AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaHumanitiesHealth Care
Germ-Free LifeQuality of LifeNeoplasms, Germ Cell and EmbryonalWheat Germ AgglutininsNutritional StatusHealth StatusTestisLifeSpermatogenesisFree RadicalsGerm Layers
Downregulated in germ-free miceMicrobiomeMicrobiota transplantationTransplantsTransplantationIncontinenceMiceUrinarySterilePrevalenceObesityAntibioticsMicrobesClinicalFliesResistanceHumansSaving LivesSciencesHumanNormalGeneticMechanismsMicrobialRadicalImmuneEnvironmentalEffectsGrowthPatientsAnimalHomesHealthQualitySocialDays of lifeFeelSaveFoundTreatmentEvidenceMonthsImproveResearch InstituteLongTimeSafe
Downregulated in germ-free mice1
  • The activation of phenethylamine/TAAR1/serotonin signaling axis as a result of aberrant R. gnavus enrichment thereby contributed to elevated gastrointestinal transit and colonic secretion in IBS-D. In our follow-up study, we further demonstrated that the mRNA expression of colonic Sert was significantly downregulated in germ-free mice monocolonized with R. gnavus and normal mice treated with phenethylamine. (edu.hk)
Microbiome12
  • Francino, M. Pilar 2018-09-29 00:00:00 Purpose of Review We review how an altered microbiome in early life impacts on immune, metabolic, and neurological development, focusing on some of the most widespread diseases related to each of these processes, namely atopic disease, obesity, and autism. (sagepub.com)
  • A solid understanding of how present day environ- mental conditions alter microbiome development, and of how an altered microbiome in early life impacts on life-long health, should inform both public health policies and the development of dietary and medical strategies to counteract early microbiota imbalances. (sagepub.com)
  • Interestingly, there is growing evidence that CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain early microbiome-host interactions during fetus development Curr Envir Health Rpt (2018) 5:512-521 513 and early infancy are critical factors that will determine life- early onset of type 2 diabetes [33], and, in the latter case, the long health or disease states [9-11]. (sagepub.com)
  • The proposition dow in the establishment of microbiome-host interactions, the that maternal bacteria reach the fetal gut is ground breaking, as precise boundaries of this window and the impact of microbial these organisms could start marking the trajectories of im- changes during later periods of infancy and childhood on life- mune, metabolic, and somatic development in utero, with long disease risks remain to be determined. (sagepub.com)
  • Composition and temporal stability of the mechanisms through which the microbiome in determining host life span, including studies in worms, flies, fish, and mice. (jeckefairsuchung.com)
  • Fecal microbiota transplant overcomes resistance to diet-induced obesity in germ-free (GF) model organisms is that the human microbiome is distinct from colocalized white subjects and connected to metabolic health. (jeckefairsuchung.com)
  • An early maturation and thus stabilisation of the microbiome seems to be worthwhile in this early stage of life. (researchgate.net)
  • Stochastic, context-dependent microbiome assembly underlies clinical therapies like fecal microbiota transplantation and probiotic administration and should inform the design of synthetic fecal transplants and dosing regimes. (bvsalud.org)
  • Last August, my post entitled Meet Your Microbiome: The Other Part of You dealt with growing recognition that trillions of microbes-mostly bacteria but also fungus-reside in and on each of us, and influence our health status. (trilinkbiotech.com)
  • Always keen to collaborate on anything relating to the brain, behaviour or microbiome - feel free to get in touch! (ox.ac.uk)
  • Latest research all about the future of the gut microbiome, faecal transplants and super-poo! (ox.ac.uk)
  • 1 2 A large number of recent papers and reviews have covered different aspects of the microbiome and its potential role in human health, including the early life 3-5 but also specific diseases, such as cardiometabolic disorders, inflammatory bowel diseases, neuropsychiatric diseases and cancer. (bmj.com)
Microbiota transplantation2
  • Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 753-759. (pumch.cn)
  • Fecal microbiota transplantation (FMT) can improve autism-related symptoms in children with ASD. (pumch.cn)
Transplants1
  • Growing evidence suggests that gut microbiota may have a role in the regulation of SERT levels in IBS-D since fecal transplants from IBS-D patients induce SERT downregulation and hence elevated peripheral serotonin levels in recipient germ-free mice. (edu.hk)
Transplantation2
  • Transplantation of young ovaries to old how to buy minipress in usa mice increased life span by increasing the accessibility of dietary nutrients. (jeckefairsuchung.com)
  • Interestingly, this 'leakiness' could be abrogated if the mice were exposed to fecal transplantation of normal gut microbes. (metabolomics.se)
Incontinence1
  • Both of those conditions result in urinary or fecal incontinence, which often impacts womenÍs social status within their communities. (asu.edu)
Mice9
  • Effects of germfree status and food restriction on longevity and growth of mice. (jeckefairsuchung.com)
  • In germ-free mice, monocolonization of R. gnavus induced IBS-Dlike diarrheal symptoms by elevating peripheral serotonin levels. (edu.hk)
  • In addition, we showed that diet low in phenylalanine, a precursor of phenethylamine, led to reduced gastrointestinal transit along with decreased levels of fecal phenethylamine and serum serotonin in normal mice. (edu.hk)
  • Germ-free mice changed everything Sudo found that mice born and raised with no bacteria behaved differently than normally germy mice. (bestfutureyou.com)
  • Germ-free mice presented a golden opportunity to investigate. (bestfutureyou.com)
  • When Sudo realized that germ-free mice had a different reaction to stress, it was confounding. (bestfutureyou.com)
  • Most of these studies use fecal transfers, and some have gone from humans to mice, thus demonstrating cross-species causality. (bestfutureyou.com)
  • The investigators reached this conclusion by comparing the integrity and development of the blood-brain barrier between two groups of mice: the first group was raised in an environment where they were exposed to normal bacteria, and the second (called germ-free mice) was kept in a sterile environment without any bacteria. (metabolomics.se)
  • Maintained into adulthood The team also showed that the increased 'leakiness' of the blood-brain barrier, observed in germ-free mice from early life, was maintained into adulthood. (metabolomics.se)
Urinary1
  • Questions about the quality and duration of prolapse and urinary, fecal, and sexual symptoms should be asked and validated questionnaires given. (medscape.com)
Sterile2
  • Fresh fecal samples were collected from individual pigs, placed into sterile containers, and stored frozen. (cdc.gov)
  • Sample RNA was extracted from 10% to 20% of fecal suspensions in sterile Eagle minimal essential medium (EMEM, Invitrogen, Carlsbad, CA, USA) by using Trizol LS (Invitrogen). (cdc.gov)
Prevalence2
  • In fact, Strachan in 1989 proposed the "hygiene hypothesis", which stated that lack of exposure to microbes during early infancy was at the source of This article is part of the Topical Collection on Early Life Environmental the observed increased prevalence of allergy and asthma in Health westernized populations [3, 4]. (sagepub.com)
  • AIMS To determine the prevalence of faecal candida in childhood diarrhoea and the relation between faecal yeasts and diarrhoea. (bmj.com)
Obesity1
  • Cox, L. M. & Blaser, M. J. Antibiotics in early life and obesity. (nature.com)
Antibiotics1
  • Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation. (ox.ac.uk)
Microbes3
  • Until recently this critical window had not been characterized in humans, but now studies suggest that the ideal time to use microbes as preventative treatments or diagnostics for asthma in humans is within the first 100 days of life. (biomedcentral.com)
  • This research has promising future implications regarding childhood immune health, as ultimately it may be possible to therapeutically administer specific microbes in early life to prevent the development of asthma in children. (biomedcentral.com)
  • These findings further underscore the importance of the maternal microbes during early life and that our bacteria are an integrated component of our body physiology", says Professor Sven Pettersson, the principal investigator at the Department of Microbiology, Tumor and Cell Biology. (metabolomics.se)
Clinical1
  • Clinical data collected prospectively included patient age, race, nutritional state (percentage weight for age), history of recent antibiotic usage, hydration status, duration of diarrhoea, stool characteristics, and evidence of oral or cutaneous candidiasis. (bmj.com)
Flies1
  • In germ-free flies fed known combinations of bacterial species, we find that some species colonize more frequently than others even when fed at the same high concentration. (bvsalud.org)
Resistance3
  • Preexisting target mutations were in vitro resistance selection, whole-genome analysis, and reverse genetics, we show that after germ granules form at the neuromuscular junction and functions in parallel with DAB-1. (sophieluis.com)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • SYN: group i.. humoral i. i. associated with circulating antibodies, in contradistinction to cellular i.. infection i. the paradoxical immune status in which resistance to reinfection coincides with the persistence of the original infection. (theodora.com)
Humans1
  • The word 'companion', with which we are already familiar, refers to an animal that lives with humans and was first proposed by zoologist and Nobel Prize winner Konrad Lorenz at an international symposium held in Vienna, Austria in 1983 [ 1 ]. (ejast.org)
Saving Lives1
Sciences2
  • Keen to promote the public understanding of the life sciences. (ox.ac.uk)
  • Professor Sven Pettersson is also affiliated to the Lee Kong Chian School of Medicine, The National Cancer Centre in Singapore and the Singapore Centre on Environmental Life Sciences Engineering at the Nanyang Technological University. (metabolomics.se)
Human4
  • Companion animals have become an increasingly important part of human life, and therefore, the health and well-being of pets have increasingly attracted interest in recent decades [ 5 ]. (ejast.org)
  • This review outlines the major mouse-model and human studies leading to characterization of the early life critical window, emphasizing studies analyzing the intestinal and airway microbiotas in asthma and atopic disease. (biomedcentral.com)
  • To detect porcine NoVs and to investigate their genetic diversity and relatedness to human NoVs, 275 fecal samples from normal US adult swine were screened by reverse transcription-polymerase chain reaction with calicivirus universal primers. (cdc.gov)
  • To detect porcine NoVs and assess their genetic diversity and relatedness to human NoVs, we screened 275 pig fecal samples from US swine by RT-PCR with a calicivirus universal primer pair p290/110 targeting the RdRp region ( 15 , 16 ), followed by sequencing the 3 kb on the 3´ end of the genome for 5 NoV strains. (cdc.gov)
Normal1
  • Norovirus RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) in 4 of 1,017 normal slaughtered pigs in Japan ( 9 ) and in 2 of 100 pooled pig fecal samples in the Netherlands ( 10 ). (cdc.gov)
Genetic1
  • Increased glycolytic activity also boosts NADPH synthesis in the archaeal tree of life potentially leading to lower genetic quality of their progeny brought about by the net effects of sperm quality. (ambi.productions)
Mechanisms1
  • Fig. 4: Mechanisms of gut microbial influence on host energy status. (nature.com)
Microbial1
  • Further, these model systems have identified an early life critical window, during which gut microbial dysbiosis is most influential in promoting hypersensitivity disorders. (biomedcentral.com)
Radical2
  • 1989. Free radical activation of monomethyl and dimethyl hydrazines in isolated hepatocytes and liver microsomes. (cdc.gov)
  • OTHER PROPERTIES Solutions of paraquat become intensely purple on reduction, due to the formation of a water soluble, relatively stable free radical, which absorbs at 400 nm. (inchem.org)
Immune4
  • However, although it is dendritic cells of the immune system have been implicated in clear that the first months of life represent a crucial time win- mediating the increased translocation level. (sagepub.com)
  • 1. The status or quality of being immune (1). (theodora.com)
  • specific i. the immune status in which there is an altered reactivity directed solely against the antigenic determinants (infectious agent or other) that stimulated it. (theodora.com)
  • The microflora hypothesis suggests that early life exposures are disrupting the composition of the microbiota and consequently, promoting immune dysregulation in the form of hypersensitivity disorders. (biomedcentral.com)
Environmental1
  • Developmental and environmental modulation of fecal thyroid hormone levels in wild Assamese macaques ( Macaca assamensis ), Am J Primatol 85: e23530. (dpz.eu)
Effects1
  • Effects of tourism and researcher presence on fecal glucocorticoid metabolite levels in wild, habituated Sulawesi crested macaques ( Macaca nigra ). (dpz.eu)
Growth2
  • Germ granules grow through fusion and this growth is a cause or effect of the mutant phages (Fig 3E and 3F). (sophieluis.com)
  • Plasticity of germ granule growth occurs. (sophieluis.com)
Patients1
  • Anuradha Khadilkar and Vandana Jain reflect on the pandemic's impact on their work with patients and other aspects of their research and daily lives.The rest of the issue is bursting with the opportunities and support available to you from ESPE. (eurospe.org)
Animal2
  • Al-Asmakh, M. & Zadjali, F. Use of germ-free animal models in microbiota-related research. (nature.com)
  • We partner with the city's municipal shelter, Austin Animal Center, along with other area rescue groups and shelters to maintain Austin's no-kill status, focusing specifically on pulling animals from euthanasia lists. (austinpetsalive.org)
Homes1
  • After all, hospitals and nursing homes are crawling with germs, right? (cdc.gov)
Health2
Quality2
  • as well as fostering collaboration and sharing solutions to improve the quality of our lives. (betterhealthguy.com)
  • Pelvic organ prolapse (POP) is a common healthcare problem that many women live with for years, causing discomfort and affecting quality of life. (medscape.com)
Social1
  • The Nonprofit Commons in Second Life is sponsored by TechSoup Global and is a program of the TechSoup Global Community & Social Media team. (avacon.org)
Days of life1
  • Using standardized strategies, all new child infants born in more than seventy seven hospitals all through Spain had been examined in the course of the first 3 days of life for main and/or minor congenital defects [url=https://archives.gov.pk/rx-pharmacy/buy-gemfibrozil/] cholesterol lowering foods herbs gemfibrozil 300 mg cheap amex[/url]. (ehd.org)
Feel1
  • And you probably feel like you're missing out on what could be the best years of your life, right? (galaxynutrients.com)
Save2
  • We're stunned by the idea with everything that we already know, we can save hundreds of thousands of lives. (cnn.com)
  • Shelters and rescue groups are able to see first hand how our programs work - and how they too can save more lives. (austinpetsalive.org)
Found1
Treatment1
  • The General Content section features 78 chapters and over 120 real life problem-solving cases, concisely describing physiology, pathophysiology and practical approaches to management and treatment in English. (eurospe.org)
Evidence1
  • According to the researchers, the findings provide experimental evidence that alterations of our indigenous microbiota may have far-reaching consequences for the blood-brain barrier function throughout life. (metabolomics.se)
Months1
  • When she passed in 2012 of sepsis, he began a grueling work on his first non fiction offering, chronicling the last brutal months of her life in a soon to be released work, yet untitled. (cdc.gov)
Improve1
  • We are constantly innovating and researching to continue to improve lives and live outcomes for animals in Central Texas as well as across the country. (austinpetsalive.org)
Research Institute1
  • Corresponding author: Younghoon Kim, Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea. (ejast.org)
Long1
  • It wasn't long before she was fighting for her life in a city hospital. (cdc.gov)
Time1
  • On page 4, we are extremely pleased to have contributions from colleagues in India about their lives in the time of COVID. (eurospe.org)
Safe1
  • Lactobacillus plantarum is a non-gas-producing lactic acid bacterium that is generally regarded as safe (GRAS) with Qualified Presumption of Safety (QPS) status. (springer.com)