Family gene factor. Medical search. Frequent questions

Translocations and other types of mutations involving the RUNX1 gene have been associated with different types of leukemia and related blood disorders, including acute lymphoblastic leukemia (ALL), chronic myelomonocytic leukemia (CMML), familial platelet disorder with predisposition to acute myeloid leukemia, and myelodysplastic syndromes (MDS). (medlineplus.gov)
The RUNX1 gene mutations associated with these diseases are somatic mutations and are not inherited. (medlineplus.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Various gene mutations (TP53) are implicated in tumor formation. (medicinenet.com)
In addition, more than 50 inherited cardiovascular conditions caused by deleterious mutations in a few genes have been recognized so far, with diagnostic tests increasingly available. (cdc.gov)
The disease is caused by mutations in a few genes related to low density lipoprotein (LDL) cholesterol. (cdc.gov)
MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
Conclusions: Since maximum number of variations exists in exon 5 of the said gene, hence one can initially go for exon5 followed by other exons, while screening for pathogenic MODY 3 mutations in the responsible gene by PCR-SSCP method. (scirp.org)
1999) High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes. (scirp.org)
Mutations in the FGFR2 gene cause Apert syndrome. (childrens.com)
However, new mutations in the gene usually cause most cases of Apert syndrome, and happen in babies with no family history of the disorder. (childrens.com)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
Abnormalities (mutations) affecting critical genes are believed to contribute to the development of cancer. (msdmanuals.com)
Gene mutations causing cancer may result from the damaging effects of chemicals, sunlight, medications, viruses, or other environmental agents. (msdmanuals.com)
Suppressor gene mutations, inherited from a parent, may underlie a certain percentage of cases of breast cancer, usually occurring at a young age and in multiple family members. (msdmanuals.com)

Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. (nih.gov)
CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. (nih.gov)
GRFs are a large gene family with highly conserved proteins. (biomedcentral.com)
Almost all of the ARF genes exhibited a constitutive expression pattern, implying that there are functional redundancies among the ARF proteins. (geneticsmr.org)
Yet, despite their abundance, the genes encoding heat shock proteins are rapidly induced in response to stressful conditions. (cshmonographs.org)
The consequence of this genetic switch, which is activated in response to a perturbation of the physiological state of the cell, is the elevated expression of constitutively expressed heat shock proteins and the de novo induction of heat shock genes that are expressed primarily in response to stress. (cshmonographs.org)
These genes produce proteins that regulate growth and alter cell division and other basic cell properties. (msdmanuals.com)
Tumor suppressor genes normally suppress the development of cancers by coding for proteins that repair damaged DNA or suppress the growth of cancerous cells. (msdmanuals.com)
These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
Three non-collagenous proteins, osteonectin, transforming growth factor β-1 (TGF-β1) and bone morphogenetic proteins (BMPs), have drawn much attention in the literature lately. (bvsalud.org)
Bone morphogenetic proteins (BMPs) form a unique group of proteins within the transforming growth factor beta (TGF-β) superfamily. (bvsalud.org)

All three tumor suppressors reduce AFP gene and protein expression. (jgld.ro)
APC, a tumor suppression gene altered in familial adenomatous polyposis. (mindmeister.com)
BRCA1 and BRCA2 are tumor suppressor genes. (medicalnewstoday.com)
What are the risk factors for developing a tumor? (medicinenet.com)
The risk factors for developing a tumor usually depend on the location of the tumor. (medicinenet.com)
Genetics: Genes are the strongest risk factor for developing a tumor. (medicinenet.com)
Family history: Close family history is a common risk factor for developing a tumor. (medicinenet.com)
Exposure to radiation is considered one of the most harmful risk factors for developing a tumor. (medicinenet.com)
Cancer is more likely when DNA damage impairs tumor suppressor gene function, allowing affected cells to multiply continuously. (msdmanuals.com)

Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). (medlineplus.gov)
Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
Provided the jobs of R2R3-MYB protein in the legislation of gene appearance, secondary fat burning capacity, and replies to environmental strains, which ssp. (buyresearchchemicalss.net)
In the present study, we describe the gene family by means of analysis of the genome sequence, in order to predict protein domain name architectures, and to assess the extent of conservation and divergence between and gene families, thus leading to a functional classification of the sugar beet genes on the basis of phylogenetic analyses. (buyresearchchemicalss.net)
In this study, we characterized the interaction between p53 family-dependent signaling pathways and the regulation of AFP at the gene and protein levels as essential determinants of therapeutic response and prognosis in HCC. (jgld.ro)
Thus, our findings reveal a novel interaction of p53 family-dependent signaling pathways and AFP regulation at the gene and protein levels in HCC. (jgld.ro)
A change in this gene results in a protein that interacts with the BRCA1 and BRCA2 genes. (medicalnewstoday.com)
The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. (microbiologyresearch.org)
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. (microbiologyresearch.org)
Internal zinc homeostasis is regulated by the cooperative activities of two metal transporter protein families. (frontiersin.org)
The FGFR2 gene produces a protein called fibroblast growth factor receptor 2. (medicalnewstoday.com)
Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
A gene is a segment of deoxyribonucleic acid ( DNA) and contains the code for a specific protein that functions in one. (msdmanuals.com)

R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)
In many patients of these families with recessive VWD, molecular basis studies have provided insights into the molecular mechanisms responsible for the heterogeneity of phenotypes. (karger.com)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)

The legume bZIP genes were categorized into 11 groups according to their phylogenetic relationships with genes from Arabidopsis. (datadryad.org)
These 77 genes were then divided into eleven subfamilies according to their homology with Arabidopsis thaliana . (biomedcentral.com)
The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. (fu-berlin.de)
Sequence comparisons indicate that DcE2F1 could be an ortholog of the AtE2FA factor of Arabidopsis thaliana. (cardiff.ac.uk)

While t(8;21) is important for leukemia development, a mutation in one or more additional genes is typically needed for the myeloid blasts to develop into cancerous leukemia cells. (medlineplus.gov)
Depending on the type of mutation, these conditions can be related to impaired regulation of gene activity or loss of normal gene function. (medlineplus.gov)
Gene mutation has been linked to occurrences in Ashkenazi Jews. (mindmeister.com)
Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
Hence study of mutation pattern in this gene is essential in our population i.e . (scirp.org)
Methods: In our study enzyme amplification (PCR) of the 10 target exons of the said gene with simultaneous mutation detection in them by PCR-SSCP (Polymerase chain reaction-single strand conformational polymorphism) reaction analysis method was attempted by screening of exon 1 - 10 with respect to normal healthy controls without Diabetes Mellitus. (scirp.org)
1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
Apert syndrome is a birth abnormality caused by a mutation of the FGFR2 gene. (medicalnewstoday.com)
When this gene mutation occurs, FGFR2 continues to signal for longer than usual, leading to early fusion of the skull, facial, feet, and hand bones. (medicalnewstoday.com)
Castaman G, Novella E, Castiglia E, Eikenboom JCJ, Rodeghiero F: A novel family with recessive von Willebrand disease due to compound heterozygosity for a splice site mutation and a missense mutation in the von Willebrand factor gene. (karger.com)

Scientists have been studying many factors that could be linked with ALS, such as heredity and environmental exposures. (cdc.gov)
Genes and heredity. (medlineplus.gov)

The functional classification was verified by experimental confirmation of the prediction that the gene encodes a flavonol regulator. (buyresearchchemicalss.net)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)

The field has shifted towards considering the complex gene-environment interaction in the susceptibility of someone developing an allergy. (news-medical.net)
The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. (bvsalud.org)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

The ARF genes comprise a large multigene family in plants. (geneticsmr.org)
Background The genes comprise among the largest transcription factor gene families in plants, playing regulatory roles in plant-specific developmental processes, metabolite accumulation and defense responses. (buyresearchchemicalss.net)
These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)

therefore, it is imperative to assess the expression of genes involved in response to flood and drought stress. (frontiersin.org)
The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)

Asthma studies have found a relationship between developing the disease and the following genes: cytokine genes, cytokine receptor genes, HLA genes and CD14 gene. (news-medical.net)

The reliability from the subgroups described based on phylogenetic analysis can be supported by extra criteria, like the gene structure and the positioning 177931-17-8 supplier and presence of introns [15]. (buyresearchchemicalss.net)
purchase Caryophyllales) may be the initial non-rosid, non-asterid eudicot that the genome continues to be sequenced [26], it really is of interest to attain a complete id and classification of genes within this species with regards to the amount, chromosome places, phylogenetic interactions, conserved motifs aswell as appearance patterns. (buyresearchchemicalss.net)

they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts. (nih.gov)
Underlining the importance of the crosstalk between the p53 family-dependent pathways and AFP regulation we identified eight novel putative binding sites for the members of the p53 family within the introns 1, 2, 3, 4, 7, 8, 11, and 12 of the AFP gene. (jgld.ro)
In addition, using Kyoto Encyclopedia of Genes and Genomes database, 191 metabolic pathways were identified. (figshare.com)

Several genes have been linked to food allergies. (news-medical.net)
Sometimes the increased risk is due to a single gene and sometimes it is due to several genes interacting together. (msdmanuals.com)
Scientists have also identified several genes that play a role in regulating brain chemicals and may contribute to ADHD development. (medlineplus.gov)

The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below: All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. (wikipedia.org)

In many organs, cell proliferation and differentiation are antagonistically regulated by multiple basic helix-loop-helix (bHLH) activator and repressor genes. (biologists.com)
In particular,the Hes bHLH repressor genes play an essential role in the development of many organs by maintaining progenitor cells and by regulating binary cell fate decisions. (biologists.com)

Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)

In recent years, studies have shown that GRF transcription factors play essential roles in plant growth development and defence responses to biological and abiotic stresses. (biomedcentral.com)
Consequently, the features of genes tend connected with regulating plant-specific procedures including supplementary and major fat burning capacity, developmental procedures, cell identification and destiny and replies to 177931-17-8 supplier biotic and abiotic strains [2,17,21]. (buyresearchchemicalss.net)
During plant growth and development, MYB transcription factors play an important role in responding to abiotic stresses and regulating the synthesis of secondary metabolites. (biomedcentral.com)

Treatment of adventitious roots of ginseng with different concentrations of NaCl revealed four up-regulated expression of PgMY B transcripts that can candidate genes for salt resistance studies in ginseng. (biomedcentral.com)
Also, the range of candidate genes linked to a certain phenotype, that is the observable characteristics resulting from the interaction of its genotype with the environment, is rather small if you compare it to the total number of genomes. (news-medical.net)

The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
Oncogenes are mutated or amplified forms of genes that in their normal state regulate cell growth. (msdmanuals.com)

Biological functions were obtained for only 324 of the 354 contigs using gene ontology. (figshare.com)

The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)

In order to predict new genes responsive to the drought and salt stresses in wheat, 6,717 expressed sequence tags (ESTs), expressed in drought and salinity stress conditions were collected from the National Center for Biotechnology Information (NCBI). (figshare.com)
The remaining contigs were used for further analysis and the search for new genes responsive to drought and salt stresses. (figshare.com)

The PITX gene encode the paired-like homeodomain transcription factor family. (nature.com)

The stx genes are located in a bacteriophage fecal samples of a 2-week-old boy who had bacteremia and HUS and in fecal samples of his asymptomatic family integrated into the bacterial genome, and the production members. (cdc.gov)
Based on genome distribution analysis, tandem duplication appears to have contributed to ARF gene expansion. (geneticsmr.org)
The advancement in the field of genomics, the study of the entirety of the organism's genes, called the genome, and the use of genome information has spurred incredible interest in this area and laying the foundation for prediction, prevention and treatment of food allergies. (news-medical.net)

This is called familial ALS and it means that two or more people in a family have ALS. (cdc.gov)
Collection of family history information through free portals such as the Surgeon General's family history tool can help remind people and healthcare providers of the importance of managing the ABCS and help identify people with inherited conditions like familial hypercholesterolemia. (cdc.gov)

There are a number of genes that could increase a person's risk of developing breast cancer. (medicalnewstoday.com)
If breast cancer runs in a person's family, they may want to undergo genetic testing. (medicalnewstoday.com)
A genetic counselor can organize a blood test to analyze the person's DNA for gene changes that could increase their risk of breast cancer. (medicalnewstoday.com)
Chromosome abnormalities Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)

Based on structural and functional features, they can be divided into different classes that have been shown to act as activators or repressors of E2F-dependent genes. (cardiff.ac.uk)
ETS factors act as transcriptional repressors, transcriptional activators, or both. (wikipedia.org)

Researchers have also linked the BRCA genes to the development of ovarian cancer . (medicalnewstoday.com)
Similar to the BRCA genes, CHEK2 helps repair DNA. (medicalnewstoday.com)

Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. (nih.gov)

Expression data further revealed that the legume bZIP genes were expressed constitutively or in an organ-specific, development-dependent manner playing roles in multiple seed developmental stages and tissues. (datadryad.org)
The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. (biologists.com)
This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis. (biologists.com)
In this primer, we describe the key features of Hes factors and detail their roles in some representative processes of embryogenesis: namely, in the development of the nervous and digestive systems, two well-characterized processes, where Hes1 (and Hes3 and Hes5 in the nervous system) regulates cell proliferation and differentiation, and in the process of somite segmentation, where Hes7 functions as a biological clock. (biologists.com)
We will mainly focus on the roles of the mouse Hes genes, but also compare them with the zebrafish Hes genes (called the her family of genes)( Table 1 ). (biologists.com)

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
These predicted genes may have applications in molecular breeding programs and wheat drought and salinity research. (figshare.com)

This change in gene activity blocks the maturation (differentiation) of blood cells and leads to the production of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis. (wikipedia.org)
In addition, ETS factors, e.g. the vertebrate Etv1 and the invertebrate Ast-1, have been shown to be important players in the specification and differentiation of dopaminergic neurons in both C. elegans and olfactory bulbs of mice. (wikipedia.org)
Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)

Within the transcription factor family, RAP2.4a has a unique function as a general transcriptional activator of chloroplast peroxidase activity. (fu-berlin.de)
Auxin response factors (ARFs) participate in the transcriptional regulation of a series of biological processes related to growth and development. (geneticsmr.org)

While the ultimate promise of genomic medicine is still a few years away, we can integrate genetics and family history now into our fight against heart disease and stroke in the United States. (cdc.gov)

We further studied the collinearity between these genes and related genes of six other species. (biomedcentral.com)
Research into the bZIP family in different species will bring new insights into its evolution and function. (biomedcentral.com)
We made a comprehensive analysis of ARF genes in this species. (geneticsmr.org)

Putative cis-elements involved in auxin response, light signaling responses, phytohormones, and defense responses were identified in promoter regions of the ARF genes. (geneticsmr.org)

The chromosome distribution and analysis for WGD-derived duplicated blocks revealed that the legume bZIP genes have expanded mainly by segmental duplication rather than tandem duplication. (datadryad.org)
The translocation, written as t(8;21), combines genetic information from chromosome 21 and chromosome 8, fusing the RUNX1 gene on chromosome 21 with a gene on chromosome 8 called RUNX1T1 (also known as ETO ). (medlineplus.gov)

Expression analyses of the carrot E2F and DP genes reveal distinctive patterns and suggest that the functions of some of them are not necessarily linked to cell proliferation. (cardiff.ac.uk)
Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)

The following ASCL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
They were found to have from one to three locations on the subgenomes A, B, and D. Full-length gene sequences were designed for these contigs, which were further validated using promoter analysis. (figshare.com)

Previous studies have shown that the bZIP TF family is involved in plant growth, development, and stress responses. (biomedcentral.com)
The members of the family have been implicated in the development of different tissues as well as cancer progression. (wikipedia.org)
Past studies have shown that growth-regulating factors ( GRFs ) and GRF -interacting factors ( GIFs ) are involved in regulating plant growth and development, responding to environmental stress, and responding to the induction of exogenous hormones. (biomedcentral.com)
The results of this study may be helpful for further study of the function of PgGRF and PgGIF genes and lay a foundation for further study of their role in the growth and development of Panax ginseng . (biomedcentral.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Multiple geenetic and environmental factors have been linked to the development of CRC. (mindmeister.com)
Researchers have linked a number of genes, including BRCA1 and BRCA2, to the development of breast cancer. (medicalnewstoday.com)
Important regulators of transcription factors in plant growth and development and secondary metabolism. (biomedcentral.com)
Recently, a Working Group in the UK recommended (12) considering the development of a national database of patients and family members, which could be used for clinical audit, diagnosis and treatment, and research. (cdc.gov)
Even though the generation of the allergic response is quite well understood, the factors contributing to the development of allergies are still not clear. (news-medical.net)
The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
Genes play an important role in the development of OA. (lu.se)

Smoking , consuming alcohol , consuming a high amount of red meat, being overweight , and having limited physical activity, are the most common risk factors for developing tumors. (medicinenet.com)
Gender: Men are at more risk of developing tumors than women because of lifestyle risk factors. (medicinenet.com)
Reproduction and hormones: Late reproductive age, late and early menopause , hormonal therapy, and prolonged use of birth control pills , are a few risk factors for developing breast tumors in women. (medicinenet.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

Ulcerative colitis tends to run in families. (harvard.edu)
ADHD tends to run in families, which may mean it's inherited. (medlineplus.gov)

ERG and ETV1 are known gene fusions found in prostate cancer. (wikipedia.org)
Men with these gene changes also have a 7% lifetime risk of developing breast cancer and a higher risk of developing prostate cancer . (medicalnewstoday.com)

Although SLTM also suppressed the ability of oestrogen to activate a reporter gene in MCF-7 breast-cancer cells, inhibition of a constitutively active beta-galactosidase gene suggested that this was primarily the consequence of a generalized inhibitory effect on transcription. (bris.ac.uk)

This record is derived from a genomic sequence (NW_014805304.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. (genscript.com)

The genes were functionally categorised which led to the identification of a sugar beet-specific clade with an atypical amino acid composition in the R3 domain, putatively encoding betalain regulators. (buyresearchchemicalss.net)

Most cases of Apert syndrome appear with no previous family history of the disorder. (medicalnewstoday.com)

However, the prognostic role of autophagy genes in cervical cancer is still unclear. (hindawi.com)
Role in viral-induced interferon regulatory factor activation. (microbiologyresearch.org)
Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding. (microbiologyresearch.org)
Public health efforts to reduce the burden of heart disease and stroke can benefit today from increased awareness of the role of family history as a risk factor . (cdc.gov)
Studies of this kind have illustrated the role of HLA gene in allergies. (news-medical.net)
But research suggests that several factors probably play a role. (medlineplus.gov)
Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
What we do know, is that several genetic, environmental and lifestyle factors play a role in increasing the risk of developing OA The more risk factors present, the higher the probability is of developing the disease. (lu.se)
It is still unclear why, but research has pointed to hormonal factors potentially playing a role. (lu.se)

SRF controls gene transcription of various actin isoforms (e.g. (jneurosci.org)
p63 and p73 belong to the family of p53-related transcription factors expressing a variety of isoforms. (jgld.ro)

GSEA enrichment analysis showed the main enrichment being in KRAS activation, genes defining epithelial and mesenchymal transition (EMT), raised in response to the low oxygen level (hypoxia) gene and NF- k B in response to TNF. (hindawi.com)
Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. (microbiologyresearch.org)

Through this study, the research team is detecting the function of UCK2 and determining whether this gene can be a potential target for treatment of hepatocellular carcinoma. (mayo.edu)

Fusions of fibroblast growth factor receptor genes with other partner genes were recently discovered in cholangiocarcinoma. (mayo.edu)

Several transcript variants have been described for this gene. (nih.gov)
Genetic variants with gene regulatory effects are associated with diisocyanate -induced asthma. (cdc.gov)
Four variants exhibited effects on gene regulation (ATF rs11571537, CDH17 rs2446824 and rs2513789, and TACR1 rs2287231). (cdc.gov)
These results demonstrate that many DA-associated genetic variants likely act by modulating gene regulation. (cdc.gov)
However, because heart disease arises from complex interactions of genetic and environmental factors, genetic variants currently have little utility for predictive screening of healthy persons . (cdc.gov)

Most PgGRF and PgGIF gene promoters contain some hormone- and stress- related cis-regulatory elements. (biomedcentral.com)
The transcription factor interferon regulatory factor (IRF)-3 is essential for viral-induced IFN-β synthesis. (microbiologyresearch.org)
Rac1 and PAK1 are upstream of IKK-ϵ and TBK-1 in the viral activation of interferon regulatory factor-3. (microbiologyresearch.org)
Ranking of DA-associated SNPs based on their likelihood to affect gene regulatory mechanisms in the lung yielded 21 prioritized SNPs. (cdc.gov)

The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
However, cell wall synthesis related genes were up-regulated under drought stress and down-regulated under flooding stress. (frontiersin.org)
Eikenboom JC, Castaman G, Kamphuisen PW, Rosendaal FR, Bertina RM: The factor VIII/von Willebrand factor ratio discriminates between reduced synthesis and increased clearance of von Willebrand factor. (karger.com)

RNA interference (RNAi) of PTPRK accelerated cell cycle progression, enhanced response to epidermal growth factor (EGF), and abrogated TGF-beta-mediated antimitogenesis. (nih.gov)
Cetuximab (Erbitux) and panitumumab (Vectibix) - monoclonal antobodies that target epidermal growth factor receptors. (mindmeister.com)

GRF genes are usually expressed at higher levels in young tissues but at lower levels in mature tissues [ 6 ]. (biomedcentral.com)
This could help researchers figure out common genes that relate to the body's loss of immune tolerance to its own tissues and organs," she added. (medscape.com)

Anatomy6

Organisms7

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes29

Technology, Industry, Agriculture1

Information Science4

Mutations17

Proteins13

Tumor9

Protein21

Phenotypes4

BZIP transcription factor family2

Arabidopsis4

Mutation10

Heredity2

Encodes2

Susceptibility3

Comprise3

Expression of ge2

Cytokine receptor1

Phylogenetic2

Pathways4

Several genes3

Highly conserved1

BHLH2

Target genes1

Abiotic3

Candidate genes2

Regulate2

Ontology1

Basic leucine zipper1

Drought and salt stresses2

Encode1

Genome3

Familial2

Person's4

Repressors2

BRCA2

Inhibits1

Roles5

Molecular2

Differentiation4

Transcriptional2

Genetics and family history1

Species3

Promoter regions1

Chromosome2

Patterns2

Sequences2

Development12

Tumors4

Tends to run2

Prostate cancer2

Constitutively active1

Prediction1

Functionally1

Cases of Apert syndrome1

Role9

Isoforms2

Epithelial2

Hepatocellular carcinoma1

Fusions1

Variants5

Regulatory4

Synthesis3

Epidermal Growth2

Tissues2