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Lipid PeroxidationFatty AcidsLipidsLipid PeroxidesMalondialdehydeFatty Acids, UnsaturatedLipid MetabolismFatty Acids, Omega-3Thiobarbituric Acid Reactive SubstancesAldehydesAntioxidantsFatty Acids, NonesterifiedOxidative StressFatty Acid SynthasesThiobarbituratesVitamin ELipid AFatty Acid DesaturasesFatty Acids, EssentialPhospholipidsFatty Acids, Omega-6LiverPeroxidesGlutathioneFree RadicalsGlutathione PeroxidaseEthaneSuperoxide DismutaseFatty Acids, MonounsaturatedCatalaseLipid BilayersAscorbic AcidOxidation-ReductionTriglyceridesFatty LiverChromatography, GasDietary FatsOleic AcidRats, WistarLinoleic AcidOleic AcidsLinoleic AcidsFree Radical ScavengersFatty Acids, VolatileF2-IsoprostanesCholesterolPalmitic AcidsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acid Transport ProteinsFish OilsReactive Oxygen SpeciesIsoprostanesPregnatrienesPlant ExtractsTrans Fatty AcidsPalmitic AcidStearic AcidsMicrosomes, LiverFerrous CompoundsPhosphatidylcholinesHydrogen PeroxideDietRats, Sprague-DawleyHydroxyl RadicalMembrane Lipidsalpha-TocopherolChromatography, Thin LayerPlant OilsGlutathione ReductaseButylated HydroxytolueneRats, Inbred StrainsFatty Acid-Binding ProteinsKineticstert-ButylhydroperoxideArachidonic AcidDietary Fats, UnsaturatedVitamin E DeficiencyIronLipoproteins, LDLProtein CarbonylationAcroleinFatty AlcoholsGas Chromatography-Mass SpectrometryDeferoxamineTime FactorsPalmitatesOxidantsDinoprostMembrane FluidityChromatography, High Pressure LiquidLipoxygenaseEstersErythrocytesAdipose TissueLiposomesDose-Response Relationship, DrugCell MembraneMalonatesBromobenzenes
OxidationPUFAReduce lipid peroxidationOmega-3 faOxidative stress assayReactiveMembraneNucleic acidsPhospholipidsMoleculesSerumHydroperoxidesApoptosisDocosahexaenoic acidFree radicalsInducesIron accumulationSupplementationEnzymesVivoCompositionMitochondrialDietaryPhospholipidBiosynthesisCellularVitaminOccurrencePUFAsCellFerroptosisCoronaryNAFLDSusceptible1991GlutathioneTherapeutic potentialEssentialLiverApoptoticCompoundsAscorbic acidArachidonic acidLevelsMoietySupplementsRadicalMechanismAnalysisBeta-CaroteneCellsHydrogenPeroxidesPhosphatidylinositolUnstableAlpha LipoLactateProducts
Oxidation6
  • Unlike catabolic oxidation of drugs, or oxidative damage to DNA or proteins (which occurs stoichiometrically), oxidation of PUFAs is particularly pernicious, proceeding through a non-enzymatic lipid peroxidation chain reaction (LPO), whereby a single ROS species can initiate a runaway autoxidation process that does not need any additional ROS to propagate. (wikipedia.org)
  • The chain oxidation proceeds inexorably through multiple steps, destroying lipid membranes and generating highly reactive toxic secondary products that damage numerous biomolecules, such as proteins and DNA, irreversibly. (wikipedia.org)
  • It has also been shown to reduce the lipid oxidation of low-density lipoprotein (LDL) particles, thus promoting cardiovascular health (6). (nutrametrix.com)
  • Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
PUFA3
  • The lipid bilayer of the cell and organelle membranes contain polyunsaturated fatty acids (PUFA) are key components of cell and organelle membranes. (wikipedia.org)
  • Fish oil is a processed form of omega 3, high in processed polyunsaturated fatty acids (PUFA). (itestosterone.com)
  • Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)
Reduce lipid peroxidation2
Omega-3 fa3
  • There is a plethora of health benefits associated with omega 3 fatty acid intake, most of which I imagine you have heard about since it seems to be in the news every other day. (itestosterone.com)
  • Whether omega-3 fatty acid will prove more useful for acute, long-term or prophylactic purposes has yet to be determined. (chicagopsychiatryassociates.org)
  • These studies show that omega-3 fatty acid supplements are generally well-tolerated even at higher doses without significant adverse effects. (chicagopsychiatryassociates.org)
Oxidative stress assay1
Reactive8
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
  • When the concentration of free radicals exceeds the neutralizing capability of the body's antioxidants, these highly reactive species can damage vital molecules such as DNA, RNA, enzymes and structural proteins and large amounts of membrane lipids though peroxidation. (nutrametrix.com)
  • It has been shown to protect critical molecules in the body such as lipids, proteins, and nucleic acids from free radicals and reactive oxygen species (1). (nutrametrix.com)
  • Glutathione peroxidases are a group of selenoprotein enzymes that reduce reactive oxygen species such as hydrogen peroxide and lipid hydroperoxides to harmless products such as water and simple alcohols. (nutrametrix.com)
  • 24 ] have also shown that 0.2% of G-rutin (a rutin-glucose derivative), given in a 20% casein diet for a period of one month to streptozotocin-induced diabetic rats, decreased thiobarbituric acid reactive substance (TBARS) in kidneys. (molvis.org)
  • Lipid peroxides are unstable to form a complex series of compounds including reactive carbonyl compounds. (creativebiomart.net)
  • It prevents damage to cellular components caused by reactive oxygen species such as peroxides, lipid peroxides, heavy metals and free radicals. (creativebiomart.net)
Membrane4
  • Phosphatidylinositols are important lipids, both as a key membrane constituent and as a participant in essential metabolic processes, both directly and via a number of metabolites. (hmdb.ca)
  • This membrane is made up of dense rows of fatty acids. (vitanetonline.com)
  • Sperm quality was evaluated for plasma membrane and acrosome intact sperm (PMAI), the amount of membrane lipid peroxidation (LPO), and the percentage of sperm with a high DNA fragmentation index (DFI). (uzh.ch)
  • dependence on plasma-membrane fatty acid composition. (microbiologyresearch.org)
Nucleic acids1
  • ROS can react with proteins, nucleic acids, and can cause lipids cell and tissue damage and can be measured using selective or general indicators. (creativebiomart.net)
Phospholipids3
  • Phosphatidylinositols are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). (hmdb.ca)
  • Peroxidation products were identified in three relatively minor classes of anionic phospholipids, cardiolipin, phosphatidylserine, and phosphatidylinositol, whereby oxygenation of polyunsaturated fatty acid residues also showed unusual substrate specificity. (cdc.gov)
  • The major components of soy are phospholipids, such as phosphatidylcholine and essential fatty acids. (jcadonline.com)
Molecules5
  • Plant oxylipins are a class of lipid-derived signaling molecules being involved in the regulation of various biotic and abiotic stress responses. (frontiersin.org)
  • The new research, published online in the journal Redox Biology , also revealed that the drug, CMS121, works by changing how brain cells metabolize fatty molecules known as lipids. (eurasiareview.com)
  • They discovered that when it came to levels of lipids-fatty molecules that play key roles in cells throughout the body-mice with the disease had several differences compared to both healthy mice and those treated with CMS121. (eurasiareview.com)
  • In particular, the researchers pinpointed differences in something known as lipid peroxidation-the degradation of lipids that produces free radical molecules that can go on to cause cell damage. (eurasiareview.com)
  • Indeed, a number of signaling functions of (phospho)lipid molecules has been discovered. (cdc.gov)
Serum5
Hydroperoxides1
  • Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
Apoptosis2
Docosahexaenoic acid3
  • 0.05) the docosahexaenoic acid (DHA) content in bulls whereas in PA bulls did not change. (uzh.ch)
  • Both saturated as well as polyunsaturated fatty acids had positive effects on quality of cryopreserved bovine sperm, although the content of docosahexaenoic acid in sperm membranes increased only in ALA bulls. (uzh.ch)
  • Cold-water fish, including cod, salmon, and mackerel, contain the essential omega-3 fatty acids Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA). (chicagopsychiatryassociates.org)
Free radicals1
Induces1
Iron accumulation1
  • In summary, findings in the present study confirmed that BP-QDs induce ferroptosis via increasing lipid peroxidation and iron accumulation in vitro and in vivo.PMID:3748. (medworm.com)
Supplementation2
  • Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty PTCA. (vitalraadet.dk)
  • ABSTRACT In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double- blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
Enzymes3
  • S. Slathia, A. Sharma and S. Choudhary, "Influence of Exogenously Applied Epibrassinolide and Putrescine on Protein Content, Antioxidant Enzymes and Lipid Peroxidation in Lycopersicon esculentum under Salinity Stress," American Journal of Plant Sciences , Vol. 3 No. 6, 2012, pp. 714-720. (scirp.org)
  • In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)
  • Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)
Vivo1
Composition3
  • For years, moderate-intensity continuous training (MICT) has been the most popular exercise modality for improving body composition, cardiorespiratory fitness, insulin resistance, and lipid profile [ 2 , 5 ]. (hindawi.com)
  • The aim of the present study was to examine the effects of feeding alpha-linolenic (ALA) acid on fatty acid composition and quality of bovine sperm and on antioxidative capacity of seminal plasma. (uzh.ch)
  • Mammalian sperm cells present highly specific lipidic composition, high content of polyunsaturated fatty acids, plasmalogenes and sphingomyelins. (scialert.net)
Mitochondrial3
  • Polyunsaturated fatty acids (PUFAs), which make up cell and mitochondrial membranes throughout the body and are vital to healthy cellular function, are the target of the LPO process due to their inherent instability. (globenewswire.com)
  • Insulin resistance occurs in almost all patients with non-alcoholic fatty liver disease (NAFLD), and mitochondrial dysfunction likely plays a pivotal role in the progression of fatty liver into non-alcoholic steatohepatitis (NASH). (spandidos-publications.com)
  • The aim of this study was to analyze the ability of curcumin to protect against the mitochondrial impairment induced by high free fatty acids (HFFAs) and to determine the underlying mechanism for this cytoprotection. (spandidos-publications.com)
Dietary3
  • Flaxseed, canola oil, and walnuts are also potential dietary sources of these omega-3 fatty acids. (chicagopsychiatryassociates.org)
  • The United States Food and Drug Administration (FDA) recommends consumption of 3 grams of EPA and DHA omega-3 fatty acids each day, with no more than 2 grams per day coming from dietary supplements. (chicagopsychiatryassociates.org)
  • There is considerable evidence for a pro- fatty acids in the diet as food additives or tective effect of dietary omega-3 fatty acids as therapeutic substances, it is important in the prevention of heart disease [ 12-15 ], to determine the extent of any effects, and especially in a high-risk population [ 16,17 ]. (who.int)
Phospholipid4
  • A test using activated sludge respiration and phospholipid fatty acid analysis of microbial populations was also employed. (rsc.org)
  • Our mass spectrometry-based oxidative lipidomics analysis of all major phospholipid classes revealed highly selective patterns of pulmonary peroxidation after inhalation exposure of mice to single-walled carbon nanotube s. (cdc.gov)
  • A similar selective phospholipid peroxidation profile was detected upon incubation of a mixture of total lung lipids with H(2)O(2)/cytochrome c known to catalyze cardiolipin and phosphatidylserine peroxidation in apoptotic cells. (cdc.gov)
  • The characterized specific phospholipid peroxidation signaling pathways indicate new approaches to the development of mitochondria-targeted regulators of cardiolipin peroxidation to protect against deleterious effects of pro-apoptotic effects of single-walled carbon nanotube s in the lung. (cdc.gov)
Biosynthesis1
  • In animal tissues, phosphatidylinositol is the primary source of the arachidonic acid required for biosynthesis of eicosanoids, including prostaglandins, via the action of the enzyme phospholipase A2. (hmdb.ca)
Cellular4
Vitamin4
  • Lipid peroxidation and changes in vitamin E levels during coronary artery bypass grafting. (vitalraadet.dk)
  • Vitamin E is a fat-soluble antioxidant that protects vulnerable fatty acids in cell membranes from lipid peroxidation. (nutrametrix.com)
  • Overview of Vitamins Vitamins may be Fat soluble (vitamins A, D, E, and K) Water soluble (B vitamins and vitamin C) The B vitamins include biotin, folate, niacin, pantothenic acid, riboflavin (B2), thiamin (B1). (merckmanuals.com)
  • Starting with Optimal Vitamin Nutrition (OVNÂŽ) , we understand that the right amount of vitamin D, vitamins E and C, key B vitamins, with beta-carotene plus essential minerals and omega 3 fatty acids nourish the immune defences which protect our pets from everyday challenges at each life stage. (issuu.com)
Occurrence1
PUFAs1
  • Several biomolecules, including PUFAs and some amino acids, cannot be made by human beings and must be supplied in the diet. (wikipedia.org)
Cell3
  • Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
  • This is an unstable condition and the free radical can remove electrons from other cell components, such as lipids, cell membranes etc. (omegafields.com)
  • Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
Ferroptosis2
  • Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
  • Furthermore, based on the ferroptosis-associated protein and mRNA expression, it was hypothesized that BP-QDs induced ferroptosis through increasing intracellular free iron and polyunsaturated fatty acid synthesis. (medworm.com)
Coronary1
  • Some previous data do not support the liter- process in the determination of morbidity ature suggesting adverse effects of omega-3 and mortality from coronary heart disease fatty acids on lipid peroxidation [ 2,21,35 ]. (who.int)
NAFLD3
  • Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease (NAFLD). (wjgnet.com)
  • Non-alcoholic fatty liver disease (NAFLD) has emerged as a substantial public health concern. (spandidos-publications.com)
  • Although the mechanisms responsible for fatty liver are not fully elucidated, an increased delivery and transport of FFAs into the liver, and augmented hepatic fatty acid synthesis are likely to play a significant role in the pathogenesis of NAFLD. (spandidos-publications.com)
Susceptible1
  • As it turns out fish oil is "susceptible to lipid peroxidation due to their high degree of unsaturation" which in plain english means it goes rancid easily and then becomes a negative source for your body. (itestosterone.com)
19911
Glutathione2
Therapeutic potential1
Essential1
  • They're looking at essential fatty acid profiles like omega-3 and omega-6, but also saturated fat, but in much more detail. (chriskresser.com)
Liver1
  • Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. (medsci.org)
Apoptotic1
  • This nonrandom peroxidation coincided with the accumulation of apoptotic cells in the lung. (cdc.gov)
Compounds1
  • While the group is pursuing clinical trials, they hope other researchers will explore additional compounds that may treat Alzheimer's by targeting FASN and lipid peroxidation. (eurasiareview.com)
Ascorbic acid1
Arachidonic acid2
  • PIs contain almost exclusively stearic acid at carbon 1 and arachidonic acid at carbon 2. (hmdb.ca)
  • A non-targeted metabolomics approach was used to reconstruct the metabolic pathways for the synthesis of oxylipins, derived from roughanic, linoleic, α-linolenic, and arachidonic acid in wild type, the oxylipin-deficient mutants of Ppaos1 and Ppaos2 , the mutants of Ppdes being deficient in all fatty acids harboring a Δ 6 -double bond and the C20-fatty acid-deficient mutants of Ppelo . (frontiersin.org)
Levels4
  • In conclusion, feeding of neither saturated nor polyunsaturated fatty acids affect the antioxidant levels in seminal plasma. (uzh.ch)
  • Plasma tocopherol levels vary with total plasma lipid levels. (merckmanuals.com)
  • Mice with Alzheimer's-like disease had higher levels of lipid peroxidation than either healthy mice or those treated with CMS121. (eurasiareview.com)
  • The researchers went on to show that CMS121 lowered levels of a lipid-producing molecule called fatty acid synthetase (FASN), which, in turn, lowered levels of lipid peroxidation. (eurasiareview.com)
Moiety1
  • The palmitoleic acid moiety is derived from animal fats and vegetable oils, while the stearic acid moiety is derived from animal fats, coco butter and sesame oil. (hmdb.ca)
Supplements1
Radical1
  • In vitro experiments showed that white peony polyphenols (WPPs) possess strong free radical scavenging capabilities toward 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). (mdpi.com)
Mechanism1
Analysis1
  • Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotube s. (cdc.gov)
Beta-Carotene1
  • Beta-Carotene is also metabolized into retinoic acid, a hormone that promotes normal embryonic development and the transcription of the gene for growth hormone (5). (nutrametrix.com)
Cells5
  • Deuterium-reinforced lipids can be used for the protection of living cells by slowing the chain reaction of lipid peroxidation. (wikipedia.org)
  • GLA treatment could also elevate lipid peroxidation in K562 cells, and antioxidant alpha-tocopherol could reverse the cytotoxicity of GLA. (omega-research.com)
  • Gathering of lipids within arterial walls is the hallmark feature in atherosclerosis that leads to fatty streak and formation of lipid-foam cells in the intima of an artery, which ultimately gets hardened and forms plaque, thereby causing artery constriction and hardening resulting in full blockage in later stages [ 7 ]. (hindawi.com)
  • Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
  • After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B cells. (medworm.com)
Hydrogen1
  • Addition of hydrogen to a compound, especially to an unsaturated fat or fatty acid. (bvsalud.org)
Peroxides2
  • Polyunsaturated fatty acid peroxides can generate 4-hydroxyalkenals upon decomposition and malonaldehyde (MDA). (creativebiomart.net)
  • The Total Lipid Hydroperoxide ELISA Assay kit allows an easy, rapid and precise quantitative determination of the total peroxides in biological samples. (eaglebio.com)
Phosphatidylinositol1
  • The inositol group that is part of every phosphatidylinositol lipid is covalently linked to the phosphate group that acts as a bridge to the lipid tail. (hmdb.ca)
Unstable1
  • STABILITY Stable in acid or neutral solutions, unstable in alkaline solutions. (inchem.org)
Alpha Lipo1
  • If you want to learn more about ALA (Alpha Lipoic Acid) though, this is a good place to start . (itestosterone.com)
Lactate1
  • The net breakdown of ATP from glycolysis results in ADP, AMP (Adenosine MonoPhosphate), phosphate, lactate and acid accumulation (acidosis). (benbest.com)
Products1