For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and ventricular tachyarrhythmias including occurrences of torsades de pointes , a potentially fatal arrhythmia. (guidelinecentral.com)
Instruct patients to swallow Hydrocodone Bitartrate Extended-Release Capsules whole to avoid exposure to a potentially fatal dose of hydrocodone. (nih.gov)
An emerging lesser known, but potentially fatal complication of T2DM is the accumulation of fat in hepatocytes (steatosis), that leads to the chronic liver disorder Non-Alcoholic Fatty Liver Disease (NAFLD) and its more advanced form, Non-Alcoholic Steato-Hepatitis (NASH). (ddw-online.com)
Anemia1
Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and cholestasis. (drugs.com)
Endpoints include overall survival1
Key secondary endpoints include overall survival (OS) and incidence of adverse events (AEs). (wapakdailynews.com)
Cytokine2
Blincyto carries a boxed warning that some clinical trial participants had problems with cytokine release syndrome (CRS), or neurological toxicities which may be life threatening or fatal (FDA, 2014). (southcarolinablues.com)
Life-threatening or fatal cytokine release syndrome (CRS) occurred in patients receiving blinatumomab (Amgen, 2014). (southcarolinablues.com)
Adverse event5
How are Crizotinib adverse event reports trending over time? (drugcite.com)
Adverse events are counted if Crizotinib is flagged as the suspect drug causing the adverse event. (drugcite.com)
For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. (drugcite.com)
How are Acetaminophen And Codeine Phosphate adverse event reports trending over time? (drugcite.com)
Adverse events are counted if Acetaminophen And Codeine Phosphate is flagged as the suspect drug causing the adverse event. (drugcite.com)
Overdose2
Accidental ingestion of Hydrocodone Bitartrate Extended-Release Capsules, especially in children, can result in a fatal overdose of hydrocodone. (nih.gov)
Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of hydrocodone. (nih.gov)
Venous2
Active or past history of venous thromboembolic events (VTE), including deep vein thrombosis, pulmonary embolism and retinal vein thrombosis. (pillintrip.com)
Raloxifene is associated with an increased risk for venous thromboembolic events that is similar to the reported risk associated with current use of hormone replacement therapy. (pillintrip.com)
Patients4
Bristol Myers Squibb (NYSE: BMY) today announced the Phase 3 CheckMate -77T trial met its primary endpoint of improved event-free survival (EFS) as assessed by Blinded Independent Central Review (BICR) in patients with resectable stage IIA to IIIB non-small cell lung cancer (NSCLC). (santaclara.com)
Instruct patients not to consume alcohol or any products containing alcohol while taking Hydrocodone Bitartrate Extended-Release Capsules because co-ingestion can result in fatal plasma hydrocodone levels. (nih.gov)
DoR, based on a later cutoff date than CR/CRi, was defined for patients who achieved CR/CRi per investigator's assessment as time since first response of CR/CRi per investigator's assessment to the date of a progression-free survival (PFS) event or censoring date if no PFS event was documented. (pfizerpro.com)
However, the recent ACCORD and ADVANCE trials in patients with longstanding T2DM have shown that aggressive glucose control in such patients has no clear benefits, or may even increase CVD events (3). (ddw-online.com)
Accumulation1
Once this has happened, the process of accumulation of plaque is slow but progressive in the event that no steps are taken to rectify the causative factors. (factdr.com)
Active3
This graph shows volume of adverse events submitted to the FDA by quarter for Crizotinib, as well as related generic and/or brandname drugs containing the same primary active ingredients . (drugcite.com)
This graph shows the top adverse events submitted to the FDA for Crizotinib, as well as related generic and/or brandname drugs containing the same primary active ingredients , from Q1 2004 to Q3 2012. (drugcite.com)
This graph shows volume of adverse events submitted to the FDA by quarter for Acetaminophen And Codeine Phosphate, as well as related generic and/or brandname drugs containing the same primary active ingredients . (drugcite.com)
Risk1
Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
Primary1
The primary endpoint of the trial is event-free survival (EFS). (santaclara.com)
Alanine2
The aim of this cross-sectional study was to present nationally representative findings on the co-occurrence of obesity and specific patterns of alcohol use associated with elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) among adults in the United States. (cdc.gov)
Includes the following terms: alanine aminotransferase increased, gamma-glutamyl transferase (GG) increased, aspartate aminotransferase increased, hepatic enzyme increased, liver function test abnormal, and transaminases increased. (zeposiahcp.com)
Transferase2
C-reactive protein (CRP) was elevated to 336 mg/L. Renal and liver function tests were normal, except for slightly elevated gamma-glutamyl transferase (77 U/L). Albumin was low (23 g/L), and the international normalized ratio (INR) was 1.37. (springer.com)
While a fasting blood glucose and cortisol level are optimal markers, gamma-glutamyl transferase (GGT) is THE single most quantitative factor that is most highly associated with the development of type 2 diabetes. (nursingworldconference.com)
Grade1
2.9% of these events were severe (Grade 3 or 4). (pfizerpro.com)
Hepatic enzyme1
In addition, most patients on carbamazepine develop mild-to-moderate elevations in gamma glutamyltranspeptidase ( GGT ) levels, probably indicative of hepatic enzyme induction rather than liver injury. (nih.gov)
Severe5
Myelosuppression can be severe and lead to fatal infections. (rxlist.com)
Carbamazepine is an aromatic anticonvulsant that is widely used in therapy of epilepsy and trigeminal neuralgia and is a well established cause of clinically apparent liver injury which can be severe and even fatal. (nih.gov)
The liver involvement ranges from mild and transient elevations in serum enzymes to abrupt onset of an acute hepatitis-like syndrome that can be severe and even fatal. (nih.gov)
Treat severe or life-threatening CRS with tocilizumab or tocilizumab and corticosteroids .Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), which may be fatal or life-threatening, occurred following treatment with ciltacabtagene autoleucel, including before CRS onset, concurrently with CRS, after CRS resolution, or in the absence of CRS. (drugs.com)
Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and nosocomial infection. (nih.gov)
Warning: Cytokine release syndrome, neurological toxicities, HLH/MAS and prolonged and recurrent cytopenia Cytokine Release Syndrome (CRS), including fatal or life-threatening reactions, occurred in patients following treatment with ciltacabtagene autoleucel. (drugs.com)
Provide supportive care and/or corticosteroids as needed.Parkinsonism and Guillain-Barré syndrome and their associated complications resulting in fatal or life-threatening reactions have occurred following treatment with ciltacabtagene autoleuce.Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS), including fatal and life-threatening reactions, occurred in patients following treatment with ciltacabtagene autoleucel. (drugs.com)
Cardiovascular2
The expanding list of nontraditional biomarkers is outweighed by the standard risk factors for predicting future cardiovascular events and adds only moderately to standard risk factors. (medscape.com)
The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)
Liver2
In fatal cases, liver histology also shows bridging, submassive or massive necrosis. (nih.gov)
Secondary outcomes include safety and tolerability of MMF and azathioprine, time to remission, changes in Model For End-Stage Liver Disease (MELD)-score, adverse events, and aspects of quality of life. (biomedcentral.com)
Onset2
Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), which may be fatal or life-threatening, occurred following treatment with CARVYKTI ® , including before CRS onset, concurrently with CRS, after CRS resolution, or in the absence of CRS. (financialcontent.com)
The median time to onset of the first thrombocytopenic event was 26.5 days. (inceptionmeetings.com)
Family1
Stress-induced agoraphobia - Stressful events such as the sudden demise of a close family member or being sexually abused can trigger this condition. (factdr.com)
Time2
Firstly, we used a Cox model with time to event as the underlying time variable. (bvsalud.org)
A statistical test to the multiplicative interaction term the exposures and the log transformed time to event metric was used to assess the proportionality of risk assumption. (bvsalud.org)
Disease1
Epigenetics is the gateway to gene expression and plays a vital role in the prevention, diagnosis, and reversal of this fatal disease. (nursingworldconference.com)
Treatment1
Most keratopathy events developed within the first 2 treatment cycles (cumulative incidence of 65% by Cycle 2). (inceptionmeetings.com)
Shows3
The present case shows the clinical features of Takotsubo cardiomyopathy induced by a hypoglycemic event in addition to underlying anorexia nervosa. (biomedcentral.com)
This graph shows volume of adverse events submitted to the FDA by quarter for Novolin, as well as related generic and/or brandname drugs containing the same primary active ingredients . (drugcite.com)
This graph shows the top adverse events submitted to the FDA for Novolin, as well as related generic and/or brandname drugs containing the same primary active ingredients , from Q1 2004 to Q3 2012. (drugcite.com)
Results1
The positive opinion is based on results from the CheckMate -816 trial, which demonstrated a statistically significant and clinically meaningful improvement in event-free survival (EFS) and pathologic complete response (pCR) with three cycles of Opdivo in combination with chemotherapy compared to chemotherapy alone when given before surgery. (wapakdailynews.com)