and glycoproteins, including fibrillin. (leeds.ac.uk)
  • Elastin is made from its soluble precursor, tropoelastin. (leeds.ac.uk)
  • Tropoelastin is secreted from the cell, and elastin fibres are assembled close to the extracellular surface of the cell, onto a scaffold of microfibrils. (leeds.ac.uk)
  • The elastin fibres are very pale staining, because elastin is an amorphous protein. (leeds.ac.uk)
  • e have colocalized elastin and fibrillin-1 with perlecan in extracellular matrix of tensional and weight-bearing connective tissues. (cardiff.ac.uk)
  • Elastin and fibrillin-1 were identified as prominent components of paraspinal blood vessels, and posterior longitudinal ligament in the human fetal spine and outer annulus fibrosus of the fetal intervertebral disc. (cardiff.ac.uk)
  • Elastin, fibrillin-1 and perlecan were co-localized in the intima and media of small blood vessels in the synovium and in human fetal paraspinal blood vessels. (cardiff.ac.uk)
  • Electrostatic interactions through the heparan sulfate chains of perlecan and core protein mediated the interactions with tropoelastin, and were both important in the coacervation of tropoelastin and deposition of elastin onto perlecan immobilized on the chip surface. (cardiff.ac.uk)
  • This may help us to understand the interactions which are expected to occur in vivo between the tropoelastin and perlecan to facilitate the deposition of elastin and formation of elastic microfibrils in situ and would be consistent with the observed distributions of these components in a number of connective tissues. (cardiff.ac.uk)
  • Collagen consists of three protein chains which wrap around each other in a helical arrangement. (leeds.ac.uk)
  • Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
  • Then, he is investigating biomimetic approaches based on cross-linking enzymes for the improvement of the angiogenic properties of hydrogels of natural polymers, including tropoelastin and collagen. (sfbmec.fr)
  • Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals , [1] making up about 25% of the total protein content. (wikidoc.org)
  • [2] Nutritionally, collagen and gelatin are poor quality protein since they do not contain all the essential amino acids that the human body requires - they are not complete proteins . (wikidoc.org)
  • It is a protein composed primarily of the amino acids glycine & proline, and it also contains sugar groups. (leeds.ac.uk)
  • You may also come across Fibronectin which is a non-collagenous fibrous connective protein that helps cells to stick to the extracellular matrix. (leeds.ac.uk)
  • Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)
  • Interactions between the tropoelastin and perlecan heparan sulfate chains were demonstrated using quartz crystal microbalance with dissipation solid phase binding studies. (cardiff.ac.uk)
  • These data suggest that heparan sulfate may sequester fibrillin at the cell surface via FUN-EGF3 prior to aggregation of the C terminus, thereby regulating microfibril assembly. (eurekamag.com)
  • Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene. (wikipedia.org)
  • Tropoelastin is encoded by the ELN gene, the set of instructions that produces certain proteins. (lionhearthealthstim.com)
  • It is the most abundant protein in mammals - 25% of total protein mass! (leeds.ac.uk)
  • Fibrillin-1 regulates endothelial sprouting during angiogenesis. (mcgill.ca)
  • Fibrillin-1 regulates arteriole integrity in the retina. (mcgill.ca)
  • 2022). Fibrillin-1 regulates white adipose tissue development, homeostasis, and function. (mcgill.ca)
  • This protein has a spring-like molecular structure that can stretch up to eight times its resting length. (lionhearthealthstim.com)
  • His biological study spans a wide range of topics, including Fusion protein and Antigen. (research.com)
  • Studies using recombinant fibrillin fragments indicate that an interaction between the N- and C-terminal regions drives head-to-tail assembly. (eurekamag.com)
  • This unique structure is due to high levels of glycine, valine, alanine and proline in the protein. (skintypesolutions.com)
  • Tropoelastin doesn't express a lot of energy loss during its extension, keeping its structure in place. (lionhearthealthstim.com)
  • In Plasmodium falciparum, he works on issues like Transport protein, which are connected to Protein structure. (research.com)
  • Here, we present the structure of a fibrillin N-terminal fragment comprising the fibrillin unique N-terminal (FUN) and the first three epidermal growth factor (EGF)-like domains (FUN-EGF3). (eurekamag.com)
  • They discovered that EPA administration to sun exposed skin caused an increase in the expression of extracellular matrix proteins, such as procollagen, tropoelastin, and fibrillin-1 by increasing transformin growth factor-b (TGF-b). (emed.com.au)
  • An increase in such proteins rebuilds the skin and improves its appearance. (emed.com.au)
  • His Cell biology research is multidisciplinary, incorporating elements of Ultrastructure, Red blood cell, Membrane protein and Cytoskeleton. (research.com)
  • 2022). Fibrillin-1 regulated miR-122 has a critical role in thoracic aortic aneurysm formation. (mcgill.ca)
  • They account for the majority of proteins in the ECM , which makes them the most abundant proteins in the human body. (amboss.com)
  • As a part of the same scientific family, Eric Hanssen mostly works in the field of Biophysics, focusing on Fibrillin and, on occasion, Microfibril. (research.com)
  • The new term corneous beta protein (CBP) has been proposed to avoid confusion with α-keratins. (wikipedia.org)
  • His Vacuole study incorporates themes from Transport protein, Prenylation, Protein prenylation and Plasmodium, Apicoplast. (research.com)
  • His study looks at the relationship between Plasmodium falciparum and fields such as Transport protein, as well as how they intersect with chemical problems. (research.com)
  • The concepts of his Plasmodium falciparum study are interwoven with issues in Transport protein, Vacuole and Protein prenylation. (research.com)