Family binds multiple calcium calcium binding proteins. Medical search. Frequent questions

It binds two calcium ions with high affinity. (nih.gov)
Likely to bind calcium ions. (embl.de)
Likely calcium ions. (embl.de)
C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl.de)
S100A1 and S100B binding to ions was also compared and differences between ion binding sites within the two highly similar proteins were determined. (umaryland.edu)
Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the presence of EDTA. (betalifesci.com)
Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcoplasmic reticulum. (betalifesci.com)
They are dependent on calcium (Ca 2+ ) ions to function, hence their name. (wikidoc.org)
When parathyroid hormone (PTH) binds to receptors on these cells, the osteocytic membrane pumps calcium ions from the bone fluid into the extracellular fluid. (medscape.com)

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. (nih.gov)
Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. (embl.de)
The ABCB4 gene (also known as MDR3 ) provides instructions for making a protein that helps move certain fats called phospholipids across the membranes of liver cells and release the phospholipids into a digestive fluid called bile. (medlineplus.gov)
Outside the liver cells, phospholipids attach (bind) to bile acids, which are a component of bile that digest fats. (medlineplus.gov)
when they are bound to phospholipids, bile acids are less toxic. (medlineplus.gov)
ABCB4 gene mutations that cause PFIC3 impair the movement of phospholipids across cell membranes, leading to a lack of phospholipids available to bind to bile acids. (medlineplus.gov)
Under most circumstances, though, enough protein is available to move an adequate amount of phospholipids out of liver cells to bind to bile acids. (medlineplus.gov)
Although the mechanism is unclear, the function of the remaining ABCB4 protein appears to be impaired during pregnancy, which may further reduce the movement of phospholipids into bile. (medlineplus.gov)
The lack of phospholipids available to bind to bile acids leads to a buildup of toxic bile acids that can impair liver function, including the regulation of bile flow. (medlineplus.gov)
Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. (assaygenie.com)

First, molecular fragments were used to differentiate between two highly similar S100 proteins, S100B and S100A1, with the goal of designing S100-specific inhibitors to block these elevated S100 proteins in various disease states. (umaryland.edu)

The biochemical properties of CaBPs from different parasites have been investigated, and despite the considerable resemblance between structural models of all family members, differences exist in the dimerization, ion-binding and drug-binding characteristics of these apparently similar proteins [ 14 ]. (biomedcentral.com)

S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. (novoprolabs.com)
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
Tegumental proteins (TegPs) belong to a family of calcium-binding proteins (CaBPs), which contain two EF-hand motifs at the N-terminal domain and a C-terminal dynein light chain-like domain [ 7 ]. (biomedcentral.com)

Interferon Beta Activity Is Modulated Via Binding of Specific S100 Pro" by Alexei S. Kazakov, Alexander D. Sofin et al. (usf.edu)
To probe selectivity of IFN-β-S100 interaction with respect to S100 proteins, we used surface plasmon resonance spectroscopy, chemical crosslinking, and crystal violet assay. (usf.edu)
Among the thirteen S100 proteins studied S100A1, S100A4, and S100A6 proteins exhibit strictly Ca2+-dependent binding to IFN-β with equilibrium dissociation constants, Kd, of 0.04-1.5 µM for their Ca2+-bound homodimeric forms. (usf.edu)
Calcium depletion abolishes the S100-IFN-β interactions. (usf.edu)
Interferon-α is unable of binding to the S100 proteins studied. (usf.edu)
The revealed direct influence of specific S100 proteins on IFN-β activity uncovers a novel regulatory role of particular S100 proteins, and opens up novel approaches to enhancement of therapeutic efficacy of IFN-β. (usf.edu)
In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. (novoprolabs.com)
EF-hand Ca2+-binding proteins (CBPs), such as calmodulin (CaM) or those belonging to the S100 protein family (S100s) undergo conformational changes upon increasing intracellular Ca2+, facilitating interactions with protein targets and inducing important biological responses. (umaryland.edu)
This research seeks to elucidate both the mechanisms of allostery and the basis of ligand- and target- specificity for S100 proteins and CaM. (umaryland.edu)
This provided insight into the specificity of S100A1 versus S100B for small molecules and will enable improved S100 protein-based drug design efforts. (umaryland.edu)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)

In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. (embl.de)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl.de)

δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)
It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin . (wikidoc.org)

The tail domain of vinculin binds to membrane lipids and to actin filaments. (wikidoc.org)
Binds to actin filaments (F-actin) and shows cross- linking activity. (string-db.org)

Here, in order to discover those membrane proteins that may be involved in JEV attachment to or entry into virus permissive BHK-21 cells, a chemically mutated cell line (designated 3A10-3F) that became less susceptible to JEV infection was preliminarily established and selected by repeated low moi JEV challenges and RT-PCR detection for viral RNA E gene fragment. (biomedcentral.com)
The noted discrepancy of membrane proteins included calcium binding proteins (annexin A1, annexin A2), and voltage-dependent anion channels proteins (VDAC 1, VDAC 2), suggesting that these molecules may affect JEV attachment to and/or entry into BHK-21 cells and worthy of further investigation. (biomedcentral.com)

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. (nih.gov)
Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca(2+)-ligated calmodulin. (nih.gov)
The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. (nih.gov)
Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. (nih.gov)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. (string-db.org)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. (string-db.org)

By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. (nih.gov)
The C2 domain is a Ca 2+ -dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. (embl.de)
ANXA2 is part of the annexin family and is involved in the regulation of cellular growth and in signal transduction pathways. (assaygenie.com)
The first step of virus infection requires the interaction between virus attachment proteins (VAPs) and cellular receptors, which is known to contribute to host range, tissue tropism and viral pathogenesis. (biomedcentral.com)
Such broad tropism of JEV rationally suggests that most possibly there exists more than one cellular receptor responsible for virus binding and entry into susceptible cells above mentioned. (biomedcentral.com)

An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
5 MAP kinase has been shown to be activated by calcium influx through both N -methyl-D-aspartate (NMDA) receptors and L-type Ca 2+ channels. (asahq.org)
The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. (string-db.org)

ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)

Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
Another study revealed an allosteric mechanism in which a peptide termed BP2, derived from the STRA6 vitamin A transporter, increased the Ca2+-binding affinity of CaM upon binding. (umaryland.edu)
The rFg-CaBP4 protein was induced and purified by affinity chromatography. (biomedcentral.com)

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (gzsys.org.cn)

Finally, the protein interaction network analysis revealed that VGLL3 is likely involved in the Hippo signaling pathway. (researchgate.net)
The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)
The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. (embl.de)
The liver fluke Fasciola gigantica secretes excretory-secretory proteins during infection to mediate its interaction with the host. (biomedcentral.com)
These findings provide additional evidence that calcium-binding EF-hand proteins play roles in host-parasite interaction. (biomedcentral.com)
May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. (string-db.org)

Taxonomy and function of C1 protein kinase C homology domains. (embl.de)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl.de)
The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. (embl.de)
It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. (string-db.org)
Protein serine kinase H2. (string-db.org)

One of the most convincing methods to verify a putative virus receptor is to transfer the receptor gene into a cell line that cannot bind virus and later demonstrate that the receptor-negative cell acquires the ability to bind virus and permit virus to replicate within it after the receptor gene is regained [ 13 ]. (biomedcentral.com)

ANXA2 is part of the putative cell surface vitamin D binding protein binding site complex and functions to mediate the chemotactic cofactor effect. (assaygenie.com)

The isopropyl-ß- D -thiogalactopyranoside-induced rFg-CaBP4 protein reacted with rat sera containing anti-rFg-CaBP4 polyclonal antibodies in a western blot analysis. (biomedcentral.com)
Horseshoe-nosed bats of several species (suborder Microchiroptera, family Rhinolophidae, genus Rhinolophus ) from different locations in southern People's Republic of China and the Hong Kong Special Administrative Region were found to be infected with SARS-like CoVs, and some of the bats had antibodies to these newly recognized coronaviruses ( 10 , 12 ). (cdc.gov)

Multiple alternatively spliced transcript variants have been observed at this gene. (nih.gov)
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Multiple alternatively spliced variants encoding the same protein have been identified. (novoprolabs.com)

The toxic effects of lead result from its interference with the physiologic actions of calcium, zinc, and iron, through the inhibition of certain enzymes, and through binding to ion channels and regulatory proteins. (cdc.gov)

The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. (gzsys.org.cn)
They play important roles in cell adhesion , ensuring that cells within tissues are bound together. (wikidoc.org)
In the blood, absorbed lead is bound to erythrocytes and then is distributed initially to multiple soft tissues and eventually into bone. (cdc.gov)

S100A1/A4 proteins inhibit IFN-β-induced suppression of MCF-7 cells viability. (usf.edu)

Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). (embl.de)

Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
In structure, they share cadherin repeats , which are the extracellular Ca 2+ - binding domains . (wikidoc.org)

Also, discussed is the first structure of a CaBP-MLT complex by X-ray crystallography, which shows that MLT has a different binding orientation than previously characterized centrin-bound peptides. (rcsb.org)

S100P is a member of large family of multifunctional Ca2+-binding proteins with cytokine-like activities. (usf.edu)

The molecular implications of these results are: (1) the recognition of hydrophobic contacts as requirements for initial binding, (2) minimum electrostatic interactions within the C-terminal end of the peptide, and (3) van der Waals interactions within MLTs N-terminal end are required for complex formation. (rcsb.org)
Principal interactions of structural proteins at cadherin-based adherens junction. (wikidoc.org)

The epidemic of severe acute respiratory syndrome (SARS) in 2002-2003 was caused by a newly emerged zoonotic coronavirus (SARS-CoV) (order Nidovirales, family Coronaviridae , genus Coronavirus ). (cdc.gov)

S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. (novoprolabs.com)

Regions with significant homology [ ( PUBMED:7559667 ) ] to the C2-domain have been found in many proteins. (embl.de)

Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)
The primary action of 1,25-(OH)2 D3 is to promote gut absorption of calcium by stimulating formation of calcium-binding protein within the intestinal epithelial cells. (medscape.com)

The C2 domain is thought to be involved in calcium-dependent phospholipid binding [ ( PUBMED:8253763 ) ] and in membrane targetting processes such as subcellular localisation. (embl.de)

This gene encodes a member of the annexin family. (nih.gov)

CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)

Please note that proteins can be included in multiple pathways, ie. (embl.de)
Autophagy is generally considered as a cell survival/protection mechanism because it removes toxic or obsolete proteins and organelles and recycles the degradation products for use as sources for energy and metabolites in anabolic pathways 3 . (nature.com)
Seems to act as a scaffold protein in multiple signaling pathways. (string-db.org)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)

Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)

Centrin is a calcium binding protein (CaBP) belonging to the EF-hand superfamily. (rcsb.org)

Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. (embl.de)
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. (embl.de)
There are multiple classes of cadherin molecule, each designated with a one-letter prefix (generally noting the type of tissue with which it is associated). (wikidoc.org)
For example, an N-cadherin will bind only to another N-cadherin molecule. (wikidoc.org)
Different members of the cadherin family are found in different locations. (wikidoc.org)
The intracellular domain contains a highly- phosphorylated region vital to beta-catenin binding and therefore to E-cadherin function. (wikidoc.org)

As with other proteins within this family, centrin is a calcium sensor with multiple biological target proteins. (rcsb.org)
Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

The recombinant human Fc/S100A4 is a disulfide-linked homodimeric protein. (novoprolabs.com)

The protein is present as a patch at the incipient bud site and in emerging buds, and at the bud periphery in small-budded cells. (embl.de)
Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)
Finally, two-dimensional electrophoresis (2-DE) coupled with LC-MS/MS was utilized to recognize the most differentially expressed proteins from membrane protein extracts of 3A10-3F and BHK-21 cells respectively. (biomedcentral.com)
Much earlier, a report stated that a 74 kDa protein on Vero cells was found to be capable of binding JEV and might be involved in virus uptake process [ 10 ]. (biomedcentral.com)
A recent paper also indicated that several proteins on the surface of C6/36 cells with masses ranging from 35-80 kDa and 150-200 kDa may bind to JEV, but failed to identify specific proteins by mass spectroscopic fingerprint analysis [ 11 ]. (biomedcentral.com)

Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. (nih.gov)

Calumenin belongs to the CREC family. (betalifesci.com)
Belongs to the tubulin family. (string-db.org)

Compared to parathyroid hormone (PTH), vitamin D exerts a much slower regulatory effect on calcium balance. (medscape.com)

Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca 2+ -binding loops are located at the end of an 8 stranded antiparallel beta sandwich. (embl.de)

For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. (assaygenie.com)

Activity of this protein is important in the regulation of the cell cycle and cytokinesis. (nih.gov)
Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. (betalifesci.com)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)

ANXA2 protein functions as an autocrine factor which increases osteoclast formation and bone resorption. (assaygenie.com)

Axl2p is predicted to be a type I transmembrane protein. (embl.de)
Cadherins are a class of type-1 transmembrane proteins . (wikidoc.org)

This chemokine is encoded by multiple genes. (lookformedical.com)

Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). (nih.gov)

In addition, δ-catenin, ARVCF, and p0071 also contain a PDZ binding motif at the C terminus. (jneurosci.org)
Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (embl.de)

A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)

Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)

This protein may function in exocytosis and endocytosis. (cancerindex.org)

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer. (betalifesci.com)

Anatomy21

Organisms14

Diseases6

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes49

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Ions9

Phospholipids10

Elevated S100 proteins1

Similar proteins1

Motifs3

S10014

Domain-containi2

P120 catenin2

Actin filaments2

Membrane Proteins2

Calmodulin9

Cellular6

Receptors4

MRNA and protein levels1

Affinity3

S100A61

Interaction7

Kinase6

Receptor1

Putative1

Antibodies2

Alternatively spliced3

Enzymes1

Tissues4

Inhibit1

Kinases1

Extracellular2

Peptides1

Multifunctional1

Interactions2

20021

Targets1

Homology1

Epithelial2

Phospholipid1

Annexin family1

Gene expression1

Pathways3

UniProt1

Mediate1

Superfamily1

Cadherin6

Biological2

Immunohistochemistry1

S100A41

Cells5

Isoforms1

Belongs2

Regulatory1

Structural1

Freeze-thaw cycles1

Regulation3

Anxa21

Transmembrane2

Genes1

Mechanism1

Motif2

Monocyte1

Localization1

Exocytosis1

Carrier protein1