Fatty glucose transporter type 5. Medical search. Frequent questions

Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
which, when activated, stimulate expression of genes involved in energy homeostasis, specifically the metabolism of glucose and fatty acids (Blaschke et al. (bodybuilding.com)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
Disorders of fat metabolism result in the unavailability of free fatty acids and ketones as alternative fuels. (medscape.com)
The first step in glycolysis (ie, conversion of glucose to glucose-6-phosphate [G6P] by glucokinase) is the rate-limiting step in glucose metabolism. (medscape.com)
In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
The aim of this review was to summarize and discuss current knowledge on the impact of dietary fibre as modulator of the relationship between glucose metabolism and microbiota composition in humans. (springer.com)
More specifically, we analysed evidence from observational studies and randomized nutritional intervention investigating the relationship between gut microbiota, short-chain fatty acids and glucose metabolism. (springer.com)
Indeed, it may influence multiple physiological mechanisms related to human health, i.e. synthesis of micronutrients, defence against pathogens, regulation of glucose and lipid metabolism, and immune function [ 1 ]. (springer.com)
Therefore, in this review, we summarized current evidence from observational and intervention studies performed in humans investigating the relationship between the composition of the gut microbiota, concentration of SCFA and glucose metabolism. (springer.com)
Significant impacts of interventions on intestinal bile acid metabolism, farnesoid X receptor (Fxr) signalling in the intestine and liver, and hepatic expression of fatty acid transporters (Fabp4, Vldlr, Cd36) were also evident. (nih.gov)
In conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction. (ox.ac.uk)
In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. (karger.com)
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans. (cdc.gov)

However, if only a little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies, the latter passing into the brain and replacing glucose as an energy source. (wikipedia.org)
However, medium-chain triglycerides (MCTs)-made from fatty acids with shorter carbon chains than LCTs-are more ketogenic. (wikipedia.org)
These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (eg, adiponectin), and the gut hormone glucagonlike peptide-1 (GLP-1). (medscape.com)
A lipase is an enzyme that helps break down fats into glycerol and fatty acids that can then be absorbed into the bloodstream. (bodybuilding.com)
They consist of glycerin (a sweet, syrupy liquid) plus 3 individual fatty acids all mixed together. (bodybuilding.com)
Cardiovascular exercise and low-moderate carbohydrate diets containing essential fatty acids are recommended for reducing triglyceride levels. (bodybuilding.com)
These changes liberate fatty acids, allowing them to either be oxidized or stored. (bodybuilding.com)
It is involved in the storage of fatty acids and is activated by leukotrienes, prostaglandins, and fatty acids. (bodybuilding.com)
State the physiological role of lysophospholipids & fatty acids produced by the breakdown of lecithin. (medical-junction.com)
2. Classify the fatty acids in details & indicate their physical properties. (medical-junction.com)
Describe the steps involved in beta oxidation of fatty acids. (firstranker.in)
Diagnostic criteria include plasma glucose levels less than 3 mmol/L with detectable serum insulin and C-peptide, low serum ketone bodies, and low serum fatty acids. (medscape.com)
After a few hours of fasting, insulin levels fall, and increased lipolysis creates free fatty acids and glycerol. (medscape.com)
Fatty acids do not cross the blood-brain barrier and, therefore, are not used by the brain. (medscape.com)
However, fatty acids are used by the heart and muscle. (medscape.com)
Increased free fatty acids result in production of ketones, and the brain is able to metabolize ketones as an alternative source of fuel. (medscape.com)
Glucose and several amino acids stimulate insulin secretion under physiologic conditions, and the sequence of events leading to insulin secretion is well delineated. (medscape.com)
Polyphenols and phenolic acids from strawberry and apple may decrease glucose uptake by blocking transport through human intestinal cells, according to a new study. (nutraingredients.com)
The research, published in Molecular Nutrition & Food Research , suggests that some polyphenols, phenolic acids and tannins extracted from apples and strawberries may block the transport of glucose across intestinal tissues, potentially blunting post-meal glucose spikes. (nutraingredients.com)
"There is recent evidence that some bioactive compounds, in particular polyphenols, phenolic acids and tannins (PPTs), can affect the shape of the blood glucose curve … Some studies have shown that these compounds may result in an altered pattern of intestinal glucose uptake, possibly due to interactions between compounds and sugar transporters," said the authors. (nutraingredients.com)
They said that PPTs have the potential to "readily affect glucose absorption in the small intestine," noting that many polyphenols, phenolic acids and tannins can interact with certain sugar transporters - for example, inhibition of sodium-dependent glucose transporter 1 (SGLT1 - an active transport mechanism in which glucose is co-transported with sodium ion) or by inhibition of GLUT2. (nutraingredients.com)
"The results obtained demonstrate that polyphenols, phenolic acids and tannin-rich extracts from strawberry and apple were able to influence glucose uptake into the cells and transport … by inhibiting activities of the glucose transporters," said the authors. (nutraingredients.com)
In addition, there is evidence that fatty acids interfere with very early stages of Glucose Transporter Type 4 (GLUT4) and hexokinase II activity [8]. (heraldopenaccess.us)
Carnitine plays a role in the transfer of long chain fatty acids from cytoplasm to mitochondria for beta-oxidation. (heraldopenaccess.us)
Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. (springer.com)
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)

This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
This observation resulted in the development of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (PET) to detect glucose uptake and lactate production for tumor imaging. (hindawi.com)
Furthermore, no interaction with tofogliflozin was observed in any of a battery of tests examining glucose-related physiological processes, such as glucose uptake, glucose oxidation, glycogen synthesis, hepatic glucose production, glucose-stimulated insulin secretion, and glucosidase reactions. (aspetjournals.org)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Some studies suggest that an increase in plasma fatty acid concentration reduces glucose uptake and phosphorylation, and this leads to reduced glycogen synthesis and glucose oxidation. (heraldopenaccess.us)

Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. (frontiersin.org)
Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. (nature.com)
In the EMPA-REG OUTCOME trial, a large randomized controlled clinical trial, the highly selective SGLT2 inhibitor empagliflozin significantly reduced the risk of three-point major adverse CV events, cardiovascular death, heart failure hospitalization and composite renal outcomes in patients with type 2 diabetes (T2D) with established cardiovascular disease 2 . (nature.com)
The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. (medscape.com)
Go to Diabetes Mellitus, Type 1 and Diabetes Mellitus, Type 2 for complete information on these topics. (medscape.com)
failure of the signals or of the B cells to adapt adequately in relation to insulin sensitivity results in inappropriate insulin levels, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes. (medscape.com)
Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. (beds.ac.uk)
It is divided into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), which account for 5-10% and 90-95% of DM cases resepectively. (xiahepublishing.com)
Sodium/glucose cotransporter 2 (SGLT2) is the predominant mediator of renal glucose reabsorption and is an emerging molecular target for the treatment of diabetes. (aspetjournals.org)
These findings demonstrate that tofogliflozin inhibits SGLT2 in a specific manner, lowers blood glucose levels by increasing renal glucose clearance, and improves pathological conditions of type 2 diabetes with a low hypoglycemic potential. (aspetjournals.org)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
Several normal variations (polymorphisms) of the SLC2A10 gene have been associated with an increased risk of peripheral artery disease in people with type 2 diabetes , a disorder in which resistance to the hormone insulin leads to excess glucose levels in the blood (hyperglycemia). (medlineplus.gov)
Problems with blood vessels, including peripheral artery disease, are common in type 2 diabetes, and are believed to be related to the effect of hyperglycemia on TGF-β signaling. (medlineplus.gov)
The development of type 2 diabetes mellitus (T2DM) is highly influenced by complex interactions between genetic and environmental (dietary and lifestyle) factors. (researchsquare.com)
Type 2 diabetes mellitus (T2DM) is a major medical problem worldwide, and its development is highly affected by complex interactions between genetic and environmental (dietary and lifestyle) factors 1 . (researchsquare.com)
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. (scielo.br)
Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. (scielo.br)
Repeated high post meal (post-prandial) blood plasma glucose 'spikes' are associated with an increased risk of developing cardiovascular diseases, metabolic syndrome and type II diabetes. (nutraingredients.com)
Obesity is a prominent risk factor for Non-insulin Dependent Diabetes Mellitus, (NIDDM), which is also called diabetes mellitus type II. (heraldopenaccess.us)
On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. (springer.com)
In particular, animal studies support a causal role between the composition of the gut microbiota and development of obesity, insulin resistance and type 2 diabetes (T2D). (springer.com)
Vitamin D deficiency and insufficiency are also more common across type 2 diabetes mellitus (T2DM) patients. (karger.com)
Vitamin D deficiency also contributes to many extraskeletal outcomes, including higher risk of type 1 or type 2 diabetes mellitus, allergy, autoimmunity, pregnancy complications, and many other pathologies. (karger.com)
Temporal Trends in Incident Hospitalization for Diabetes-Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study. (tangello.com.au)
Haider KS, Haider A, Saad F, Doros G, Hanefeld M, Dhindsa S, Dandona P, Traish A. Remission of type 2 diabetes following long‐term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11‐year data from a real‐world registry study. (tangello.com.au)
In diabetes, more fat and less carbohydrate is used, due to the reduced induction of GLUT4 glucose transporters to the cell surfaces. (wikidoc.org)
In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagon-like peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
In obese patients with type 2 diabetes mellitus who require insulin therapy, at least one of the following is suggested: metformin, pramlintide, or GLP-1 agonists to mitigate associated weight gain due to insulin. (medscape.com)
Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes mellitus who are obese. (medscape.com)
A multi-pronged approach built on a foundation of strong educational and behavioral support and psychosocial care is essential to help improve the health of patients with type 2 diabetes (T2D). (medscape.com)
The ADA/European Association for the Study of Diabetes T2D algorithm (included in the ADA SOC) emphasizes the use of medications with high dual efficacy in lowering glucose and promoting weight loss, such as semaglutide and tirzepatide . (medscape.com)
Data-driven subgroups of newly diagnosed type 2 diabetes and the relationship with cardiovascular diseases at genetic and clinical levels in Chinese adults. (cdc.gov)
Association of Met420del Variant of Metformin Transporter Gene SLC22A1 with Metformin Treatment Response in Ethiopian Patients with Type 2 Diabetes. (cdc.gov)
The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome. (cdc.gov)
RS3480 Polymorphism of FNDC5/Irisin Is Associated with Type 2 Diabetes Mellitus in Maya-Mestizo Women. (cdc.gov)
Patients with type 1 diabetes mellitus are treated with insulin and also benefit from diet and exercise. (msdmanuals.com)
The anti-CD3 monoclonal antibody teplizumab can delay progression to symptomatic type 1 diabetes in patients who are presymptomatic and have mild glucose elevations and autoantibodies. (msdmanuals.com)
Patients with type 2 diabetes mellitus are often initially treated with only diet and exercise. (msdmanuals.com)
Insulin is also used in the management of many patients with type 2 diabetes. (msdmanuals.com)
Insulin replacement in type 1 diabetes should ideally mimic beta-cell function to provide basal and prandial requirements (physiologic replacement or basal-bolus dosing). (msdmanuals.com)

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a unique class of oral antidiabetic medications that reduce glucose reabsorption in the renal proximal tubules, thereby enhancing urinary glucose excretion 1 . (nature.com)
The selectivity of tofogliflozin toward human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1 was the highest among the tested SGLT2 inhibitors under clinical development. (aspetjournals.org)

Brain communications 2023 8 5 (4): fcad216. (cdc.gov)

Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. (org.ua)
SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. (org.ua)
For example, the use of a sodium-glucose cotransporter 2 (SGLT2) inhibitor combined with a ketogenic/low-carbohydrate diet increases the risk for euglycemic diabetic ketoacidosis . (medscape.com)

Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
In this review, we will consider obesity with special attention to adipocyte types, microbiota, and microbial products, LPS and bacteriocins. (heraldopenaccess.us)
At the moment of writing this article, 41 million children of age 5 or less are affected by obesity in the world [1]. (heraldopenaccess.us)
In a study of 8430 men and 7034 women affected by obesity, it was shown that people with ectopic fat obesity are in the greatest risk of NIDDM [5]. (heraldopenaccess.us)
Most individuals with T2D struggle with overweight and obesity, so it is important to recognize the effects obesity management has on optimizing glucose regulation . (medscape.com)

reported that chronic administration of empagliflozin enhanced ATP production in the heart of db/db mice, although they argued that this was due to an increase in glucose and fatty acid oxidation rather than the utilization of ketone bodies 8 . (nature.com)
Name the site where beta oxidation of fatty acid occurs. (firstranker.in)
The rate of glucose entry into the beta cell is facilitated by a glucose transporter, and the entry rate exceeds the oxidation rate of glucose. (medscape.com)
L-carnitine supplementation decreases serum glucose but has no effect on glucose oxidation [11]. (heraldopenaccess.us)
Accumulating evidence suggests that n-3 LC-PUFAs are efficacious in regulating lipogenesis and fatty acid oxidation. (nih.gov)
Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)

thus, insulin resistance results in increased insulin secretion to maintain normal glucose and lipid homeostasis. (medscape.com)
Glycogen storage disease (GSD) type I, also known as von Gierke disease, is a group of inherited autosomal recessive metabolic disorders of the glucose-6- phosphatase system which helps maintain glucose homeostasis. (medscape.com)
An understanding of glucose homeostasis can help narrow the differential diagnosis. (medscape.com)
Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase. (scielo.br)

Basal glycolysis and glycogen concentration were not changed, yet insulin stimulated glycolysis was decreased by 32%, accompanied by 33% lower insulin stimulated glucose transporter, GLUT4, protein levels in rat hearts following isoproterenol infusion, compared with controls. (ox.ac.uk)
However, contraction itself plays a part in bringing GLUT4 transporters to the surface [2] . (wikidoc.org)

Non-alcoholic fatty liver disease (NAFLD) is associated with the development of cardiovascular disease. (e-cmh.org)
40IU/L and ultrasonographical features of Non Alcoholic Fatty Liver Disease (NAFLD). (who.int)
Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults and at present no licensed medication has been approved. (nih.gov)

By stimulating the expression of glucose transporters and glycolytic enzymes, HIF-1 promotes glycolysis to generate more pyruvate [ 5 ]. (hindawi.com)

In addition to the change in plasma fatty acid levels, hepatic apoA-I andapoA-II are increased by PPAR-alpha activation, which improves cholesterol levels by increasing HDL levels (Chinetti et al. (bodybuilding.com)
GSD type VI, also known as Hers disease, belongs to the group of hepatic glycogenoses and represents a heterogenous disease. (medscape.com)

The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
this type of protein moves the simple sugar glucose across cell membranes and helps maintain proper levels of glucose within cells. (medlineplus.gov)
Accepted August 23, 2012 ABSTRACT The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. (studyres.com)
Fatty acid transporter protein levels were 11-52% lower and triglyceride concentrations were 55% lower in isoproterenol-infused rat hearts. (ox.ac.uk)

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. (org.ua)

For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)
GSD type IV, also known as amylopectinosis, Glycogen Branching enzyme deficiency (GBE) or Andersen disease, is a rare disease that leads to early death. (medscape.com)
5. Mention the enzyme defective in galactosemia. (firstranker.in)

About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. (studyres.com)
Research demonstrates that either of these approaches improves glucose regulation via weight loss, with additional metabolic benefits depending on mechanism of action. (medscape.com)

Normally carbohydrates in food are converted into glucose, which is then transported around the body and is important in fueling brain function. (wikipedia.org)

Hypoglycemia associated with elevated insulin levels makes certain disorders unlikely, such as defects in gluconeogenesis, free fatty acid synthesis and ketogenesis, growth hormone deficiency, and cortisol deficiency. (medscape.com)

A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. (aspetjournals.org)
DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)

Maternal diet apparently does not have a significant role on neonatal cord blood insulin, C-peptide, or plasma glucose levels although a lower maternal glycemic load appears to be associated with lower adiposity in infants born to these women. (medscape.com)

Muscle phosphorylase deficiency adversely affecting the glycolytic pathway in skeletal musculature causes GSD type V. Like other forms of GSD, McArdle disease is heterogeneous. (medscape.com)

This research is designed to assess whether insulin resistance is associated with a stronger preference for sugar-sweetened, thus elevating blood glucose responses in obese people with varying degrees of insulin resistance. (bvsalud.org)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. (org.ua)

Laboratory tests include the plasma glucose level, the fasting insulin level, and a lipid profile, among others. (medscape.com)

While FLAV reduced body (-28-30%), adipose tissue (-45-50%) weights and serum insulin (-22-25%) as observed following an intra-peritoneal glucose tolerance test, n-3 downregulated the expression of Srebf1 and the lipogenic genes (Acaca, Fasn). (nih.gov)

However, GLUT10 has some structural differences from other glucose transporters, and its role in the movement of glucose or other substances is unclear. (medlineplus.gov)
We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)

GSD type II, also known as alpha glucosidase deficiency (GAA, acid maltase deficiency) or Pompe disease, is a prototypic lysosomal disease. (medscape.com)
GSD type III is also known as Forbes-Cori disease or limit dextrinosis. (medscape.com)
Peripheral artery disease is a condition in which an accumulation of fatty deposits and scar-like tissue in the lining of the arteries (atherosclerosis) reduces blood flow to the legs, causing pain when walking. (medlineplus.gov)
however, weight loss of 10%-15% shows greater improvement in glycemic status - one that could potentially result in remission and improvement in comorbidities including cardiovascular (CV) health and nonalcoholic fatty liver disease . (medscape.com)
Physicians now recognize that zinc supplementation can reduce the incidence and severity of diarrheal disease, and an ORS of reduced osmolarity (i.e., proportionally reduced concentrations of sodium and glucose) has been developed for global use. (cdc.gov)
Glycogen storage disease (GSD) type I is also known as von Gierke disease or hepatorenal glycogenosis. (medscape.com)
GSD type IV, also known as amylopectinosis or Andersen disease, is a rare disease that leads to early death. (medscape.com)
GSD type V, also known as McArdle disease, affects the skeletal muscles. (medscape.com)

To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. (frontiersin.org)

Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)
Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle . (wikidoc.org)

The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. (mdpi.com)
No blood glucose reduction was observed in normoglycemic SD rats treated with tofogliflozin. (aspetjournals.org)
Reduction, or blunting, of post-prandial glucose concentration in blood is potentially beneficial. (nutraingredients.com)
1. Weight management is an important part of achieving and maintaining healthy blood glucose levels in patients with T2D. (medscape.com)
It is also important to be aware of concomitant medications that promote weight gain and may increase blood glucose (eg, certain antidepressants and pain medications). (medscape.com)
Individuals should be assessed for episodes of hypoglycemia and hypoglycemia unawareness , and they should be educated on potential triggers and how to detect and respond to low blood glucose. (medscape.com)
Patients on combination therapy with a glucagon-like peptide 1 (GLP-1) receptor agonist/glucose-dependent insulinotropic polypeptide (GIP) will probably require dose reduction or withholding of glucose-lowering agents (sulfonylureas or insulin) to avoid low blood glucose. (medscape.com)

In 2019, this is now recognized to be an oversimplification as HDL-C measurements do not necessarily reflect either the overall abundance of HDL particles, the distribution of HDL subspecies,4 or RCT capacity.5 Additionally, data from human genetic studies6 and a host of negative HDL-raising clinical trials have led to much controversy over the HDL hypothesis. (skanestugan.se)

In adipose tissue, NXT reduced fatty acid synthase while activating hormone-sensitive lipase expression. (academic-accelerator.com)

Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. (aspetjournals.org)
In db/db mice, 4-week tofogliflozin treatment reduced glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test 4 days after the final administration. (aspetjournals.org)

The expression levels of LPL (lipoprotein lipase), HSL (Hormone-sensitive lipase), FAS (fatty acid synthase), and PPARα/PPARγ (peroxisome proliferator-activated receptor alpha/gamma) were significantly changed in the sheep preadipocytes during differentiation for 7 days. (academic-accelerator.com)

By using sodium-containing (to activate both SGLT1 and GLUT2 glucose transporters) and sodium-free (activating GLUT2 only) conditions, the researchers showed that PPTs inhibit the action of GLUT2 receptors more than SGLT1. (nutraingredients.com)

1. Glucose and fructose form similar osazone crystals. (medical-junction.com)

Anatomy16

Organisms6

Diseases4

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes21

Technology, Industry, Agriculture1

Information Science3

Metabolism14

Acids27

Uptake10

Diabetes41

Inhibitors2

20231

SGLT23

Obesity5

Oxidation6

Homeostasis4

GLUT42

NAFLD3

Expression of glucose1

Hepatic2

Protein5

Sodium-glucose1

Enzyme3

Regulation2

Carbohydrates1

Synthesis1

Diabetic4

Plasma glucose levels1

Glycolytic1

Obese3

Insulin sensitivity1

Lipid1

Serum1

GLUT103

Disease8

T2DM1

Skeletal2

Blood7

20191

Adipose tissue1

Tolerance test2

Levels1

SGLT11

Fructose1