Fate cell polarity. Medical search. Frequent questions

We report that a membrane-tethered form of aPKC (aPKC-CAAX) suppresses primary neurogenesis and promotes cell proliferation. (bath.ac.uk)
Furthermore, we show that the ligands Wnt5a/b are upstream regulators of the non-canonical signature and moreover regulate proliferation of cancer cells in a β-catenin-independent manner. (nature.com)
Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)
The framework will allow to label for up to 10 markers to visualize at the same time ANXA1, centrosomes, chromosomes, cell-cell adhesion molecules, differentiation markers, proliferation, and apoptosis. (southampton.ac.uk)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
The coordination of cell proliferation and cell fate determination is critical during development but the mechanisms through which this is accomplished are unclear. (cipsm.de)
In response to internal and external cues, eukaryotic cells remodel their MT network in a regulated manner in order to assemble physiologically important arrays for cell growth, cell proliferation, or for cells to cope with biotic or abiotic stresses. (nsf.gov)
Wnt signaling regulates cell proliferation, cell polarity and cell-fate determination. (biomedcentral.com)
MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. (umbc.edu)
Wnt signaling pathway is mediated by Wnt family of 19 secreted glycoproteins (bearing22 or 24 cysteine residues) which are essential for cell proliferation, embryonic development, cell polarity, and tissue homeostasis [ 9 ]. (biomedcentral.com)

Par proteins, like Cdc42, play conserved roles in cell polarity in many contexts, from early embryos to epithelial apical-basal polarity ( Goldstein and Macara, 2007 ). (rupress.org)
2004 We present that apical recruitment of Crb3 handles apical-basal polarity in airway epithelial cells induces binding of Yap to turned on Lats1/2 kinases at apical junctions to market phosphorylation and cytoplasmic sequestration of Yap and therefore initiates airway progenitor differentiation. (ecolowood.com)
These results suggest that apical-basal polarity cues control the localization of Yap in mammalian advancement acting as important mediators of cell destiny during organogenesis. (ecolowood.com)
Outcomes Apical-basal polarity regulators are coordinated with adjustments in the localization of Yap through the proximal patterning from the lung epithelium The Hippo pathway effector Yap handles the patterning of lung epithelial progenitors with distinctive intracellular. (ecolowood.com)

loss of epithelial cell polarity by Lgl2 overexpression changes the position of the cells and is permissive for a change in cell fate. (bath.ac.uk)
Indeed, loss of epithelial cell polarity is associated with tumor development and metastasis. (rupress.org)

a) genes whose products organize the cytoskeleton and establish the initial polarity of the embryo, (b) genes that encode cell signaling pathways, (c) genes whose products regulate mRNA translation and protein stability, and (d) genes that encode positive and negative regulators of transcription. (pewtrusts.org)
Many proteins in these pathways are deregulated in cancer, and we are developing targeted chemical probes to modulate their activity in cells and organisms. (stanford.edu)
While most current cancer investigations focus on specific disease pathways, Dr. Wrana believes cancer involves a complex network of pathways that work together to misregulate cells and cause disease. (lunenfeld.ca)
His current interests build on his discovery of the TGFbeta signalling pathway, the Smurf family of ubiquitin ligases that play key roles in cell polarity, and more recently on how these pathways are integrated with the Hippo tissue size control pathway. (lunenfeld.ca)
Using cell biological, genetic, and genomic approaches, we will rigorously dissect the primary effects of abscission dysregulation on cell polarity and fates, as well as the molecular pathways activated. (virginia.edu)
The first step in the Wnt signal occurs when extracellular Wnt ligand binds Frizzled receptors on the cell surface, leading to the activation of several distinct transduction pathways (see Figure 1 ). (biomedcentral.com)
SGG/GSK-3 are a master switch in the Wnt/Wingless(Wg) pathways and are involved in fundamental developmental processes in animals such as cell fate specification, pattern formation and body axis formation [ 2 , 6 , 7 ]. (biomedcentral.com)
Glioblastoma stem cells play an important role in tumor formation by activation of several signaling pathways. (biomedcentral.com)
There are two Wnt pathways which determine the cell fate. (biomedcentral.com)
Wnt4 and Wnt11 cooperatively contribute to NMJ formation in mice through activation of both the canonical and Vangl2-dependent core planar cell polarity pathways. (silverchair.com)

It is not known whether the proteins that affect cell polarity also affect cell fate and how membrane polarity information may be transmitted to the nucleus. (bath.ac.uk)
During my postdoc, I characterize novel mechanisms and polarity proteins in the development of stomata, the major drivers of gas exchange and carbon fixation in the leaf epidermis of vascular plants. (oeaw.ac.at)
Polarity proteins orient divisions in stomatal precursor cells to determine stomatal fate and patterning. (oeaw.ac.at)
To understand the molecular role of polarity proteins in plant development, it is important to characterize their interactome, including their protein-protein interaction partners. (oeaw.ac.at)
I adapted the biotin ligase (BirA)-based proximity labeling method for polarity proteins in the stomatal lineage and identified the respective plasma membrane proteomes. (oeaw.ac.at)
The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells. (stanford.edu)
We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour. (southampton.ac.uk)
183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. (rupress.org)
In its GTP-bound form, Cdc42 binds several effectors that help direct polarized cell growth: repolarizing actin and microtubules, directing polarized exocytosis via this reoriented cytoskeleton and by direct contact with exocytic machinery, and recruiting proteins such as septins that form a boundary restricting the region of cell growth. (rupress.org)
The authors demonstrate that the opposing polarity domains of these proteins are linked to cell division orientation. (sciety.org)
While both proteins have been studied previously in other systems, there was no prior evidence of cooperative functions in a single cell type, as shown here. (sciety.org)
The Ubl SUMO regulates a growing number of recognized proteins involved in the cell cycle, DNA repair, the stress response, nuclear transport, transcription, and signal transduction. (enzolifesciences.com)
By studying the brain phenotypes and the cellular roles of the encoded proteins, with both in vivo and in vitro experiments, we hope to understand how small changes at the single-cell level can cause dramatic changes in overall brain structure. (virginia.edu)
It is intriguing what proteins are associated with plant‐specific MTOC s and how plant cells activate or inactivate MT nucleation activities in spatiotemporally regulated manners. (nsf.gov)
Membrane-spanning proteins often function as receptors involved in recognition and cell adhesion, whereas nuclear proteins frequently play a role in regulating gene expression and transcription. (biomedcentral.com)
Meclizine 2HCl Proteins very important to generating and preserving polarity immediate Yap localization (Genevet and Tapon 2011 Specifically proteins that define the evolutionary conserved Crumbs complicated which may identify the apical domains of epithelial cells (Pocha and Knust 2013 possess important assignments in managing Hippo pathway activity to market the cytoplasmic localization of Yap (Chen et al. (ecolowood.com)

Prickle is another protein in the planar cell polarity signaling pathway. (wikipedia.org)
Their work was built on top of earlier research, where it was demonstrated that the Wnt signaling pathway - an evolutionarily conserved pathway that regulates certain aspects of cell fate determination, cell migration, and cell polarity, among other things - was essential both for tissue repair and stem cell development in other parts of the body like the skin, brain, and intestines. (naturalnews.com)
In this review, we discuss about the significance of glioblastoma stem cells in cancer progression through Wnt signaling pathway and highlight the clinical targets being potentially considered for therapy in glioblastoma. (biomedcentral.com)
Canonical Wnt signaling pathway is essential for embryonic development [ 10 ] and non-canonical Wnt pathway regulates cell movement and tissue polarity [ 11 ]. (biomedcentral.com)
The current review focuses on the importance of Wnt signaling pathway in glioblastoma stem cell progression and explores targeting of Wnt signaling molecules as a potential therapy for glioblastoma. (biomedcentral.com)
The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)

Strabismus was originally identified as a Drosophila protein involved in planar cell polarity. (wikipedia.org)
Frizzled receptors can also initiate an independent ' non-canonical ' Wnt pathway that diverges to regulate complex developmental events involved in planar cell polarity and convergent extension movements during embryo development, via small GTPases and the JNK kinase. (biomedcentral.com)

Polarised epithelial cell divisions represent a critical mechanism for correct partitioning of fate determinants and genomic material into the daughter cells during tissue homeostasis and morphogenesis, and their disruption can lead to severe developmental disorders and diseases such as cancer. (southampton.ac.uk)
Cytoskeletal microtubules ( MT s) have a multitude of functions including intracellular distribution of molecules and organelles, cell morphogenesis, as well as segregation of the genetic material and separation of the cytoplasm during cell division among eukaryotic organisms. (nsf.gov)
Cell competition shape mammalian morphogenesis - Ellis et al. (colorado.edu)

WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)

Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues. (rupress.org)
Nearly twenty years ago Cdc42 was recognized as an essential link between polarity cues and the machinery that generates cell polarity ( Bender and Pringle, 1989 ). (rupress.org)
Our results demonstrate that polarity-dependent cues control airway cell differentiation providing important molecular understanding into body organ patterning. (ecolowood.com)

In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells. (wikipedia.org)
A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. (rupress.org)
Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
We found apical accumulation of both Drosophila E-Cadherin (DE-Cad) and the apical cue Bazooka (Baz) as cells first form. (rupress.org)
In Drosophila , a pool of SGG isoenzymes encoded by a single gene is necessary to establish cell fate and polarity within embryonic segments [ 8 ] as well as for development of the nervous system [ 9 ]. (biomedcentral.com)
3Taylor J,Abramova N,Charlton J,et al.Van Gogh: a new Drosophila tissue polarity gene\[J\].Genetics,1998,150(1):199 210. (paperopen.com)
4Wolff T, Rubin GM.Strabismus,a novel gene that regulates tissue polarity and cell fate decisions in Drosophila\[J\].Development,1998,125(6): 1149 1159. (paperopen.com)

At the core of AJs, cadherins mediate cell-cell adhesion through Ca 2+ -dependent homophilic interactions between their extracellular domains. (rupress.org)
We found that disruption of ANXA1 function results in mitotic spindle misorientation and impaired cell-cell adhesion and genome instability, affecting the outcomes of cell division. (southampton.ac.uk)
The Notch signalling cascade is highly conserved and plays a crucial role in stem cell self-renewal, cell fate determination, epithelial cell polarity/adhesion, cell division and apoptosis in organisms from nematodes to vertebrates. (uhnresearch.ca)

This work has revealed new mechanisms underlying cell fate determination and tissue regeneration in multiple models. (lunenfeld.ca)

These observations suggest that aPKC has a function in the nucleus that is important for cell fate specification during primary neurogenesis. (bath.ac.uk)
and the link between endocytosis, cell polarity, and cell fate specification. (boku.ac.at)
Our understanding of the molecular events driving cell specification in early mammalian development relies mainly on mouse studies, and it remains unclear whether these mechanisms are conserved across mammals, including humans. (bvsalud.org)
Numb establishes cell polarity in the gonadal coelomic epithelium and is required for asymmetric cell division and somatic cell fate specification during gonadogenesis. (silverchair.com)

In the Xenopus embryo , XProfilin2 is temporally expressed throughout embryogenesis and it is spatially expressed in cells undergoing morphogenetic movement during gastrulation. (xenbase.org)
In the embryo, the cortex begins as an epithelial sheet of neural stem cells. (virginia.edu)
In contexts with limited single-cell samples, such as the early human embryo inference of transcription factor-gene regulatory network (GRN) interactions is especially difficult. (bvsalud.org)
Here, we assessed application of different linear or non-linear GRN predictions to single-cell simulated and human embryo transcriptome datasets. (bvsalud.org)

Gastrulation is a critical morphogenetic event during vertebrate embryogenesis, and it is comprised of directional cell movement resulting from the polarization and reorganization of the actin cytoskeleton . (xenbase.org)
This is a still image from a live imaging movie of a COS-7 cell expressing the marker LifeAct showing the intricate network of the actin cytoskeleton. (bscb.org)

Thus, Baz acts upstream of AJs during epithelial polarity establishment. (rupress.org)
AJs localize to the boundary between the apical and basolateral domains, and are thought to be critical landmarks for establishing epithelial polarity ( Nelson, 2003 ). (rupress.org)
Epithelial cells undergo powerful polarity adjustments as organs pattern however the relationship between epithelial polarity and cell destiny is poorly realized. (ecolowood.com)

Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation. (stanford.edu)
Our novel gene discoveries have led to cellular and molecular studies on topics such as cell division, cytokinesis, neuron polarization, and axon guidance. (virginia.edu)
such studies have defined the molecules that ensure signals initiated at the cell surface are efficiently transmitted to the cell nucleus, where they often result in the induction of a specific gene-expression program. (biomedcentral.com)
The degradation machinery is inhibited by Dsh, leading to the accumulation of β-catenin, which in turn translocates to the nucleus and initiates a gene expression program by interacting with transcription factors such as T-cell-specific transcription factor (TCF) . (biomedcentral.com)
Overall, our comparative analysis of GRN prediction methods defines a pipeline that can be applied to single-cell multi-omics datasets in especially challenging contexts to infer interactions between transcription factor expression and target gene regulation. (bvsalud.org)

We found that the UCDs and their orientation at the ascidian third cleavage rely on the spindle tilting in an anisotropic cell shape, and cortical polarity domains exerting different effects on spindle astral microtubules. (elifesciences.org)
We therefore propose that the spindle position during UCD is set by the combined activities of cell geometry and polarity domains, where cell geometry modulates the effect of cortical polarity domain(s). (elifesciences.org)
I then joined the C.Cabernard Lab (Switzerland) for my first postdoc, to explore how asymmetric spindle and cortical polarity are coupled to regulate asymmetric stem cell division and cell fate acquisition, in vivo. (bscb.org)

Yet, the precise mechanisms coordinating cell polarity and correct mitotic spindle dynamics and chromosome segregation fidelity, to ensure proper epithelial integrity and differentiation remain ill defined. (southampton.ac.uk)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
Lack of Crb3 in developing mouse airways or in isolated adult airway progenitors leads to unrestricted nuclear Yap activity and consequent cell differentiation flaws. (ecolowood.com)
Nuclear Yap activity Meclizine 2HCl also promotes airway basal progenitor identification Meclizine 2HCl with removal of nuclear Yap generating airway cell differentiation (Mahoney et al. (ecolowood.com)
We also present that lack of leads to the aberrant deposition of nuclear Yap and following avoidance of airway epithelial cell differentiation. (ecolowood.com)

During neurogenesis in Xenopus, apicobasally polarised superficial and non-polar deep cells take up different fates: deep cells become primary neurons while superficial cells stay as progenitors. (bath.ac.uk)
Ubiquitin itself can direct its targets to a number of different fates, including proteasomal degradation and membrane protein transport. (enzolifesciences.com)

This volume is a must for any investigator doing worm studies but it has been written and rigorously edited to illuminate for a wider community of investigators in cell and molecular biology who should know how new knowledge of C. elegans relates to their own specialty. (cshlpress.com)
Our work will lay the foundation for a more ambitious, collaborative project bringing together expertise in cell and molecular biology, cancer biology, physics, and mathematics, to investigate the causal relationship between ANXA1-mediated defects in cell divisions and tumour heterogeneity, and the underlying mechanisms. (southampton.ac.uk)
Dr. Wrana's group is currently exploiting human patient specimens, animal models, and 3D organoid models, together with single cell technologies, to understand at the cellular and molecular level, the intimate link between the acquisition of stem cell phenotypes, tissue regeneration and the initiation and progression of cancer. (lunenfeld.ca)
France), I worked on the molecular mechanisms underlying the cortical remodelling and successive shape modifications that accompany symmetric cell division (S.Carreno and F.Payre Labs). (bscb.org)

TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)
They can be derived directly from isolated organs or differentiated from embryonic stem cells or induced pluripotent stem cells. (springeropen.com)
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. (nature.com)

One consequence of defective abscission in the embryonic neural stem cells is p53 elevation and programmed cell death (apoptosis). (virginia.edu)

By systematically varying mitotic cell shape, we could modulate the effect of attractive and repulsive polarity domains and consequently generate predicted daughter cell size asymmetries and position. (elifesciences.org)
Plants modulate stomatal cell fate and patterning through key transcriptional factors and signaling cascades. (dgist.ac.kr)

Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis. (elifesciences.org)
Depending on the level of cell shape anisotropy or the strength of the polarity domain, one dominates the other and determines the orientation of the spindle. (elifesciences.org)
Their findings provide a new perspective on the roles of cell polarity and shape in the control of spindle positioning, and are of broad interest to cell and developmental biologists. (elifesciences.org)
or embryos ( Minc and Piel, 2012 ) and is the result of spindle alignment with the longest axis of the cell. (elifesciences.org)
Although cell shape often predicts spindle orientation, there are numerous examples where this is not the case in somatic cells ( Finegan and Bergstralh, 2019 ). (elifesciences.org)
These deviations from the length-dependent spindle positioning mechanism are usually due to local alteration of microtubule-associated forces by polarity domains. (elifesciences.org)
Yet, whether and how cell geometry and polarity domains compete with each other not only to determine the orientation but also the centering of the mitotic spindle leading to equal or unequal cell divisions (UCDs) remains unclear. (elifesciences.org)
We recently used a proteomic-based screen to identify a novel mitotic complex including the membrane-associated Annexin A1 (ANXA1) protein that interacts with and regulates cortical recruitment of the LGN spindle orientation complex in mitotic mammary epithelial cells. (southampton.ac.uk)
During animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow equatorial zone. (cipsm.de)
Of note, compared to fungal and animal systems, relatively little is known about how plant cells remodel the spindle microtubule array during anaphase. (nsf.gov)
MT ‐dependent MT nucleation is particularly noticeable in plant cells because it accounts for the primary source of MT generation for assembling spindle, phragmoplast, and cortical arrays when the γ‐tubulin ring complex is anchored and activated by the augmin complex. (nsf.gov)
Here, we describe detailed analyses of acentrosomal spindle assembly and disassembly in time-lapse images, from live meiotic cells of Zea mays. (nsf.gov)

VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis. (wikipedia.org)
Yet apart from a proximal polarity module that includes PANGLOSS1 (PAN1) and guides nuclear migration, little is known regarding the developmental processes that form SCs. (sciety.org)
Both polarity domains are required for the formative SC division yet exhibit distinct roles in regulating pre-mitotic nuclear migration and SMC division plane orientation, respectively. (sciety.org)

Organoids are cultured cellular structures that consist of the major cell types of a tissue including tissue stem cells and other differentiated cells, resemble the basic features and possess the functions of the tissue. (springeropen.com)
Human liver organoid (HLO) derived from human pluripotent stem cells offers. (springeropen.com)
Human pluripotent stem cells (hPSCs)-derived brain organ. (springeropen.com)
In order to fix this, Sharpe and his team thought that it could be useful to mobilize stem cells in the dental pulp and boost the natural healing abilities of teeth. (naturalnews.com)
In most experiments that involve the use of stem cells, some unfortunate side effects just can't be avoided. (naturalnews.com)
Later, the stem cells divide asymmetrically, eventually generating billions of neurons and glia. (virginia.edu)
The highly polarized structure of neuroepithelial stem cells places special constraints on the cell cycle and mitosis. (virginia.edu)
The stem cells must make a faithful copy of their genome, and then split in half while maintaining their polarity and attachments within the epithelial sheet. (virginia.edu)
They must also produce daughter cells in the right order: first more stem cells, then neurons, and finally glia. (virginia.edu)
Orienting muscle stem cells - Feige et al. (colorado.edu)
During adult airway epithelial homeostasis in mice, FGFR2 signalling is required for self-renewing divisions of basal stem cells and to maintain expression of the key transcription factor SOX2. (silverchair.com)

Here, we show that cell geometry and polarity domains cooperate, rather than compete, in positioning the cleavage plane during UCDs in early ascidian embryos. (elifesciences.org)
We have shown that the establishment of cell polarity via aPKC is a conserved event in the initiation of the trophectoderm (TE) placental programme in mouse, cow and human embryos. (bvsalud.org)
However, the mechanisms transducing cell polarity into cell fate in cow and human embryos are unknown. (bvsalud.org)

Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs. (springeropen.com)
The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. (rupress.org)
Building on these exciting discoveries, we propose to elucidate the in vivo roles of abscission regulation in neural stem cell fates and proper corticogenesis. (virginia.edu)

Studies of the cells and genes of the nematode C. elegans have become a cornerstone of current biology. (cshlpress.com)
Therefore, anyone with an interest in cell and developmental biology, regardless of their area of specialisation, would benefit from reading C. elegans II . (cshlpress.com)
The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors. (stanford.edu)
Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. (stanford.edu)
Dedicated to the advancement of research in all branches of cell biology. (bscb.org)
I then moved to the Beatson Institute in Glasgow to pursue my Doctoral degree in Cancer Cell Biology and have just recently graduated. (bscb.org)
Although my degree was in Biochemistry, I guess I was quite influenced by the many cell biologists who taught me and so it was a rather natural transition for me to go into cell biology for my graduate work. (bscb.org)
When this connection was made, it launched a whole new field," says Isidore Rigoutsos, Ph.D., professor of pathology, anatomy, and cell biology and director of the Computational Medicine Center at Thomas Jefferson University. (pharmaceuticalintelligence.com)

Embryonic patterning in C. elegans begins during the first few divisions of the fertilized egg as sister cells become committed to distinct developmental fates. (pewtrusts.org)
The plant hormone auxin and its directional intercellular transport play a major role in these processes because they provide positional information and link cell polarity With tissue patterning. (boku.ac.at)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
2014 Morrisey and Hogan 2010 Structural features from the epithelium relate with lung patterning: the first distal epithelium that provides rise to alveolar lineages comprises cuboidal cells whereas the epithelium in the proximal airways displays a columnar pseudostratified morphology. (ecolowood.com)

The regulation of SGG/GSK-3 represents a conserved strategy during evolution for establishing embryonic polarity of both invertebrate and vertebrates. (biomedcentral.com)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)

J Cell Biol (2004) 167 (1): 135-147. (rupress.org)
J Cell Biol (2008) 183 (6): 971-974. (rupress.org)
Nature Cell Biol. (nature.com)
J Cell Biol. (bscb.org)

Identify and characterize genes that control cell fate and cell polarity during early C. elegans development. (pewtrusts.org)
Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)

The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
Cdc42 also affects other aspects of cell polarity, including microtubule dynamics, centrosome positioning, and Golgi reorientation. (rupress.org)
In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing centers like the centrosome. (nsf.gov)

I discovered a novel polarity protein in Arabidopsis thaliana that polarizes at distinct developmental stages in stomatal precursors. (oeaw.ac.at)

Using the early embryonic divisions of the ascidian Phallusia mammillata as a model to investigate mechanisms of unequal cell division, this study convincingly demonstrates that cell shape and cortical domains are cooperating, rather than competing, in order to establish cell size asymmetry, a significant conceptual advance for the field. (elifesciences.org)

Wnt deregulation in brain is associated with congenital disorders [ 7 ], whereas it promotes malignancy in somatic cells of neuronal origin [ 8 ]. (biomedcentral.com)
A single cell of the somatic gonad, the anchor cell, organizes the development of the vulva from epidermal precursors as well as the physical connection of the epidermis with the uterus. (wormbook.org)

We present evidence that the Snail-related transcription factor CES-1 of Caenorhabditis elegans coordinates these processes in a specific cell lineage. (cipsm.de)
The reversed polarity of the posterior 2 ° precursor cell lineage requires WNT signaling mediated by both Frizzled class and Ryk class WNT-receptors LIN-17 and LIN-18 , respectively. (wormbook.org)
The uninduced VPCs generate a 3 ° lineage, which make epidermal cells that fuse with the large syncytial epidermis hyp7. (wormbook.org)

Transcriptome Analysis of Soybean Leaf Abscission Identifies Transcriptional Regulators of Organ Polarity and Cell Fate. (stembook.org)

Here, we examine the role of the polarity components, apically enriched aPKC and basolateral Lgl2, in primary neurogenesis. (bath.ac.uk)

The sheet expands and balloons outward due to symmetric divisions of these polarized cells. (virginia.edu)
We are studying the mechanisms of these unusual cell divisions, and how the way that the cells divide influences the structure and fate of daughter cells. (virginia.edu)

Using the genetic model grass Brachypodium distachyon , we identified BdPOLAR, which forms a novel, distal polarity domain in SMCs that is reciprocal to the proximal PAN1 domain. (sciety.org)

Although it has been shown that the lateral SC contributes to rapid stomatal opening and closing, little is known about how the SC is generated from the subsidiary mother cell (SMC) and how the SMC acquires its intracellular polarity. (sciety.org)

Using genetic tools and confocal microscopy, I study the role and protein dynamics of this novel polarity domain in stomatal development (and beyond). (oeaw.ac.at)
centrosome dynamics), and tumour cell fate, behaviour and heterogeneity. (southampton.ac.uk)

With further clarification of some of the localization findings, this study will be of strong interest to plant cell biologists and those interested in asymmetric cell division generally. (sciety.org)
Subsidiary mother cells (SMCs) strongly polarise before an asymmetric division forms a SC. (sciety.org)
This study reveals a unique developmental process of grass stomata, where two opposing polarity factors form domains in the SMC and ensure asymmetric cell division and SC generation. (sciety.org)
Understanding this, and investigating the role of asymmetric mitotic nuclear envelope remodelling on cell fate, is what I aim to study in the future. (bscb.org)
2010 Right here we describe that in developing mouse airway cells the cytoplasmic localization of Yap correlates specifically with the appearance and asymmetric distribution of Crb3 the main Crumbs isoform portrayed in the lung (Lemmers et al. (ecolowood.com)
The in(side) & outs(ide) of asymmetric stem cell division. (colorado.edu)

Prickle is recruited to the cell surface membrane by strabismus. (wikipedia.org)
Instead, flexible MTOC s may emerge on the plasma membrane, the nuclear envelope, and even organelles depending on types of cells and organisms and/or physiological conditions. (nsf.gov)
Fluorescent probe used to investigate membrane qualities of the phospholipid bilayers of cell membranes, sensitive to membrane phase transitions as well as other alterations to membrane fluidity such as the penetration of water. (adipogen.com)
Lipophilic orange-red fluorescent membrane stain that diffuses laterally to stain the entire cell. (adipogen.com)

During gastrulation the absence of AJs results in widespread cell dissociation and depolarization. (rupress.org)
Specifically, we show that XProfilin2 modulates cell polarization and axial alignment of mesodermal cells undergoing gastrulation independent of XProfilin1 . (xenbase.org)

SEGGA is an easy to use software that allows for the quantitative analysis of changes in cell shape, movement and polarity at single-cell resolution during epithelial remodeling in various species. (silverchair.com)

While collaborating in the lab of Liam Dolan, I am exploring cell fate and cell polarity mechanisms beyond stomatal formation, using the non-vascular plant Marchantia polymorpha . (oeaw.ac.at)
Stomata are cellular pores on the leaf epidermis that Grass stomata recruit lateral subsidiary cells (SCs), which are key to the unique stomatal morphology and the efficient plant-atmosphere gas exchange in grasses. (sciety.org)
In summary, we identified two opposing polarity domains that coordinate the SC division, a process crucial for grass stomatal physiology. (sciety.org)

Whether and how such competition is also at work to determine unequal cell division (UCD), producing daughter cells of different size, remains unclear. (elifesciences.org)

renders six epidermal precursor cells competent to respond to other developmental signals. (wormbook.org)
Both EGF and LIN-12 prevent precursor cells from adopting the 3 ° fate, which generates non-specialized epidermis. (wormbook.org)
The two 2 ° precursor cells generate vulA, vulB1, vulB2, vulC and vulD cells but in mirror symmetric polar patterns: ABCD and DCBA. (wormbook.org)
During the L1 and L2 stages, six vulval precursor cells (VPCs) are specified among the 11 Pn.p cells, which are located in the ventral epidermis. (wormbook.org)

The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. (springeropen.com)

Ident- cult to deduce interaction rules from observations of the ified transcription factors for specific cell fates are, for entire system. (lu.se)

interactions between cells. (lu.se)
In particular, vulva development represents a well-understood case in which invariant development arises from multiple cell-cell interactions. (wormbook.org)

Anatomy45

Organisms18

Diseases3

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes45

Disciplines and Occupations1

Information Science4

Proliferation10

Apical-basal polarity4

Loss of epithelial cell polarity2

Pathways10

Proteins16

Signaling pathway6

Involved in planar cell pol2

Morphogenesis3

Movement and tissue polarity1

Cues3

Drosophila8

Adhesion3

Determination1

Specification4

EMBRYO4

Cytoskeleton2

Epithelial polarity3

Gene6

Cortical polarity3

Differentiation5

Different fates2

Molecular4

Embryonic stem3

Apoptosis1

Modulate2

Spindle12

Migration3

Stem cells11

Embryos3

Roles3

Biology8

Patterning4

Vertebrates1

Kinase2

Biol4

Genes2

Microtubule3

Distinct developmental1

Asymmetry1

Somatic2

Lineage3

Regulators1

APKC1

Divisions2

Proximal1

Intracellular1

Dynamics2

Asymmetric6

Membrane4

Gastrulation2

Quantitative1

Stomatal3

Remains unclear1

Precursor cells4

Evolution1

Transcription factors1

Interactions2