Fates cell movement. Medical search. Frequent questions

These processes include cell proliferation, differentiation, cellular movement and programmed cell death. (wikipedia.org)
Newer cell fate determination techniques include lineage tracing performed using inducible Cre-lox transgenic mice, where specific cell populations can be experimentally mapped using reporters like brainbow, a colorful reporter that is useful in the brain and other tissues to follow the differentiation path of a cell. (wikipedia.org)
Determination is followed by differentiation, the actual changes in biochemistry, structure, and function that result in specific cell types. (wikipedia.org)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)
The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
One of the crucial questions is cell fate determination and differentiation, tissue formation, and what, what cell phenotype type each cell will become. (catsboard.com)
The process reaches its limit when a cell undergoes terminal differentiation to form one of the highly specialized cell types of the adult body. (catsboard.com)
Many histone modifiers and chromatin remodelers have been implicated in stem cell pluripotency, cellular differentiation and development. (catsboard.com)
While a range of cell morphologies in the EGL has long been known, how they reflect the cells' differentiation status has previously only been inferred. (bvsalud.org)
To do this, we electroporated granule cell precursors in chick with plasmids encoding fluorescent proteins and probed labelled cells with markers of both proliferation (phosphohistone H3) and differentiation (Axonin1/TAG1 and NeuroD1). (bvsalud.org)
Overexpression of full length NeuroD1 within granule cell precursors does not abolish proliferation, but biases granule cells towards precocious differentiation, alters their migration path and results in a smaller and less foliated cerebellum. (bvsalud.org)
Our results show that granule cells show a greater flexibility in differentiation than previously assumed. (bvsalud.org)
This resulted in the downregulation of the thyroid hormone-responsive gene RORα and the Purkinje cell-specific differentiation marker LHX1/5 at day 6. (bvsalud.org)
Early administration of the thyroid hormone analogue 3,5,3'-triiodothyroacetic acid partially rescued early Purkinje cell differentiation. (bvsalud.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)

They could, however, distort the data in studies using BrdU to quantify cell proliferation in postnatal and adult brain tissue. (vetscite.org)
Wnt signaling orchestrates multiple aspects of central nervous system development, including cell proliferation and cell fate choices. (biologists.com)
Organ formation requires the establishment of pattern in relatively broad domains, leading to specific fate choices by individual cells, along with coordinated proliferation. (biologists.com)
Wnt signaling pathway is mediated by Wnt family of 19 secreted glycoproteins (bearing22 or 24 cysteine residues) which are essential for cell proliferation, embryonic development, cell polarity, and tissue homeostasis [ 9 ]. (biomedcentral.com)
We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. (southampton.ac.uk)
Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
MCT8-deficient Purkinje cells also induced non-autonomous effects as they led to a reduced granule cell precursor proliferation, a thinner external germinal layer and a loss of PAX6 expression. (bvsalud.org)

As embryos mature, more complex fate determination occurs as structures appear, and cells differentiate, beginning to perform specific functions. (wikipedia.org)
As a result of work done on an ongoing BBSRC grant studying neural crest stem cells in zebrafish embryos, we are proposing a revolutionary new view, which we believe reconciles these conflicts. (bath.ac.uk)
Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)
We demonstrate how left-right signals affect the behavior of zebrafish somite cell precursors by using live imaging and fate mapping studies in dand5 homozygous mutants compared to wildtype embryos. (unl.pt)

These precursors are multipotent, having the flexibility to develop into any one of many types of working cells (e.g. neurons, blood or skin cells). (bath.ac.uk)
A major problem in developmental biology is to understand how these flexible precursors make a specific choice of cell-type to adopt. (bath.ac.uk)
We see evidence for only some very broadly multipotent precursors, leading us to propose our novel Cyclical Fate Restriction model. (bath.ac.uk)
The morphogenetic movements of gastrulation rearrange the three germ layers precursors, positioning mesodermal cells between outer ectodermal and inner endodermal cells to shape the head-to-tail body axis. (nature.com)
Muscle precursors need to be correctly positioned during embryonic development for proper body movement. (zfin.org)
Being the source of most of the peripheral nervous system, pigment cells and ectomesenchyme, the embryonic NC is considered to be a multipotent population of precursors. (ehu.eus)
Evidence suggests that the premigratory NC still resident in the dorsal neural tube epithelium is composed both of multipotent as well as of fate-restricted precursors, supporting the notion of an early appearance of cellular heterogeneity. (ehu.eus)
The EGL is comprised solely of granule cell precursors, whose progeny migrate inwardly to form the internal granule cell layer. (bvsalud.org)
We show that granule cell precursors can display a range of complex forms throughout the EGL while mitotically active. (bvsalud.org)
Electroporation of an MCT8-RNAi vector into the cerebellar anlage of a 3-day-old embryo allowed knockdown of MCT8 in Purkinje cell precursors. (bvsalud.org)

Cell polarity controls orientated cell division, cell shape changes, as well as cell movement. (nature.com)
WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
Christine Jacobs-Wagner's studies of a bacterial species have changed how scientists think about cell shape and polarity. (the-scientist.com)
Her pioneering studies on the molecular mechanisms underlying cell shape and cell polarity in Caulobacter crescentus , says Errington, "have helped change the way people think about bacteria. (the-scientist.com)
Canonical Wnt signaling pathway is essential for embryonic development [ 10 ] and non-canonical Wnt pathway regulates cell movement and tissue polarity [ 11 ]. (biomedcentral.com)

Developmental transitions steer cells into different pathways until a complete repertoire of cell types and tissues is achieved. (hws.edu)
We also now show that tyrosine phosphorylation/activation of GSK3 by ZAK2 and ZAK1 separately regulate GSK3 in distinct differentiated cell populations, and that ZAK2 acts in both autonomous and non-autonomous pathways to regulate these cell-type differentiations. (biologists.com)
These results were confirmed by transcriptomic analyses that highlighted the specific genes involved in these cell death pathways. (stanford.edu)
Glioblastoma stem cells play an important role in tumor formation by activation of several signaling pathways. (biomedcentral.com)
There are two Wnt pathways which determine the cell fate. (biomedcentral.com)
In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer.At almost every stage of the development of a tumour, cells are exposed to some form of stress. (southampton.ac.uk)
Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
A particular interest of our work has been how HDM2 and HDMX protein synthesis is controlled in response to cell-signalling pathways in different cell types, and how this affects p53 function in these cells. (southampton.ac.uk)

We will integrate the two approaches, experimentally investigating biological features relevant to the models, including direct assessment of the direction of change of progenitor cells, and quantitative investigation of the key fate specification signals in the neural crest. (bath.ac.uk)
Furthermore, titration of hhex with a dexamethasone-inducible hhex -VP16GR fusion construct suggested that endogenous hhex activity during gastrulation is essential for the formation of ventral pancreatic progenitor cells. (xenbase.org)
Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

The process of gastrulation is linked to determination of mesodermal cell fates, such that patterning of tissue fates and patterning of cell behavior are interconnected. (nature.com)
2010. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. . (ucsf.edu)

This technique of fate mapping is used to study cells as they differentiate and gain specified function. (wikipedia.org)
In general, this means that a cell determined to differentiate into a brain cell cannot be transformed into a skin cell. (wikipedia.org)
From the point of fertilization onward embryonic cells have to grow, divide, migrate, organize and finally differentiate into a vast number of cell types and tissues. (hws.edu)
6. Transcription factors - proteins that regulate which genes are transcribed in a cell - appear to be essential to determining the pathway particular stem cells take as they differentiate. (catsboard.com)
Each swarmer cell will eventually differentiate into a stalk cell and begin the cycle again. (the-scientist.com)

Each cell in an embryo receives molecular signals from neighboring cells in the form of proteins, RNAs and even surface interactions. (wikipedia.org)
The development of new molecular tools including GFP, and major advances in imaging technology including fluorescence microscopy, have made possible the mapping of the cell lineage of Caenorhabditis elegans including its embryo. (wikipedia.org)
During embryogenesis, for a number of cell cleavages (the specific number depends on the type of organism) all the cells of an embryo will be morphologically and developmentally equivalent. (wikipedia.org)
We will then use a sensitive technique to look at such cell-types directly in the embryo. (bath.ac.uk)
In order to break the initial "egg shape" of the embryo, cells need to polarize in a precise and coordinated manner. (nature.com)
The embryo of the frog Xenopus laevis is widely used as a model of cell polarization, migration, and morphogenesis due to its unique experimental advantages. (nature.com)
In the Xenopus embryo , XProfilin2 is temporally expressed throughout embryogenesis and it is spatially expressed in cells undergoing morphogenetic movement during gastrulation. (xenbase.org)
During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
We examined the contribution of pSHF cells, labeled by lipophilic dye at the 4- to 6-somite stage, to regions of the heart at 20 to 25 somites, using mouse embryo culture. (pasteur.fr)
Fate mapping revealed that more NKSTCs integrated somites on the left side of the embryo. (unl.pt)
Thus formed, the blastocyst consists of two layers of cells, an inner layer termed the embryoblast that becomes the embryo and an outer layer termed the trophoblasts that forms the embryonic part of the placenta. (medscape.com)

Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The Importance of Neuronal Subtype, Cell Source and Connectivity for Functional Recovery. (lu.se)

Her lab uses a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics-the analysis of proteins-and genomics, the study of entire collections of genes. (carnegiescience.edu)
hundreds of human genes encode signal proteins, cell-surface receptors, cell adhesion proteins, or ion channels that are either not present in yeast or present in much smaller numbers. (catsboard.com)
Both the genes a cell expresses and the way it behaves depend on the cell's past, as well as on its present circumstances. (catsboard.com)
Moreover, the presence of tubulovesicular structures in the brain medulla alongside the over-expression of prion disease genes in late cycle suggested a cell-to-cell, prion-like propagation recalling the conformational disorders typical of some human neurodegenerative diseases. (stanford.edu)
We found that neurons in the brain and cells of the vascular network both express multiple genes for voltage gated Na+ and Ca2+ ion channels homologous (based on sequence) to mammalian ion channel genes. (stanford.edu)
These genes are required for movement away from somites and later to partition two muscles within the fin bud. (zfin.org)
In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)

While we have previously shown XProfilin1 regulates blastopore closure, overexpression or depletion of XProfilin2 specifically affects convergent extension movement independent of mesodermal specification. (xenbase.org)
Specifically, we show that XProfilin2 modulates cell polarization and axial alignment of mesodermal cells undergoing gastrulation independent of XProfilin1 . (xenbase.org)

Involution follows bottle cell contraction and spreads laterally and ventrally leading to the formation of the blastopore, a ring of involuting cells that encircles the yolky vegetal endoderm cells. (nature.com)
ventral pancreatic precursor 1 ( vpp1 ) is a marker gene that is differentially expressed in a cell population within the dorsal endoderm in a pattern partially overlapping with that of hematopoietically expressed homeobox ( hhex ) during gastrulation. (xenbase.org)
L) Statistic analysis of phospho- histone H3-positive cells on the whole surface of bisected vegetal endoderm , as demarcated by the red dashed lines in J and K. As the distribution of phospho-histone H3-positive cells across the whole vegetal endoderm sur - face did not show obvious bias, for simplicity, we counted the whole area rather than only putative vpp1 -positive area. (xenbase.org)
The coupling of gene expression with the mechanics of cell movement is important for formation of both the trophectoderm and endoderm. (lu.se)
Our model, which couples gene expression with mechanics, suggests that differential adhesion between different cell types is a critical determinant in robust endoderm formation. (lu.se)
In addition to differential adhesion, two different testable hypotheses emerge when considering endoderm formation: (1) A directional force acts on certain cells and moves them into forming the endoderm layer, which separates the blastocoel and the cells of the inner cell mass (ICM), where the blastocoel simply acts as a static boundary. (lu.se)
2) The blastocoel dynamically applies pressure upon the cells in contact, such that cell segregation in the presence of differential adhesion leads to endoderm formation. (lu.se)

During embryogenesis, cells exist in three germ layers, and undergo gastrulation. (wikipedia.org)
Cell polarization is essential during gastrulation, driving asymmetric cell division, cell movements, and cell shape changes. (nature.com)
Loss of Fry function drastically affects the movement and morphological polarization of cells during gastrulation and disrupts dorsal mesoderm convergent extension, responsible for head-to-tail elongation. (nature.com)
At the beginning of Xenopus gastrulation, the presumptive anterior mesoderm cells located at the dorsal marginal zone (DMZ) roll inward at the midline of the blastopore lip in a process called involution. (nature.com)
Gastrulation movements are orchestrated by a small, heterogeneous group of cells with inductive and morphogenetic properties located in the dorsal lip of the blastopore (DBL) of the amphibian gastrula known as the Spemann-Mangold organizer or dorsal organizer. (nature.com)
Gastrulation is a critical morphogenetic event during vertebrate embryogenesis, and it is comprised of directional cell movement resulting from the polarization and reorganization of the actin cytoskeleton . (xenbase.org)
These observations suggest that, beyond its role in liver development, hhex controls specification of a vpp1 -positive endodermal cell population during gastrulation that is required for the formation of the ventral pancreas . (xenbase.org)

The Bejsovec Lab's hypothesis is that molecules that aid the movement of mutant Wg protein will be able to influence the wild type Wg protein. (duke.edu)
During immunological synapse (IS) formation, T cell receptor (TCR) signaling complexes, integrins, and costimulatory molecules exhibit a particular spatial localization. (ox.ac.uk)
The current review focuses on the importance of Wnt signaling pathway in glioblastoma stem cell progression and explores targeting of Wnt signaling molecules as a potential therapy for glioblastoma. (biomedcentral.com)
The receptor then conveys both molecules to the inside of the cell. (gpnotebook.com)

In studies of embryonic development, when much cell division is occurring, these factors are not hugely problematic. (vetscite.org)

The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
In addition to the cells originating from the OC, and thus the neural tube, neural crest-derived mesenchymal cells contribute to the formation of the ciliary folds, forming connective tissues and ciliary muscles( Beebe, 1986 ). (biologists.com)
The progressive generation of chick and mouse axial tissues - the spinal cord, skeleton and musculature of the body - has long been proposed to depend on the activity of multipotent stem cells. (silverchair.com)

In Dictyostelium , the interaction of secreted cAMP with specific cell surface receptors regulates the activation/de-activation of GSK3, which mediates developmental cell patterning. (biologists.com)

These observations show asymmetric fate of the pSHF, resulting in unexpected left/right contributions to both poles of the heart and can be integrated into a model of the morphogenetic movement of cells during cardiac looping. (pasteur.fr)

In addition, Dictyostelium cells polarize in response to extracellular cAMP, although a potential role for GSK3 in this pathway has not been investigated. (biologists.com)
Our findings demonstrate a conserved muscle precursor motility pathway, identify dynamic cell movements that generate posterior hypaxial and fin muscles, and demonstrate flexibility in muscle precursor fates. (zfin.org)
In this review, we discuss about the significance of glioblastoma stem cells in cancer progression through Wnt signaling pathway and highlight the clinical targets being potentially considered for therapy in glioblastoma. (biomedcentral.com)
In some circumstances, the activation of a stress-response pathway will actually help the tumour cell to survive and proliferate. (southampton.ac.uk)
In the late 1990s work from a number of groups, including Blaydes et al , demonstrated that HDM2 could be targeted in cancer cells to re-activate the p53 stress-response pathway. (southampton.ac.uk)

1 Institute for Stem Cell Research and MRC Centre for Regenerative Medicine,University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ,UK. (silverchair.com)

Understanding these changing states of commitment is a prerequisite for deciphering molecular mechanisms that regulate fate segregation of the embryonic NC. (ehu.eus)
We also review the location and molecular characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension. (silverchair.com)
CtBP activity is modified by UV radiation and glycolytic metabolism, suggesting that CtBPs regulate cell survival in response to cellular stress. (southampton.ac.uk)

Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)

The scale of the problem is illustrated by the fact that for one key exemplar, neural crest stem cells, there is still uncertainty about how the process works even after four decades of research - do fully multipotent cells 'jump' straight to a specific chosen fate, or do they go through a series of steps in which their options become more and more limited, until eventually they choose a single cell-type? (bath.ac.uk)
We have been looking at the formation of pigment cell-types from the neural crest, as a model of neural crest development in general. (bath.ac.uk)
A key experiment is to use a complementary technique to look at gene activity in thousands of neural crest cells, looking comprehensively at their cell-profiles so as to study the range of identifiable precursor states in the neural crest. (bath.ac.uk)
Together, these studies will test a revolutionary view of neural crest stem cell biology. (bath.ac.uk)
Kenyon, K. L., Zaghloul N., and S. A. Moody (2001) "Transcription factors of the anterior neural plate alter cell movements of epidermal progenitors to specify a retinal fate. (hws.edu)
Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate. (stanford.edu)
Cells from this region contribute to the neural tube and the somites, as well as to the notochord. (silverchair.com)

Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. (elifesciences.org)

The technique has been used routinely for decades to identify replicating cells, and particularly to investigate neurogenesis, the generation of neurons in the developing brain. (vetscite.org)

The aim of this study was to map the fate of the posterior SHF (pSHF). (pasteur.fr)
We show that NKSTCs originate in a cluster of cells aligned with the midline, posterior to the LRO, and leave that cluster in a left-right alternating manner, primarily from the left side. (unl.pt)
Cell exit from the posterior cluster became bilaterally synchronous in dand5−/− mutants. (unl.pt)

After a voluntary ten-year break in the transplant of dopamine-producing cells to treat Parkinson's disease, new trials will now be carried out. (lu.se)
The patients selected for a transplant must be under 60, have had Parkinson's disease for no more than ten years and have no involuntary movements. (lu.se)
Parkinson's disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. (lu.se)
Parkinson's Disease is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements. (lu.se)

Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)

In Drosophila Melanogaster (fruit flies), wingless (wg) a Wnt growth factor responsible for cell to cell communication operates in two parts, a signal transduction and movement (of this signal) to other neighboring cells. (duke.edu)

Merely observing a cell as it becomes differentiated during embryogenesis provides no indication of the mechanisms that drive the specification. (wikipedia.org)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)

Within the field of developmental biology, one goal is to understand how a particular cell develops into a final cell type, known as fate determination. (wikipedia.org)
Cells' fate determination mechanisms were categorized into three different types, autonomously specified cells, conditionally specified cells, or syncytial specified cells. (wikipedia.org)
The use of molecular techniques, including gene and protein knock downs, knock outs and overexpression allows investigation into the mechanisms of fate determination. (wikipedia.org)
The determination of a cell to a particular fate can be broken down into two states where the cell can be specified (committed) or determined. (wikipedia.org)
Cell determination starts early and progressively narrows the options as the cell steps through a programmed series of intermediate states-guided at each step by its genome, its history, and its interactions with neighbors. (catsboard.com)

Increasingly, stem cell biology is being explored using a mathematical modelling approach which has often given key insights into how they function. (bath.ac.uk)
In parallel we will explore the mathematical basis for the three models, developing current models to describe PFR, and applying novel theoretical insights to stem cell biology to investigate the plausibility of both DFR and our novel Cyclical model. (bath.ac.uk)

In addition, the entire vascular network undergoes slow rhythmic contractions that appear to arise from processes endogenous to vascular epithelial cells. (stanford.edu)
Born as an epithelium, NC progenitors undergo an epithelial-to-mesenchymal transition that generates cellular movement away from the CNS. (ehu.eus)
In this cord, there is the presence of countless chemical mediators, including EGF (epithelial growth factor), a substance secreted by the epithelial cells having the capacity of stimulating the formation of clasts and consequently a bone resorption, making impossible the filling of the cord area by alveolar bone, always leaving a space surrounding this cord, so-called the gubernacular canal (figures 1 to 3 ) 8.9 . (bvsalud.org)

Nov. 22, 2023 Tandem solar cells based on perovskite semiconductors convert sunlight to electricity more efficiently than conventional silicon solar cells. (sciencedaily.com)

The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
Mammalian embryogenesis is a dynamic process involving gene expression and mechanical forces between proliferating cells. (lu.se)
The development of animals is dominated by cell-cell interactions and by differential gene expression. (catsboard.com)
8. The chromatin state - the packaging of DNA with both histone and non-histone proteins - has marked effects on gene expression and is believed to contribute to the establishment and the maintenance of cell identities. (catsboard.com)

Molecular mechanisms coordinate the activities of embryogenesis to ensure that cells obtain information such as position (e.g., head versus tail/feet), growth (e.g., size versus cell number) and function (e.g., eye versus leg) as they develop. (hws.edu)
During this process, the participation of different anatomic structures, cells, chemical and molecular mediators occurs and although there have been a great advancement in the scientific knowledge regarding this issue, still today the cellular, molecular and anatomic mechanisms involved in tooth eruption process are not fully understood 17,28,29 . (bvsalud.org)

We describe a population of cells in the vicinity of the LRO, named Non-KV Sox17:GFP+ Tailbud Cells (NKSTCs), which migrate anteriorly and contribute to future somites. (unl.pt)

At a purely mechanical level, we demonstrate that the perpendicular alignment of the animal-vegetal (a-v) and embryonic-abembryonic (eb-ab) axes is a result of minimizing the total elastic conformational energy of the entire collection of cells constrained by the zona pellucida. (lu.se)

Specifically, we have been looking at melanocytes (black pigment cells, well-known for their roles in skin and hair colour in humans, and giving rise to melanoma), and iridophores, a shiny silver cell-type that is prominent in most fishes. (bath.ac.uk)

All cell types in the body derive from stem or other precursor cells. (bath.ac.uk)
Ectopic expression of a critical dose of hhex led to a greatly enlarged vpp1 -positive domain and, subsequently, to the formation of giant ventral pancreata, putatively by conversion of intestinal to ventral pancreatic precursor cells. (xenbase.org)

10. The Sugar Code forms information-rich structures that influence the arrangement of different cell types during embryological development. (catsboard.com)
The eye field comprises groups of cells biased to develop into various eye structures. (biologists.com)
Soluble and cell free antigens, immunoglobulin structures. (muni.cz)

Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)

While studying the different model systems, cells fate was discovered to be determined via multiple ways, two of which are by the combination of transcription factors the cells have and by the cell-cell interaction. (wikipedia.org)
Working with experts in protein chemistry, genetics, beta-lactamase biochemistry, cell wall synthesis, and medical microbiology - in Belgium, France, the United States, and Sweden - Jacobs-Wagner discovered a regulatory protein that can sense the peptidoglycans that accumulate when antibiotics disrupt cell wall synthesis, and then activate transcription of beta-lactamase, the enzyme that disarms the drugs. (the-scientist.com)

Detailed lineage analysis and fate-mapping studies have revealed that subdomains exist within these primordia. (silverchair.com)

Developmental Cell 5:1-20. (hws.edu)

Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. (elifesciences.org)

Furthermore, the cells' fate was determined mainly using two types of experiments, cell ablation and transplantation. (wikipedia.org)
The developmental equivalence of these cells is usually established via transplantation and cell ablation experiments. (wikipedia.org)
Targeted ablation of Sox14+ cells by conditional viral expression of diphtheria toxin leads to significantly impaired motor learning. (bvsalud.org)

Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)
2008. Biomechanical regulation of cell orientation and fate. . (ucsf.edu)

Cranial pSHF cells also contribute to the outflow tract: proximal and distal at 4 somites, and distal only at 6 somites. (pasteur.fr)

The energy for this transport is derived from the concentration gradient for sodium across the cell membrane. (gpnotebook.com)

I use a multidisciplinary methodology that integrates advanced single cell RNAseq, imaging, multi-parameter flow cytometric isolation of cellular populations and transplantation assays to elucidate the cellular and genetic changes associated with neuronal degeneration process in young and old colonies. (stanford.edu)
Wnt deregulation in brain is associated with congenital disorders [ 7 ], whereas it promotes malignancy in somatic cells of neuronal origin [ 8 ]. (biomedcentral.com)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

WPC Research Spotlight: Stem cells for treating PD - hope or hype? (lu.se)

The resultant study, Curious Rituals, documents such involuntary acts as Cell Trance, where people talking on the phone wander around, often into the paths of others, and Lazy Viewer, the crazy positions we adopt on beds and couches to make late-night laptop use comfortable. (metropolismag.com)
Some patients saw their condition deteriorate, for example 15 per cent developed more involuntary movements, and the possibility could not be excluded that this was as a result of the transplant. (lu.se)

This means, each cell has the same development potential and all cells are essentially interchangeable, thus establishing an equivalence group. (wikipedia.org)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
and the influence of cell structural development on cell fates. (carnegiescience.edu)
Bioretention cells (BRCs) are a promising low-impact development (LID) practice that are commonly used in urban settings to improve the water quality and mitigate the hydrological effects of stormwater runoff. (mdpi.com)
7. Cell Memory Underlies Cell Decision-Making Underlying the richness and astonishingly complex outcomes of development is cell memory. (catsboard.com)
Over the past 10 years that success has played out in a handful of papers in Cell, Science, and other high-impact journals, where Jacobs-Wagner, now at Yale University, has showcased her award-winning work on bacterial physiology and development. (the-scientist.com)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)
By the end of week 2, the development of primary chorionic villi is observed, the primary yolk sac is replaced by the secondary yolk sac, and the amniotic cavity appears as a space between the cytotrophoblasts and the inner cell mass. (medscape.com)

She has received numerous honors including a PEW Scholar Award and the Women in Cell Biology Award. (carnegiescience.edu)
My expertise is in the areas of regeneration, evolution, the nervous system and cell biology. (stanford.edu)
Now there's a whole new field of people who are working on bacterial cell biology using the same sorts of approaches used to study eukaryotes. (the-scientist.com)

Anatomy61

Organisms17

Diseases4

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology15

Phenomena and Processes64

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science11

Health Care1

Differentiation18

Proliferation7

Embryos5

Precursors10

Polarity5

Pathways9

Progenitor5

Behavior2

Differentiate5

Embryo11

Replacement Therapy for Parkinson's Disease1

Genes7

Mesodermal2

Endoderm7

Gastrulation7

Molecules4

Embryonic development1

Tissues3

Regulates1

Morphogenetic1

Pathway5

Regenerative Medicine1

Regulate3

Dopaminergic Neurons1

Neural7

Zebrafish1

Neurons in the devel1

Posterior3

Parkinson's Disease4

Vascular smooth muscl1

Signal Transduction1

Specification1

Receptors1

Determination5

Stem cell biology2

Epithelial3

20231

Gene4

Mechanisms2

Migrate1

Vegetal1

Pigment cells1

Precursor cells2

Structures3

Processes1

Transcription2

Lineage1

Developmental Cell1

Tissue movements1

Ablation3

Regulation2

Somites1

Membrane1

Neuronal6

Spotlight1

Involuntary2

Development8

Biology3