• RhoA
  • The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. (wikipedia.org)
  • regulation
  • 1998).[supplied by OMIM] This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. (wikipedia.org)
  • The dynamic regulation of G protein signalling is necessarily complex and the 130 or more GEFs, GAPs and GDIs described thus far for the Rho family are considered to be the primary determinants of their spatiotemporal activity. (wikipedia.org)
  • guanine
  • Asef2 is a recently identified Rho-family guanine nucleotide exchange factor (GEF) that has been implicated in the modulation of actin, but its function in cell migration and adhesion dynamics is not well understood. (biologists.org)
  • regulators
  • The human genome sequence has revealed the full extent of the Rho GEF and Rho GAP families (over 80 members for each) and the challenge of identifying the molecular interactions and cellular pathways influenced by each of these regulators is a daunting prospect. (onlinebookplace.com)
  • protein kinase
  • Cell Motility Mediated by Rho and Rho-Associated Protein Kinase Plays a Critical Role in Intrahepatic Metastasis of Human Hepatocellular Carcinoma. (wikipedia.org)
  • Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. (wikipedia.org)
  • dynamics
  • Asef2 signaling leads to an overall decrease in Rho activity, which is crucial for stimulating migration and adhesion dynamics. (biologists.org)
  • subfamilies
  • This family is divided into four subfamilies (A-D) and it is subfamilies A and B that are involved in the pathway described here. (wikipedia.org)
  • GEFs
  • This pathway involves RhoG-dependent activation of Rac via the DOCK (dedicator of cytokinesis)-family of GEFs. (wikipedia.org)
  • inhibition
  • However, pharmacological inhibition of Rho kinase I/II or myosin light chain kinase did not attenuate ATP release. (physiology.org)
  • activation
  • In a 1998 review article, Alan Hall compiled evidence showing that not only do fibroblasts form processes upon Rho activation, but so do virtually all eukaryotic cells. (wikipedia.org)
  • The ability to elicit Rho activation correlated with the markedly higher efficacy of thrombin and LPA, relative to carbachol, as ATP secretagogues. (physiology.org)
  • phosphorylation
  • The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. (wikipedia.org)