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Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTrans-ActivatorsBinding SitesTranscriptional ActivationProtein BindingRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsNuclear ProteinsCell LineRepressor ProteinsTranscription Factor AP-1Amino Acid SequenceSignal TransductionHomeodomain ProteinsForkhead Transcription FactorsGene Expression Regulation, DevelopmentalDNAMutationBasic-Leucine Zipper Transcription FactorsTransfectionTranscription Factor AP-2Cell NucleusSTAT3 Transcription FactorCell DifferentiationTranscription Factors, TFIIKruppel-Like Transcription FactorsGenes, ReporterCells, CulturedChromatin ImmunoprecipitationHeLa CellsTranscription Factor TFIIDYY1 Transcription FactorGATA4 Transcription FactorNF-kappa BActivating Transcription Factor 3NFATC Transcription FactorsReverse Transcriptase Polymerase Chain ReactionTranscription Factor TFIIBZinc FingersSp3 Transcription FactorTranscription Initiation SiteElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticRecombinant Fusion ProteinsPlasmidsRNA Polymerase IIPaired Box Transcription FactorsActivating Transcription Factor 2Regulatory Sequences, Nucleic AcidCloning, MolecularSTAT1 Transcription FactorGene ExpressionGene Expression ProfilingE2F1 Transcription FactorGene Expression Regulation, FungalBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPhosphorylationMEF2 Transcription FactorsProtein Structure, TertiaryGATA3 Transcription FactorGATA1 Transcription FactorTCF Transcription FactorsSaccharomyces cerevisiaeLuciferasesGATA Transcription FactorsGATA2 Transcription FactorSaccharomyces cerevisiae ProteinsCell Line, TumorMicrophthalmia-Associated Transcription FactorActivating Transcription FactorsChromatinModels, BiologicalSequence Homology, Amino AcidTranscription Factor RelAHelix-Loop-Helix MotifsOligonucleotide Array Sequence AnalysisE2F Transcription FactorsGene Expression Regulation, PlantBlotting, WesternProto-Oncogene ProteinsCyclic AMP Response Element-Binding ProteinMice, KnockoutTATA BoxTranscription Factor 7-Like 1 ProteinTumor Cells, CulturedGATA6 Transcription FactorActivating Transcription Factor 4Activating Transcription Factor 1Sequence AlignmentDown-RegulationModels, GeneticDrosophila ProteinsUp-Regulation

E2F5RepressorTranscriptionalInhibitorProteinsGenesRegulateEncodesProteinRegulationCell cyclePromotersSequencesExpressionMotifGeneHaving significantlyMechanismsHigherRiskFunctionDomainCellsGrowthActivationTreatment

E2F52

• In repressors E2F4 and E2F5, pocket protein binding (more often p107 and p130 than pRB) mediates recruitment of repression complexes to silence target genes. (wikipedia.org)
• E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)

Repressor1

• The balance between repressor and activator E2F regulate cell cycle progression. (wikipedia.org)

Transcriptional2

• Moreover, immune infiltrations analysis showed that transcriptional levels and somatic copy number alterations (SCNA) in E2F family were significantly correlated with several immune cell recruitments, including B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, and dendritic cells. (fortunepublish.com)
• We previously found that promoting transcriptional activity of the Class I bHLH factor E47 in highly aggressive PDA cells induced stable growth arrest in vitro and in vivo . (oncotarget.com)

Inhibitor2

• The activation of E2F-3a genes follows upon the growth factor stimulation and the subsequent phosphorylation of the E2F inhibitor retinoblastoma protein, pRB. (wikipedia.org)
• inhibitor of growth family membe. (gsea-msigdb.org)

Proteins4

• Activator E2F proteins can then transcribe S phase promoting genes. (wikipedia.org)
• When activator E2F family proteins are knocked out, repressors become active to inhibit E2F target genes. (wikipedia.org)
• The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
• Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

Genes4

• E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. (wikipedia.org)
• Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
• Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
• Cis-acting DNA sequences which can increase transcription of genes. (lookformedical.com)

Regulate2

• In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
• During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. (oncotarget.com)

Encodes1

• This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. (cancerindex.org)

Protein3

• Schematic diagram of the amino acid sequences of E2F family members (N-terminus to the left, C-terminus to the right) highlighting the relative locations of functional domains within each member: Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database. (wikipedia.org)
• DNA microarray analysis reveals unique sets of target promoters among E2F family members suggesting that each protein has a unique role in the cell cycle. (wikipedia.org)
• The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. (wikipedia.org)

Regulation1

• By binding to pRB, they stop the regulation of E2F transcription factors and drive the cell cycle to enable virus genome replication. (wikipedia.org)

Cell cycle3

• E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway). (wikipedia.org)
• Activators such as E2F1, E2F2, E2F3a promote and help carryout the cell cycle, while repressors inhibit the cell cycle. (wikipedia.org)
• Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)

Promoters1

• Activators are maximally expressed late in G1 and can be found in association with E2F regulated promoters during the G1/S transition. (wikipedia.org)

Sequences1

• DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)

Expression2

• E2F activator levels are cyclic, with maximal expression during G1/S. In contrast, E2F repressors stay constant, especially since they are often expressed in quiescent cells. (wikipedia.org)
• Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)

Motif2

• X-ray crystallographic analysis has shown that the E2F family of transcription factors has a fold similar to the winged-helix DNA-binding motif. (wikipedia.org)
• LIG_RB_pABgroove_1 (LxDLFD), LIG_RB_LxCxE_1 (LxCxE) and LIG_RBL1_LxSxE_2 (LxSxE).The LxDLFD motif binds to a deep groove formed between the A and B subdomains and is present in E2F family transcription factors (E2F1-5). (eu.org)

Gene1

• Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)

Having significantly1

• Women from Bangladesh had a significantly higher pregnancy count, family history of DM and overweight/obese status, despite having significantly lower age, which could be responsible for their higher rates of DM. (bvsalud.org)

Mechanisms1

• This comprehensive review explores the underlying mechanisms of OH, examines numerous factors influencing its development, and provides insights into effective treatment strategies such as hydration, gradual postural changes, leg exercises, compression stockings, and tilt-table training for BPH management. (bvsalud.org)

Higher1

• Higher age, lower education status, higher prior pregnancy count, prior history of GDM, family history of DM, and postpartum overweight/obese status were significantly associated with incident DM. (bvsalud.org)

Risk1

• AIM: To study, the incidence and risk factors for postpartum diabetes (DM), in women with gestational diabetes mellitus (GDM) from South Asia (Bangladesh, India and Sri Lanka), followed for nearly two years after delivery. (bvsalud.org)

Function1

• The E2F family is generally split by function into two groups: transcription activators and repressors. (wikipedia.org)

Domain1

• In activators, E2F binding with pRB has been shown to mask the transactivation domain responsible for transcription activation. (wikipedia.org)

Cells2

• In REF52 cells, overexpression of activator E2F1 is able to push quiescent cells into S phase. (wikipedia.org)
• Aims: The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced apoptosis. (eurekaselect.com)

Growth1

• growth factor receptor bound pro. (gsea-msigdb.org)

Activation1

• The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)

Treatment1

• Similar trend was observed in MCF-7 whereby TZT treatment down-regulated the anti-apoptotic catalase and PON2, increased the proapoptotic, B cell lymphoma 2 (Bcl-2)-associated agonist of cell death (Bad) and Bcl-2-associated X (Bax), second mitochondria-derived activator of caspase (SMAC) and HtrA serine peptidase 2 (HTRA2) as well as TRAIL receptors (TRAIL R1 and TRAIL R2). (eurekaselect.com)