Family bacterial proteins. Medical search. Frequent questions

It is a conserved, hypothetical protein with sequence homologues found exclusively in bacteria. (wikipedia.org)
Research in mice and zebrafish shows how a protein from gut bacteria could drive the development of diabetes, opening up new pathways for treatment. (medicalnewstoday.com)
A new study published in Cell Metabolism shows that a protein called beta cell expansion factor A (BefA) secreted by gut bacteria could induce the replication of insulin-producing beta cells in neonatal mice. (medicalnewstoday.com)
Moreover, the authors had also identified a version of the BefA protein synthesized by gut bacteria in humans that could stimulate the proliferation of beta cells in zebrafish. (medicalnewstoday.com)
Moreover, although the abundance of most protein groups reflected that of related bacterial populations, we found a specific independent regulation of bacteria-derived cell envelope proteins. (bmj.com)
Tiny proteins found in the genomes of some types of bacteria are effective weapons against a wide range of other bacteria, opening the door for the development of new therapies in the age of antibiotic resistance, according to new research at the University of Notre Dame. (nd.edu)
The team sequenced the genome of a bacterial species isolated from the seed and discovered a portion of one bacteriocin, AS-48, would interact with the membranes of certain types of bacteria like E. coli. (nd.edu)
Limited sequence homology hasbeen found with the proteins FtsZ and Misato, which are involved in celldivision in bacteria and Drosophila, respectively. (embl-heidelberg.de)
Indeed, some of modern medicine's most reliable antibiotics disarm harmful bacteria by disrupting the proteins that build their protective armor. (harvard.edu)
The newly profiled protein, RodA, belongs to a family collectively known as SEDS proteins, present in nearly all bacteria. (harvard.edu)
SEDS" near-ubiquity renders these proteins ideal targets for the development of broad-spectrum antibiotics to disrupt their structure and function, effectively neutralizing a range of harmful bacteria. (harvard.edu)
In a set of experiments, researchers altered the structure of RodA in two bacterial species-the textbook representatives of the two broad classes that make up most of disease-causing bacteria. (harvard.edu)
Additionally, because the protein is highly conserved across all bacterial species, the discovery of an inhibiting compound means that, at least in theory, a drug could work against many kinds of harmful bacteria. (harvard.edu)
The protein - a cell receptor called NOD2 found in several types of immune cells - has long been known for its role in fighting off bacterial invaders by sensing their presence and alerting immune cells to release chemicals that weaken or destroy the harmful bacteria. (hopkinsmedicine.org)
Specifically, tetracycline-speicific efflux pumps and ribosomal protection proteins are commonly employed by bacteria. (kenyon.edu)
Derived from tetracycline, glycylcyclines have added substituents that interfere with the mechanisms bacteria employ to resist tetracycline, including both the efflux pumps and ribosomal protection proteins. (kenyon.edu)
At least four phylogenetically distinct groups of bacteria encode repeat proteins with the common ability to bind specific DNA sequences with a unique but conserved code. (uni-muenchen.de)
This unity of terminology belies disunity in the lifestyles of these different bacteria, and the biological roles fulfilled by these proteins. (uni-muenchen.de)
e.g. lipopolysaccharide (LPS) of gram-negative bacteria are recognized by TLR4 while TLR5 recognizes the bacterial protein flagellin. (antibodies-online.com)
The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. (embl.de)
Of note, domains found in membrane-attack complex proteins of complement and perforin (MACPF) resemble cholesterol-dependent cytolysins from Gram-positive bacteria, and the Bcl family of apoptosis regulators share similar architectures with Escherichia coli pore-forming colicins. (nih.gov)
By cross-linking bacterial surface proteins to fibrinogen, factor XIIIa causes bacteria to be immobilized and killed. (medscape.com)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it triggers a response to attack the invading viruses or bacteria. (medlineplus.gov)
Bacteria found in your mouth and digestive tract produce hydrogen sulfide during the digestion of food containing vegetable or animal proteins. (cdc.gov)

They correspond to functions allowing opportunistic pathogens to colonise the mucus layers, breach the host barriers and invade the mucosae, which could still be aggravated by decreased host-derived pancreatic zymogen granule membrane protein GP2 in CD patients. (bmj.com)
The coronaviruses are a family of viruses that includes a series of very different pathogens. (helmholtz-hzi.de)
I am a researcher in bacterial genetics and my interest is in understanding the development of resistance in bacterial pathogens using next generation sequencing techniques. (wellcomeconnectingscience.org)
I am a graduate student at the Wellcome Sanger Institute, where I research the virulence and the molecular genetics of bacterial pathogens as part of the Infection Genomics programme. (wellcomeconnectingscience.org)
We therefore asked ourselves whether widespread fungal pathogens have strategies to adapt to the chemical defenses of plants of the cabbage family,' Jingyuan Chen, the first author of the study, explains. (mpg.de)
Bacterial pathogens causing neonatal sepsis and their antibiotic susceptibility pattern may change over time and differ between countries. (who.int)
Typical bacterial pathogens that cause CAP include Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis . (medscape.com)
The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)

The biogenesis of several bacterial polytopic membrane proteins has been shown to require signal recognition particle (SRP) and protein transport machinery, and one such protein, the major light-harvesting chlorophyll- binding protein (LHCP) exhibits these requirements in chloroplasts. (soton.ac.uk)
Of the membrane proteins whose insertion into thylakoids has been analyzed, five have now been shown to insert by a SRP/Sec-independent mechanism, suggesting that this is a mainstream form of targeting pathway. (soton.ac.uk)
The new compounds were able to solubilize membrane proteins from bacterial membranes, insect cells, as well as Madin Darby Canine Kidney (MDCK) cells. (calixar.com)
Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins. (calixar.com)
She studied molecular simulations of bacte-rial membrane proteins. (biophysics.org)
We are interested in a wide range of biological molecules including membrane proteins and peptides, DNA, lipids, and carbohy-drates," Khalid says. (biophysics.org)
We are cur-rently working together on a project with Oxford Nanopores Technologies Ltd. who use membrane proteins as molecular machines for DNA sequencing," she says. (biophysics.org)
She shares, "We have worked together on a number of projects trying to under-stand the relationship between membrane proteins and their lipid surroundings. (biophysics.org)

The eukaryotic transactivation domain, which lends this group their name, allows them to activate specifically targeted host genes for the benefit of the bacterial invader. (uni-muenchen.de)
We based our search on the known bacterial SaxA proteins to select candidate genes for further investigations. (mpg.de)
We then tested whether these genes are actually expressed in greater quantities in fungi exposed to the toxins, and whether the resulting protein can render the toxins harmless,' explains Daniel Vassão, one of the study leaders. (mpg.de)
Proteins are the fundamental materials from which all organisms are built, and there are billions of genes coding for them. (embo.org)
We will only be able to do experiments on a small fraction of genes and proteins: to understand the functions of those we don't do experiments on, we need to transfer knowledge from the ones we do," says Bateman, who also leads a research group that studies bacterial cell surface proteins that mediate host colonization. (embo.org)
These genes provide instructions for making proteins that play a critical role in the immune system. (medlineplus.gov)
The proteins produced from the HLA-DQA1 and HLA-DQB1 genes attach (bind) to each other to form a functional protein complex called an antigen-binding DQαβ heterodimer . (medlineplus.gov)

In molecular biology, YecM refers to a protein domain found in Escherichia coli. (wikipedia.org)
Conclusions This study provides the first evidence that quantifiable bacterial protein signals are associated with CD, which can have a profound impact on future molecular diagnosis. (bmj.com)
The possible roles of molecular hydrogen, a common by-product of bacterial fermentation, are also addressed. (techscience.com)
Molecular linkage analyses of affected families have identified NOD2 (nucleotide-binding domain 2) as a susceptibility gene in CD. (medscape.com)
Bacterial cell division ends with septation, the constriction of the cellwall and cell membranes that leads to the formation of two daughter cells.During septation, FtsZ, a protein of relative molecular mass 40,000 whichis ubiquitous in eubacteria and is also found in archaea and chloroplasts,localizes early at the division site to form a ring-shaped septum. (embl-heidelberg.de)
Now, in another scientific first described March 28 in Nature , members of the same research team have revealed the molecular building blocks-and a structural weak spot-of a key member of that family. (harvard.edu)
Specifically, the protein's molecular profile reveals structural features reminiscent of other proteins whose architecture Kruse has disassembled. (harvard.edu)
By understanding each of these families, we can learn a huge amount about molecular machinery. (embo.org)
The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)

A new study reports that a protein called beta cell expansion factor A (BefA) secreted by certain gut bacterial species could induce the proliferation of beta cells in young mice and zebrafish. (medicalnewstoday.com)
Many proteins, largely derived from Bacteroides species, were over-represented, while under-represented proteins were mostly from Firmicutes and some Prevotella members. (bmj.com)
In addition, in silico analysis of FI proteins suggests that they represent recent acquisitions of conjugative plasmids, i.e., are not shared by members of the same plasmid species. (frontiersin.org)
Therefore, this study aims to assess the causative bacterial species, their antimicrobial susceptibility pattern and possible associated risk factors of neonatal sepsis. (who.int)

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. (nih.gov)
Additionally, because the NOD2 protein is regulated by a gene implicated in the inflammatory intestinal condition Crohn's disease, the findings offer a new explanation for the severe CMV infections that sometimes occur in patients with Crohn's. (hopkinsmedicine.org)
A short period of desiccation-elevated peptidoglycan recognition protein-LC ( PGRP-LC ) expression in MTs, increased antimicrobial peptide ( AMP ) gene induction, and protected animals from bacterial infection. (biomedcentral.com)
Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)

We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
[ 11 , 12 ] NOD2 encodes a protein that binds to intracellular bacterial peptidoglycans, subsequently activates NF-kB (nuclear factor-kappaB), and may be involved both in preventing excessive immune activation and in combating luminal microbes. (medscape.com)
Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. (bdbiosciences.com)
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. (bdbiosciences.com)
Overexpression of the enhanced intracellular survival (Eis) protein by Mtb confers resistance to the second-line antibiotic kanamycin (KAN). Eis is an acetyltransferase that acetylates KAN, inactivating its antimicrobial function. (cdc.gov)

The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)

A key aspect of our work is developing new models of bacterial membranes which incorporate their inherent complexity allowing us to bridge some of the divide that currently exists between model systems and real biology. (biophysics.org)

Giannella RA (1981) Pathogenesis of acute bacterial diarrheal disorders. (springer.com)

This family contains bacterial and phage tail fibre assembly proteins. (nih.gov)
Using the lambda phage members as examples, there are both gptfa and gpK tail proteins here. (nih.gov)
TTCs form the platform on which the tail-tube proteins self-assemble and are also the attachment point for fibers or receptor-binding proteins that mediate phage-adsorption to the surface of the host cell. (nih.gov)
several bacterial cold-shock and phage shock proteins. (embl.de)
Once the TA system detects the invading phage, the toxin is activated, compromising the viability of the infected bacterial cell. (lu.se)

Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)
In nature, many of these proteins exist as circular forms, so using this approach assured that the team optimized the peptides to the point where they're as effective as their natural counterparts. (nd.edu)
This complex, which is present on the surface of certain immune system cells, attaches to protein fragments (peptides) outside the cell. (medlineplus.gov)

Intriguingly, helical localization patterns were reported for many other fluorescently tagged bacterial proteins (e.g. chemoreceptors, secretion proteins, RNase E, and the chromosome partitioning protein SetB) but often the questions remains how well these observations reflect the true situation 6 . (nature.com)

For example, alteration of host cell metabolism can provide the increased nucleotides necessary for genome replication or increased free amino acids needed for rapid viral protein synthesis. (estme.org)
That same protein, the Johns Hopkins team found, also appears to regulate the body's immune response to CMV by initiating a chemical signaling cascade that curbs viral spread. (hopkinsmedicine.org)
Exposure to foreign antigens, such as an infectious (bacterial or viral) or toxic agent, may be the instigating event. (msdmanuals.com)

Use bioinformatics to probe genomes, to explore and represent DNA and protein sequences. (wellcomeconnectingscience.org)
The course will be of interest to undergraduates, post-graduates, researchers, bioinformaticians, biomedical researchers, microbiologists, healthcare professionals and all those who are interested in learning about the underlying mechanisms of bacterial disease, DNA sequences and protein data, or how to use online analytical tools to probe genomes. (wellcomeconnectingscience.org)
The opportunity to use online computational tools in the context of bacterial genomes will also be of interest to teachers and their 16-18-year-old science and computing students. (wellcomeconnectingscience.org)
A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)

In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Modelling by template has a vast practical potential because if the structure of at least one protein from which functional family is known, then it is possible to try to build models for almost every protein in this family. (custom-essay.org)
Two other members, however, namely an early light-inducible protein 2 (Elip2) and photosystem II subunit S (PsbS), can insert efficiently in the complete absence of SRP, SecA activity, nucleoside triphosphates, or a functional Sec system. (soton.ac.uk)
Biologists often gain structural and functional insights into a proteinsequence by constructing a multiple alignment model of the family. (embl.de)

This review summarizes the major families of bacterial toxins and also describes the specific structure-function properties of the botulinum neurotoxins. (springer.com)

The NOD2 protein is a known susceptibility marker for Crohn's disease, so the findings may offer a new explanation for the severe CMV infections seen in some patients with Crohn's. (hopkinsmedicine.org)
2. Determine the susceptibility pattern of bacterial isolates to commonly used antibiotics. (who.int)

The Department Structure and Function of Proteins uses protein crystallography to investigate proteins that play a role in infectious disease, e.g. by controlling the production of toxic molecules or by acting as toxins themselves. (helmholtz-hzi.de)

However, they exhibit no additional sequence homology to any member of other GPCR families. (bdbiosciences.com)

The yellow represents a newly synthesized bacterial cell wall. (harvard.edu)

However, YecM structural homologues reveal that all the proteins bind a divalent metal cation. (wikipedia.org)
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Until very recently, the Cdc25 family was the only subfamily of tyrosine phosphates for which no three-dimensional structural data were available. (embl.de)
A structure-activity relationship study of 38 compounds in this structural family yielded highly potent (IC(50) 1M) Eis inhibitors, which did not inhibit other acetyltransferases. (cdc.gov)
Structural and mechanistic understanding of protein function has lagged behind due to the challenging and lowthroughput nature of structural and biochemical approaches. (lu.se)

The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. (bdbiosciences.com)

Use bioinformatics to explore DNA sequences and protein functions, to find the determinants of virulence in microbes. (wellcomeconnectingscience.org)
indeed, pore-forming toxins (PFTs) are well known as important bacterial virulence factors. (nih.gov)

Several bacterial YecM proteins in this particular family are of unknown function. (wikipedia.org)

Bacterial toxins are often characterized based upon the secretion mechanism that delivers the toxin out of the bacterium, termed types I-VII. (springer.com)

These ubiquitous microbial genetic elements are composed of a protein toxin inhibited by an antitoxin. (lu.se)

Traditionally, prediction of the functions of bacterial proteins is carried out for poorly studied molecules or hypothetical proteins predicted based on these genome sequences. (custom-essay.org)
Our work can help scientists identify the proteins encoded in a genome sequence, learn how they interact, and understand their function. (embo.org)

Because this was derived from a commensal bacterium in a plant source, it may have application as an agricultural product to prevent bacterial infection in plants and crops. (nd.edu)
Scientists at Johns Hopkins have identified a protein that regulates the body's immune response to infection with cytomegalovirus, a common pathogen. (hopkinsmedicine.org)
Bacterial toxins damage the host at the site of bacterial infection or distant from the site. (springer.com)
We show that desiccation increased ecdysone synthesis in MTs, while inhibition of ecdysone synthesis or ecdysone receptor expression, specifically within MTs, prevented induction of PGRP-LC and reduced protection from bacterial infection. (biomedcentral.com)
Given the central role PGRP-LC plays in sensing systemic bacterial infections, steroid hormone regulation provides a significant degree of modulation on the ability of cells or animals to respond to bacterial infection. (biomedcentral.com)
3. Immune encephalitis, aseptic meningitis, genetic metabolic brain injury, brain tumor, space occupying and trauma without intracranial bacterial infection. (who.int)

Within the RNaseA superfamily there is a group of highly cationic proteins secreted by innate immune cells with anti-infective and immune-regulatory properties. (frontiersin.org)

Fields, the lead author on the paper published in February 2018 in The Journal of Antibiotics, completed his research with other colleagues in the lab of Shaun Lee, the Monahan Family Associate Professor of Rare and Neglected Diseases in the Department of Biological Sciences and the Eck Institute for Global Health . (nd.edu)
In addition the TALEs and RipTALs may simply represent one face of the TALE-likes, a protein family mediating as yet unknown biological roles as bacterial DNA binding proteins. (uni-muenchen.de)

Fluorescence-tags, commonly used to visualize the spatial distribution of proteins within cells, can influence the localization of the tagged proteins by affecting their stability, interaction with other proteins or the induction of oligomerization artifacts. (nature.com)
Taxonomic distribution of proteins containing Tubulin domain. (embl-heidelberg.de)

Then, use databases to find protein sequences' conserved domains and investigate their functions. (wellcomeconnectingscience.org)
By identifying distant relationships and mergingfamilies into superfamilies in this way, this analysis further confirmsthe notion that proteins evolved from relatively few ancient sequences.Moreover, this method automatically generates models of these ancientconserved regions for rapid and sensitive screening of sequences. (embl.de)

What makes us excited is that this protein has a fairly discrete pocket that looks like it could be easily and effectively targeted with a drug that binds to it and interferes with the protein's ability to do its job," said study co-senior author David Rudner , professor of microbiology and immunobiology at Harvard Medical School. (harvard.edu)
A chemical compound-an inhibitor-that binds to this pocket would interfere with the protein's ability to synthesize and maintain the bacterial wall," Rudner said. (harvard.edu)
The tigecycline antibiotic is structurally very similar to minocycline and similarly binds to the bacterial 30S ribosome unit. (kenyon.edu)
The manner in which the molecule binds prevents amino-acyl tRNAs from binding to the A site of the ribosome and subsequently prevents peptide formation and bacterial growth. (kenyon.edu)

The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. (bdbiosciences.com)
Nickel ABC transporter, substrate-binding protein NikA / Solute-binding protein family 5, conserved site / Bacterial extracellular solute-binding proteins, family 5 signature. (pdbj.org)

Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)

Except for the competence protein these proteins bind two zinc ions per molecule as cofactor. (embl.de)

In this paper, we report four sets of crystal structures of bacterial initially transcribing complexes that demonstrate and define details of stepwise, RNA-extension-driven displacement of the "σ-finger" of the bacterial transcription initiation factor σ. (osti.gov)
Bacterial toxins can be single proteins or oligomeric protein complexes that are organized with distinct AB structure-function properties. (springer.com)
LU-Fold specialises in high-throughput prediction of protein complexes to predict novel protein-protein interactions. (lu.se)

Eight metabotropic glutamate receptors (mGluR1-8) and several Ca[2+] sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. (bdbiosciences.com)
DAP-type PGN is sensed by two receptors, both members of the peptidoglycan recognition protein (PGRPs) family of receptors. (biomedcentral.com)
Investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors α v β 3 integrin and VEGFR-2. (medscape.com)

Infectious disease specialists at the Johns Hopkins Children's Center have identified a protein that regulates the body's immune response to cytomegalovirus (CMV), a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune systems. (hopkinsmedicine.org)

Since protein structure is more conserved over evolutionary timescales than its amino acid sequence, reliable structure prediction by AlphaFold has revolutionised our ability to predict protein function. (lu.se)

The protein induction of autophagy was analyzed by RT-qPCR, western blot, immunofluorescence, and electron microscopy. (frontiersin.org)

Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)

However, at present no ssEM protocol was available to investigate protein localization in entire bacterial cells. (nature.com)
2. Investigate associated acute phase reactive proteins/cells of neonatal sepsis o Specific: this study aims to 1. (who.int)
4. Investigate the utility of some biomarkers (e.g. complement reactive proteins, pro- calcitonin) and inflammatory cells in detecting neonatal sepsis. (who.int)
In addition, it wil investigate associated reactive proteins (CRP, Pro-calcitonin) and cel ular response during neonatal sepsis in major NICUs in Sana'a. (who.int)

This approach typically requires permeabilization or removal of the bacterial cell envelope in order to allow antibody penetration into bacterial cells. (nature.com)

In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. (lu.se)

Gupta DD, Saha S, Chakrabarti MK (2005) Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. (springer.com)

It is necessary to carry out pairwise alignment, which allows revealing conservative residues in the whole family or separate subfamilies of proteins. (custom-essay.org)
A sequence comparison of the relevant metallo-beta-lactamases,based on this protein structure, highlights a few well-conserved aminoacid residues. (embl.de)

Crystal structure of the bacterial cell-division protein FtsZ. (embl-heidelberg.de)

On the other hand, if it is not possible to find a template for modelling protein structure, then physical and chemical methods are used. (custom-essay.org)
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. (bdbiosciences.com)

Based on the results of this analysis, we also predict that the budding yeast arsenate resistance protein Acr2 and the ORF Ygr203w encode protein phosphatases with catalytic properties similar to that of the Cdc25 family. (embl.de)

antigenically distinct enterotoxin proteins (3,4). (cdc.gov)
Kim, Soo Jung , Jansson, Stefan , Hoffman, Neil E. , Robinson, Colin and Mant, Alexandra (1999) Distinct 'assisted' and 'spontaneous' mechanisms for the insertion of polytopic chlorophyll-binding proteins into the thylakoid membrane. (soton.ac.uk)

Priaary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases. (genome.jp)

Apart from the beta-lactamases a number of other proteins contain this domain ( PUBMED:7588620 ). (embl.de)

One way to achieve this goal is the detection of proteins by immunofluorescence. (nature.com)
The findings, published March 26 in the open-access journal PLOS One , offer what the Johns Hopkins teams says is a first-of-its-kind evidence that a protein that specializes in bacterial detection is also turned on when it sniffs out a virus from the DNA family. (hopkinsmedicine.org)

These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. (embl.de)
In particular, native human adenosine receptor (A2AR) and bacterial transporter BmrA were solubilized efficiently. (calixar.com)

In other words, the BefA proteins secreted by gut microbes in humans and zebrafish share a similar structure and function. (medicalnewstoday.com)
One of the most critical tasks of modern bioinformatics is to predict and foretell the structure and, consequently, the functions of bacterial proteins. (custom-essay.org)
In addition, knowledge of protein structure may prompt potential partners for protein interaction and thus encourage researchers to develop or improve new enzymes or antibodies, or, for example, to explain the phenotype of the mutations performed or to help determine the location of the mutations in order to change specific phenotypes. (custom-essay.org)
Prediction of protein structure and functions is a complex task for two reasons. (custom-essay.org)
With the growth of the structure database, such modelling becomes possible for more and more proteins. (custom-essay.org)
This essay on Predicting Bacterial Proteins' Structure and Function was written by a student just like you. (custom-essay.org)
When researchers induced even mild alterations to the structure of RodA's cavity, the protein lost its ability to perform its work. (harvard.edu)
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereusreveals a new type of protein fold. (embl.de)
The 3-D structure of Bacillus cereus (569/H/9) beta-lactamase (EC3.5.2.6), which catalyses the hydrolysis of nearly all beta-lactams, hasbeen solved at 2.5 A resolution by the multiple isomorphous replacementmethod, with density modification and phase combination, from crystals ofthe native protein and of a specially designed mutant (T97C). (embl.de)
But they fall into a relatively small number of families, which can be linked through similarities in sequence, structure and function. (embo.org)
Machine learning presents the opportunity to take a sequence and accurately predict a protein structure, which provides a powerful way of finding similarities," he says. (embo.org)

This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. (nih.gov)
Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
These are likely to play a role in protein interactions. (embl.de)

E.coli contains several members of this family although the function of these proteins is uncertain. (nih.gov)

Understanding the mechanisms underlying the actions of BefA protein could help develop therapies to stimulate beta cell proliferation in individuals with diabetes. (medicalnewstoday.com)
Now, the researchers have predicted and validated numerous new TAs (1,2), advancing the field of bacterial antiviral immunity mechanisms. (lu.se)

In the case of the RipTALs this work should begin to unravel the role these proteins play in bacterial wilt disease, as a means to fight this devastating pathogen. (uni-muenchen.de)

The protein represents a new target for diagnostics, treatment and prevention of what can be a devastating illness in newborns and in people with weakened immune systems. (hopkinsmedicine.org)
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. (medlineplus.gov)
However, people with silent celiac disease do have immune proteins in their blood (antibodies) that are common in celiac disease. (medlineplus.gov)
Celiac disease is associated with an inappropriate immune response to a segment of the gluten protein called gliadin . (medlineplus.gov)

FtsZ has two domains, one of which is a GTPasedomain with a fold related to one found in the proteins p21ras andelongation factor EF-Tu. (embl-heidelberg.de)
An alpha beta fold found duplicated in the Rhodanese protein. (embl.de)

Anatomy19

Organisms27

Diseases1

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes67

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Health Care1

Bacteria25

Pathogens8

Membrane proteins8

Genes7

Molecular9

Species4

Gene4

Intracellular5

Common bacterial1

Membranes1

Pathogenesis1

Phage5

Peptides3

Chromosome1

Viral3

Genomes5

Functional4

Botulinum neurotoxins1

Susceptibility2

Function of Proteins1

Sequence homology1

Synthesized bacterial cell1

Structural6

Putative1

Virulence2

Several bacterial1

Secretion1

Toxin1

Genome2

Infection6

Superfamily1

Biological2

Distribution of proteins2

Sequences2

Binds4

Extracellular2

Annotation1

Bind1

Complexes3

Receptors3

Infectious1

Amino acid1

Induction1

Lipids1

Investigate4

Antibody1

Complement1

Escherichia1

Residues2

Cell-division protein1

Methods2

Resistance1

Distinct2

Pancreatic1

PUBMED1

Detection2

Transporter2

Structure11

Interactions3

Coli1

Mechanisms2

Unravel1

Immune4

Fold2