ThrombocytopeniaChemotherapy-Induced Febrile NeutropeniaChildren with febrile neutropeniaMajor cause of morbidityEmpiric therapyFeverPediatricDose-limiting tComplicationDurationNeutrophil countPatients who undergoAntibiotic discontinuationMortality rateMorbidityGuidelineAntifungalComplicationsOccurrenceAcuteOutcomesAdult patientsClinicalLeukemiaOutpatientGradeTreatmentManagementAssessToxicityEffectivenessRiskGradesTherapyBloodFindingsStudy
Thrombocytopenia2
- The most common adverse reactions (incidence ≥20%) of pemetrexed for injection when administered with cisplatin are vomiting, neutropenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation. (nih.gov)
- Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
Chemotherapy-Induced Febrile Neutropenia1
- In the MONITOR-GCSF study of chemotherapy-induced (febrile) neutropenia with biosimilar filgrastim, 56.6% of patients were prophylacted according to amended EORTC guidelines, but 17.4% were prophylacted below and 26.0% above guideline recommendations. (unibas.ch)
Children with febrile neutropenia2
- This study aimed to measure the parents' knowledge and behavior about infection management control implementation in children with febrile neutropenia. (journalpress.id)
- Parents' infection management control in children with febrile neutropenia is effective in reducing the incidence of infection and the length of stay for children in the hospital, as well as improving the quality of life for children. (journalpress.id)
Major cause of morbidity2
- Despite recent therapeutic advances, febrile neutropenia is still a major cause of morbidity and mortality among cancer patients in Latin America and worldwide. (ijpsonline.com)
- Febrile neutropenia remains a major cause of morbidity in solid cancer patients. (druglib.com)
Empiric therapy1
- Scholars@Duke publication: Institutional experience with voriconazole compared with liposomal amphotericin B as empiric therapy for febrile neutropenia. (duke.edu)
Fever7
- Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a type of white blood cell) in the blood. (wikipedia.org)
- Fever Febrile neutropenia can develop in any form of neutropenia, but is most generally recognized as a complication of chemotherapy when it is myelosuppressive (suppresses the bone marrow from producing blood cells). (wikipedia.org)
- Piperacillin/tazobactam might be the preferred antibiotic for the treatment of cancer patients with fever and neutropenia, while cefepime should not be used. (wikipedia.org)
- [1] Febrile neutropenia is defined as an oncological emergency where the patient presents with fever accompanied by an absolute neutrophil level of under 500/mcl. (clinfowiki.org)
- In this prospective, case-control study , participants were divided into 3 groups ALL patients with FN (Group A), ALL patients without neutropenia and fever (Group B), and healthy children without infection and chronic disease (Group C). There were 30 cases in each group. (bvsalud.org)
- IL-33 and sST2 levels were not associated with fever duration, neutropenia duration or length of hospitalization . (bvsalud.org)
- the empirical treatment of presumed fungal infections in febrile neutropenic patients, where the fever has failed to respond to broad spectrum antibiotics and appropriate investigations have failed to define a bacterial or viral cause. (medicines.org.uk)
Pediatric3
- This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients' charts from 135 participants retrospectively. (biomedcentral.com)
- Serum interleukin-33 and soluble suppression of tumorigenicity 2 in pediatric leukemia with febrile neutropenia. (bvsalud.org)
- The purpose of this study was to evaluate the association between interleukin-33 ( IL-33 ) and its receptor Soluble Suppression of Tumorigenicity-2 (sST2) levels and bacterial infections during febrile neutropenia (FN) in pediatric patients with acute lymphoblastic leukemia (ALL). (bvsalud.org)
Dose-limiting t2
- Neutropenia and its complications represent the major dose-limiting toxicities associated with systemic cancer chemotherapy and is associated with considerable morbidity, mortality, and cost. (jnccn.org)
- Myelosuppression, particularly febrile neutropenia (FN), are serious dose-limiting toxicities that occur frequently during the first cycle of chemotherapy. (wustl.edu)
Complication5
- Febrile neutropenia is a common and serious complication of cancer chemotherapy. (ijpsonline.com)
- Therefore, information available on febrile neutropenia was compiled to create a comprehensive protocol of the complication. (ijpsonline.com)
- Febrile Neutropenia (FN) is a common complication of chemotherapy and a main cause of morbidity and mortality in cancer patients[ 1 ]. (ijpsonline.com)
- Febrile neutropenia (FN) is a common and serious complication in patients with leukemia. (afsu.edu.tr)
- Febrile neutropenia (FN) is a complication of chemotherapy resulting in a temperature 100.4⁰F or greater plus an absolute neutrophil count (ANC) below 500 cells/mm 3 or an ANC below 1000 cells/mm 3 and expected to decrease below 500 cells/mm 3 within 48 hours. (baptisthealth.net)
Duration3
- A positive but statistically nonsignificant correlation between ETP values at t1 and duration of neutropenia was observed. (afsu.edu.tr)
- There is an unresolved question regarding the appropriate duration of antibiotic treatment for patients with febrile neutropenia of unknown origin. (druglib.com)
- Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)
Neutrophil count1
- Neutropenia Neutropenia is a reduction in the blood neutrophil count. (msdmanuals.com)
Patients who undergo1
- Patients who undergo outpatient autologous stem cell transplantations (ASCTs) not only report lower costs and higher satisfaction, but they also have lower odds of developing febrile neutropenia and septicemia than patients who undergo inpatient ASCT, according to the results of a new analysis. (ajmc.com)
Antibiotic discontinuation1
- Several studies have demonstrated the safety of early antibiotic discontinuation in patients with febrile neutropenia. (druglib.com)
Mortality rate1
- â ¢ Febrile neutropenia has a high mortality rate if not treated effectively. (bvsalud.org)
Morbidity1
- Neutropenia and its complications, including febrile neutropenia (FN), represent major toxicities associated with cancer chemotherapy, resulting in considerable morbidity, mortality, and costs. (jnccn.org)
Guideline1
- The objective of this protocol was to develop a reference tool for the evaluation and management of febrile neutropenia in a fourth-level cancer hospital in Ecuador and provide a guideline for a timely and adequate care of cancer patients. (ijpsonline.com)
Antifungal2
- PATIENTS: Fifty-five adult patients who started empiric antifungal therapy for febrile neutropenia between January 1, 2002, and December 31, 2003, encompassing 58 treatment episodes (defined as a hospitalization during which empiric antifungal therapy was administered). (duke.edu)
- CONCLUSION: Our institution's algorithm incorporating voriconazole into the empiric management of febrile neutropenia was associated with effectiveness outcomes comparable to those observed with L-AmB as well as a lower frequency of adverse effects and overall expenditures for antifungal drugs. (duke.edu)
Complications5
- citation needed] The Multinational Association for Supportive Care in Cancer (MASCC) risk index can be used to identify low-risk patients (score ≥21 points) for serious complications of febrile neutropenia (including death, intensive care unit admission, confusion, cardiac complications, respiratory failure, kidney failure, low blood pressure, bleeding, and other serious medical complications). (wikipedia.org)
- A prospective trial demonstrated that a modified MASCC score can identify patients with febrile neutropenia at low risk of complications, as well. (wikipedia.org)
- Cytotoxic chemotherapy often induces febrile neutropenia and may lead to serious complications including mortality. (ijpsonline.com)
- The myeloid growth factors such as granulocyte colony-stimulating factor (G-CSF) have been shown to reduce the risk of neutropenia complications while enabling safe and effective chemotherapy dose intensity. (jnccn.org)
- Febrile neutropenia (FN) is one of the most important life-threatening complications in haemato-oncology. (wustl.edu)
Occurrence1
- Multivariate analysis of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma: data from the INC-EU Prospective Observational European Neutropenia Study. (wustl.edu)
Acute3
- In people with cancer who have febrile neutropenia (excluding patients with acute leukaemia), oral treatment is an acceptable alternative to intravenous antibiotic treatment if they are hemodynamically stable, without organ failure, without pneumonia and with no infection of a central line or severe soft-tissue infection. (wikipedia.org)
- We aimed to investigate the course of thrombin formation in febrile neutropenia attack of children with acute lymphoblastic leukemia (ALL). (afsu.edu.tr)
- Acute care hospitals continue to specialize in the treatment of many patients with cancer who are at increased risk for infection (e.g., hematopoietic stem cell transplant recipients, patients with febrile neutropenia), with programs and policies that promote adherence to infection control standards. (cdc.gov)
Outcomes1
- Data in Perspectives undergoes a demanding quality control process and this dataset has been utilized in a number of outcomes studies.22 -25 In 2006 nearly 5.5 million hospital discharges that signifies approximately 15% of all hospitalizations were captured in Perspectives.22 Etoposide (VP-16) Patient Selection We analyzed individuals with neutropenia treated from 2000-2010. (bio-cavagnou.info)
Adult patients1
- Assist prescribers towards best practice in the initial management of febrile neutropenia in adult patients. (sa.gov.au)
Clinical1
- In contrast, the Clinical Index of Stable Febrile Neutropenia (CISNE) score is specific of patients with solid tumors and seemingly stable episodes. (wikipedia.org)
Leukemia1
- Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia. (cdc.gov)
Outpatient3
- Furthermore, outpatient treatment for low‐risk febrile neutropenia in people with cancer probably makes little or no difference to treatment failure and mortality compared with the standard hospital (inpatient) treatment and may reduce time that patients need to be treated in hospital. (wikipedia.org)
- This meta-analysis is the first to pool together a multitude of studies and conclude that patients who underwent outpatient ASCT had significantly lower odds at developing febrile neutropenia and septicemia than patients who underwent inpatient ASCT. (ajmc.com)
- Owattanapanich W, Suphadirekkul K, Kunacheewa C, Ungprasert P, Prayongratana K. Risk of febrile neutropenia among patients with multiple myeloma or lymphoma who undergo inpatient versus outpatient autologous stem cell transplantation: a systematic review and meta-analysis. (ajmc.com)
Grade1
- Grade 3-4 febrile neutropenia occurred in 6.8% of participants. (nih.gov)
Treatment7
- This document compiles updated information available on the definition, risk factors, evaluation methods, treatment and special situations in cancer patients with febrile neutropenia. (ijpsonline.com)
- The purpose of this study is to determine whether short-course antibiotic therapy is safe and effective for the treatment of cancer patients with febrile neutropenia. (druglib.com)
- Development of tools and processes to improve treatment times in patients with febrile neutropenia. (journalpress.id)
- Background Current guidelines at MMUH for the antimicrobial treatment of febrile neutropenia are based on an escalation approach as recommended by the Infectious Diseases Society of America (IDSA) and European Conference on Infections in Leukaemia 3 (ECIL3). (bmj.com)
- Purpose To establish the appropriateness of local antimicrobial guidelines for the treatment of febrile neutropenia in MMUH patients. (bmj.com)
- Conclusions The MMUH guidelines for the antimicrobial treatment of febrile neutropenia require modification to reflect quinolone resistance. (bmj.com)
- STUDY OBJECTIVE: To assess the effectiveness, safety, and cost of empiric treatment of febrile neutropenia before and after implementing an algorithm in which voriconazole was substituted for liposomal amphotericin B (L-AmB). (duke.edu)
Management3
- Febrile neutropenia mostly happens among children with cancer and can be prevented by infection management control. (journalpress.id)
- Management of infection and febrile neutropenia in patients with solid cancer. (journalpress.id)
- The Infectious Diseases Society of America (IDSA) guidelines on management of febrile neutropenia. (ubc.ca)
Assess2
- Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy. (brainandnervecenter.com)
- In 2009, a retrospective audit of positive blood cultures from 2006-2008 in MMUH haematology patients with febrile neutropenia was used to assess the appropriateness of the guidelines in use at that time. (bmj.com)
Toxicity1
- [ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
Effectiveness1
- Effectiveness of a conservation energy model for febrile neutropenia in children with cancer. (journalpress.id)
Risk1
- Genetic Sequence Variants in TLR4, MBL or IL-1 Receptor Antagonist is not Associated to Increased Risk for Febrile Neutropenia in Children with ALL. (cdc.gov)
Grades1
- Rates of chemotherapy-induced neutropenia (CIN) (all grades), FN, and CIN-related hospitalizations were consistently lower in over-prophylacted patients relative to under- and correctly-prophylacted patients. (unibas.ch)
Therapy1
- longer durations of therapy may be required for deep seated infections or in cases of prolonged courses of chemotherapy or neutropenia. (medicines.org.uk)
Blood3
- Described here is a streamlined bioinformatics workflow for analyzing whole genome shotgun reads from blood in 6 Febrile Neutropenia and 5 bone marrow transplant patients. (arizona.edu)
- Neutropenia is a decrease in circulating (ie, nonmarginal) neutrophils in the blood. (medscape.com)
- Neutropenia, pronounced noo-troh-PEE-nee-uh, is a low white blood cell count. (cdc.gov)
Findings1
- Some findings were consistent between the two cycles, e.g. higher bacteraemia rate among patients with profound neutropenia. (bmj.com)
Study1
- The study sample consisted of 30 parents of children with cancer who were treated with febrile neutropenia. (journalpress.id)