• protein
  • These results provide the first evidence for the involvement of a Rho family G protein in the control of the activity of a Ras exchange factor. (hud.ac.uk)
  • The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. (wikipedia.org)
  • Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene. (wikipedia.org)
  • pathways
  • The human genome sequence has revealed the full extent of the Rho GEF and Rho GAP families (over 80 members for each) and the challenge of identifying the molecular interactions and cellular pathways influenced by each of these regulators is a daunting prospect. (onlinebookplace.com)
  • activation
  • The ability to elicit Rho activation correlated with the markedly higher efficacy of thrombin and LPA, relative to carbachol, as ATP secretagogues. (physiology.org)
  • active
  • Thrombin (or other PAR1 peptide agonists), LPA, and carbachol triggered quantitatively similar Ca 2+ mobilization responses, but only thrombin and LPA caused rapid accumulation of active GTP-bound Rho. (physiology.org)