Any severe neutropenia can be fatal if not detected and managed, since it makes people vulnerable to infection. (smiadviser.org)
Acute, severe neutropenia, particularly if another factor (eg, cancer) is present, significantly impairs the immune system and can lead to rapidly fatal infections. (msdmanuals.com)
Aplastic anemia1
This medication may rarely cause serious (possibly fatal) allergic reactions and other side effects such as a severe peeling skin rash (such as Stevens-Johnson syndrome), blood disorders (such as agranulocytosis, aplastic anemia), liver damage, or lung injury. (uprx.com)
Leukopenia2
Because of procainamide's arrhythmogenic potential, lack of evidence for improved survival for class I antiarrhythmic agents, and risk of serious, potentially fatal adverse hematologic effects (see Boxed Warning), particularly leukopenia or agranulocytosis, use for less severe arrhythmias not recommended. (drugs.com)
All health professionals caring for patients taking clozapine should be aware that clozapine-induced constipation is highly prevalent, often difficult to detect and potentially fatal. (bpac.org.nz)
The VigiBase search indicated major underreporting regarding clozapine and its fatal outcomes. (bvsalud.org)
By comparison, the United Kingdom had less than half the population of these Eastern European countries but reported to VigiBase more clozapine ADRs by 89-fold and clozapine fatal outcomes by almost 300-fold. (bvsalud.org)
Major improvement is needed in reporting clozapine ADRs and fatal outcomes in Eastern European countries. (bvsalud.org)
Potentially4
Neuroleptic Malignant Syndrome (NMS) , which is a potentially fatal reaction. (biospace.com)
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. (psychopharmacopeia.com)
Myelosuppression can be severe and lead to fatal infections. (guidelinecentral.com)
Reticular dysgenesis is a rare form of severe immunodeficiency that is usually fatal unless a successful stem cell transplant is performed. (lu.se)
There has been some concern about its use, however, since it has been associated with both frequent mild allergic reactions and rare but serious adverse effects including Stevens-Johnson syndrome, myelosuppression, agranulocytosis, as well as severe liver damage (cholostatic hepatosis, hepatitis, liver necrosis, fulminant liver failure) and renal impairment up to acute renal failure and anuria. (the-medical-dictionary.com)
Severe and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), may occur during therapy. (ziprx.ca)
Outcomes1
Events resolved in 78% (39/50), while 18% (9/50) had persistent changes, and 2% (1/50) had fatal outcomes (agranulocytosis). (uni-muenchen.de)
Adverse1
NSAIDs cause increased risk of serious gastrointestinal adverse event including, ulceration, and perforation of the stomach or intestines, which can be fatal. (nih.gov)
Conclusion1
Conclusion: Hem-irAE can affect all haematopoietic blood cell lineages and may persist or even be fatal. (uni-muenchen.de)
Patients3
500/mm 3 ) has been reported with quetiapine, including fatal cases and cases in patients without pre-existing risk factors. (medlibrary.org)
In using ACCUPRIL, consideration should be given to the fact that another ACE inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease. (pfizermedicalinformation.com)
In using VASOTEC consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that VASOTEC does not have a similar risk (see WARNINGS ). (rxlist.com)
Cases2
Pecazine was implicated in a number of cases of agranulocytosis and was subsequently withdrawn from the market. (wikipedia.org)
Authenticated cases of agranulocytosis associated with the drug have occurred in man, fatal reactions, although rare, have been reported in dogs after long-term therapy. (powerhorsevet.com)
Sudden1
Agranulocytosis is usually a sudden drop of neutrophils to a very low level, is thought to be autoimmune, is not permanent, and is a medical emergency. (smiadviser.org)
Blood1
Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. (pfizermedicalinformation.com)